The DOI matches its Crossref record; 104 of the 111 references it cites were found in a registry or an index; none of the 111 sources its claims cite is checked for support yet.
Complementary and alternative medicine therapies for perinatal depression
Open accessAbstract
Complementary and alternative medicine therapies are increasingly sought out by people with psychiatric disorders. In this chapter, we review the evidence for several commonly used CAM therapies (i.e. omega-3 fatty acids, folate, S-adenosyl-methionine, St John's Wort, bright light therapy, exercise, massage, and acupuncture) in the treatment of perinatal depression. A number of these treatments may be reasonable to consider for women during pregnancy or postpartum, but the safety and efficacy of these relative to standard treatments must still be systematically determined. Evidence-based use of complementary and alternative medicine therapies treatments for perinatal depression is discussed. Adequately powered systematic studies are necessary to determine the role of complementary and alternative medicine therapies in the treatment of perinatal depression.
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Claims the paper makes
72 Not checked yet · 9 Own interpretation · 1 Own result
None of the sources cited for this claim have been checked yet.
In the paper
“they are best studied as an augmentation treatment [23-25] rather than monotherapy [26].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > OMEGA-3 FATTY ACIDS
What the sources say
- Not checked yetcites [23] Su, 2003, Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial, Eur Neuropsychopharmacol source
- Not checked yetcites [24] Nemets, 2002, Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder, Am J Psychiatry source
- Not checked yetcites [25] Kumar, 1984, A prospective study of emotional disorders in childbearing women, Br J Psychiatry source
- Not checked yetcites [26] Freeman, 2006, Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry, J Clin Psychiatry source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Untreated depression during pregnancy poses risks to the mother and baby, including obstetrical and neonatal complications [3-8].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > Abstract
What the sources say
- Not checked yetcites [3] Bodnar, 2009, Prepregnancy body mass index, gestational weight gain, and the likelihood of major depressive disorder during pregnancy, J Clin Psychiatry source
- Not checked yetcites [4] Britton, 2011, Infant temperament and maternal anxiety and depressed mood in the early postpartum period, Women Health source
- Not checked yetcites [5] Chung, 2001, Antepartum depressive symptomatology is associated with adverse obstetric and neonatal outcomes, Psychosom Med source
- Not checked yetcites [6] Cripe, 2011, Risk of preterm delivery and hypertensive disorders of pregnancy in relation to maternal co-morbid mood and migraine disorders during pregnancy, Paediatr Perinat Epidemiol source
- Not checked yetcites [7] Grote, 2010, A meta-analysis of depression during pregnancy and the risk of preterm birth, low birth weight, and intrauterine growth restriction, Arch Gen Psychiatry source
- Not checked yetcites [8] Jablensky, 2005, Pregnancy, delivery, and neonatal complications in a population cohort of women with schizophrenia and major affective disorders, Am J Psychiatry source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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In the paper
“increased risk of developmental delay and lower IQ scores [12]”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > Abstract
What the sources say
- Not checked yetcites [12] Lindahl, 2005, Prevalence of suicidality during pregnancy and the postpartum, Arch Womens Ment Health source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“In a recent UK study, more than a quarter of women reported use of a CAM during pregnancy [14].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > Abstract
What the sources say
- Not checked yetcites [14] Wu, 2007, Use of complementary and alternative medicine among women with depression: results of a national survey, Psychiatr Serv source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Meta-analyses of randomized controlled trials demonstrate a statistically significant antidepressant benefit of omega-3 fatty acids in mood disorders overall”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > OMEGA-3 FATTY ACIDS
What the sources say
- Not checked yetcites [23] Su, 2003, Omega-3 fatty acids in major depressive disorder. A preliminary double-blind, placebo-controlled trial, Eur Neuropsychopharmacol source
- Not checked yetcites [24] Nemets, 2002, Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder, Am J Psychiatry source
- Not checked yetcites [25] Kumar, 1984, A prospective study of emotional disorders in childbearing women, Br J Psychiatry source
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
In the paper
“In one small prospective observational study women who were (N=33) treated with hypericum while breastfeeding their infants, increased rates of adverse events in infants were reported, such as colic, drowsiness, and lethargy, compared to infants of matched depressed and non-depressed controls [61].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ST. JOHN’S WORT (HYPERICUM PERFORATUM)
What the sources say
- Not checked yetcites [61] Lee, 2003, The safety of St John's wort (Hypericum perforatum) during breastfeeding, J Clin Psychiatry source
plaindirectn = 33- Asserted: passes — The authors put it forward as true.
