GLUCOCORTICOID RECEPTOR-RELATED GENES: GENOTYPE AND BRAIN GENE EXPRESSION RELATIONSHIPS TO SUICIDE AND MAJOR DEPRESSIVE DISORDER: Research Article: Glucocorticoid Receptor-Related Genes and Suicide

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 11,930 · see citing works

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works

Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment

Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works

Columbia Classification Algorithm of Suicide Assessment (C-CASA): classification of suicidal events in the FDA’s pediatric suicidal risk analysis of antidepressants

Posner, K., Oquendo, M. A., Gould, M., Stanley, B., & Davies, M. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.7.1035 · Cited by 1,025 · see citing works

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

Binder, E. B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.021 · Cited by 968 · see citing works

Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma

Perroud, N., Paoloni-Giacobino, A., Prada, P., Olié, E., Salzmann, A., Nicastro, R., Guillaume, S., Mouthon, D., Stouder, C., Dieben, K., et al. (2011) · Translational Psychiatry · doi:10.1038/tp.2011.60 · Cited by 516 · see citing works

Candidate endophenotypes for genetic studies of suicidal behavior

Mann, J. J., Arango, V. A., Avenevoli, S., Brent, D. A., Champagne, F. A., Clayton, P., Currier, D., Dougherty, D. M., Haghighi, F., Hodge, S. E., et al. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.021 · Cited by 398 · see citing works

Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression

van Rossum, E. F. C., Binder, E. B., Majer, M., Koper, J. W., Ising, M., Modell, S., Salyakina, D., Lamberts, S. W. J., & Holsboer, F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.007 · Cited by 324 · see citing works

Positron Emission Tomography of Regional Brain Metabolic Responses to a Serotonergic Challenge and Lethality of Suicide Attempts in Major Depression

Oquendo, M. A., Placidi, G. P. A., Malone, K. M., Campbell, C., Keilp, J., Brodsky, B., Kegeles, L. S., Cooper, T. B., Parsey, R. V., Van Heertum, R. L., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.1.14 · Cited by 313 · see citing works

Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide

Roy, A., Gorodetsky, E., Yuan, Q., Goldman, D., & Enoch, M.-A. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.236 · Cited by 282 · see citing works

Validity of DSM‐III‐R diagnosis by psychological autopsy: a comparison with clinician ante‐mortem diagnosis

Kelly, T. M., & Mann, J. J. (1996) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1996.tb09869.x · Cited by 272 · see citing works

MicroRNA-301 Mediates Proliferation and Invasion in Human Breast Cancer

Shi, W., Gerster, K., Alajez, N. M., Tsang, J., Waldron, L., Pintilie, M., Hui, A. B., Sykes, J. R., P’ng, C., Miller, N. A., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3369 · Cited by 266 · see citing works

Early-life stress and HPA axis trigger recurrent adulthood depression.

Juruena, M. F. (2014) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2013.10.020 · Cited by 232 · see citing works

Can biological tests assist prediction of suicide in mood disorders?

Mann, J. J., Currier, D., Stanley, B., Oquendo, M. A., Amsel, L. V., & Ellis, S. P. (2006) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005687 · Cited by 215 · see citing works

Are SSRIs better than TCAs? Comparison of SSRIs and TCAs: A meta-analysis

Steffens, D. C., Krishnan, K. R., & Helms, M. J. (1997) · Depression and Anxiety · doi:10.1002/(sici)1520-6394(1997)6:1 · Cited by 194 · see citing works

Identification and replication of a combined epigenetic and genetic biomarker predicting suicide and suicidal behaviors

Guintivano, J., Brown, T., Newcomer, A., Jones, M., Cox, O., Maher, B. S., Eaton, W. W., Payne, J. L., Wilcox, H. C., & Kaminsky, Z. A. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.14010008 · Cited by 193 · see citing works

Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior

Roy, A., Hodgkinson, C. A., Luca, V. D., Goldman, D. A., & Enoch, M. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.009 · Cited by 168 · see citing works

Glucocorticoid Receptor Gene-Based SNP Analysis in Patients with Recurrent Major Depression

