Categorization of biologically relevant chemical signals in the medial amygdala
Open accessAbstract
Many species employ chemical signals to convey messages between members of the same species (conspecific), but chemosignals may also provide information to another species (heterospecific). Here, we found that conspecific chemosignals (male, female mouse urine) increased immediate early gene-protein (IEG) expression in both anterior and posterior medial amygdala of male mice, whereas most heterospecific chemosignals (e.g.: hamster vaginal fluid, steer urine) increased expression only in anterior medial amygdala. This categorization of responses in medial amygdala conforms to our previously reported findings in male hamsters. The same characteristic pattern of IEG expression appears in the medial amygdala of each species in response to conspecific stimuli for that species. These results suggest that the amygdala categorizes stimuli according to the biological relevance for the tested species. Thus, a heterospecific predator (cat collar) stimulus, which elicited behavioral avoidance in mice, increased IEG expression in mouse posterior medial amygdala (like conspecific stimuli). Further analysis suggests reproduction related and potentially threatening stimuli produce increased IEG expression in different sub-regions of posterior medial amygdala (dorsal and ventral, respectively). These patterns of IEG expression in medial amygdala may provide glimpses of a tertiary sorting of chemosensory signals beyond the primary-level selectivity of chemosensory neurons and the secondary sorting in main and accessory olfactory bulbs.
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The MeA facilitates the ability of a mouse to discriminate between chemosignals of different conspecifics.
“Indeed, the MeA facilitates the ability of a mouse to discriminate between chemosignals of different conspecifics 12 .”
From Ucn3 and CRF-R2 in the medial amygdala regulate complex social dynamics (2016) · cites this paper as [12]
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Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Chemical Signals in Vertebrates
Müller‐Schwarze, D., & Mozell, M. M. (1977) · Springer eBooks · doi:10.1007/978-1-4684-2364-8 · Cited by 1,142 · see citing works
Chemical Signals in Vertebrates 3
Duvall, D., Müller-Schwarze, D., & Silverstein, R. M. (1983) · Springer eBooks · doi:10.1007/978-0-387-73945-8 · Cited by 1,060 · see citing works
Pitkänen, A., Savander, V., & LeDoux, J. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01125-9 · Cited by 980 · see citing works
Cerebral hemisphere regulation of motivated behavior
Swanson, L. W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02905-x · Cited by 846 · see citing works
Innate versus learned odour processing in the mouse olfactory bulb
Kobayakawa, K., Kobayakawa, R., Matsumoto, H., Oka, Y., Imai, T., Ikawa, M., Okabe, M., Ikeda, T., Itohara, S., Kikusui, T., et al. (2007) · Nature · doi:10.1038/nature06281 · Cited by 659 · see citing works
Ultrasensitive pheromone detection by mammalian vomeronasal neurons
Leinders-Zufall, T., Lane, A. P., Puche, A. C., Ma, W., Novotny, M. V., Shipley, M. T., & Zufall, F. (2000) · Nature · doi:10.1038/35015572 · Cited by 576 · see citing works
Identification of protein pheromones that promote aggressive behaviour
Chamero, P., Marton, T. F., Logan, D. W., Flanagan, K. A., Cruz, J. R., Saghatelian, A., Cravatt, B. F., & Stowers, L. (2007) · Nature · doi:10.1038/nature05997 · Cited by 529 · see citing works
Dielenberg, R. A., Hunt, G. E., & McGregor, I. S. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00150-6 · Cited by 487 · see citing works
Scent wars: the chemobiology of competitive signalling in mice
Hurst, J. L., & Beynon, R. J. (2004) · BioEssays · doi:10.1002/bies.20147 · Cited by 474 · see citing works
The medial hypothalamic defensive system: Hodological organization and functional implications
Canteras, N. S. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00685-2 · Cited by 463 · see citing works
Choi, G. B., Dong, H.-W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Swanson, L. W., & Anderson, D. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.011 · Cited by 462 · see citing works
Shipley, M. T., & Adamek, G. D. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90148-5 · Cited by 324 · see citing works
Spehr, M., Kelliher, K. R., Li, X., Boehm, T. L. J., Leinders‐Zufall, T., & Zufall, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4939-05.2006 · Cited by 301 · see citing works
Determining the Stage of the Estrous Cycle in the Mouse by the Appearance of the Vagina
Champlin, A. K., Dorr, D. L., & Gates, A. H. (1973) · Biology of Reproduction · doi:10.1093/biolreprod/8.4.491 · Cited by 300 · see citing works
The smell of danger: A behavioral and neural analysis of predator odor-induced fear
Takahashi, L. K., Nakashima, B. R., Hong, H., & Watanabe, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.008 · Cited by 298 · see citing works
Medial Nucleus of the Amygdala Mediates Chemosensory Control of Male Hamster Sexual Behavior
Lehman, M. N., Winans, S. S., & Powers, J. B. (1980) · Science · doi:10.1126/science.7423209 · Cited by 282 · see citing works
Coolen, L. M., & Wood, R. I. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980921)399:2 · Cited by 207 · see citing works
Discrimination by female mice between the odours of parasitized and non-parasitized males
Kavaliers, M., & Colwell, D. D. (1995) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1995.0113 · Cited by 205 · see citing works
Pankevich, D. E., Baum, M. J., & Cherry, J. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2376-04.2004 · Cited by 203 · see citing works