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In the paper
“Limited data in 54 human pregnancies indicated no increased risk of major malformations or prematurity rate for infants born to women taking St. John’s Wort during pregnancy and matched controls [59].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ST. JOHN’S WORT (HYPERICUM PERFORATUM)
What the sources say
- Not checked yetcites [59] Moretti, 2009, Evaluating the safety of St. John's Wort in human pregnancy, Reprod Toxicol source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Most, but not all [62], studies demonstrate that bright light therapy is an efficacious, first-line treatment for both seasonal and non-seasonal MDD [63,64].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > BRIGHT LIGHT THERAPY
What the sources say
- Not checked yetcites [63] Eastman, 1998, Bright light treatment of winter depression: a placebo-controlled trial, Arch Gen Psychiatry source
- Not checked yetcites [64] Golden, 2005, The efficacy of light therapy in the treatment of mood disorders: a review and meta-analysis of the evidence, Am J Psychiatry source
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“Other studies have provided promising preliminary data regarding feasibility, tolerability, and efficacy in perinatal depression [36,37].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > OMEGA-3 FATTY ACIDS
What the sources say
- Not checked yetcites [36] Freeman, 2006, An open trial of omega-3 fatty acids for depression in pregnancy, Acta Neuropsychiatr source
- Not checked yetcites [37] Kendrick, 2008, A longitudinal study of blood folate levels and depressive symptoms among young women in the Southampton Women's Survey, J Epidemiol Community Health source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“There have been no studies published on the efficacy of folate monotherapy or augmentation therapy for perinatal depression.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > FOLATE
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Probably not a substantial claim. 11
- It may state two separate claims as one. 23
In the paper
“In general, women use CAM treatments more frequently than men, and are also more likely to suffer from disorders such as MDD and anxiety disorders, for which CAM treatments are commonly pursued [15].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > COMPLIMENTARY & ALTERNATIVE MEDICINE
What the sources say
- Not checked yetcites [15] Barnes, 2009, Complementary and alternative medicine use among adults and children: United States, 2007, Natl Health Stat Report
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“maternal suicide accounts for up to 20% of postnatal deaths in depressed women [13].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > Abstract
What the sources say
- Not checked yetcites [13] Bishop, 2011, The use of complementary and alternative medicine in pregnancy: data from the Avon Longitudinal Study of Parents and Children (ALSPAC), Complement Ther Med source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“attachment insecurity [11]”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > Abstract
What the sources say
- Not checked yetcites [11] Deave, 2008, The impact of maternal depression in pregnancy on early child development, BJOG source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“In general, women use CAM treatments more frequently than men, and are also more likely to suffer from disorders such as MDD and anxiety disorders, for which CAM treatments are commonly pursued [15].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > COMPLIMENTARY & ALTERNATIVE MEDICINE
What the sources say
- Not checked yetcites [15] Barnes, 2009, Complementary and alternative medicine use among adults and children: United States, 2007, Natl Health Stat Report
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Despite the growing prevalence of CAM use, the number of adequately powered, well-designed randomized clinical trials of CAM treatments is limited.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > COMPLIMENTARY & ALTERNATIVE MEDICINE
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Depression during pregnancy is a major risk factor for postnatal depression [9].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > Abstract
What the sources say
- Not checked yetcites [9] Gotlib, 1991, Prospective investigation of postpartum depression: factors involved in onset and recovery, J Abnorm Psychol source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Omega-3 fatty acids are essential fatty acids with well-established health benefits and particular benefits for obstetrical outcomes and infant development [17,18].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > OMEGA-3 FATTY ACIDS
What the sources say
- Not checked yetcites [17] McGregor, 2001, The omega-3 story: nutritional prevention of preterm birth and other adverse pregnancy outcomes, Obstet Gynecol Surv source
- Not checked yetcites [18] Koletzko, 2008, The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations, J Perinat Med source
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“including difficult infant and childhood temperament [10]”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > Abstract
What the sources say
- Not checked yetcites [10] Forman, 2007, Effective treatment for postpartum depression is not sufficient to improve the developing mother-child relationship, Dev Psychopathol source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Omega-3 fatty acids are among the most commonly used CAM treatments in the United States (U.S.) [16].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > OMEGA-3 FATTY ACIDS
What the sources say
- Not checked yetcites [16] Hibbeln, 2007, Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study, Lancet source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Folate has been studied in a placebo-controlled trial an adjunctive treatment to fluoxetine, with significantly greater improvement in the folate group, a difference most pronounced in women [43].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > FOLATE
What the sources say
- Not checked yetcites [43] Papakostas, 2012, l-Methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials, Am J Psychiatry source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“St. John’s Wort, at a daily dosage of 300-1200mg, had an advantage over placebo and efficacy similar to tricyclic or SSRI antidepressants, with better efficacy than the standard antidepressant in a subgroup of patients with mild to moderate depression [55].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ST. JOHN’S WORT (HYPERICUM PERFORATUM)
What the sources say
- Not checked yetcites [55] Murphy, 2005, Interaction of St John's Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding, Contraception source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Several placebo-controlled RCTs and two meta-analyses found SAMe, studied in doses of 200-1600mg per day, significantly more efficacious than placebo and equivalent to tricyclic antidepressants, in the treatment of depression, while a couple of studies report it equivalent to placebo [48-50].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > S-ADENOSYL L-METHIONINE (SAMe)
What the sources say
- Not checked yetcites [48] Bressa, 1994, S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies, Acta Neurol Scand Suppl source
- Not checked yetcites [49] Hardy, 2002
- Not checked yetcites [50] Papakostas, 2010, S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial, Am J Psychiatry source
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
In the paper
“There were fewer very preterm births (<34 weeks’ gestation) in the DHA group compared with the control group but more post-term births requiring obstetric intervention in the DHA group compared with the control group.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > OMEGA-3 FATTY ACIDS
What the sources say
- Not checked yetcites [34] Su, 2008, Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial, J Clin Psychiatry source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“depressive symptoms, measured by the Edinburgh Postnatal Depression Scale (EPDS) at 6 weeks and 6 months postnatally did not differ between groups, nor did neurodevelopmental outcomes of their offspring differ at 18 months age [34].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > OMEGA-3 FATTY ACIDS
What the sources say
- Not checked yetcites [34] Su, 2008, Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial, J Clin Psychiatry source