West, D. V., Eede, F. V. D., Del‐Favero, J., Souery, D., Norrback, K., van Duijn, C. M., Sluijs, S., Adolfsson, R., Mendlewicz, J., Deboutte, D., et al. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300898 · Cited by 155 · see citing works

Association between Glucocorticoid Receptor Methylation and Hippocampal Subfields in Major Depressive Disorder

Na, K., Chang, H. S., Won, E., Han, K., Choi, S., Tae, W., Yoon, H., Kim, Y., Joe, S., Jung, I., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085425 · Cited by 144 · see citing works

Methylation of the glucocorticoid receptor gene promoter in bulimic women: Associations with borderline personality disorder, suicidality, and exposure to childhood abuse

Steiger, H., Labonté, B., Groleau, P., Turecki, G., & Israël, M. (2013) · International Journal of Eating Disorders · doi:10.1002/eat.22113 · Cited by 133 · see citing works

Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorder

Tatro, E. T., Everall, I. P., Kaul, M., & Achim, C. L. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.036 · Cited by 125 · see citing works

Gene Expression Profiling of Depression and Suicide in Human Prefrontal Cortex

Sibille, E. L., Arango, V., Galfalvy, H., Pavlidis, P., Erraji-Benchekroun, L., Ellis, S., & Mann, J. J. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300335 · Cited by 125 · see citing works

Positron Emission Tomography Quantification of Serotonin_1AReceptor Binding in Suicide Attempters With Major Depressive Disorder

Sullivan, G. M., Oquendo, M. A., Milak, M., Miller, J. M., Burke, A., Ogden, R. T., Parsey, R. V., & Mann, J. J. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.2406 · Cited by 118 · see citing works

FK506-Binding Protein 51 Regulates Nuclear Transport of the Glucocorticoid Receptor β and Glucocorticoid Responsiveness

Zhang, X., Clark, A. F., & Yorio, T. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1279 · Cited by 116 · see citing works

Rapid glucocorticoid receptor-mediated inhibition of hypothalamic-pituitary-adrenal ultradian activity in healthy males

Russell, G. M., Henley, D. E., Leendertz, J., Douthwaite, J. A., Wood, S. A., Stevens, A., Woltersdorf, W. W., Peeters, B. W. M. M., Ruigt, G. S. F., White, A., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5332-09.2010 · Cited by 111 · see citing works

The DSM-III-R Field Trial of Disruptive Behavior Disorders

Spitzer, R. L., Davies, M., & Barkley, R. A. (1990) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199009000-00003 · Cited by 107 · see citing works

Genetics of cortisol secretion and depressive symptoms: a candidate gene and genome wide association approach

Velders, F. P., Kuningas, M., Kumari, M., Dekker, M. J., Uitterlinden, A. G., Kirschbaum, C., Hek, K., Hofman, A., Verhulst, F. C., Kivimaki, M., et al. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.01.003 · Cited by 106 · see citing works

A genome‐wide association study of suicidal behavior

Galfalvy, H., Haghighi, F., Hodgkinson, C., Goldman, D., Oquendo, M. A., Burke, A., Huang, Y., Giegling, I., Rujescu, D., Bureau, A., et al. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32330 · Cited by 102 · see citing works

FKBP5 polymorphism is associated with major depression but not with bipolar disorder

Szczepankiewicz, A., Leszczyńska-Rodziewicz, A., Pawlak, J., Narozna, B., Rajewska-Rager, A., Wilkosc, M., Zaremba, D., Maciukiewicz, M., & Twarowska-Hauser, J. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.002 · Cited by 100 · see citing works

Glucocorticoid receptor polymorphism is associated with major depression and predominance of depression in the course of bipolar disorder

Szczepankiewicz, A., Leszczyńska-Rodziewicz, A., Pawlak, J., Rajewska‐Rager, A., Dmitrzak‐Węglarz, M., Wiłkość-Dębczyńska, M., Skibińska, M., & Hauser, J. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.06.020 · Cited by 86 · see citing works

Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor

Rice, L., Waters, C. E., Eccles, J., Garside, H., Sommer, P., Kay, P., Blackhall, F. H., Zeef, L. A. H., Telfer, B. A., Stratford, I. J., et al. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0019 · Cited by 83 · see citing works

