Developmental consequences of prenatal tobacco exposure
Open accessAbstract
PURPOSE OF REVIEW: This paper reviews results from published, in press, and conference proceedings from 2007 and 2008 that link in-utero tobacco exposure to neurodevelopmental outcomes in exposed offspring. RECENT FINDINGS: Prenatal tobacco exposure (PTE) affected speech processing, levels of irritability and hypertonicity, attention levels, ability to self-regulate, need to be handled, and response to novelty preference in infants. In early childhood, PTE effects were mostly behavioral outcomes including activity and inattention and externalizing behaviors, including conduct disorder and antisocial behavior. In adolescents, PTE predicted increased attention deficit hyperactivity disorder, modulation of the cerebral cortex and white matter structure, and nicotine addiction. Several studies found moderating effects with PTE and genetic susceptibilities including dopamine transporter, serotonergic synaptic function, and monomine oxidase pathways. Other studies suggested that environmental and genetic factors might be more important than the direct teratological effects of PTE. SUMMARY: The majority of studies reviewed were prospective and tobacco exposure was quantified biologically. Most demonstrated a direct association between PTE and neurodevelopmental outcomes. More work is needed to examine multifactorial influences. Effects of PTE on the offspring appear to be moderated by genetic variability, neurobehavioral disinhibition, and sex.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Children exposed to tobacco smoke during gestation exhibit non-clinical deficits in various cognitive domains.
“A number of studies have also shown that children exposed to tobacco smoke during gestation exhibit non-clinical deficits in various cognitive domains [3, 8–10].”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [9]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The maternal and fetal physiologic effects of nicotine
Lambers, D. S., & Clark, K. E. (1996) · Seminars in Perinatology · doi:10.1016/s0146-0005(96)80079-6 · Cited by 577 · see citing works
Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype
Neuman, R. J., Lobos, E., Reich, W., Henderson, C. A., Sun, L.-W., & Todd, R. D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.049 · Cited by 277 · see citing works
D'Onofrio, B. M., Hulle, C. A. V., Waldman, I. D., Rodgers, J. L., Harden, K. P., Rathouz, P. J., & Lahey, B. B. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000072 · Cited by 267 · see citing works
Arria, A. M., Derauf, C., LaGasse, L. L., Grant, P., Shah, R., Smith, L. M., Haning, W., Huestis, M. A., Strauss, A. A., Grotta, S. A. D., et al. (2006) · Maternal and Child Health Journal · doi:10.1007/s10995-005-0052-0 · Cited by 225 · see citing works
Slotkin, T. A. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2007.09.002 · Cited by 206 · see citing works
Cigarette smoking during pregnancy
Shea, A. K., & Steiner, M. S. (2008) · Nicotine & Tobacco Research · doi:10.1080/14622200701825908 · Cited by 203 · see citing works
Beck, L. F., Morrow, B., Lipscomb, L. E., Johnson, C. H., Gaffield, M. E., Rogers, M., & Gilbert, B. C. (2002) · PubMed · Cited by 189 · see citing works
Rivkin, M. J., Davis, P. E., Lemaster, J. L., Cabral, H. J., Warfield, S. K., Mulkern, R. V., Robson, C. D., Rose-Jacobs, R., & Frank, D. A. (2008) · PEDIATRICS · doi:10.1542/peds.2007-1399 · Cited by 172 · see citing works
Gilman, S. E., Gardener, H. E., & Buka, S. L. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn175 · Cited by 172 · see citing works
Prenatal Exposure to Maternal Cigarette Smoking and the Adolescent Cerebral Cortex
Toro, R., Leonard, G. T., Lerner, J. V., Lerner, R. M., Perron, M., Pike, G. B., Richer, L., Veillette, S., Pausová, Z., & Paus, T. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301484 · Cited by 166 · see citing works
Slotkin, T. A., MacKillop, E. A., Rudder, C. L., Ryde, I. T., Tate, C. A., & Seidler, F. J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301231 · Cited by 149 · see citing works