plainn = 2,399- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“It appears to be excreted into breast milk at undetectable to low levels, comparable to other antidepressants and its bioactive components at or below the limit of quantification in infant plasma [60].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ST. JOHN’S WORT (HYPERICUM PERFORATUM)
What the sources say
- Not checked yetcites [60] Klier, 2006, St John's wort (Hypericum perforatum) and breastfeeding: plasma and breast milk concentrations of hyperforin for 5 mothers and 2 infants, J Clin Psychiatry source
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Bright light therapy is generally well tolerated, although there is a risk of induction of mania in individuals with bipolar disorder [64,65].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > BRIGHT LIGHT THERAPY
What the sources say
plainconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Few studies have investigated the safety of St. John’s Wort during the perinatal period, and no published RCTs have evaluated efficacy or safety in perinatal depression.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ST. JOHN’S WORT (HYPERICUM PERFORATUM)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“improvement was found with 15mg per day but not the 7.5 mg per day dose [44].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > FOLATE
What the sources say
- Not checked yetcites [44] Inskip, 2009, Women's compliance with nutrition and lifestyle recommendations before pregnancy: general population cohort study, BMJ source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Current evidence may support the use of 1-9 g supplement of EPA + DHA daily for patients with mood disorders, though use of greater than 3 g daily should be monitored by a physician due to the risk of bleeding [27].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > OMEGA-3 FATTY ACIDS
What the sources say
- Not checked yetcites [27] Golding, 2009, High levels of depressive symptoms in pregnancy with low omega-3 fatty acid intake from fish, Epidemiology source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Results from the individual studies were mixed with a more robust effect seen in patients with mild to moderate depressive symptoms and less evidence of effectiveness in severe MDD.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ST. JOHN’S WORT (HYPERICUM PERFORATUM)
What the sources say
- Not checked yetcites [54] Roder, 2004, Meta-analysis of effectiveness and tolerability of treatment of mild to moderate depression with St. John's Wort [in German], Fortschr Neurol Psychiatr
- Not checked yetcites [55] Murphy, 2005, Interaction of St John's Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding, Contraception source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“A smaller study of electroacupuncture compared to sham acupuncture for the treatment of postnatal depression demonstrated that both treatments were associated with improvement in depression symptoms, with no between-group difference in outcome measures [97].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ACUPUNCTURE
What the sources say
- Not checked yetcites [97] Chung, 2012, Randomized non-invasive sham-controlled pilot trial of electroacupuncture for postpartum depression, J Affect Disord source
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“An 8-week “Mother and Baby” program, including exercise, was associated with lower EPDS scores in the intervention group at study end, but between-group significance was lost at follow up one month later [80].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > EXERCISE
What the sources say
- Not checked yetcites [80] Norman, 2010, An exercise and education program improves well-being of new mothers: a randomized controlled trial, Phys Ther source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In participants who received at least three weeks of bright light therapy, depression scores improved by a mean of 49%; among participants who completed at least five weeks, scores improved by 59%. No significant side effects were reported, except treatment-related nausea.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > BRIGHT LIGHT THERAPY
What the sources say
- Not checked yetcites [66] Oren, 2002, An open trial of morning light therapy for treatment of antepartum depression, Am J Psychiatry source
plaincorrelationaln = 16- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Bright light therapy produced a significantly greater antidepressant response than dim light, with significant differences at the end of the extension phase. One participant who received bright light therapy experienced hypomania, which resolved upon reduction of the duration of daily light exposure.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > BRIGHT LIGHT THERAPY
What the sources say
- Not checked yetcites [67] Epperson, 2004, Randomized clinical trial of bright light therapy for antepartum depression: preliminary findings, J Clin Psychiatry source
plaindirectn = 10- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Additionally, establishing a truly blinded placebo condition for acupuncture research is challenging.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ACUPUNCTURE
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“epidemiological data suggest that regular exercise is associated with decreased risk of depressive symptoms [72], although not all trials have consistently demonstrated benefit [73].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > EXERCISE
What the sources say
- Not checked yetcites [72] Strawbridge, 2002, Physical activity reduces the risk of subsequent depression for older adults, Am J Epidemiol source
- Not checked yetcites [73] Chalder, 2012, A pragmatic randomised controlled trial to evaluate the cost-effectiveness of a physical activity intervention as a treatment for depression: the treating depression with physical activity (TREAD) trial, Health Technol Assess source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Because acupuncture is often practiced in the context of other cultural practices, it is difficult to assess through the lens of Western medicine, as diagnostic and symptom assessments may not be standardized across studies and acupuncture techniques may vary across sites and studies.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ACUPUNCTURE
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Support for its neuroendocrine effects include demonstration of message to decrease salivary and urinary cortisol levels and increase urinary serotonin and dopamine levels over the therapy period [84].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > MASSAGE
What the sources say
- Not checked yetcites [84] Field, 2005, Cortisol decreases and serotonin and dopamine increase following massage therapy, Int J Neurosci source
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“bright light was associated with a greater reduction of depressive symptoms, with 81.3% of women receiving bright light experiencing ≥50% reduction in symptoms as compared to 45.5% who received placebo dim light. The treatment was tolerated well, without adverse effects reported [68].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > BRIGHT LIGHT THERAPY
What the sources say
- Not checked yetcites [68] Wirz-Justice, 2011, A randomized, double-blind, placebo-controlled study of light therapy for antepartum depression, J Clin Psychiatry source
plaincorrelationaln = 27- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Some acupuncture points have been reported to hasten cervical ripening at term and advance labour and delivery [94].”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > ACUPUNCTURE
What the sources say
- Not checked yetcites [94] Gaudet, 2008, Effectiveness of acupuncture for the initiation of labour at term: a pilot randomized controlled trial, J Obstet Gynaecol Can source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Both groups experienced significant improvement from baseline, without differences in response.”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > BRIGHT LIGHT THERAPY
What the sources say
- Not checked yetcites [69] Corral, 2007, Morning light therapy for postpartum depression, Arch Womens Ment Health source
plainn = 15- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper relies on this without support.
Omega-3 supplements are well tolerated by perinatal women and free of significant mercury or other contaminants.
“Omega-3 fatty acid supplements have been well tolerated by perinatal women and appear free of significant levels of mercury or other contaminants.”
The paper relies on this without support.
SAMe is generally well tolerated with infrequent mild side effects.
“SAMe is generally well tolerated, with infrequently reported side effects that include mild gastrointestinal symptoms, sweating, dizziness, irritability and anxiety.”