HPA-related CSF neuropeptides in suicide attempters

Träskman‐Bendz, L., Ekman, R., Regnéll, G., & Öhman, R. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90018-4 · Cited by 82 · see citing works

Gene and protein alterations of FKBP5 and glucocorticoid receptor in the amygdala of suicide victims

Pérez‐Ortiz, J. M., García‐Gutiérrez, M. S., Navarrete, F., Giner, S., & Manzanares, J. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.11.008 · Cited by 75 · see citing works

Hyperactivity of the hypothalamic–pituitary–adrenal axis and mortality in major depressive disorder

Coryell, W. H., Young, E. A., & Carroll, B. J. (2005) · Psychiatry Research · doi:10.1016/j.psychres.2005.08.009 · Cited by 71 · see citing works

Association of FKBP5 gene haplotypes with completed suicide in the Japanese population

Supriyanto, I., Sasada, T., Fukutake, M., Asano, M., Ueno, Y., Nagasaki, Y., Shirakawa, O., & Hishimoto, A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.019 · Cited by 67 · see citing works

Genetics of HPA-axis, depression and suicidality

Wasserman, D., Wasserman, J., & Sokolowski, M. (2010) · European Psychiatry · doi:10.1016/j.eurpsy.2009.12.016 · Cited by 63 · see citing works

Increased cortisol awakening response was associated with time to recurrence of major depressive disorder

Hardeveld, F., Spijker, J., Vreeburg, S. A., Graaf, R. D., Hendriks, S. M., Licht, C. M. M., Nolen, W. A., Penninx, B. W. J. H., & Beekman, A. T. F. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.027 · Cited by 58 · see citing works

Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance

Kumsta, R., Moser, D., Streit, F., Koper, J. W., Meyer, J., & Wüst, S. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30837 · Cited by 52 · see citing works

Hypothalamic-pituitary-adrenal axis dysfunction as a neurobiological correlate of emotion dysregulation in adolescent suicide

Braquehais, M. D., Picouto, M. D., Casas, M., & Sher, L. (2012) · World Journal of Pediatrics · doi:10.1007/s12519-012-0358-0 · Cited by 51 · see citing works

Glucocorticoid Receptor Gene Polymorphisms in Premenopausal Women with Major Depression

Krishnamurthy, P., Romagni, P., Torvik, S., Gold, P. W., Charney, D. S., Detera‐Wadleigh, S. D., & Cizza, G. (2008) · Hormone and Metabolic Research · doi:10.1055/s-2007-1004541 · Cited by 45 · see citing works

Suicidal behavior and hypothalamic-pituitary-adrenocortical axis indices in child psychiatric inpatients

Pfeffer, C. R., Stokes, P. E., & Shindledecker, R. D. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90057-s · Cited by 43 · see citing works

Isoform-level brain expression profiling of the spermidine/spermine N1-Acetyltransferase1 ( SAT1 ) gene in major depression and suicide

Pantazatos, S. P., Andrews, S. J., Dunning-Broadbent, J., Pang, J., Huang, Y.-Y., Arango, V., Nagy, P. L., & John Mann, J. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.014 · Cited by 38 · see citing works

Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls

Iacob, E., Light, K. C., Tadler, S. C., Weeks, H. R., White, A. T., Hughen, R. W., VanHaitsma, T. A., Bushnell, L., & Light, A. R. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-273 · Cited by 36 · see citing works

Thyroid stimulating hormone and serum, plasma, and platelet brain-derived neurotrophic factor during a 3-month follow-up in patients with major depressive disorder

Baek, J. H., Kang, E., D, M. F. M., Mischoulon, D., Nierenberg, A. A., Lee, D., Heo, J.-Y., & Jeon, H. J. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.08.009 · Cited by 29 · see citing works

Relationship between urinary free cortisol and CSF opioid binding activity in depressed patients and normal volunteers.

