Risk of preterm delivery and hypertensive disorders of pregnancy in relation to maternal co‐morbid mood and migraine disorders during pregnancy
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Summary: Cripe SM, Frederick IO, Qiu CF, Williams MA. Risk of preterm delivery and hypertensive disorders of pregnancy in relation to maternal co‐morbid mood and migraine disorders during pregnancy. Paediatric and Perinatal Epidemiology 2011. We evaluated the risks of preterm delivery and hypertensive disorders of pregnancy among pregnant women with mood and migraine disorders, using a cohort study of 3432 pregnant women. Maternal pre‐pregnancy or early pregnancy (<20 weeks gestation) mood disorder and pre‐pregnancy migraine diagnoses were ascertained from interview and medical record review. We fitted generalised linear models to derive risk ratios (RR) and 95% confidence intervals (CI) of preterm delivery and hypertensive disorders of pregnancy for women with isolated mood, isolated migraine and co‐morbid mood‐migraine disorders, respectively. Reported RR were adjusted for maternal age, race/ethnicity, marital status, parity, smoking status, chronic hypertension or pre‐existing diabetes mellitus, and pre‐pregnancy body mass index. Women without mood or migraine disorders were defined as the reference group. The risks for preterm delivery and hypertensive disorders of pregnancy were more consistently elevated among women with co‐morbid mood‐migraine disorders than among women with isolated mood or migraine disorder. Women with co‐morbid disorders were almost twice as likely to deliver preterm (adjusted RR = 1.87, 95% CI 1.05, 3.34) compared with the reference group. There was no clear evidence of increased risks of preterm delivery and its subtypes with isolated migraine disorder. Women with mood disorder had elevated risks of pre‐eclampsia (adjusted RR = 3.57, 95% CI 1.83, 6.99). Our results suggest an association between isolated migraine disorder and pregnancy‐induced hypertension (adjusted RR = 1.42, 95% CI 1.00, 2.01). This is the first study examining perinatal outcomes in women with co‐morbid mood‐migraine disorders. Pregnant women with a history of migraine may benefit from screening for depression during prenatal care and vigilant monitoring, especially for women with co‐morbid mood and migraine disorders.
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Untreated depression during pregnancy is associated with obstetrical and neonatal complications.
“Untreated depression during pregnancy poses risks to the mother and baby, including obstetrical and neonatal complications [3-8].”
From Complementary and alternative medicine therapies for perinatal depression (2014) · cites this paper as [6]
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- Authors
- Cripe, S. M., Frederick, I. O., Qiu, C., & Williams, M. A.
- Affiliations
- University of Washington (US)
- Swedish Medical Center (US)
- Corresponding author
- Cripe, Swee May
- Venue
- Paediatric and Perinatal Epidemiology
- Publisher
- Wiley
- Published
- 2011-01-14
- Volume
- 25
- Issue
- 2
- Pages
- 116-123
- ISSN
- 0269-5022 (ISSN-L)
- 1365-3016
- PMC
- PMC3756187
- OpenAlex
- W2135725798
- Cited by
- 86
- References
- 36
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 12 · 2013: 8 · 2012: 4
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Paediatric and Perinatal Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD055566, R01HD032562)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Keywords
- preterm birth, hypertensive disorders of pregnancy, mood disorders, migraine, comorbidities, preeclampsia, gestational hypertension, maternal depression, prenatal screening, perinatal outcomes
- MeSH terms
- Adult, Female, Humans, Infant, Newborn, Infant, Premature, Migraine Disorders, Pregnancy, Prospective Studies, Risk Factors, Cohort Studies, Comorbidity, Mood Disorders, Hypertension, Pregnancy-Induced, Premature Birth
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