Neuronal depletion of omega-3 fatty acids induces flax seed dietary self-selection in the rat
Abstract
The impact of essential dietary fatty acid deficiency on self-selection of fatty acid enriched foods is little studied in spite of widespread health promotion claims for fatty acid supplemented diets. Accordingly, the present studies investigated the consequences of consumption over four weeks of omega-3 fatty acid replete and deficient diets on dietary fatty acid self-selection and brain lipid composition in rats. Dietary omega-3 fatty acid deficiency produced correspondingly low levels (50-55% decrease) of omega-3 fatty acids in the forebrain relative to rats consuming an omega-3 fatty acid replete diet. The state of omega-3 fatty acid deficiency generated a robust preference for consumption of an omega-3 fatty acid replete diet. Moreover, omega-3 fatty acid self-selection developed slowly and was not present in rats maintained on laboratory chow diet suggesting that post-ingestive nutritional cues, rather than taste, odor or texture cues, were employed in guiding the preference for the omega-3 fatty acid enriched diet. These results provide evidence for the ability of rats with declining brain levels of omega-3 fatty acids to detect a dietary deficiency of this essential class of lipids and to identify and consume a food source capable of restoring fatty acid repletion.
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Restriction of omega-3 fatty acids triggers a preference for omega-3 rich foods.
“restriction of omega-3 fatty acids triggers a preference for omega-3 rich foods”
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Cites
Specific hungers and poison avoidance as adaptive specializations of learning.
Rozin, P. N., & Kalat, J. W. (1971) · Psychological Review · doi:10.1037/h0031878 · Cited by 1,165 · see citing works
(2006) · Elsevier eBooks · doi:10.1016/b978-0-12-074903-4.x5000-6 · Cited by 1,073 · see citing works
Adams, P. B., Lawson, S., Sanigorski, A. J., & Sinclair, A. J. (1996) · Lipids · doi:10.1007/bf02637069 · Cited by 468 · see citing works
Moriguchi, T., Greiner, R. S., & Salem, N. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0752563.x · Cited by 421 · see citing works
Essential Fatty Acids and the Brain
Haag, M. (2003) · The Canadian Journal of Psychiatry · doi:10.1177/070674370304800308 · Cited by 421 · see citing works
Dietary essential fatty acids and brain function: a developmental perspective on mechanisms
Wainwright, P. E. (2002) · Proceedings of the Nutrition Society · doi:10.1079/pns2001130 · Cited by 346 · see citing works
Adipose tissue biomarkers of fatty acid intake
Baylín, A., Kabagambe, E. K., Siles, X., & Campos, H. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.4.750 · Cited by 332 · see citing works
Recovery of brain docosahexaenoate leads to recovery of spatial task performance
Moriguchi, T., & Salem, N. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01966.x · Cited by 209 · see citing works
Fish oil prevents the adrenal activation elicited by mental stress in healthy men
Delarue, J., Matzinger, O., Binnert, C., Schneiter, P., Chioléro, R., & Tappy, L. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70039-3 · Cited by 202 · see citing works
Suzuki, H., Park, S. J., Tamura, M., & Ando, S. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00169-3 · Cited by 194 · see citing works
Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum
Moriguchi, T., Loewke, J., Garrison, M. E., Catalan, J. N., & Salem, N. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31666-7 · Cited by 185 · see citing works
Zimmer, L., Delpal, S., Guilloteau, D., Aı̈oun, J., Durand, G., & Chalon, S. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)00950-2 · Cited by 167 · see citing works
Yehuda, S., & Carasso, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10345 · Cited by 163 · see citing works
Evolutionary Aspects of Diet and Essential Fatty Acids
Simopoulos, A. P. (2000) · KARGER eBooks · doi:10.1159/000059742 · Cited by 149 · see citing works
Possible regulatory mechanism of DHA-induced anti-stress reaction in rats
Takeuchi, T., Iwanaga, M., & Harada, E. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04113-6 · Cited by 141 · see citing works
Dietary n-3 fatty acid deficiency decreases nerve growth factor content in rat hippocampus
Ikemoto, A., Nitta, A., Furukawa, S., Ohishi, M., Nakamura, A., Fujii, Y., & Okuyama, H. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01035-1 · Cited by 137 · see citing works
Macronutrient diet selection in thirteen mouse strains
Smith, B. K., Andrews, P. K., & West, D. B. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.278.4.r797 · Cited by 130 · see citing works
Dietary n-3 Fatty Acid Deficiency Decreases Nerve Growth Factor Content in Rat Hippocampus.
Ikemoto, Atsushi, A., Nitta, Atsumi, Furukawa, Shoei, Ohishi, Masayo, Nakamura, Akira, A., et al. (2001) · 岐阜藥科大學紀要 = The annual proceedings of Gifu College of Pharmacy · Cited by 121 · see citing works
Nakashima, Y., Yuasa, S., Hukamizu, Y., Okuyama, H., Oh-hara, T., Kameyama, T., & Nabeshima, T. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40751-5 · Cited by 120 · see citing works
Salem, N., Moriguchi, T., Greiner, R. S., McBride, K., Ahmad, A., Catalan, J. N., & Slotnick, B. M. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:16:2-3:299 · Cited by 118 · see citing works
Raygada, M. J., Cho, E., & Hilakivi‐Clarke, L. (1998) · Journal of Nutrition · doi:10.1093/jn/128.12.2505 · Cited by 113 · see citing works
Lipid profile of rats fed high-fat diets based on flaxseed, peanut, trout, or chicken skin
Cintra, D. E., Costa, A. V., Pelúzio, M. D. C. G., da Matta, S. L. P., Silva, M. T. C., & Costa, N. M. B. (2006) · Nutrition · doi:10.1016/j.nut.2005.09.003 · Cited by 102 · see citing works
A contrarian view of the wisdom of the body as it relates to dietary self-selection.
