The fibroblast growth factor system is downregulated following social defeat
Open accessAbstract
The fibroblast growth factor (FGF) system has previously been found to be altered in post-mortem brains of individuals with major depressive disorder (MDD). The present study tested whether the FGF system is altered following acute social defeat. Rats were exposed to four consecutive days of either a social defeat paradigm or novel cages. Animals were sacrificed after the last social defeat session and gene expression was assessed in the hippocampus by mRNA in situ hybridization. Molecular components of the FGF system were significantly downregulated following social defeat. Specifically, FGF2 and FGFR1 mRNA expression was decreased in various subfields of the hippocampus. Decreased tone of the FGF system following an acute social stressor is congruent with human post-mortem results of FGF system downregulation in depression. These findings suggest that modulating the FGF system may have therapeutic value in the treatment of MDD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rodents, social defeat stress reduces mRNA expression of FGF2 and its main receptor FGFR1 in the CA1, CA2, CA3, and DG.
“Turner et al. reported reduced mRNA expression of FGF2 and its main receptor FGFR1 in the CA1, CA2, CA3, and DG following social defeat stress, a well-established model of depression (Turner et al. 2008a).”
From Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression (2018) · cites this paper as Turner et al. 2008a
Cites
Kuhn, H., Dickinson-Anson, H., & Gage, F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-06-02027.1996 · Cited by 3,139 · see citing works
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
Berton, O., McClung, C. A., DiLeone, R. J., Krishnan, V., Renthal, W., Russo, S. J., Graham, D., Tsankova, N. M., Bolanos, C. A., Rios, M., et al. (2006) · Science · doi:10.1126/science.1120972 · Cited by 2,129 · see citing works
McEwen, B. S. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02950-4 · Cited by 1,827 · see citing works
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780 · see citing works
Palmer, T. D., Markakis, E. A., Willhoite, A. R., Safar, F., & Gage, F. H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-19-08487.1999 · Cited by 909 · see citing works
Dysregulation of the fibroblast growth factor system in major depression
Evans, S. J., Choudary, P. V., Neal, C. R., Li, J. Z., Vawter, M. P., Tomita, H., Lopez, J. F., Thompson, R. C., Meng, F., Stead, J. D., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406788101 · Cited by 424 · see citing works
Self-citationFibroblast growth factors and their receptors in the central nervous system
Reuß, B., & Halbach, O. V. B. U. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0756-7 · Cited by 412 · see citing works
Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression
Russo-Neustadt, A. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00059-7 · Cited by 411 · see citing works
Czéh, B., Keuker, J. I. H., Ryguła, R., Abumaria, N., Hiemke, C., Domenici, E., & Fuchs, E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301275 · Cited by 397 · see citing works
Czéh, B., Welt, T., Fischer, A., Erhardt, A., Schmitt, W. B., Müller, M. B., Toschi, N., Fuchs, E., & Keck, M. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01457-9 · Cited by 370 · see citing works
(1997) · PubMed · Cited by 350 · see citing works
Kabbaj, M., Devine, D. P., Savage, V. R., & Akil, H. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06983.2000 · Cited by 350 · see citing works
Self-citationLong-term effects of social stress on brain and behavior: a focus on hippocampal functioning
Buwalda, B., Kole, M. H. P., Veenema, A. H., Huininga, M., de Boer, S. F., Korte, S. M., & Koolhaas, J. M. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.05.005 · Cited by 304 · see citing works
Fibroblast Growth Factors In The Developing Central Nervous System
Ford‐Perriss, M., Abud, H., & Murphy, M. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03477.x · Cited by 264 · see citing works
A comprehensive analysis of the distribution of FGF-2 and FGFR1 in the rat brain