Rubinow, D., Post, R., Pickar, D., Naber, D., Ballenger, J. C., Gold, P., & Bunney, W. (1981) · Psychiatry Research · doi:10.1016/0165-1781(81)90064-0 · Cited by 23 · see citing works

Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus–infected individuals

Tatro, E. T., Nguyen, T. B., Bousman, C., Masliah, E., Grant, I., Atkinson, J. H., & Everall, I. (2010) · Journal of NeuroVirology · doi:10.3109/13550284.2010.504248 · Cited by 23 · see citing works

Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients

Shinozaki, G., Jowsey‐Gregoire, S. G., Amer, H., Biernacka, J. M., Colby, C. L., Walker, D. L., Black, J. L., Rundell, J. R., Stegall, M. D., & Mrazek, D. A. (2011) · Depression and Anxiety · doi:10.1002/da.20879 · Cited by 22 · see citing works

Depressed suicidal adolescent males have an altered cortisol response to a pharmacological challenge

Ghaziuddin, N., King, C. A., Welch, K., & Ghaziuddin, M. (2013) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2013.10.005 · Cited by 16 · see citing works

Association, Haplotype, and Gene‐Gene Interactions of the HPA Axis Genes with Suicidal Behaviour in Affective Disorders

Leszczyńska-Rodziewicz, A., Szczepankiewicz, A., Pawlak, J., Dmitrzak-Weglarz, M., & Hauser, J. (2013) · The Scientific World Journal · doi:10.1155/2013/207361 · Cited by 15 · see citing works

Biomarkers of Suicide Attempt Behavior: Towards a Biological Model of Risk

Sudol, K., & Mann, J. J. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0781-y · Cited by 225 · see citing works

A brain-centric model of suicidal behavior

Mann, J. J., & Rizk, M. M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20081224 · Cited by 214 · see citing works

Blunted HPA axis activity prior to suicide attempt and increased inflammation in attempters

Melhem, N. M., Munroe, S., Marsland, A., Gray, K., Brent, D., Porta, G., Douaihy, A., Laudenslager, M. L., DePietro, F., Diler, R., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.01.001 · Cited by 124 · see citing works

Resilience Is Associated With Larger Dentate Gyrus, While Suicide Decedents With Major Depressive Disorder Have Fewer Granule Neurons

Boldrini, M., Galfalvy, H., Dwork, A. J., Rosoklija, G. B., Trencevska-Ivanovska, I., Pavlovski, G., Hen, R., Arango, V., & Mann, J. J. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.12.022 · Cited by 116 · see citing works

The receptor hypothesis and the pathogenesis of depression: Genetic bases and biological correlates

Wang, H., Wang, Z., & Chen, N. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105542 · Cited by 117 · see citing works

The Life Span Model of Suicide and Its Neurobiological Foundation

Ludwig, B., Roy, B., Wang, Q., Birur, B., & Dwivedi, Y. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00074 · Cited by 52 · see citing works

The role of substance use, smoking, and inflammation in risk for suicidal behavior

Chang, H. B., Munroe, S., Gray, K., Porta, G., Douaihy, A. B., Marsland, A. L., Brent, D. A., & Melhem, N. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.005 · Cited by 47 · see citing works

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

Ishiguro, H., Horiuchi, Y., Tabata, K., Liu, Q., Arinami, T., & Onaivi, E. S. (2018) · Molecules · doi:10.3390/molecules23081836 · Cited by 44 · see citing works

Association between FKBP5 and CRHR1 genes with suicidal behavior: A systematic review

la Cruz-Cano, E. D. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.032 · Cited by 30 · see citing works

A Slice of the Suicidal Brain: What Have Postmortem Molecular Studies Taught Us?

Almeida, D. M., & Turecki, G. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-016-0736-8 · Cited by 33 · see citing works

Cortisol Stress Response and in Vivo PET Imaging of Human Brain Serotonin 1A Receptor Binding

Steinberg, L. J., Rubin‐Falcone, H., Galfalvy, H., Kaufman, J., Miller, J. M., Sublette, M. E., Cooper, T. B., Min, E., Keilp, J. G., Stanley, B., et al. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz009 · Cited by 34 · see citing works

Abnormal stress responsiveness and suicidal behavior: a risk phenotype

Steinberg, L. J., & Mann, J. J. (2020) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2020.100011 · Cited by 29 · see citing works

Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101)

Rew, Y., Du, X., Eksterowicz, J. E., Zhou, H., Jahchan, N. S., Zhu, L., Yan, X., Kawai, H., McGee, L. R., Medina, J. C., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00743 · Cited by 29 · see citing works

Sex differences in brain gene expression among suicide completers

Cabrera‐Mendoza, B., Fresno, C., Monroy‐Jaramillo, N., Fries, G. R., Walss‐Bass, C., Glahn, D. C., Ostrosky‐Wegman, P., Mendoza-Morales, R., García‐Dolores, F., Díaz‐Otañez, C. E., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.167 · Cited by 24 · see citing works

Targeted sequencing approach: Comprehensive analysis of DNA methylation and gene expression across blood and brain regions in suicide victims

Kouter, K., Zupanc, T., & Paska, A. V. (2022) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2022.2046291 · Cited by 25 · see citing works

The impulsiveness level influences the salivary cortisol response and social stress sensitivity in suicidal patients

Alacreu‐Crespo, A., Hidalgo, V., Girod, C., Olié, É., & Courtet, P. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.10.008 · Cited by 21 · see citing works

Efficacy, cost-utility and physiological effects of Acceptance and Commitment Therapy (ACT) and Behavioural Activation Treatment for Depression (BATD) in patients with chronic low back pain and depression: study protocol of a randomised, controlled trial including mobile-technology-based ecological momentary assessment (IMPACT study)

Sanabria-Mazo, J. P., Forero, C. G., Cristobal-Narváez, P., Suso-Ribera, C., García-Palacios, A., Colomer-Carbonell, A., Pérez-Aranda, A., Andrés-Rodríguez, L., McCracken, L. M., D'Amico, F., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2020-038107 · Cited by 16 · see citing works

Interactions of the GABRG2 polymorphisms and childhood trauma on suicide attempt and related traits in depressed patients

Yin, H., Galfalvy, H., Zhang, B., Tang, W., Xin, Q., Li, E., Xue, X., Li, Q., Ye, J., Yan, N., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.126 · Cited by 17 · see citing works

Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review

Hernández‐Díaz, Y., Mendoza, A. D. G., González‐Castro, T. B., Tovilla‐Zárate, C. A., Juárez‐Rojop, I. E., López‐Narváez, M. L., & Nicolini, H. (2021) · Genes · doi:10.3390/genes12101608 · Cited by 19 · see citing works

Polymorphisms of stress pathway genes and emergence of suicidal ideation at antidepressant treatment onset

Nobile, B., Ramoz, N., Jaussent, I., Dubois, J., Guillaume, S., Gorwood, P. A. P. M., & Courtet, P. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01003-0 · Cited by 16 · see citing works

SKA2 enhances stress-related glucocorticoid receptor signaling through FKBP4–FKBP5 interactions in neurons

Hartmann, J., Klengel, C., Dillmann, L. J., Hisey, E. E., Hafner, K., Shukla, R., Estruch, M. S., Bajaj, T., Ebert, T., Mabbott, K. G., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2417728121 · Cited by 16 · see citing works

Molecular Changes Associated with Suicide

Navarro, D., Marín, M., Gasparyan, A., García‐Gutiérrez, M. S., Rubio, G., & Manzanares, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316726 · Cited by 16 · see citing works

Familial Linkage and Association of the NR3C1 Gene with Type 2 Diabetes and Depression Comorbidity

Amin, M., Syed, S., Wu, R., Postolache, T. T., & Gragnoli, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911951 · Cited by 15 · see citing works

Transcription Factor Motifs Associated with Anterior Insula Gene Expression Underlying Mood Disorder Phenotypes

Arasappan, D., Eickhoff, S. B., Nemeroff, C. B., Hofmann, H. A., & Jabbi, M. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02195-8 · Cited by 11 · see citing works

Brain and Blood Biomarkers of Major Depressive Disorder

Zallar, L. J., & Dupont, M. B. (2026) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2025.4613 · Cited by 12 · see citing works

Gene Expression Analysis in Postmortem Brains from Individuals Who Died by Suicide: A Systematic Review