The paper relies on this without support.
St John's Wort may interact with oral contraceptives, reducing oestrogen plasma concentration and effectiveness.
“St. John’s Wort may interact with medications including oral contraceptives, reducing oestrogen plasma concentration and effectiveness.”
The paper relies on this without support.
Mood episodes are highly prevalent during pregnancy and the postpartum in the course of bipolar disorder, even if not previously diagnosed.
“Considering the high prevalence of mood episodes during pregnancy and the postpartum in the course of bipolar disorder, even if not previously diagnosed”
The paper relies on this without support.
Women often discontinue antidepressant treatment during attempts to conceive or during pregnancy.
“women often discontinue antidepressant treatment during attempts to conceive or during pregnancy.”
The paper relies on this without support.
Dietary intake of omega-3 fatty acids by perinatal women in the United States and United Kingdom is deficient.
“dietary intake by perinatal women in the U.S. and U.K. has been noted as deficient”
The paper relies on this without support.
Exercise is integral to optimal health in pregnancy and to prevention of heart disease, obesity, and diabetes, which are more common in people with MDD than in the general population.
“Exercise is integral to optimal health in pregnancy, as well as in the prevention of heart disease, obesity and diabetes, comorbid conditions that those with MDD are more likely than the general population to develop.”
The paper relies on this without support.
St John's Wort contains high concentrations of hyperforin, which induces CYP3A4 and inhibits a membrane-bound transporter that facilitates transport across the intestinal lumen and the blood-brain barrier.
“St. John’s Wort contains high concentrations of the bioactive component hyperforin which induces the cytochrome P450 system (CYP3A4) and inhibits a membrane-bound transporter that facilitates transport across the intestinal lumen and the blood-brain barrier.”
The paper relies on this without support.
The MTHFR enzyme is affected by a polymorphism common in patients with depression that impairs transformation to L-methylfolate and is associated with MDD.
“however this enzyme is affected by a polymorphism common in patients with depression which impairs transformation to L-methylfolate and is associated with MDD.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Reasons for use of these approaches include motivation to have greater control over childbearing experiences and concerns about the risks to their infants from using pharmaceuticals to treat depression.46,47,49”
From Perinatal Depression: Challenges and Opportunities (2021) · cites this paper as [49]
In the citing paper
“However, concerns have been raised about the use of these approaches for which the evidence for full efficacy and safety remains limited.49”
From Perinatal Depression: Challenges and Opportunities (2021) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > COMPLIMENTARY & ALTERNATIVE MEDICINE
“we have reviewed the following seven CAM therapies”
§ Complementary and Alternative Medicine Therapies for Perinatal Depression > COMPLIMENTARY & ALTERNATIVE MEDICINE
“omega-3 fatty acids, folate, S-adenosyl-methionine, St. John’s Wort, bright light therapy, exercise, massage and acupuncture.”
Citations
Cites
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
Lang, U. E., & Borgwardt, S. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350094 · Cited by 8,526
Yatham, L. N., & Malhi, G. S. (2011) · Oxford University Press eBooks · doi:10.1093/med/9780199562305.001.0001 · Cited by 3,515
Perinatal Depression: A Systematic Review of Prevalence and Incidence
Gavin, N. I., Gaynes, B. N., Lohr, K. N., Meltzer-Brody, S., Gartlehner, G., & Swinson, T. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000183597.31630.db · Cited by 3,282
Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007
Barnes, P. M., Bloom, B. E., & Nahin, R. L. (2008) · PsycEXTRA Dataset · doi:10.1037/e623942009-001 · Cited by 3,144
Grote, N. K., Bridge, J. A., Gavin, A. R., Melville, J. L., Iyengar, S., & Katon, W. J. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.111 · Cited by 1,882
(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.7.979 · Cited by 1,485 · cited 1×
“The lifetime prevalence of major depressive disorder (MDD) is about twice as high in women as compared to men [1].”
BackgroundEFSA Panel on Dietetic Products, N. (2010) · EFSA Journal · doi:10.2903/j.efsa.2010.1461 · Cited by 1,353
Lawlor, D. A., & Hopker, S. W. (2001) · BMJ · doi:10.1136/bmj.322.7289.763 · Cited by 995
Hibbeln, J. R., Davis, J. M., Steer, C., Emmett, P., Rogers, I., Williams, C., & Golding, J. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60277-3 · Cited by 987
A Prospective Study of Emotional Disorders in Childbearing Women
Kumar, R., & Robson, K. M. (1984) · British Journal of Psychiatry · doi:10.1192/bjp.144.1.35 · Cited by 980
Cited by
Sorted by citations
Stewart, D. E., & Vigod, S. (2016) · New England Journal of Medicine · doi:10.1056/nejmcp1607649 · Cited by 500
Postpartum psychiatric disorders
Meltzer-Brody, S., Howard, L. M., Bergink, V., Vigod, S., Jones, I., Munk-Olsen, T., Honikman, S., & Milgrom, J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.22 · Cited by 357
Perinatal Depression: Challenges and Opportunities
Dagher, R. K., Bruckheim, H. E., Colpe, L. J., Edwards, E., & White, D. B. (2021) · Journal of Women's Health · doi:10.1089/jwh.2020.8862 · Cited by 285
“However, concerns have been raised about the use of these approaches for which the evidence for full efficacy and safety remains limited.(49) Additional research involving more rigorous study designs with larger, diverse samples compared to more conventional psychotherapies and pharmacotherapies and research to unders…”
BackgroundPerinatal Depression: An Update and Overview
Stuart-Parrigon, K. L., & Stuart, S. P. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0468-6 · Cited by 178
“3 Please see Deligiannidis and Freeman (2014) “Complementary and alternative treatments for perinatal depression” for a detailed description of these therapies [45].”