Lehman, M. N., & Winans, S. S. (1982) · Brain Research · doi:10.1016/0006-8993(82)90641-2 · Cited by 188 · see citing works
Blanchard, D. C., Canteras, N. S., Markham, C. M., Pentkowski, N. S., & Blanchard, R. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.019 · Cited by 179 · see citing works
Fernandez-Fewell, G. D., & Meredith, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03643.1994 · Cited by 176 · see citing works
Self-citationLin, W., Margolskee, R. F., Donnert, G., Hell, S. W., & Restrepo, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610201104 · Cited by 173 · see citing works
Encoding Gender and Individual Information in the Mouse Vomeronasal Organ
He, J., Ma, L., Kim, S. S., Nakai, J., & Yu, C. (2008) · Science · doi:10.1126/science.1154476 · Cited by 167 · see citing works
The causation of two scent-marking behaviour patterns in female hamsters (Mesocricetus auratus)
Johnston, R. E. (1977) · Animal Behaviour · doi:10.1016/0003-3472(77)90007-0 · Cited by 161 · see citing works
Bressler, S., & Baum, M. J. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00493-9 · Cited by 156 · see citing works
Boissy, A., Terlouw, C. E. M., & Neindre, P. L. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00466-6 · Cited by 144 · see citing works
Distinctive Responses in the Medial Amygdala to Same-Species and Different-Species Pheromones
Meredith, M. J., & Westberry, J. M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1139-04.2004 · Cited by 131 · see citing works
Self-citationVomeronasal, Olfactory, Hormonal Convergence in the Brain: Cooperation or Coincidence? <sup>a</sup>
MEREDITH, M. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10593.x · Cited by 121 · see citing works
Self-citationBlanchard, D. C., Markham, C. M., Yang, M., Hubbard, D. T., Madarang, E., & Blanchard, R. J. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.2.360 · Cited by 110 · see citing works
Fendt, M. (2006) · Journal of Chemical Ecology · doi:10.1007/s10886-006-9186-9 · Cited by 103 · see citing works
Low-Dose Midazolam Attenuates Predatory Odor Avoidance in Rats
Dielenberg, R. A., Arnold, J. C., & McGregor, I. S. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00064-1 · Cited by 101 · see citing works
Odor preferences of female house mice (Mus domesticus) in seminatural enclosures.
Mossman, C. A., & Drickamer, L. C. (1996) · Journal of comparative psychology · doi:10.1037/0735-7036.110.2.131 · Cited by 96 · see citing works
Predator odor-induced conditioned fear involves the basolateral and medial amygdala.
Takahashi, L. K., Hubbard, D. T., Lee, I., Dar, Y., & Sipes, S. M. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.1.100 · Cited by 94 · see citing works
Petrulis, A., & Johnston, R. E. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.2.345 · Cited by 84 · see citing works
Petrulis, A., & Johnston, R. E. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.2.345 · Cited by 73 · see citing works
Martel, K. L., & Baum, M. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06564.x · Cited by 70 · see citing works
Pankevich, D. E., Cherry, J. A., & Baum, M. J. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.4.925 · Cited by 69 · see citing works
Murphy, M. R. (1980) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(80)91210-8 · Cited by 63 · see citing works
Li, H. L., Roch, J., Sundsmo, M. P., Otero, D. A. C., Sisodia, S. S., Thomas, R. G., & Saitoh, T. (1997) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199705)32:5 · Cited by 56 · see citing works
Species-specificity of scent marking in hamsters
Johnston, R. E., & Brenner, D. (1982) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(82)91266-3 · Cited by 42 · see citing works
Nakamura, K., Kikusui, T., Takeuchi, Y., & Mori, Y. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.10.014 · Cited by 24 · see citing works
Gouat, P., Patris, B., & Lalande, C. (1998) · Comptes Rendus de l Académie des Sciences - Series III - Sciences de la Vie · doi:10.1016/s0764-4469(98)80459-9 · Cited by 20 · see citing works
Meredith, M. J., Samuelsen, C. L., Blake, C. B., & Westberry, J. M. (2007) · Springer eBooks · doi:10.1007/978-0-387-73945-8_35 · Cited by 10 · see citing works
Self-citationHowe, J. L. (1907) · Science · doi:10.1126/science.25.640.535 · Cited by 2 · see citing works
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Yao, S., Bergan, J., Lanjuin, A., & Dulac, C. (2017) · eLife · doi:10.7554/elife.31373 · Cited by 151 · see citing works
Vasopressin, oxytocin, and social odor recognition
Wacker, D. W., & Ludwig, M. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.08.014 · Cited by 112 · see citing works
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- Authors
- Samuelsen, C. L., & Meredith, M.
- Affiliations
- Florida State University (US)
- Corresponding author
- Samuelsen, Chad L.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 1263
- Pages
- 33-42
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC2798152
- OpenAlex
- W1991429950
- Cited by
- 64
- References
- 46
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 4
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (T32 DC00044, F31DC008062, dc 005813, R01DC005813, F31 DC08062, T32DC000044)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- medial amygdala, chemosignals, immediate early gene expression, olfactory processing, stimulus classification, predator avoidance, mouse urine, olfactory bulb
- MeSH terms
- Amygdala, Analysis of Variance, Animals, Body Fluids, Cats, Cattle, Exploratory Behavior, Female, Cricetinae, Immunohistochemistry, Male, Mice, Inbred C57BL, Pheromones, Physical Stimulation, Urine, Vagina, Gene Expression, Proto-Oncogene Proteins c-fos, Genes, Immediate-Early, Mice
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