Characterization of the 3xTg-AD mouse model of Alzheimer’s disease: Part 2. Behavioral and cognitive changes

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

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Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

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Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

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The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease.

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Estrogen Replacement Therapy in Older Women

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Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s disease

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Proteomic Profiling of Cerebrum Mitochondria, Myelin Sheath, and Synaptosome Revealed Mitochondrial Damage and Synaptic Impairments in Association with 3 × Tg‐AD Mice Model

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Transgenic autoinhibition of p21-activated kinase exacerbates synaptic impairments and fronto-dependent behavioral deficits in an animal model of Alzheimer’s disease

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Deciphering Brain Function by Miniaturized Fluorescence Microscopy in Freely Behaving Animals

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Mitochondria exert age-divergent effects on recovery from spinal cord injury

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Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation

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Standardized Herbal Formula PM012 Decreases Cognitive Impairment and Promotes Neurogenesis in the 3xTg AD Mouse Model of Alzheimer’s Disease

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Age-related neuropsychiatric symptoms in presenilins conditional double knockout mice

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Experimental diffuse brain injury and a model of Alzheimer's disease exhibit disease‐specific changes in sleep and incongruous peripheral inflammation

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Cognitive Dysfunction and Anxiety Resulting from Synaptic Downscaling, Hippocampal Atrophy, and Ventricular Enlargement with Intracerebroventricular Streptozotocin Injection in Male Wistar Rats

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Early postnatal handling and environmental enrichment improve the behavioral responses of 17-month-old 3xTg-AD and non-transgenic mice in the Forced Swim Test in a gender-dependent manner

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Evaluation of attention in APP/PS1 mice shows impulsive and compulsive behaviours

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Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport

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The complexities of behavioural assessment in neurodegenerative disorders: A focus on Alzheimer’s disease

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Olfactory dysfunction in the 3xTg-AD model of Alzheimer’s disease

Mitrano, D. A., Houle, S., Pearce, P., Quintanilla, R. M., Lockhart, B. K., Genovese, B. C., Schendzielos, R., Croushore, E. E., Dymond, E. M., Bogenpohl, J. W., et al. (2021) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2020.12.004 · Cited by 21

Drotaverine Inhibitor of PDE4: Reverses the Streptozotocin Induced Alzheimer’s Disease in Mice

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Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease

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Loss of miR-369 Promotes Tau Phosphorylation by Targeting the Fyn and Serine/Threonine-Protein Kinase 2 Signaling Pathways in Alzheimer’s Disease Mice

Yao, X., Xian, X., Fang, M., Fan, S., & Li, W. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00365 · Cited by 21

Anxiety and Alzheimer’s disease pathogenesis: focus on 5-HT and CRF systems in 3xTg-AD and TgF344-AD animal models

Reyna, N. C., Clark, B. J., Hamilton, D. A., & Pentkowski, N. S. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1251075 · Cited by 21

B6e GFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments

Nagy, P. M., & Aubert, I. (2013) · Brain and Behavior · doi:10.1002/brb3.139 · Cited by 21

Genotype Load Modulates Amyloid Burden and Anxiety-Like Patterns in Male 3xTg-AD Survivors despite Similar Neuro-Immunoendocrine, Synaptic and Cognitive Impairments

Muntsant-Soria, A., & Giménez‐Llort, L. (2021) · Biomedicines · doi:10.3390/biomedicines9070715 · Cited by 21

Characterization of a 3xTg‐AD mouse model of Alzheimer's disease with the senescence accelerated mouse prone 8 (SAMP8) background

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Evaluating the Effect of Interleukin-4 in the 3xTg Mouse Model of Alzheimer’s Disease

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Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice

Arsenault, D., Tremblay, C., Émond, V., & Calon, F. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00337-0 · Cited by 19

Crosstalk of Alzheimer’s disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: A translational neuroscience approach

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With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions

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Additive-color multi-harmonic generation microscopy for simultaneous label-free differentiation of plaques, tangles, and neuronal axons

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Ibuprofen partially attenuates neurodegenerative symptoms in presenilin conditional double-knockout mice

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IL-34 exacerbates pathogenic features of Alzheimer’s disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice

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Cholecystokinin B receptor agonists alleviates anterograde amnesia in cholecystokinin-deficient and aged Alzheimer's disease mice

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Persistence of behaviours in the Forced Swim Test in 3xTg-AD mice at advanced stages of disease

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Deficits in memory-guided limb movements impair obstacle avoidance locomotion in Alzheimer's disease mouse model

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Role of mitogen-activated protein kinase inhibitors in Alzheimer's disease: Rouge of brain kinases

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Ezetimibe Lowers Risk of Alzheimer’s and Related Dementias over Sevenfold, Reducing Aggregation in Model Systems by Inhibiting 14-3-3G::Hexokinase Interaction

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Circadian wheel running behavior is altered in an APP/E4 mouse model of late onset Alzheimer's disease

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Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer’s disease-associated markers in 3xTg-AD mice

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Early Intervention with a Multi-Ingredient Dietary Supplement Improves Mood and Spatial Memory in a Triple Transgenic Mouse Model of Alzheimer’s Disease

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APOE4 genotype or ovarian hormone loss influence open field exploration in an EFAD mouse model of Alzheimer's disease

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Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model