González‐Castro, T. B., Mendoza, A. D. G., López‐Narváez, M. L., Juárez‐Rojop, I. E., Ramos-Méndez, M. Á., Tovilla‐Zárate, C. A., & Nicolini, H. (2023) · Brain Sciences · doi:10.3390/brainsci13060906 · Cited by 10 · see citing works

Targeted Sequencing of FKBP5 in Suicide Attempters with Bipolar Disorder

Breen, M. E., Gaynor, S. C., Monson, E. T., de Klerk, K., Parsons, M. G., Braun, T. A., DeLuca, A. P., Zandi, P. P., Potash, J. B., & Willour, V. L. (2016) · PLoS ONE · doi:10.1371/journal.pone.0169158 · Cited by 10 · see citing works

History of suicide attempt associated with amygdala and hippocampus changes among individuals with schizophrenia

Yin, Y., Tong, J., Huang, J., Wang, L., Tian, B., Chen, S., Tan, S., Wang, Z., Yu, T. Y., Li, Y., et al. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01554-5 · Cited by 10 · see citing works

A Stress Protein–Based Suicide Prediction Score and Relationship to Reported Early-Life Adversity and Recent Life Stress

Underwood, M. D., Galfalvy, H., Hsiung, S., Liu, Y., Simpson, N. R., Bakalian, M. J., Rosoklija, G. B., Dwork, A. J., Arango, V., & Mann, J. J. (2023) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyad025 · Cited by 10 · see citing works

Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633)

Du, X., Eksterowicz, J. E., Zhou, H., Rew, Y., Zhu, L., Yan, X., Medina, J. C., Huang, T. H.-W., Chen, X., Sutimantanapi, D., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b00711 · Cited by 10 · see citing works

NR3C1 and NR3C2 Genes Increase the Risk of Suicide Attempt in Psychiatric Disorder Patients with History of Childhood Trauma

Sanabrais‐Jiménez, M. A., Esquivel-López, A., Sotelo-Ramírez, C. E., Aguilar-Garcı́a, A., Ordoñez-Martínez, B., Pavón, J. J., Madrigal-Lara, M., Díaz-Vivanco, A., & Camarena, B. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s431176 · Cited by 9 · see citing works

Etiopathogenesis of Suicide: A Conceptual Analysis of Risk and Prevention Within a Comprehensive, Deterministic Model

Lennon, J. C. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02087 · Cited by 8 · see citing works

Decreased mononuclear cell NR3C1 SKA2 and FKPB5 expression levels among adult survivors of suicide bombing terror attacks in childhood are associated with the development of PTSD

Goltser‐Dubner, T., Shalev, A., Benarroch, F., Canetti, L., Yogev, M., Kalla, C., Masarwa, R., Martin, J., Pevzner, D., Oz, O., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02278-7 · Cited by 6 · see citing works

Childhood trauma cortisol and immune cell glucocorticoid transcript levels are associated with increased risk for suicidality in adolescence

Goltser‐Dubner, T., Benarroch, F., Lavon, M., Amer, R., Canetti, L., Giesser, R., Kianski, E., Martin, J., Pevzner, D., Weinberg, P. B., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02923-3 · Cited by 6 · see citing works

The rs7208505 Polymorphism and Differential Expression of the SKA 2 Gene in the Prefrontal Cortex of Suicide Victims from the Mexican Population

Valenzuela‐García, L. I., Ayala‐García, V. M., Ramos-Rosales, D. F., Jacquez-Flores, R. E., Úrtiz-Estrada, N., Hernández, E., & Barraza-Salas, M. (2023) · Archives of Suicide Research · doi:10.1080/13811118.2023.2209155 · Cited by 5 · see citing works

The role of SKA2 on affective disorder, post-traumatic stress disorder and suicide behavior: systematic review and in silico analysis

González‐Castro, T. B., Rodríguez-Fuentes, I., Tovilla‐Zárate, C. A., Juárez‐Rojop, I. E., Hernández‐Díaz, Y., López‐Narváez, M. L., Uresti‐Rivera, E. E., & Hernández-Vicencio, J. L. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01346-3 · Cited by 5 · see citing works