BackgroundPearlstein, T. B. (2015) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2015.04.004 · Cited by 149
Batt, M. M., Duffy, K. A., Novick, A. M., Metcalf, C. A., & Epperson, C. N. (2020) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20190045 · Cited by 157
Identification and Management of Peripartum Depression.
Langan, R. C., & Goodbred, A. J. (2016) · PubMed · Cited by 101
Frawley, J., Adams, J., Steel, A., Broom, A. F., Gallois, C., & Sibbritt, D. W. (2015) · Women s Health Issues · doi:10.1016/j.whi.2015.03.001 · Cited by 78
“Some authors have voiced concern about the use of St. John’s wort during pregnancy (Deligiannidis & Freeman, 2014); however, an observational study has shown no differences in major malformations, live birth, and prematurity rates between women who used St. John’s wort, women who used a…”
BackgroundPharmacotherapy of postpartum depression: an update
Kim, D. R., Epperson, C. N., Weiss, A. R., & Wisner, K. L. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.911842 · Cited by 80
“Thought to increase inflammatory dysregulation, low levels of DHA have been associated with increased rates of PPD in some [64-66] but not all studies [67-69].”
A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.
Berardis, D. D., Orsolini, L., Serroni, N., Girinelli, G., Iasevoli, F., Tomasetti, C., de Bartolomeis, A., Mazza, M., Valchera, A., Fornaro, M., et al. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150821103825 · Cited by 74
The effect of music, massage, yoga and exercise on antenatal depression: A meta-analysis
Zhu, Y., Wang, R., Tang, X., Li, Q., Xu, G., & Zhang, A. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.05.122 · Cited by 68
Massage Therapy for Psychiatric Disorders
Rapaport, M. H., Schettler, P. J., Larson, E. R., Carroll, D., Sharenko, M., Nettles, J. H., & Kinkead, B. L. (2018) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20170043 · Cited by 63
Hamel, C., Lang, E., Morissette, K., Beck, A., Stevens, A., Skidmore, B., Colquhoun, H., LeBlanc, J., Moore, A., Riva, J. J., et al. (2019) · Systematic Reviews · doi:10.1186/s13643-018-0930-3 · Cited by 55
“peer support, non-directive counselling and self-care such as exercise), psychological therapies, and antidepressant medications [36, 37].”
BackgroundBirdee, G. S., Kemper, K. J., Rothman, R. L., & Gardiner, P. M. (2014) · Journal of Women s Health · doi:10.1089/jwh.2013.4568 · Cited by 57
“CAM therapies are also frequently used for mood disorders in the general population,(1) though the role of CAM for women suffering postpartum depression is not clear.(16) With the effects of many CAM modalities on maternal and fetal health unknown, patterns of CAM utilization during pregnancy and after delivery are im…”
Zhu, Y., Li, S.-L., Zhu, C., Wang, W., Zuo, W.-F., & Qiu, X. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112832 · Cited by 49
Eustis, E. H., Ernst, S., Sutton, K., & Battle, C. L. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1121-1 · Cited by 45
Psychotherapeutic Treatments for Depression During Pregnancy
Genovez, M., Vanderkruik, R. C., Lemon, E. L., & Dimidjian, S. (2018) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000388 · Cited by 40
Perinatal anxiety: approach to diagnosis and management in the obstetric setting
Thorsness, K. R., Watson, C., & LaRusso, E. M. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.05.017 · Cited by 45
Perinatal depression: Heterogeneity of disease and in animal models
Qiu, W., Hodges, T. E., Clark, E. L., Blankers, S. A., & Galea, L. A. M. (2020) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2020.100854 · Cited by 39
Trim the fat: the role of omega-3 fatty acids in psychopharmacology
Nasir, M., & Bloch, M. H. (2019) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125319869791 · Cited by 38
Bosch, P., van den Noort, M., Staudte, H., & Lim, S. (2015) · EXPLORE · doi:10.1016/j.explore.2015.04.004 · Cited by 35
“During the last two decades, the use of complementary and alternative medicine (CAM), including acupuncture,(12) as an add‐on treatment in Western medicine(13) has been on the rise, especially among psychiatric patients.(14,15) CAM is particularly used in the treatment of depression.”
BackgroundA systematic review of acupuncture and Chinese herbal medicine for postpartum depression
Yang, L., Di, Y. M., Shergis, J. L., Li, Y., Zhang, A. L., Lu, C., Guo, X., & Xue, C. C. (2018) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2018.08.006 · Cited by 34
Eggart, M., Queri, S., & Müller-Oerlinghausen, B. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.05.004 · Cited by 30
“therapy have also been shown in the perinatal period [27,28].”
BackgroundPeripartum depression: Early recognition improves outcomes
Howard, M. M., Mehta, N. D., & Powrie, R. O. (2017) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.84a.14060 · Cited by 30
S‐Adenosyl Methionine in the Therapy of Depression and Other Psychiatric Disorders
Kuželički, N. K. (2016) · Drug Development Research · doi:10.1002/ddr.21345 · Cited by 29
Precision medicine in perinatal depression in light of the human microbiome
Bernabé, B. P., Maki, P. M., Dowty, S. M., Salas, M. L. C., Cralle, L. E., Shah, Z., & Gilbert, J. A. (2020) · Psychopharmacology · doi:10.1007/s00213-019-05436-4 · Cited by 26
“Probiotics and other nutritional supplements Limited evidence suggests that some natural supplements, such as omega-3 fatty acids, can reduce perinatal depressive symptoms (Deligiannidis and Freeman 2014; Leung and Kaplan 2009).”
BackgroundPietrantoni, E., CHIERICO, F. D., Rigon, G., Vernocchi, P., Salvatori, G., Manco, M., Signore, F., & Putignani, L. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15058024 · Cited by 23
“, fish consumption) with higher rates of anti-depressive therapy up to one year postnatally [42,43], resulting in social behaviour development difficulties of the related infants [42,44].”
