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Expression of the deubiquitinating enzyme mUBPy in the mouse brain

Bruzzone, Federica, Vallarino, Mauro, Berruti, Giovanna, Angelini, Cristiano·2008·Brain Research
DOI 10.1016/j.brainres.2007.12.014
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Abstract

Mouse UBPy (mUBPy) is an ubiquitin-specific protease which belongs to a family of deubiquitinating enzymes (DUBs) implicated in several cellular processes related to both cell growth and differentiation. Previously, Northern blot analysis revealed an important expression of mUBPy in the testis and brain. However, a more comprehensive map of mUBPy localization in the central nervous system (CNS) is still lacking. In this study, we mapped the distribution of mUBPy in the mouse brain using nonradioactive in situ hybridization and immunohistochemical techniques. In general, transcript and protein showed a similar and widespread distribution. In particular, mUBPy was strongly expressed in the hippocampal formation, septal region, ventral pallidum, preoptic nucleus, periventricular nucleus of hypothalamus, compact part of the substantia nigra, ventral tegmental area, cochlear nucleus and granular cell layer of cerebellum. A moderate expression of mUBPy was found in the amygdaloid complex, supraoptic nucleus, arcuate and ventromedial nuclei of hypothalamus, lateral hypothalamic area and lateral and reticular part of the substantia nigra. Double labelling with the mUBPy antiserum and antisera against specific cell markers showed that the enzyme is generally expressed in neurons and, in specific regions, also in oligodendrocytes. Moreover, by using antisera to TH and mUBPy we found that mUBPy is localized in dopaminergic neurons. The different distribution of mUBPy in the distinct reg…

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Research works printed but not linked: 34

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Metadata

Authors
Bruzzone, F., Vallarino, M., Berruti, G., & Angelini, C.
Venue
Brain Research
Publisher
Elsevier BV
Published
2008-02
Volume
1195
Pages
56-66
ISSN
0006-8993
DOI
10.1016/j.brainres.2007.12.014
Cited by
19
References
1
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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