Visual recognition memory and auditory brainstem response in infant rhesus monkeys exposed perinatally to environmental tobacco smoke
Abstract
The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual recognition memory and auditory function (auditory brainstem response). The ETS group showed significantly less novelty preference in the visual recognition task whereas no effects on auditory function were detected. These preliminary results support the view that perinatal ETS exposure has adverse effects on cognitive function and indicate further that rhesus monkeys may provide a valuable nonhuman primate model for investigating this link.
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Nicotine is a key cause of the neurodevelopmental harm from tobacco smoke exposure.
“and these studies show that nicotine itself is a critical contributor to the harmful neurodevelopmental effects of tobacco smoke exposure.(307-310)”
From Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products (2017) · cites this paper as [308]
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Slotkin, T. A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.06.001 · Cited by 544 · see citing works
Self-citationHuizink, A. C., & Mulder, E. J. H. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.005 · Cited by 468 · see citing works
Slotkin, T. A., Seidler, F. J., Qiao, D., Aldridge, J. E., Tate, C. A., Cousins, M. M., Proskocil, B. J., Sekhon, H. S., Clark, J. A., Lupo, S. L., et al. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300544 · Cited by 101 · see citing works
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Developmental consequences of prenatal tobacco exposure
Cornelius, M. D., & Day, N. L. (2009) · Current Opinion in Neurology · doi:10.1097/wco.0b013e328326f6dc · Cited by 209 · see citing works
Slotkin, T. A. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.09.002 · Cited by 206 · see citing works
Self-citationEngland, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181 · see citing works
Self-citationHall, B. J., Cauley, M., Burke, D. A., Kiany, A., Slotkin, T. A., & Levin, E. D. (2016) · Toxicological Sciences · doi:10.1093/toxsci/kfw042 · Cited by 57 · see citing works
- Authors
- Golub, M. S., Slotkin, T. A., Tarantal, A. F., & Pinkerton, K. E.
- Affiliations
- University of California, Davis (US)
- Duke Medical Center (US)
- Corresponding author
- Pinkerton, Kent E.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 1151
- Pages
- 102-106
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2048573021
- Cited by
- 22
- References
- 3
- Citations by year
- 2023: 1 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Philip Morris International
- University of California, Davis
- National Institute of Environmental Health Sciences (R01ES011634, ES 011634, ES05707)
- National Center for Research Resources (P51RR000169, RR-00169)
- California National Primate Research Center
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
- Keywords
- environmental tobacco smoke, perinatal exposure, rhesus monkeys, visual recognition memory, novelty preference, auditory brainstem response, auditory function, cognitive development, prenatal exposure, nonhuman primate model
- MeSH terms
- Acoustic Stimulation, Animals, Animals, Newborn, Female, Macaca mulatta, Male, Pattern Recognition, Visual, Photic Stimulation, Pregnancy, Prenatal Exposure Delayed Effects, Tobacco Smoke Pollution, Evoked Potentials, Auditory, Brain Stem
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