Relationship between suicide rate and antidepressant prescription: An ecological study in the People's Republic of China

Xin, Q., Paudel, D., Li, L., Zhang, B., & Yin, H. (2020) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2760 · Cited by 4 · see citing works

Global DNA methylation in suicidal ideation and suicide attempt in schizophrenia

Bani‐Fatemi, A., Raymond, R., Adanty, C., Dai, N., Gerretsen, P., Graff, A., Nóbrega, J. N., & Luca, V. D. (2020) · Psychiatric Genetics · doi:10.1097/ypg.0000000000000273 · Cited by 4 · see citing works

Cultured hippocampal neurons of dystrophic mdx mice respond differently from those of wild type mice to an acute treatment with corticosterone

Fragapane, P., Cosmi, F., & Stefano, M. E. D. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.111715 · Cited by 4 · see citing works

Epigenetics of Major Depressive Disorder

Wang, K. Z., Dada, O. O., Bani‐Fatemi, A., Tasmim, S., Monda, M., Graff, A., & Luca, V. D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-58131-8.00002-1 · Cited by 4 · see citing works

Individual and Combined Effect of MAO-A/MAO-B Gene Variants and Adverse Childhood Experiences on the Severity of Major Depressive Disorder

Toledo-Lozano, C. G., López-Hernández, L. B., Suárez‐Cuenca, J. A., Villalobos-Gallegos, L., Jiménez-Hernández, D. A., Alcaráz‐Estrada, S. L., Mondragón‐Terán, P., Joya-Laureano, L., Coral‐Vázquez, R. M., & Garcı́a, S. (2023) · Behavioral Sciences · doi:10.3390/bs13100795 · Cited by 3 · see citing works

Suicidality, perceived chronic stress, and stress‐induced cortisol changes of individuals with schizophrenia

Yin, Y., Tong, J., Huang, J., Tian, B., Chen, S., Tan, S., Wang, Z., Tong, Y., Fan, F., Kochunov, P. V., et al. (2024) · Stress and Health · doi:10.1002/smi.3482 · Cited by 3 · see citing works

Unerwartete Folgen einer HNO-Standardtherapie

Huseynov, J., & Mozet, C. (2018) · Laryngo-Rhino-Otologie · doi:10.1055/s-0044-100257 · Cited by 2 · see citing works

Changes in cortical gene expression in major depressive disorders: More evidence implicating inflammatory-related pathways in disease etiology

Dean, B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817935-2.00037-4 · Cited by 2 · see citing works

Methylation of APC2, NR3C1, and DRD2 gene promoters in turkish patients with tobacco use disorder

Çınarka, H., Niksarlıoğlu Elif, Y., Aytaç, H. M., Sacide, P., Oyacı, Y., Deniz, D., & Uysal, M. A. (2022) · Nigerian Journal of Clinical Practice · doi:10.4103/njcp.njcp_25_21 · Cited by 2 · see citing works

Characterizing suicidal thoughts and behaviours in individuals presenting to a psychiatric emergency department: a protocol for a multimethod approach for suicide prevention research

Baharikhoob, P., Maslej, M. M., Wong, A. H. C., Mulsant, B. H., Blumberger, D. M., Courtney, D., Husain, M. I., Kurdyak, P. A., Kleinman, R. A., Torfason, A., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-087561 · Cited by 1 · see citing works

Glucocorticoid Signaling in PSC-Derived Neural Systems to Elucidate Mechanisms of Stress-Induced Psychiatric Vulnerability

Molin, E. A. D., Kaster, M. P., & Nascimento, J. M. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-06041-1 · Cited by 2 · see citing works

The stress response HPA-axis hormone, glucocorticoid, reduces cellular SKA complex gene expression

Zhao, J., Zhang, P., He, Z., Chen, S., Golden, T. A., Li, L., Li, M., & Wu, N. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.12.024 · Cited by 1 · see citing works

Recent Progress in Functional Genomic Studies of Depression and Suicide

Almeida, D. M., & Turecki, G. (2017) · Current Genetic Medicine Reports · doi:10.1007/s40142-017-0112-y · Cited by 1 · see citing works