Jacobsen, L. K., Picciotto, M. R., Heath, C. J., Frost, S. J., Tsou, K. A., Dwan, R. A., Jackowski, M. P., Constable, R. T., & Mencl, W. E. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2402-07.2007 · Cited by 147 · see citing works
Jacobsen, L. K., Slotkin, T. A., Mencl, W. E., Frost, S. J., & Pugh, K. R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301398 · Cited by 144 · see citing works
Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms
Becker, K., El-Faddagh, M., Schmidt, M. H., Esser, G., & Laucht, M. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.07.004 · Cited by 142 · see citing works
Wakschlag, L. S., Kistner, E. O., Pine, D. S., Biesecker, G., Pickett, K. E., Skol, A. D., Dukić, V., Blair, J., LEVENTHAL, B. L., Cox, N. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.22 · Cited by 135 · see citing works
Maternal smoking during pregnancy and child behaviour problems: The Generation R Study
Roza, S. J., Verhulst, F. C., Jaddoe, V. W., Steegers, E. A., Mackenbach, J. P., Hofman, A., & Tiemeier, H. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyn163 · Cited by 118 · see citing works
Langley, K., Holmans, P., van den Bree, M. B. M., & Thapar, A. (2007) · BMC Psychiatry · doi:10.1186/1471-244x-7-26 · Cited by 115 · see citing works
The relationship of maternal smoking to psychological problems in the offspring
Button, T. M. M., Maughan, B., & McGuffin, P. (2007) · Early Human Development · doi:10.1016/j.earlhumdev.2007.07.006 · Cited by 113 · see citing works
Direct and Passive Prenatal Nicotine Exposure and the Development of Externalizing Psychopathology
Gatzke‐Kopp, L. M., & Beauchaine, T. P. (2007) · Child Psychiatry & Human Development · doi:10.1007/s10578-007-0059-4 · Cited by 103 · see citing works
Maternal Smoking during Pregnancy and Newborn Neurobehavior: Effects at 10 to 27 Days
Stroud, L. R., Paster, R. L., Papandonatos, G. D., Niaura, R., Salisbury, A. L., Battle, C., Lagasse, L. L., & Lester, B. (2009) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2008.07.048 · Cited by 102 · see citing works
Maternal smoking during pregnancy and neonatal behavior: a large-scale community study
Stroud, L. R., Paster, R. L., Goodwin, M. S., Shenassa, E., Buka, S., Niaura, R., Rosenblith, J. F., & Lipsitt, L. P. (2009) · PEDIATRICS · doi:10.1542/peds.2008-2084 · Cited by 96 · see citing works
Maternal prenatal smoking, parental antisocial behavior, and early childhood physical aggression
Huijbregts, S. C. J., Séguin, J. R., Zoccolillo, M., Boivin, M., & Tremblay, R. E. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000217 · Cited by 89 · see citing works
Smoking during pregnancy affects speech-processing ability in newborn infants
Key, A. P. F., Ferguson, M., Molfese, D. L., Peach, K., Lehman, C., & Molfese, V. J. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9521 · Cited by 78 · see citing works
Smoking during teenage pregnancies: Effects on behavioral problems in offspring
Cornelius, M. D., Goldschmidt, L., Genna, N. M. D., & Day, N. L. (2007) · Nicotine & Tobacco Research · doi:10.1080/14622200701416971 · Cited by 77 · see citing works
Self-citationAdverse health effects related to tobacco smoke exposure in a cohort of three‐year olds
Johansson, A., Ludvigsson, J., & Hermansson, G. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2007.00619.x · Cited by 62 · see citing works
Prenatal Cocaine and Tobacco Effects on Children's Language Trajectories
Lewis, B. A., Kirchner, H. L., Short, E. J., Minnes, S., Weishampel, P., Satayathum, S., & Singer, L. T. (2007) · PEDIATRICS · doi:10.1542/peds.2006-2563 · Cited by 59 · see citing works
Mansi, G., Raimondi, F., Pichini, S., Capasso, L., Sarno, M., Zuccaro, P., Pacifici, R., Garcia-Algar, Ó., Romano, A., & Paludetto, R. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e31802d89eb · Cited by 56 · see citing works
Wiebe, S. A., Espy, K. A., Stopp, C. D., Respass, J., Stewart, P., Jameson, T. R., Gilbert, D. G., & Huggenvik, J. I. (2009) · Developmental Psychology · doi:10.1037/a0014550 · Cited by 56 · see citing works
