Cited by 64Olfactory and Sensory Function StudiesMemory and Neural MechanismsNeuroendocrine regulation and behavior

Categorization of biologically relevant chemical signals in the medial amygdala

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Samuelsen, Chad L., Meredith, Michael·2009·Brain Research

Abstract

Many species employ chemical signals to convey messages between members of the same species (conspecific), but chemosignals may also provide information to another species (heterospecific). Here, we found that conspecific chemosignals (male, female mouse urine) increased immediate early gene-protein (IEG) expression in both anterior and posterior medial amygdala of male mice, whereas most heterospecific chemosignals (e.g.: hamster vaginal fluid, steer urine) increased expression only in anterior medial amygdala. This categorization of responses in medial amygdala conforms to our previously reported findings in male hamsters. The same characteristic pattern of IEG expression appears in the medial amygdala of each species in response to conspecific stimuli for that species. These results suggest that the amygdala categorizes stimuli according to the biological relevance for the tested species. Thus, a heterospecific predator (cat collar) stimulus, which elicited behavioral avoidance in mice, increased IEG expression in mouse posterior medial amygdala (like conspecific stimuli). Further analysis suggests reproduction related and potentially threatening stimuli produce increased IEG expression in different sub-regions of posterior medial amygdala (dorsal and ventral, respectively). These patterns of IEG expression in medial amygdala may provide glimpses of a tertiary sorting of chemosensory signals beyond the primary-level selectivity of chemosensory neurons and the secondary sorting in main and accessory olfactory bulbs.

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Crossref · 10.1016/j.brainres.2009.01.048

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  1. Aggleton JP The amygdala 2000 Oxford UP New York Ed 2.

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Authors
Samuelsen, C. L., & Meredith, M.
Affiliations
Florida State University (US)
Corresponding author
Samuelsen, Chad L.
Venue
Brain Research
Publisher
Elsevier BV
Published
2009-03
Volume
1263
Pages
33-42
ISSN
0006-8993 (ISSN-L)
OpenAlex
W1991429950
Cited by
64
References
46
Citations by year
2024: 2 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 6 · 2013: 6 · 2012: 4
FWCI
3.08
Type
journal article
Language
en
Open access
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Deafness and Other Communication Disorders (T32 DC00044, F31DC008062, dc 005813, R01DC005813, F31 DC08062, T32DC000044)
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
medial amygdala, chemosignals, immediate early gene expression, olfactory processing, stimulus classification, predator avoidance, mouse urine, olfactory bulb
MeSH terms
Amygdala, Analysis of Variance, Animals, Body Fluids, Cats, Cattle, Exploratory Behavior, Female, Cricetinae, Immunohistochemistry, Male, Mice, Inbred C57BL, Pheromones, Physical Stimulation, Urine, Vagina, Gene Expression, Proto-Oncogene Proteins c-fos, Genes, Immediate-Early, Mice

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