Gonzalez, A. M., Berry, M., Maher, P. A., Logan, A., & Baird, A. (1995) · Brain Research · doi:10.1016/0006-8993(95)01002-x · Cited by 262 · see citing works
Gómez‐Pinilla, F., So, V., & Kesslak, J. P. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00576-9 · Cited by 262 · see citing works
Social Stress in Hamsters: Defeat Activates Specific Neurocircuits within the Brain
Kollack‐Walker, S., Watson, S. J., & Akil, H. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-22-08842.1997 · Cited by 253 · see citing works
Self-citationThomas, R. M., Hotsenpiller, G., & Peterson, D. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3849-06.2007 · Cited by 239 · see citing works
Changes in Behaviour and Body Weight Following a Single or Double Social Defeat in Rats
Meerlo, P., Overkamp, G. J. F., Daan, S., van den Hoofdakker, R. H., & Koolhaas, J. M. (1996) · Stress · doi:10.3109/10253899609001093 · Cited by 215 · see citing works
Maternal care influences neuronal survival in the hippocampus of the rat
Bredy, T. W., Grant, R. J., Champagne, D. L., & Meaney, M. J. (2003) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2003.02965.x · Cited by 208 · see citing works
Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice
Pizarro, J. M., Lumley, L. A., Medina, W., Robison, C. L., Chang, W. E., Alagappan, A., Bah, M. J., Dawood, M. Y., Shah, J. D., Mark, B., et al. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.085 · Cited by 196 · see citing works
Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder
Gaughran, F., Payne, J., Sedgwick, P. M., Cotter, D., & Berry, M. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.04.008 · Cited by 178 · see citing works
Zhao, M., Li, D., Shimazu, K., Zhou, Y.-X., Lu, B., & Deng, C.-X. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.019 · Cited by 171 · see citing works
Social stress, autonomic neural activation, and cardiac activity in rats
Sgoifo, A., Koolhaas, J. M., de Boer, S. F., Musso, E., Stilli, D., Buwalda, B., & Meerlo, P. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00025-1 · Cited by 160 · see citing works
Kabbaj, M., Norton, C., Kollack‐Walker, S., Watson, S. J., Robinson, T. E., & Akil, H. (2001) · Psychopharmacology · doi:10.1007/s002130100918 · Cited by 141 · see citing works
Self-citationVEGF, a Mediator of the Effect of Experience on Hippocampal Neurogenesis
During, M., & Cao, L. (2006) · Current Alzheimer Research · doi:10.2174/156720506775697133 · Cited by 131 · see citing works
McEwen, B. S., & Olié, J. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001648 · Cited by 127 · see citing works
Mallei, A., Shi, B., & Mocchetti, I. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.5.1017 · Cited by 125 · see citing works
Kollack‐Walker, Don, Watson, & Akil (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00354.x · Cited by 113 · see citing works
Self-citationMolteni, R., Fumagalli, F., Magnaghi, V., Roceri, M., Gennarelli, M., Racagni, G., Melcangi, R. C., & Riva, M. A. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00128-x · Cited by 108 · see citing works
Repeated brief social defeat episodes in mice: Effects on cell proliferation in the dentate gyrus
Yap, J. J., Takase, L. F., Kochman, L. J., Fornal, C. A., Miczek, K. A., & Jacobs, B. L. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.027 · Cited by 93 · see citing works
Diazepam induces FGF-2 mRNA in the hippocampus and striatum
Gómez‐Pinilla, F., Dao, L., Choi, J., & Ryba, E. A. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00342-7 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The FGF family: biology, pathophysiology and therapy
Beenken, A., & Mohammadi, M. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2792 · Cited by 1,945 · see citing works
Revisiting the Stress Concept: Implications for Affective Disorders
McEwen, B. S., & Akil, H. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0733-19.2019 · Cited by 686 · see citing works
“…FGF2 functions as a resilience factor, protecting animals against social defeat stress, enhancing extinction of learned fear, and decreasing anxiety behavior in animals genetically bred for high vulnerability to stress (Turner et al., 2008,b, 2011, 2012; Perez et al., 2009; Prater et al., 2017).”