Pickett, K. E., Wood, C., Adamson, J., Souza, L. R. D., & Wakschlag, L. S. (2008) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2006.058768 · Cited by 53 · see citing works
Carter, S., Paterson, J., Gao, W., & Iusitini, L. (2008) · Early Human Development · doi:10.1016/j.earlhumdev.2007.03.009 · Cited by 41 · see citing works
Golub, M. S., Slotkin, T. A., Tarantal, A. F., & Pinkerton, K. E. (2007) · Brain Research · doi:10.1016/j.brainres.2007.03.001 · Cited by 22 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [32]Pickett K Wakschlag L The short-term and long-term developmental consequences of maternal smoking during pregnancy Preece P Riley E Drugs in pregnancy: the price for the child: exposure to fetal teratogens and long term neurodevelopmental outcomes London Mac Keith Press in press
Cited by
Sorted by citations
A Comprehensive Assessment of Parental Age and Psychiatric Disorders
McGrath, J. J., Petersen, L., Agerbo, E., Mors, O., Mortensen, P. B., & Pedersen, C. B. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.4081 · Cited by 253 · see citing works
Kolla, N. J., & Bortolato, M. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101875 · Cited by 138 · see citing works
Zhu, J., Zhang, X., Xu, Y., Spencer, T. J., Biederman, J., & Bhide, P. G. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1041-12.2012 · Cited by 125 · see citing works
Stroud, L. R., Papandonatos, G. D., Rodriguez, D., McCallum, M., Salisbury, A. L., Phipps, M. G., Lester, B., Huestis, M. A., Niaura, R., Padbury, J. F., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.05.017 · Cited by 104 · see citing works
Sloboda, Z., Glantz, M. D., & Tarter, R. E. (2012) · Substance Use & Misuse · doi:10.3109/10826084.2012.663280 · Cited by 94 · see citing works
Tran, P. L., Lehti, V., Lampi, K. M., Helenius, H., Suominen, A., Gissler, M., Brown, A. S., & Sourander, A. (2013) · Paediatric and Perinatal Epidemiology · doi:10.1111/ppe.12043 · Cited by 77 · see citing works
Johnston, Z. C., Bellingham, M., Filis, P., Soffientini, U., Hough, D., Bhattacharya, S., Simard, M., Hammond, G. L., King, P., O’Shaughnessy, P. J., et al. (2018) · BMC Medicine · doi:10.1186/s12916-018-1009-7 · Cited by 44 · see citing works
Horst, N. K., Heath, C. J., Neugebauer, N. M., Kimchi, E. Y., Laubach, M., & Picciotto, M. R. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.002 · Cited by 17 · see citing works
- Authors
- Cornelius, M. D., & Day, N. L.
- Corresponding author
- Cornelius, Marie D
- ORCID
- Cornelius, Marie D
- Venue
- Current Opinion in Neurology
- Published
- 2009-04
- Volume
- 22
- Issue
- 2
- Pages
- 121-125
- ISSN
- 1350-7540 (ISSN-L)
- PMC
- PMC2745235
- OpenAlex
- W2010579794
- Cited by
- 209
- References
- 31
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 9 · 2023: 12 · 2022: 10 · 2021: 10 · 2020: 13 · 2019: 9 · 2018: 9 · 2017: 16 · 2016: 8 · 2015: 12 · 2014: 19 · 2013: 20 · 2012: 20
- FWCI
- 15.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (AA-08284, AA07453, R21AA015728, R29AA008284, AA015728, T32AA007453)
- National Institute of Mental Health (MH-067924, R01MH067924)
- National Institute on Drug Abuse (DA019482, DA09275, DA008916, R01DA003874, R01DA009275, DA 03874, R01DA008916, R01DA019482)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK066266, R01DK066266)
- National Institute of Environmental Health Sciences (ES0112059)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- prenatal tobacco exposure, brain development, nicotine, speech processing, irritability, attention, self-regulation, novelty preference, externalizing problems, conduct disorder, antisocial behavior, attention deficit hyperactivity disorder, white matter structure, cerebral cortex, nicotine dependence, genetic susceptibility, dopamine transporter, monoamine oxidase, sex differences, genetic and environmental factors
- MeSH terms
- Adolescent, Adolescent Behavior, Attention Deficit Disorder with Hyperactivity, Child, Child Behavior Disorders, Female, Humans, Infant, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Smoking, Teratogens, Nicotiana, Tobacco Products
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
