Cited by 68Treatment of Major DepressionFibroblast Growth Factor ResearchStress Responses and Cortisol

The fibroblast growth factor system is downregulated following social defeat

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Turner, Cortney A., Calvo, Nelson, Frost, Douglas O., Akil, Huda, Watson, Stanley J.·2008·Neuroscience Letters

Abstract

The fibroblast growth factor (FGF) system has previously been found to be altered in post-mortem brains of individuals with major depressive disorder (MDD). The present study tested whether the FGF system is altered following acute social defeat. Rats were exposed to four consecutive days of either a social defeat paradigm or novel cages. Animals were sacrificed after the last social defeat session and gene expression was assessed in the hippocampus by mRNA in situ hybridization. Molecular components of the FGF system were significantly downregulated following social defeat. Specifically, FGF2 and FGFR1 mRNA expression was decreased in various subfields of the hippocampus. Decreased tone of the FGF system following an acute social stressor is congruent with human post-mortem results of FGF system downregulation in depression. These findings suggest that modulating the FGF system may have therapeutic value in the treatment of MDD.

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Crossref · 10.1016/j.neulet.2007.10.041

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  • In rodents, social defeat stress reduces mRNA expression of FGF2 and its main receptor FGFR1 in the CA1, CA2, CA3, and DG.

    “Turner et al. reported reduced mRNA expression of FGF2 and its main receptor FGFR1 in the CA1, CA2, CA3, and DG following social defeat stress, a well-established model of depression (Turner et al. 2008a).”

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Authors
Turner, C. A., Calvo, N., Frost, D. O., Akil, H., & Watson, S. J.
Affiliations
  • University of Michigan (US)
  • University of Maryland, Baltimore (US)
Corresponding author
Turner, Cortney A.
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
2008-01
Volume
430
Issue
2
Pages
147-150
ISSN
0304-3940 (ISSN-L)
OpenAlex
W1996962495
Cited by
68
References
32
Citations by year
2026: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 6
FWCI
3.32
Type
journal article
Language
en
Open access
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (P50MH060398, MH42251-01, #L99MH60398, P01MH042251)
  • National Institute on Drug Abuse (P01DA021633)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
FGF2, FGFR1, social defeat, major depressive disorder, hippocampus, gene expression, social stress, depression treatment
MeSH terms
Animals, Behavior, Animal, Fibroblast Growth Factors, Hippocampus, Male, Social Behavior, Stress, Psychological, Down-Regulation, Rats, Sprague-Dawley, Rats

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