BackgroundSelf-citationNeurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
Levy, M. J. F., Boulle, F., Steinbusch, H. W., van den Hove, D. L. A., Kenis, G., & Lanfumey, L. (2018) · Psychopharmacology · doi:10.1007/s00213-018-4950-4 · Cited by 308 · see citing works
Duman, R. S. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/rsduman · Cited by 210 · see citing works
Rodent Models of Depression: Neurotrophic and Neuroinflammatory Biomarkers
Stepanichev, M. Y., Дыгало, Н. Н., Grigoryan, G. A., Shishkina, G. T., & Gulyaeva, N. V. (2014) · BioMed Research International · doi:10.1155/2014/932757 · Cited by 172 · see citing works
Antidepressant Effects of Fibroblast Growth Factor-2 in Behavioral and Cellular Models of Depression
Elsayed, M., Banasr, M., Duric, V., Fournier, N. M., Licznerski, P., & Duman, R. S. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.003 · Cited by 169 · see citing works
The Fibroblast Growth Factor Family: Neuromodulation of Affective Behavior
Turner, C. A., Watson, S. J., & Akil, H. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.037 · Cited by 160 · see citing works
Self-citationErnst, C., Mechawar, N., & Turecki, G. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.09.001 · Cited by 160 · see citing works
A New Role for FGF2 as an Endogenous Inhibitor of Anxiety
Perez, J. A., Clinton, S. M., Turner, C. A., Watson, S. J., & Akil, H. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4829-08.2009 · Cited by 145 · see citing works
Self-citationMesenchymal stem cells increase hippocampal neurogenesis and counteract depressive-like behavior
Tfilin, M., Sudai, E., Merenlender, A., Gispan, I. H., Yadid, G., & Turgeman, G. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.110 · Cited by 129 · see citing works
Borroto‐Escuela, D. O., Romero‐Fernandez, W., Mudò, G., Pérez‐Alea, M., Ciruela, F., Tarakanov, A. O., Narváez, M., Liberto, V. D., Agnati, L. F., Belluardo, N., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.012 · Cited by 126 · see citing works
Antidepressant-like effects of intracerebroventricular FGF2 in rats
Turner, C. A., Gula, E. L., Taylor, L. P., Watson, S. J., & Akil, H. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.088 · Cited by 125 · see citing works
Self-citationĐurić, V., & Duman, R. S. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1020-7 · Cited by 78 · see citing works
Cheng, Y., Rodriguiz, R. M., Murthy, S. R. K., Senatorov, V. V., Thouënnon, E., Cawley, N. X., Aryal, D. K., Ahn, S., Lecka‐Czernik, B., Wetsel, W. C., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.136 · Cited by 77 · see citing works
Fibroblast Growth Factors in Schizophrenia
van Scheltinga, A. F. T., Bakker, S. C., & Kahn, R. S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp033 · Cited by 77 · see citing works
Fibroblast Growth Factors in Depression
Deng, Z. H., Deng, S., Zhang, M.-R., & Tang, M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00060 · Cited by 68 · see citing works
Tang, M., Lin, W., Zhang, J., Zhao, Y., & Li, Y. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.05.013 · Cited by 61 · see citing works
Fibroblast Growth Factors in Neurodevelopment and Psychopathology
van Scheltinga, A. F. T., Bakker, S. C., Kahn, R. S., & Kas, M. J. (2013) · The Neuroscientist · doi:10.1177/1073858412472399 · Cited by 60 · see citing works
Fibroblast growth factor 9 is a novel modulator of negative affect
Aurbach, E. L., Inui, E. G., Turner, C. A., Hagenauer, M. H., Prater, K. E., Li, J. Z., Absher, D., Shah, N., Blandino, P., Bunney, W. E., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510456112 · Cited by 57 · see citing works
Self-citationVasconcelos, M., Stein, D. J., & de Almeida, R. M. M. (2015) · Trends in Psychiatry and Psychotherapy · doi:10.1590/2237-6089-2014-0034 · Cited by 55 · see citing works
Eren‐Koçak, E., Turner, C. A., Watson, S. J., & Akil, H. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.11.020 · Cited by 53 · see citing works