Galef, B. G. (1991) · Psychological Review · doi:10.1037/0033-295x.98.2.218 · Cited by 78 · see citing works
Unlearned specific appetite for protein
Deutsch, J. A., Moore, B. O., & Heinrichs, S. C. (1989) · Physiology & Behavior · doi:10.1016/0031-9384(89)90341-7 · Cited by 77 · see citing works
Self-citationMaternal Diet Fatty Acid Composition Affects Neurodevelopment in Rat Pups
Saste, M. D., Carver, J. D., Stockard, J. E., Benford, V. J., Chen, L. T., & Phelps, C. P. (1998) · Journal of Nutrition · doi:10.1093/jn/128.4.740 · Cited by 74 · see citing works
Favrelière, S., Barrier, L., Durand, G., Chalon, S., & Tallineau, C. (1998) · Lipids · doi:10.1007/s11745-998-0221-y · Cited by 67 · see citing works
Effect of dietary α-linolenic acid deficiency on habituation
Francès, H., Moníer, C., Clément, M., Lecorsier, A., Debray, M., & Bourre, J. M. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00164-6 · Cited by 65 · see citing works
Determinants of dietary self-selection in experimental animals
Kanarek, R. (1985) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/42.5.940 · Cited by 52 · see citing works
Marteinsdóttir, Í., Horrobin, D. F., Stenfors, C., Theodorsson, E., & Mathé, A. A. (1998) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(98)00052-9 · Cited by 51 · see citing works
Specific hunger for thiamine: Recovery from deficiency and thiamine preference.
Rozin, P. N. (1965) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0021612 · Cited by 36 · see citing works
Francès, H., Drai, P., Smirnova, M., Carrié, I., Debray, M., & Bourre, J. M. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01065-x · Cited by 32 · see citing works
Olfactory self-selection of protein-containing foods
Heinrichs, S. C., Deutsch, J. A., & Moore, B. O. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90101-9 · Cited by 30 · see citing works
Self-citationThe preference-aversion behavior of rats for nutritionally-controlled diets containing oil or fat
Naim, M., Brand, J. G., & Kare, M. R. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90223-x · Cited by 30 · see citing works
Gray and White Matter Brain Volume in Aged Rats Raised onn-3 Fatty Acid Deficient Diets
Ahmad, A., Momenan, R., van Gelderen, P., Moriguchi, T., Greiner, R. S., & Salem, N. (2004) · Nutritional Neuroscience · doi:10.1080/1028415042000202009 · Cited by 14 · see citing works
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1 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The endocrinology of food intake
Begg, D. P., & Woods, S. C. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.136 · Cited by 199 · see citing works
FGF21 and the physiological regulation of macronutrient preference
Hill, C. M., Qualls-Creekmore, E., Berthoud, H.-R., Soto, P., Yu, S., McDougal, D. H., Münzberg, H., & Morrison, C. D. (2020) · Endocrinology · doi:10.1210/endocr/bqaa019 · Cited by 99 · see citing works
Dietary ω‐3 fatty acid supplementation for optimizing neuronal structure and function
Heinrichs, S. C. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900201 · Cited by 88 · see citing works
Self-citationNeural and metabolic regulation of macronutrient intake and selection
Berthoud, H.-R., Münzberg, H., Richards, B. K., & Morrison, C. D. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000559 · Cited by 87 · see citing works
The metabolic syndrome of ω3-depleted rats. I. Liver data
Malaisse (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000214 · Cited by 9 · see citing works
The metabolic syndrome of ω3-depleted rats. III. Brain phospholipids
Malaisse (2009) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000230 · Cited by 7 · see citing works
The Metabolic Syndrome of ω3-Depleted Rats. X: Comprehensive View
Malaisse, W. J. (2011) · The Open Physiology Journal · doi:10.2174/1874360901104010001 · Cited by 2 · see citing works
The metabolic syndrome of omega-3-depleted rats.IX.Food intake
Zhang, Y., Bulur, N., Louchamil, K., Hacquebard, M., & Larondelle, Y. (2010) · DIAL (Catholic University of Leuven) · Cited by 2 · see citing works
- Authors
- Dunlap, S., & Heinrichs, S. C.
- Affiliations
- Boston College (US)
- Corresponding author
- Heinrichs, Stephen C.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 1250
- Pages
- 113-119
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2014020919
- Cited by
- 8
- References
- 35
- Citations by year
- 2020: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- omega-3 deficiency, dietary self-selection, flaxseed, brain lipid composition, essential fatty acid deficiency, food preferences, dietary supplementation, rats
- MeSH terms
- Analysis of Variance, Animals, Body Weight, Brain, Brain Chemistry, Diet, Fatty Acids, Food Preferences, Male, Neurons, Seeds, Fatty Acids, Omega-3, Prosencephalon, Rats, Wistar, Flax, Rats
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