BackgroundToler, S., Stapleton, S. R., Kertsburg, K., Callahan, T. J., & Hastings‐Tolsma, M. (2018) · Midwifery · doi:10.1016/j.midw.2018.03.016 · Cited by 29
Gökşin, İ., & Ayaz‐Alkaya, S. (2020) · Stress and Health · doi:10.1002/smi.2921 · Cited by 24
Efficacy of nondrug interventions in perinatal depression: A meta-analysis
Jiang, X., Li, H., Wang, D., Shan, L., Wang, F., & Kang, Y. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114916 · Cited by 22
(2019) · doi:10.1016/j.heliyon.2019.e02787 · Cited by 22
“It is also known to be used for perinatal mental health problems and for pain relief during labour [9, 10].”
BackgroundTextbook of Women’s Reproductive Mental Health
(2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545 · Cited by 22
Massage During Pregnancy and Postpartum
Pachtman, S. L., & Fogarty, S. (2021) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000638 · Cited by 19
A Literature Review of Alternative Therapies for Postpartum Depression
Nguyen, J. (2017) · Nursing for Women s Health · doi:10.1016/j.nwh.2017.07.003 · Cited by 19
Nonpharmacologic Treatments for Depression Related to Reproductive Events
Brandon, A. R., Crowley, S. K., Gordon, J. L., & Girdler, S. S. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0526-0 · Cited by 15
Perspectives from Patients and Healthcare Providers on the Practice of Maternal Placentophagy
Schuette, S., Brown, K. M., Cuthbert, D., Coyle, C. W., Wisner, K. L., Hoffman, M. C., Yang, A., Ciolino, J. D., Newmark, R. L., & Clark, C. T. (2016) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2016.0147 · Cited by 13
Geary, O., Grealish, A., & Bright, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0294156 · Cited by 21
Acupuncture for Major Depressive Disorder: A Systematic Review
Sorbero, M. E. S., Reynolds, K. A., Colaiaco, B., Lovejoy, S. L., Farris, C. A., Vaughan, C., Sloan, J., Kandrack, R., Apaydin, E. A., & Herman, P. M. (2015) · Rand health quarterly · doi:10.7249/rhq-05-04-07 · Cited by 11
Effect of Yoga on Postpartum Depression: A Randomized controlled trial
reyad, M., Refaye, G. E. E., awad, M., & gabr, A. (2022) · Egyptian Journal of Physical Therapy · doi:10.21608/ejpt.2021.80875.1044 · Cited by 10
“Ladies with sadness may lock in complementary intercessions for a few reasons: a desire for a characteristic approach with negligible side impacts, arrangement with individual convictions, and encountering challenges with conventional medicines (6).”
Background(2019) · doi:10.26911/thejmch.2019.04.02.07 · Cited by 10
“Pregnant women who have psychological problems prefer complementary therapy to pharmacological therapy because they have minimal and easy side effects to do (Labor and Maguire, 2008; Deligiannidis and Freeman, 2014;).”
BackgroundColombo, A., Cafaro, R., Bernardo, I. D., Mereghetti, M., Cerolini, L., Giacovelli, L., Giorgetti, F., Vanzetto, S., Girone, N., Savasi, V. M., et al. (2023) · International Clinical Psychopharmacology · doi:10.1097/yic.0000000000000520 · Cited by 10
“…CYP2D6 and CYP2C9 enzymes, whose overexpression during pregnancy is responsible for the increased metabolism of some psychotropic drugs, suggesting that many pregnant women on antidepressants may require dose increases to maintain euthymia (Deligiannidis and Freeman, 2014; Feghali et al., 2015).”
BackgroundWang, C., Kennedy, J. J., & Wu, C. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.01.014 · Cited by 10
Experience of postpartum depression among Chinese women: A meta-synthesis of qualitative research
Xiao, G., Hu, J., Wang, H., Li, Q., Peng, S., Qin, C., & Li, Y. (2023) · Midwifery · doi:10.1016/j.midw.2023.103795 · Cited by 9
Schieffler, D. A., & Matta, S. E. (2021) · Military Medicine · doi:10.1093/milmed/usab130 · Cited by 10
Complementary health approaches for postpartum depression: A systematic review
McCloskey, R. J., & Reno, R. (2018) · Social Work in Mental Health · doi:10.1080/15332985.2018.1509412 · Cited by 10
“This study demonstrates the pressing need for additional research to measure the extent to which CHA are safe and effective (Deligiannidis & Freeman, 2014), to ensure social work and medical practice with postpartum women is evidence-based.”
BackgroundPerinatal Mood and Anxiety Disorders: Research and Implications for Nursing Care
Beck, C. T. (2021) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1016/j.jogn.2021.02.007 · Cited by 8
Investigation of the embryotoxic and teratogenic effect of Hypericum perforatum in pregnant rats
Kahyaoğlu, F., Gökçımen, A., & Demirci, B. (2018) · Journal of Turkish Society of Obstetric and Gynecology · doi:10.4274/tjod.84429 · Cited by 8
“As in all herbal medicines, HP is considered innocuous and widely used against depression, and even women who are pregnant or lactating are also exposed to HP(6).”
