Cited by 48Genomics, phytochemicals, and oxidative stressNeurological Disorders and TreatmentsNeurological Disease Mechanisms and Treatments

1,5-Dicaffeoylquinic acid-mediated glutathione synthesis through activation of Nrf2 protects against OGD/reperfusion-induced oxidative stress in astrocytes

Cao, Xu, Xiao, Haibing, Zhang, Ying, Zou, Liangyu, Chu, Yinghao, Chu, Xiaofan·2010·Brain Research

Abstract

Oxidative stress plays an important role in pathological processes of cerebral ischemia followed by reperfusion. The effect of 1, 5-dicaffeoylquinic acid (1, 5-diCQA) on primary culture rat cortical astrocytes induced by oxygen and glucose deprivation (OGD)/reperfusion was evaluated in this study. Appropriate concentration of 1, 5-diCQA pretreatment significantly suppressed cell death, reduced the production of reactive oxygen species, prevented glutathione (GSH) depletion, increased the activity of glutamate-cysteine ligase (GCL), and triggered Nrf2 nuclear translocation in astrocytes induced by 4h of OGD and 20 h of reperfusion. Interestingly, these protective effects were greatly attenuated in Nrf2 siRNA-transfected cells. We conclude that 1, 5-diCQA has antioxidant signaling properties that upregulate GSH synthesis by stimulating the Nrf2 pathway in astrocytes and protects them from cell death in an in vitro model of ischemia/reperfusion.

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2010.05.072

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Cao, X., Xiao, H., Zhang, Y., Zou, L., Chu, Y., & Chu, X.
Affiliations
  • Jinan University (CN)
  • Wuhan Union Hospital (CN)
Corresponding author
  • Chu, Yinghao
  • Chu, Xiaofan
Venue
Brain Research
Publisher
Elsevier BV
Published
2010-08
Volume
1347
Pages
142-148
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2153259281
Cited by
48
References
38
Citations by year
2024: 5 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 5
FWCI
1.43
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (30971024, 30870845)
  • Guangdong Provincial Natural Science Foundation (91510515000009)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
1,5-dicaffeoylquinic acid, glutathione synthesis, Nrf2, astrocytes, oxygen-glucose deprivation/reoxygenation, cerebral ischemia-reperfusion injury, oxidative stress, gamma-glutamylcysteine synthetase, reactive oxygen species, neuroprotection, antioxidant signaling
MeSH terms
Analysis of Variance, Animals, Animals, Newborn, Hypoxia, Astrocytes, Cell Survival, Cells, Cultured, Cerebral Cortex, Glutamate-Cysteine Ligase, Glutathione, Quinic Acid, Transfection, Reperfusion, Reactive Oxygen Species, Oxidative Stress, RNA, Small Interfering, NF-E2-Related Factor 2, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review