Cited by 125Stress Responses and CortisolSignaling Pathways in DiseaseEstrogen and related hormone effects

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Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder

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Tatro, Erick T., Everall, Ian P., Kaul, Marcus, Achim, Cristian L.·2009·Brain Research

DOI 10.1016/j.brainres.2009.06.036PMC PMC2724600

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Abstract

Mood disorders associated with dysfunction of the hypothalamic-pituitary-adrenal (HPA) axis are common psychiatric conditions. The glucocorticoid receptor (GR) is a steroid-activated nuclear receptor that, upon binding to cortisol, translocates to the nucleus where it targets genes related to neuronal metabolism and plasticity. In patients suffering from major depressive disorder (MDD), hypercortisolemia is a common finding. In the current study we investigated the molecular events associated with the FK506 binding proteins (FKBP) -52 and -51 response to cortisol exposure in neuronal cell cultures and their effect on GR translocation. We noted that FK506 altered nuclear localization of the GR and inhibited expression of GR-responsive genes. Furthermore, si-RNA knockdown of FKBP4 gene, coding for the immunophilin FKBP52, inhibited cortisol-activated GR nuclear translocation, while knockdown of FKBP5, coding for immunophilin FKBP51, was associated with increased baseline GR nuclear localization. We propose that immunophilins are modulators of the cortisol-HPA axis response to stress and related chronic brain disorders.

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“In fact, transgenicmice thatunder-orover-express GR have been used asmodels ofMDDor PTSD (Alexandre Urani, 2003;Chourbaji et al., 2008;Gasset al., 2001).”
BackgroundInfluential
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343
Association of <emph type="ital">FKBP5</emph> Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362
Predictors of posttraumatic stress disorder and symptoms in adults: A meta-analysis.
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Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147
Clinical and Biochemical Manifestations of Depression
Gold, P. W., Goodwin, F. K., & Chrousos, G. P. (1988) · New England Journal of Medicine · doi:10.1056/nejm198808183190706 · Cited by 1,057
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Binder, E. B., Salyakina, D., Lichtner, P., Wochnik, G. M., Ising, M., Pütz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M. A., et al. (2004) · Nature Genetics · doi:10.1038/ng1479 · Cited by 977
DNA binding site sequence directs glucocorticoid receptor structure and activity
Meijsing, S. H., Pufall, M. A., So, A. Y., Bates, D. L., Chen, L., & Yamamoto, K. R. (2009) · Science · doi:10.1126/science.1164265 · Cited by 673
FK506-binding Proteins 51 and 52 Differentially Regulate Dynein Interaction and Nuclear Translocation of the Glucocorticoid Receptor in Mammalian Cells
Wochnik, G. M., Rüegg, J., Abel, G. A., Schmidt, U., Holsboer, F., & Rein, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m407498200 · Cited by 638
Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation
Påhlman, S., Ruusala, A.-I., Abrahamsson, L., Mattsson, M. E. K., & Esscher, T. (1984) · Cell Differentiation · doi:10.1016/0045-6039(84)90038-1 · Cited by 571

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Limited, A.S., 2008. Antibody Review to Mouse Anti FKBP51 ab46002. Vol., ed.^eds. AbCam Incorporated, Cambridge, MA.

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Authors: Tatro, E. T., Everall, I. P., Kaul, M., & Achim, C. L.
Affiliations: University of Pittsburgh (US)
University of California San Diego (US)
Sanford Burnham Prebys Medical Discovery Institute (US)
Corresponding author: Tatro, Erick T.
ORCID: Everall, Ian P.
Kaul, Marcus
Venue: Brain Research
Publisher: Elsevier BV
Published: 2009-08
Volume: 1286
Pages: 1-12
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2009.06.036
PMC: PMC2724600
OpenAlex: W2000320359
Semantic Scholar: ae62fcaaab9cb7f8eb6e5a37d39b2b7868c8dc1d
Cited by: 125
References: 61
Citations by year: 2026: 2 · 2024: 8 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 14 · 2015: 8 · 2014: 9 · 2013: 4 · 2012: 5
FWCI: 2.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Center for AIDS Research, University of Washington
University of California, San Diego
National Institute of Mental Health (R01MH079881, P30MH62512, MH076681, R41MH079728, R25MH074508, R21MH076681, R25MH081482, P30MH062512)
National Institute of Allergy and Infectious Diseases (AI-36214, P30AI036214)
National Institute of Neurological Disorders and Stroke (R01NS050621)
National Institute of Biomedical Imaging and Bioengineering (T32EB001026)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: glucocorticoid receptor, nuclear translocation, FKBP51, FKBP52, FKBP4, immunophilins, major depressive disorder, hypothalamic-pituitary-adrenal axis, cortisol, hypercortisolism, neuronal gene expression, stress response, siRNA knockdown
MeSH terms: Tacrolimus Binding Protein 5, Cells, Cultured, Depressive Disorder, Major, Major Depressive Disorder, Fluorescent Antibody Technique, Gene Expression Regulation, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Neurons, Pituitary-Adrenal System, Receptors, Glucocorticoid, Gene Expression, Protein Transport, Tacrolimus Binding Proteins, RNA, Small Interfering

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Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder

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