BackgroundA Pilot Study of Partner Chair Massage Effects on Perinatal Mood, Anxiety, and Pain
Robin B. Thomas, L. (2019) · International Journal of Therapeutic Massage & Bodywork Research Education & Practice · doi:10.3822/ijtmb.v12i2.437 · Cited by 8
St John’s wort (Hypericum perforatum L)
Coppock, R. W., & Dziwenka, M. M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821038-3.00040-9 · Cited by 7
Perinatal Depression Treatment Guidelines for Obstetric Providers
Higgins, N. E., Rose, M. J., Gardner, T. J., & Crawford, J. N. (2023) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2023.03.009 · Cited by 7
Racial and Ethnic Variation in Complementary and Integrative Health Therapy Use Among US Veterans
Tobin, J. L., Zeliadt, S. B., Upchurch, D. M., DeFaccio, R., Douglas, J. H., Gelman, H. M., Hawrilenko, M., Frochen, S., McGinty, N. K., Resnick, A., et al. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.18020 · Cited by 7
Behandlung psychischer Störungen in Schwangerschaft und Stillzeit
Kittel-Schneider, S., & Reif, A. (2016) · Der Nervenarzt · doi:10.1007/s00115-016-0177-y · Cited by 5
Evidence‐Based Treatments and Pathways to Care
O’Hara, M. W., Dennis, C., McCabe, J. E., & Galbally, M. (2015) · Wiley eBooks · doi:10.1002/9781118509722.ch11 · Cited by 7
Tuina plus acupuncture for post-stroke depression
Meng, M., Hu, G., Yang, K., Wang, H., Han, Y., Pan, T. J., Lou, H., Zhang, Y., Wang, Y., & Cong, D. (2021) · Medicine · doi:10.1097/md.0000000000026013 · Cited by 6
Perinatal Dönem Ruh Sağlığı Sorunları ve Hemşirelik Yaklaşımı
Beji, N. K., Murat, M., & Köse, S. (2021) · Black Sea Journal of Health Science · doi:10.19127/bshealthscience.897439 · Cited by 5
St. John’s Wort accelerates the liver clearance of technetium-99-sestamibi in rats
Mohammadinia, S., Abedi, S. M., & Noaparast, Z. (2018) · Nuclear Medicine Communications · doi:10.1097/mnm.0000000000000880 · Cited by 5
Quiñones, F., Winters, C. G., Hu, L., & Suvarnakar, A. M. (2023) · Georgetown Medical Review · doi:10.52504/001c.83340 · Cited by 6
Stohl, H. E., Kohm, A. D., & Dossett, E. C. (2016) · Journal of Neonatal-Perinatal Medicine · doi:10.3233/npm-16915057 · Cited by 5
“New evidence suggests that Omega-3 Fatty Acids are moderately beneficial in depression and anxiety [28].”
BackgroundUse of Herbal Products and Complementary and Alternative Medicine (CAM) During Pregnancy
Kargar, A., & Kızıltan, G. (2022) · Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi · doi:10.22312/sdusbed.1017158 · Cited by 4
Acupuncture for Depression: The Mechanism Underlying Its Therapeutic Effect
Muthmainah, M., & Nurwati, I. (2016) · Medical Acupuncture · doi:10.1089/acu.2016.1180 · Cited by 3
“11,12 A survey in the United Kingdom involving 9408 respondents reported that psychiatric problems, including stress, anxiety and depression, are the second most common reasons for an individual to seek help from an acupuncturist.”
Perinatal Mood and Anxiety Disorders: Research and Implications for Nursing Care
Beck, C. T. (2021) · Nursing for Women s Health · doi:10.1016/j.nwh.2021.02.003 · Cited by 5
Complementary and alternative therapies for poststroke depression
Song, K., Xiong, F., Wang, Y., Wang, H., Huang, A., & Zhang, H. (2020) · Medicine · doi:10.1097/md.0000000000021995 · Cited by 3
Aromatherapy, music, and acupuncture for optimizing emotional wellbeing in pregnancy
Einion, A., Suzuki, S., & Tobea, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-818309-0.00021-6 · Cited by 3
Nutraceuticals and dietary supplements: Disparities in usage and potential for harm
Kaptur, B. D., Peterman, N., & Lee, J. (2022) · Nutrition and Health · doi:10.1177/02601060221099690 · Cited by 2
“…enhancement, medically indicated dietary deficiency, sport and performance enhancement, alternative medicine treatment, weight loss, and many more (Deligiannidis and Freeman, 2014; Divella et al., 2020; Makkar et al., 2020; Nath, 2017; Quigley, 2020; Raut and Wairkar, 2018; Santini and Novellino,…”
BackgroundVanderkruik, R. C., Lemon, E. L., River, L. M., & Dimidjian, S. (2020) · Wiley eBooks · doi:10.1002/9781119057840.ch153 · Cited by 2
Acute Psychiatric Conditions in Pregnancy
Puryear, L. J. (2018) · Wiley eBooks · doi:10.1002/9781119129400.ch33 · Cited by 2
S-Adenosyl-L-Methionine for Major Depressive Disorder
Berardis, D. D., Orsolini, L., Iasevoli, F., Tomasetti, C., Mazza, M., Valchera, A., Fornaro, M., Perna, G., Piersanti, M., Nicola, M. D., et al. (2016) · Springer eBooks · doi:10.1007/978-81-322-2803-5_49 · Cited by 2
Acupuncture versus antidepressants in the management of postpartum depression: A systematic review
Komori, A., Arthur, D. G., Radford, S. K., Tan, H. Y., Li, Z., An, M., Umeda, R., & Zheng, Z. (2018) · British Journal of Midwifery · doi:10.12968/bjom.2018.26.10.670 · Cited by 2
Underrated Diagnosis: Prenatal Depression
Koçak, Ö., & KOÇAK, S. (2023) · Kafkas Journal of Medical Sciences · doi:10.5505/kjms.2023.21033 · Cited by 1
Efficacy and safety of massage in the treatment of poststroke depression
Shen, Y. C., Nie, Q., Zhang, Y., & Xu, L. (2021) · Medicine · doi:10.1097/md.0000000000023908 · Cited by 1
Brown, K. M., & Kathol, D. (2019) · Springer eBooks · doi:10.1007/978-3-030-04245-5_18 · Cited by 1
Isomura, M., Sagawa, K., Tobe, C., & Suzuki, S. (2020) · Traditional & Kampo Medicine · doi:10.1002/tkm2.1269 · Cited by 1
Chapter 1. The Reproductive Life Cycle
