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Antidepressant-like effects of intracerebroventricular FGF2 in rats
Open accessAbstract
The fibroblast growth factor (FGF) system is altered in post-mortem brains of individuals with major depressive disorder (MDD), but the functional relevance of this observation remains to be elucidated. To this end, we tested whether administering agents that act on FGF receptors would have antidepressant-like effects in rodents. We microinjected either FGF2 (200 ng, i.c.v.) or the FG loop (FGL) of neural cell adhesion molecule (NCAM) (5 microg, i.c.v.) into the lateral ventricle of rats and tested them on the forced swim test. Activating FGF receptors acutely had an antidepressant-like effect in the forced swim test. Furthermore, chronic FGF2 decreased depression-like behavior as assessed by two independent tests. Finally, the FGF system itself was altered after FGF2 administration. Specifically, there was an increase in FGFR1 mRNA in the dentate gyrus 24 h post-FGF2, suggesting the potential for self-amplification of the initial signal. These results support the potential therapeutic use of FGF2 or related molecules in the treatment of MDD and point to alternate mechanisms of neuronal remodeling that may be critical in this treatment.
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“Injection of FGF2 was also shown to reduce depressive-like behavior in rats (Turner et al. 2008b).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Turner et al. 2008b
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Metadata
- Authors
- Turner, C. A., Gula, E. L., Taylor, L. P., Watson, S. J., & Akil, H.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Turner, Cortney A.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 1224
- Pages
- 63-68
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC2532793
- OpenAlex
- W1978696776
- Cited by
- 125
- References
- 33
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 9 · 2018: 11 · 2017: 6 · 2016: 4 · 2015: 8 · 2014: 5 · 2013: 11 · 2012: 11
- FWCI
- 7.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH042251, MH060398, P50MH060398, P01MH042251)
- National Institute on Drug Abuse (DA007267, P01DA021633, DA007268, T32DA007268, T32DA007267, DA021633)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- fibroblast growth factor 2, antidepressant-like effects, major depressive disorder, fibroblast growth factor receptor, FG loop, CD56, dentate gyrus, forced swim test, depression-like behavior, intracerebroventricular microinjection, neuronal remodeling, FGF signaling
- MeSH terms
- Animals, Behavior, Animal, Brain, Depressive Disorder, Disease Models, Animal, Injections, Intraventricular, Male, Neuropsychological Tests, RNA, Messenger, Stress, Psychological, Fibroblast Growth Factor 2, Rats, Sprague-Dawley, In Situ Hybridization, Dentate Gyrus, Rats, Receptor, Fibroblast Growth Factor, Type 1
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