Pathogenesis of adenomyosis, an update on molecular mechanisms
Open accessAbstract
Adenomyosis is a uterine disorder becoming more commonly diagnosed in women of reproductive age because of diagnostic imaging advancements. The new epidemiological scenario and the clinical evidence of pelvic pain, abnormal uterine bleeding and infertility are changing the classic perspective of adenomyosis as a premenopausal disease. In the last decade, the evaluation of multiple molecular mediators has improved our knowledge of pathogenic mechanisms of adenomyosis, supporting that this is an independent disease from endometriosis. Although they share common genetic mutations and epigenetic changes in sex steroid hormone receptors and similar inflammatory mediators, an increasing number of recent studies have shown pathogenic pathways specific for adenomyosis. A PubMed search up to October 2016 summarizes the key mediators of pain, abnormal uterine bleeding and infertility in adenomyosis, including sex steroid hormone receptors, inflammatory molecules, extracellular matrix enzymes, growth factors and neuroangiogenic factors.
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Adenomyosis is a common gynecologic disorder with poorly understood pathogenesis and pathophysiology.
“Adenomyosis, defined as the presence of endometrial glands and stroma infiltrated deep and haphazardly into the myometrium [1], is a common gynecologic disorder with poorly understood pathogenesis and pathophysiology [2,3,4].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [3]
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Yalaza, C., Canacankatan, N., Gürses, İ., Aytan, H., & Taşdelen, B. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05742-9 · Cited by 19 · see citing works
Unveiling the Pathogenesis of Adenomyosis through Animal Models
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Self-citationThe challenge of endometriosis for female sexual health
Vannuccini, S., Maseroli, E., Vignozzi, L., & Petraglia, F. (2023) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdad004 · Cited by 18 · see citing works
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Adenomyosis: Disease, uterine aging process leading to symptoms, or both?
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- Authors
- Vannuccini, S., Tosti, C., Carmona, F., Huang, S. J., Chapron, C., Guo, S.-W., & Petraglia, F.
- Affiliations
- University of Siena (IT)
- Hospital Clínic de Barcelona (ES)
- Inserm (FR)
- Fudan University (CN)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Corresponding author
- Petraglia, Felice
- ORCID
- Venue
- Reproductive BioMedicine Online
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 35
- Issue
- 5
- Pages
- 592-601
- ISSN
- 1472-6483 (ISSN-L)
- OpenAlex
- W2733336491
- Cited by
- 326
- References
- 114
- Citations by year
- 2026: 31 · 2025: 40 · 2024: 42 · 2023: 44 · 2022: 46 · 2021: 46 · 2020: 49 · 2019: 19 · 2018: 7 · 2017: 1
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Reproductive BioMedicine Online (publishedVersion)
- PubMed (publishedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Keywords
- adenomyosis, pathogenesis, molecular mechanisms, sex hormone receptors, inflammatory mediators, growth factors, pelvic pain, abnormal uterine bleeding, infertility, endometriosis, epigenetic modifications
- MeSH terms
- Adult, Female, Humans, Middle Aged, Adenomyosis
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