Lighten, A., Zein, M., Olgun, M., & Catapano, L. A. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg01 · Cited by 1
Hsu, C.-Y., Chen, C.-L., Tsai, L., & Tsai, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.870659 · Cited by 1
Thomas, R. (2018) · UA Campus Repository (The University of Arizona) · Cited by 1
Chapter 18. Trauma and Reproductive Health
Gopalan, P. R., Albertini, E., Amin, P., Curley, M., Glance, J. B., Kalia, S., & Shenai, N. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg18 · Cited by 1
Kroll-Desrosiers, A., Wallace, K. F., Higgins, D. M., Martino, S., Marteeny, V., Walker, L., & Mattocks, K. (2024) · Women's health issues · doi:10.1016/j.whi.2024.07.004 · Cited by 3
Integrative Approaches to Perinatal Depression
Pirec, V., & Brogan, K. (2015) · CRC Press eBooks · doi:10.1201/b19089-29 · Cited by 1
Plantas medicinais com potencial uso na fitoterapia antidepressiva: uma revisão
Viana, D. S., do Nascimento, P. R. S., & Miranda, R. N. C. (2021) · Research Society and Development · doi:10.33448/rsd-v10i15.22819 · Cited by 1
Working with Worry and Inspiring Hope: Relationships with Anxious and Fearful Women
Dahlen, H. G., Teate, A., Ormsby, S., & Schmied, V. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-21063-2_8 · Cited by 1
Рубінштейн, А. М., & Golyanovskiy, O. V. (2022) · EUREKA Health Sciences · doi:10.21303/2504-5679.2022.002372 · Cited by 1
Valpey, R., Sachdeva, J., & Moel, J. E. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg22
Appendix. Pregnancy and Lactation Considerations for Psychotropic Medications
(2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.bm01
The effect of curcumax on postpartum women’s depression: a randomized controlled trial
Nikpour, F., Ansari, S., Abedi, P., Jahanfar, S., Sharifat, N., Hooshmand, G., & Maraghi, E. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1302174 · Cited by 1
Givrad, S., Paul, J. J., Wittmann, C., Nadal-Vicens, M. F., & John‐Larkin, C. S. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg12
(2024) · doi:10.46799/jhs.v5i2.1226
“Besides that CAM can used as prophylaxis For disturbance chronic and treatment psychological during the perinatal period (Deligiannidis et al., 2014).”
BackgroundChapter 23. Attention-Deficit/Hyperactivity Disorder
Hutner, L. A., Amin, J., Coulehan, J., Rao, M., Olgun, M., & Levine, M. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg23
Chapter 13. Depressive Disorders
Osborne, L. M., & Birndorf, C. A. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg13
Mental Health Conditions in the Perinatal Period
Comella, N., & Ayala, N. K. (2025) · Contemporary surgical clerkships · doi:10.1007/978-3-031-96541-8_21
Chapter 9. A Clinical Approach to Psychiatric Diagnosis and Treatment in the Postpartum Period
Gorun, A., Zein, M., Olgun, M., & Catapano, L. A. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg09
Chapter 15. Bipolar Disorder and Related Disorders
Nagle-Yang, S. M., DeBrunner, S. A., Favini, A., Novick, A. M., Hasser, C., Prakash, C., & Nathan, M. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg15
Chapter 14. Integrative Approaches to Perinatal Depression
Becker, M. A., Hoffman, M. C., Ballone, N. T., & Shah, R. N. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg14
Chapter 16. Postpartum Psychosis
Hasser, C., Martinovic, J., Lakshmin, P., Zein, M., Olgun, M., Hutner, L. A., Nagle-Yang, S. M., & Osborne, L. M. (2021) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615379545.lg16
POSTPARTUM DEPRESYONDA TAMAMLAYICI VE ALTERNATİF TEDAVİLER
Bilgiç, D., Dağlar, G., Özkan, S. A., & Kadıoğlu, M. (2016) · DergiPark (Istanbul University)
Depression in Pregnancy: A Role for Yoga, a Lifestyle Practice to Complement Nutrition
Battle, C. L., & Fritzson, A. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-90988-2_17 · Cited by 1
Metadata
- Authors
- Deligiannidis, K. M., & Freeman, M. P.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Massachusetts General Hospital (US)
- Corresponding author
- Deligiannidis, Kristina M.
- Venue
- Best Practice & Research Clinical Obstetrics & Gynaecology
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 28
- Issue
- 1
- Pages
- 85-95
- ISSN
- 1521-6934 (ISSN-L)
- PMC
- PMC3992885
- OpenAlex
- W1968107818
- Cited by
- 124
- References
- 111
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 39 · 2020: 11 · 2019: 10 · 2018: 14 · 2017: 2 · 2016: 10 · 2015: 8 · 2014: 6
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Best Practice & Research Clinical Obstetrics & Gynaecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship@UMassChan (submittedVersion)
- Funders
- National Institutes of Health (UL1TR000161)
- National Institute of Mental Health (K23MH097794)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- perinatal depression, complementary and alternative medicine, omega-3 fatty acids, folic acid, S-adenosylmethionine, Hypericum perforatum, bright light therapy, physical activity, massage, acupuncture, pregnancy, postpartum depression, treatment efficacy and safety
- MeSH terms
- Complementary Therapies, Depression, Female, Folic Acid, Humans, Massage, Mothers, Phototherapy, Pregnancy, S-Adenosylmethionine, Exercise, Fatty Acids, Omega-3, Acupuncture Therapy, Depression, Postpartum, Dietary Supplements, Hypericum, Peripartum Period
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