Self-citationStachowiak, M. K., Kucinski, A. J., Curl, R., Syposs, C., Yang, Y., Narla, S. T., Terranova, C. J., Prokop, D., Klejbor, I., Bencherif, M., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.004 · Cited by 53 · see citing works
FGFR1–5-HT1A Heteroreceptor Complexes: Implications for Understanding and Treating Major Depression
Borroto‐Escuela, D. O., Tarakanov, A. O., & Fuxé, K. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.11.003 · Cited by 50 · see citing works
Kalinina, J., Byron, S. A., Makarenkova, H. P., Olsen, S. K., Eliseenkova, A. V., LaRochelle, W. J., Dhanabal, M., Blais, S. P., Ornitz, D. M., Day, L. A., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01780-08 · Cited by 50 · see citing works
Callaghan, B. L., Graham, B. M., Li, S., & Richardson, R. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00090 · Cited by 48 · see citing works
Learning and Memory Depend on Fibroblast Growth Factor Receptor 2 Functioning in Hippocampus
Stevens, H. E., Jiang, G. Y., Schwartz, M. L., & Vaccarino, F. M. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.013 · Cited by 46 · see citing works
Shen, H., Zhang, T., Hong, B., Peng, D., Su, H. L., Lin, Z., Fang, Y., Jiang, K., Liu, X., & Li, H. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.07.035 · Cited by 39 · see citing works
Liberto, V. D., Frinchi, M., Verdi, V., Vitale, A., Plescia, F., Cannizzaro, C., Massenti, M. F., Belluardo, N., & Mudò, G. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4498-0 · Cited by 41 · see citing works
Yao, Z., Zhang, Z., Zhang, J., Cai, X., Zheng, Z., Huang, Y., & Qu, S. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.01.005 · Cited by 40 · see citing works
Role of the Axonal Initial Segment in Psychiatric Disorders: Function, Dysfunction, and Intervention
Hsu, W., Nilsson, C., & Laezza, F. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00109 · Cited by 37 · see citing works
Fibroblast growth factor 2 is necessary for the antidepressant effects of fluoxetine
Simard, S., Shail, P., MacGregor, J., Sayed, M. E., Duman, R. S., Vaccarino, F. M., & Salmaso, N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0204980 · Cited by 39 · see citing works
Roles of exogenous and endogenous FGF-2 in animal models of depression
Jarosik, J., Legutko, B., Werner, S., Unsicker, K., & Halbach, O. V. B. U. (2011) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-2011-0588 · Cited by 37 · see citing works
Jiang, X., Du, B., Chen, J., Liu, L., Shao, W.-B., & Song, J. (2014) · PubMed Central · Cited by 36 · see citing works
Gonçalves, L., Dafré, A. L., Carobrez, S. G., & Gasparotto, O. C. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.04.010 · Cited by 31 · see citing works
Neonatal FGF2 alters cocaine self-administration in the adult rat
Turner, C. A., Capriles, N., Flagel, S. B., Perez, J. A., Clinton, S. M., Watson, S. J., & Akil, H. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.10.018 · Cited by 29 · see citing works
Self-citationInvolvement of FGF-2 modulation in the antidepressant-like effects of liquiritin in mice
Chen, M., Zhang, Q., Zhu, J., Cheng, J., Liu, Q., Xu, G., Li, C., & Yi, L. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173297 · Cited by 26 · see citing works
Heterogeneity in major depressive disorder: The need for biomarker-based personalized treatments
Suseelan, S., & Pinna, G. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.09.001 · Cited by 26 · see citing works
Hebda‐Bauer, E. K., Dokas, L. A., Watson, S. J., & Akil, H. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.06.005 · Cited by 23 · see citing works
Self-citationQuantitative assessment of fibroblast growth factor receptor 1 expression in neurons and glia
Choubey, L., Collette, J. C., & Smith, K. M. (2017) · PeerJ · doi:10.7717/peerj.3173 · Cited by 19 · see citing works
Yun, Z., Meng, F., Li, S., & Zhang, P. (2021) · Aging · doi:10.18632/aging.202540 · Cited by 18 · see citing works
Fibroblast Growth Factor-2: An Endogenous Antidepressant and Anxiolytic Molecule?