Cognitive Distortion in Suicidal Behavior

Yin, H. (2020) · Scholarly Journal of Psychology and Behavioral Sciences · doi:10.32474/sjpbs.2020.03.000168 · Cited by 1 · see citing works

Transcription factor motifs associated with anterior insula gene-expression underlying mood disorder phenotypesPreprint

Arasappan, D., Eickhoff, S. B., Nemeroff, C. B., Hofmann, H. A., & Jabbi, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/864900

Current and Emergent Suicidal Ideation in Schizophrenia: Effect of Stressful Life Events and Genome-Wide Methylation

Wang, K. Z. (2020) · TSpace (University of Toronto)

Estudio de interacción entre genes del eje hipotálamo-hipófisis-adrenal y el trauma en la infancia en el intento suicida

Sanabrais‐Jiménez, M. A. (2020) · doi:10.24275/uami.8g84mm39n

Estudio post-mortem de las alteraciones en la expresión de RNA en el cerebro de pacientes suicidasPreprint

Cabrera‐Mendoza, B. (2020) · doi:10.31237/osf.io/cmvjb

Neurobiological signature in suicidal behavior: concerning immune systems and blood hormones-I

Kundu, S. R., & Sarkar, J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33112-1.00001-x

The Interaction Between CRHBP and FKBP5 Genes and Childhood Trauma Increases the Risk of Suicide Attempt in Patients with Schizophrenia and Bipolar Disorder

Sanabrais‐Jiménez, M. A., Elguea-Ortiz, Z. C., Morales-Cedillo, I. P., Pavón, J. J., Rosel-Vales, M., Saracco-Álvarez, R. A., & Camarena, B. (2025) · Brain Sciences · doi:10.3390/brainsci15111224

NR3C1 Exon 1F Promoter Methylation and mRNA Expression in the Dorsolateral Prefrontal Cortex of Individuals Who Died by Suicide: A Post-Mortem Case–Control Study from Northern Mexico

Amador-Segovia, Y. M., Ramos-Rosales, D. F., Ayala‐García, V. M., Úrtiz-Estrada, N., Cervantes-Flores, M., Valenzuela‐García, L. I., Torres-Herrera, S. I., Salas-Pacheco, J. M., López, M. A. L., & Barraza-Salas, M. (2026) · Brain Sciences · doi:10.3390/brainsci16101059

BindingDB Entry 50009397: Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633).

BindingDB (2021) · UC San Diego · doi:10.7270/q26d5xfh

BindingDB Entry 50001790: Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).

BindingDB (2020) · UC San Diego · doi:10.7270/q2c53pdj

Comparison of gene transcription and depressive-like symptoms following chronic morphine and dexamethasone administration in mice

Barut, J., Skupio, U., Marut, L., & Przewłocki, R. (2016) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(16)31188-9

Association of FKBP5 gene haplotypes with completed suicide in the Japanese population

Supriyanto, I., Sasada, T., Fukutake, M., Asano, M., Ueno, Y., Nagasaki, Y., Shirakawa, O., & Hishimoto, A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.11.019 · Cited by 67 · see citing works

Interaction between rs10052957 polymorphism of glucocorticoid receptor gene and environmental factors increases the risk of suicide: a study of 66 cases

Yanhua1, Z., Yibin, L., Ming, Q., Binhui, H., & Linna, Z. (2023) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.16016/j.2097-0927.202210180

Association between FKBP5 Functional Polymorphisms and Completed Suicide

Fudalej, S., Kopera, M., Wołyńczyk-Gmaj, D., Fudalej, M., Krajewski, P., Wasilewska, K., Szymański, K., Chojnicka, I., Podgórska, A., Wojnar, M., et al. (2015) · Neuropsychobiology · doi:10.1159/000441659 · Cited by 30 · see citing works

Association of FKBP5 Polymorphisms With Suicidal Events in the Treatment of Resistant Depression in Adolescents (TORDIA) Study

Brent, D., Melhem, N., Ferrell, R., Emslie, G., Wagner, K. D., Ryan, N., Vitiello, B., Birmaher, B., Mayes, T., Zelazny, J., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09040576 · Cited by 138 · see citing works