Understanding the Neuroepigenetic Constituents of Suicide Brain
Abstract
Stressful life incidents often cause a predisposition for developing mental disorders such as major depressive disorder (MDD). Impaired neurocognitive and neuro-vegetative functions of the central nervous system are the hallmarks of this mental illness. Blunted responses from emotionally salient regions of the brain including cortex, hippocampus, and amygdala have been associated with MDD-related behavioral changes. Moreover, improper signal processing and neuronal atrophy were held responsible for the overall dysfunctionality of these vulnerable regions in the MDD brain. The prevalence of genetic susceptibility along with adverse environmental stimuli often makes the situation worse for MDD patients, leading to an increased risk of suicidal behavior and eventually death by suicide. Despite considerable efforts to understand the complex neurobiology associated with MDD and suicidal behavior, their pathological determinants remain mostly elusive. Recent research, however, has shown that epigenetic perturbations have a formidable impact on the etiopathogenesis of MDD. Understanding the neuroepigenetic nature of this mental disorder may provide opportunities to devise more effective treatment strategies. Moreover, this can potentially lead to identifying predictive biomarkers associated with suicide risk. The present chapter critically reviews studies pertaining to epigenetic signatures of MDD and suicide brain.
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Heritability of suicidal behavior is independent of major psychiatric syndromes.
“Human genetic studies have made three major observations: 1) heritability of fatal or nonfatal suicidal behavior and even ideation is moderate; 2) heritability of suicidal behavior is independent of major psychiatric syndromes; and 3) heritability of suicidal behavior is mediated by many gene variants of small effect (44-47).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [44]
Heritability of fatal or nonfatal suicidal behavior and even ideation is moderate.
“Human genetic studies have made three major observations: 1) heritability of fatal or nonfatal suicidal behavior and even ideation is moderate; 2) heritability of suicidal behavior is independent of major psychiatric syndromes; and 3) heritability of suicidal behavior is mediated by many gene variants of small effect (44-47).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [44]
Heritability of suicidal behavior is mediated by many gene variants of small effect.
“Human genetic studies have made three major observations: 1) heritability of fatal or nonfatal suicidal behavior and even ideation is moderate; 2) heritability of suicidal behavior is independent of major psychiatric syndromes; and 3) heritability of suicidal behavior is mediated by many gene variants of small effect (44-47).”
From A brain-centric model of suicidal behavior (2020) · cites this paper as [44]
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A brain-centric model of suicidal behavior
Mann, J. J., & Rizk, M. M. (2020) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2020.20081224 · Cited by 214 · see citing works
Pritchard, C., Hansen, L., Dray, R., & Sharif, J. (2023) · Archives of Suicide Research · doi:10.1080/13811118.2021.1974624 · Cited by 8 · see citing works
- Authors
- Roy, B., & Dwivedi, Y.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Dwivedi, Yogesh
- Venue
- Progress in Molecular Biology and Translational Science
- Publisher
- Elsevier
- Published
- 2018
- Volume
- 157
- Pages
- 233-262
- ISSN
- 1877-1173 (ISSN-L)
- OpenAlex
- W2808885250
- Cited by
- 17
- References
- 129
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 1
- FWCI
- 19.74
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in molecular biology and translational science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Family Process Institute
- National Institute of Mental Health (R21MH081099, R01MH082802, R01MH100616)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- major depressive disorder, suicide, epigenetics, neuroepigenetics, epigenetic signatures, hippocampus, amygdala, cortical dysfunction, neuronal atrophy, genetic susceptibility, environmental stress, etiopathogenesis
- MeSH terms
- Brain, Histones, Humans, Suicide, DNA Methylation, MicroRNAs, Epigenesis, Genetic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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