Turner, C. A., Watson, S. J., & Akil, H. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.025 · Cited by 15 · see citing works
Self-citationInactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors
Yamanaka, Y., Kitano, A., Takao, K., Prasansuklab, A., Mushiroda, T., Yamazaki, K., Kumada, T., Shibata, M., Takaoka, Y., Awaya, T., et al. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.09.003 · Cited by 15 · see citing works
Stevens, H. E., Scuderi, S., Collica, S. C., Tomasi, S., Horváth, T. L., & Vaccarino, F. M. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02372-y · Cited by 13 · see citing works
He, K., Han, S., An, L., & Zhang, J. (2021) · Lung · doi:10.1007/s00408-020-00415-5 · Cited by 14 · see citing works
New Approaches to the Pharmacological Management of Major Depressive Disorder
Witkin, J. M., & Li, X. (2009) · Advances in pharmacology · doi:10.1016/s1054-3589(08)57009-8 · Cited by 14 · see citing works
Zhang, J., Li, J., Li, S., Zhou, C., Qin, Y., & Li, X. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4765 · Cited by 12 · see citing works
RetractedFibroblast Growth Factor 2 Implicated in Childhood Anxiety and Depression Symptoms
Lebowitz, E. R., Orbach, M., Marin, C. E., Salmaso, N., Vaccarino, F. M., & Silverman, W. K. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.055 · Cited by 12 · see citing works
Li, A., Tian, J., Yang, J., Ren, X., Zhou, Z., & Zhou, W. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001591 · Cited by 8 · see citing works
Bryant, E. M., Richardson, R., & Graham, B. M. (2022) · Chronic Stress · doi:10.1177/24705470221114787 · Cited by 8 · see citing works
Shimada, T., Kohyama, K., Yoshida, T., & Yamagata, K. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0129-23.2024 · Cited by 7 · see citing works
Memory impairments in rodent depression models: A link with depression theories
Sałaciak, K., Koszałka, A., Lustyk, K., Żmudzka, E., Jagielska, A., & Pytka, K. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110774 · Cited by 6 · see citing works
Zhen, C., Huang, J., & Lu, J. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.8072 · Cited by 6 · see citing works
Zhang, L., Zhu, Z.-R., Tan, Z., Luo, H., Hu, X., & Li, Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.021 · Cited by 5 · see citing works
FGFR1 (Fibroblast Growth Factor Receptor 1)
Huret, J. L. (2011) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/44609 · Cited by 4 · see citing works
Epigenetic regulation of BDNF-TrkB signaling in the pathophysiology and treatment of mood disorders
Boulle, F. (2013) · doi:10.26481/dis.20131129fb · Cited by 4 · see citing works
Harmon‐Jones, S. K., Graham, B. M., King, G., & Richardson, R. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107448 · Cited by 2 · see citing works
Wang, Y., Wang, Z., Li, K., Xiang, W., Chen, B., Jin, L., & Hao, K. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.874667 · Cited by 2 · see citing works
Stress fitness: A neuroscientific approach to building emotional resilience
Akil, H., Maras, P. M., & Turner, C. A. (2026) · Neuron · doi:10.1016/j.neuron.2026.03.032 · Cited by 1 · see citing works
Self-citationRepeated unpredictable stress blunts alcohol-induced memory deficit in adolescent rat
Sircar, R. (2020) · Neuroreport · doi:10.1097/wnr.0000000000001519 · Cited by 1 · see citing works
An unexpected role for fibroblast growth factor-2 in modulating anxiety and hippocampal stem cells
Pérez, J. A. (2008) · Deep Blue (University of Michigan) · Cited by 1 · see citing works
A Role for the Fibroblast Growth Factor Family in Depression and Circadian Rhythms.
Inui, E. G. (2010) · Deep Blue (University of Michigan)
A role for astroctye-related genes in suicide
Ernst, C. (2009)
EL-MENYAWI, M. D. S. M. M. A. I., FATEN ABBAS, M. D. *. N. S., & BAZ, M. D. A. E. (2022) · The Medical Journal of Cairo University/The Medical Journal of Cairo University · doi:10.21608/mjcu.2022.296226
Epigenetic regulation of BDNF-TRKB signaling in the pathophysiology and treatment of mood disorders
Boulle, F. (2013) · theses.fr (ABES) · doi:10.70675/7796cc83z9f91z48c6zadb1zb6a90897b5d5
Ryznar, G., Gałecki, P., & Bliźniewska-Kowalska, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198464
- Authors
- Turner, C. A., Calvo, N., Frost, D. O., Akil, H., & Watson, S. J.
- Affiliations
- University of Michigan (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Turner, Cortney A.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 430
- Issue
- 2
- Pages
- 147-150
- ISSN
- 0304-3940 (ISSN-L)
- PMC
- PMC2241657
- OpenAlex
- W1996962495
- Cited by
- 68
- References
- 32
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 6
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (P50MH060398, MH42251-01, #L99MH60398, P01MH042251)
- National Institute on Drug Abuse (P01DA021633)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- FGF2, FGFR1, social defeat, major depressive disorder, hippocampus, gene expression, social stress, depression treatment
- MeSH terms
- Animals, Behavior, Animal, Fibroblast Growth Factors, Hippocampus, Male, Social Behavior, Stress, Psychological, Down-Regulation, Rats, Sprague-Dawley, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review