Multiple receptors mediate the trophic effects of serotonin on ventroposterior thalamic neurons in vitro
Open accessAbstract
Serotonin (5-HT) exerts prominent morphogenetic roles during development. For example, somatosensory cortical barrel formation is altered in mouse models characterized by excessive extracellular 5-HT, suggesting that 5-HT affects development of thalamic afferents and/or neocortical target regions. The present study assessed 5-HT effects in primary cultures of fetal ventroposterior thalamic (VPT) neurons. 5-HT produces concentration-dependent trophic effects, with impressive 59% and 106% peak increases in total neurite length and number of branching points, respectively, at a dose of 30 microM 5-HT. The exposure of VPT neurons to specific 5-HT receptor agonists 8-OH-DPAT (5-HT(1A)), CGS-12066A (5-HT(1B)), DOI (5-HT(2A/2C)), and m-CPBG (5-HT(3)), enhances primary neurite length and number of branching points with rank-order potency 5-HT(1B) > 5-HT(2A/2C) = 5-HT(3) > 5-HT(1A) = vehicle. Trophic 5-HT effects on embryonic VPT neurons are thus much more prominent than previously reported, and can be mediated by multiple 5-HT receptor subtypes.
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DOI increases dendritic growth in cultured cortical neurons.
“DOI, one of the more readily accessible psychedelics to researchers, has been shown to increase dendritic growth (Persico et al., 2006;Ohtani et al., 2014;Ly, Greb et al., 2018;Ly et al., 2021), synaptic puncta, spine density (Yoshida et al., 2011;Ly et al., 2018), and spine size (Jones et al., 2009) in cultured cortical neurons.”
From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Persico et al., 2006
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Smidt, M. P., & van Hooft, J. A. (2013)
- Authors
- Persico, A. M., Di Pino, G., & Levitt, P.
- Affiliations
- Università Campus Bio-Medico (IT)
- Vanderbilt University (US)
- Corresponding author
- Persico, Antonio M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 1095
- Issue
- 1
- Pages
- 17-25
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1967611336
- Cited by
- 35
- References
- 36
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
- Funders
- H. Lundbeck A/S
- National Institute of Mental Health (MH45507)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD015052, P30 HD-15052)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- serotonin, serotonin receptors, thalamic neurons, neurite outgrowth, receptor subtypes, 5-HT1B receptor, 5-HT2A/2C receptors, 5-HT3 receptor, 5-HT1A receptor, embryonic development, somatosensory cortex
- MeSH terms
- Analysis of Variance, Animals, Cells, Cultured, Dose-Response Relationship, Drug, Embryo, Mammalian, Female, Immunohistochemistry, Mice, Inbred C57BL, Neurons, Pregnancy, Receptors, Serotonin, Serotonin, Thalamus, Neurites, Serotonin Agents, Mice
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