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Retinal Biomarkers of Alzheimer’s Disease: Insights from Transgenic Mouse Models

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Oleocanthal Ameliorates Metabolic and Behavioral Phenotypes in a Mouse Model of Alzheimer’s Disease

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Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer’s Disease from Premorbid to Advanced Stages and Compared to Normal Aging

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Genetic and chemical disruption of amyloid precursor protein processing impairs zebrafish sleep maintenance

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Mesenchymal Stem Cells: New Alternatives for Nervous System Disorders

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Temporal Appearance of Enhanced Innate Anxiety in Alzheimer Model Mice

Szabó, A., Farkas, S., Fazekas, C. L., Correia, P., Chaves, T., Sipos, E., Makkai, B., Török, B., & Zelena, D. (2023) · Biomedicines · doi:10.3390/biomedicines11020262 · Cited by 12

Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer’s Disease

Maglione, A., do Nascimento, B. P. P., Ribeiro, M. O., de Souza, T. J. L., da Silva, R. E. C., Sato, M. A., Penatti, C. A. A., Britto, L. R., de Souza, J. S., Maciel, R. M. B., et al. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01055-9 · Cited by 11

Role of Kalirin and mouse strain in retention of spatial memory training in an Alzheimer’s disease model mouse line

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Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model

Saaoud, F., Liu, L., Xu, K., Lu, Y., Shao, Y., Issa, M., Jiang, X., Wang, X., Liu, X., Autieri, M. V., et al. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251329583 · Cited by 13

Lithium Ions as Modulators of Complex Biological Processes: The Conundrum of Multiple Targets, Responsiveness and Non-Responsiveness, and the Potential to Prevent or Correct Dysregulation of Systems during Aging and in Disease

Hart, D. A. (2024) · Biomolecules · doi:10.3390/biom14080905 · Cited by 9

Advancement in modeling of Alzheimer’s disease: a comprehensive review of preclinical screening platforms

Adak, S., Singh, S., Jain, R., Tiwari, A., Singh, B., Kumar, S., Dadhwal, A., Chakroborty, A., Sharma, A. K., Singh, R. P., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1646551 · Cited by 12

Rodent models of Alzheimer's disease: Critical analysis of current hypotheses and pathways for future research

Singhaarachchi, P. H., Antal, P., Calon, F., Culmsee, C., Delpech, J.-C., Feldotto, M., Geertsema, J., Hoeksema, E. E., Kőrösi, A., Layé, S., et al. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102821 · Cited by 13

[Regular Paper] Texture Biomarkers of Alzheimer's Disease and Disease Progression in the Mouse Retina

Nunes, A., Ambrósio, A. F., Castelo-Branco, M. S., & Bernardes, R. (2018) · IEEE International Conference on Bioinformatics and Bioengineering (BIBE) · doi:10.1109/bibe.2018.00016 · Cited by 9

Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer’s Disease

Martínez-Iglesias, O. A., Naidoo, V., Carrera, I., & Cacabelos, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052446 · Cited by 10

Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg ‐ AD mice

Pfitzer, J. C., Pinky, P. D., Perman, S., Redmon, E., Cmelak, L., Suppiramaniam, V. D., Coric, V., Qureshi, I., Gramlich, M. W., & Reed, M. N. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16215 · Cited by 8

BMAL1 upregulates STX17 levels to promote autophagosome-lysosome fusion in hippocampal neurons to ameliorate Alzheimer’s disease

Zhou, X., Du, K., Mao, T., Wang, N., Zhang, L., Tian, Y., Liu, T., Wang, L., & Wang, X. (2024) · iScience · doi:10.1016/j.isci.2024.111413 · Cited by 8

The 3xTg-AD Mouse Model: A Comprehensive Tool for Understanding Alzheimer’s Disease

Pattanayak, A., & Firdous, S. M. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01655-w · Cited by 13

DeepDrugDiscovery identifies blood–brain barrier permeable autophagy enhancers for Alzheimer’s disease

Dong, Y., Xiao, X., Zhuang, X., Wu, W., Wang, Z.-Y., Zhang, S., Li, J.-T., Zhang, K., Fu, W.-Y., Chen, J., et al. (2026) · Nature Biomedical Engineering · doi:10.1038/s41551-026-01667-x · Cited by 8

Characterization of the retinal changes of the 3×Tg-AD mouse model of Alzheimer’s disease

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Timing impairments in early Alzheimer’s disease: Evidence from a mouse model.

Armstrong, P., Pardon, M., & Bonardi, C. (2020) · Behavioral Neuroscience · doi:10.1037/bne0000359 · Cited by 7

Multi-target PET evaluation in APP/PS1/tau mouse model of Alzheimer's disease.

Liu, Y., Xu, Y.-P., Li, M.-Z., Pan, D., Li, Y.-Q., Wang, Y., Wang, L.-Z., Wu, Q., & Yang, M. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.134938 · Cited by 8

Assessing Sex-Specific Circadian, Metabolic, and Cognitive Phenotypes in the AβPP/PS1 and APPNL-F/NL-F Models of Alzheimer’s Disease

Britz, J., Ojo, E. A., Dhukhwa, A., Saito, T., Saido, T. C., Hascup, E. R., Hascup, K. N., & Tischkau, S. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210629 · Cited by 8

Neuroprotective Effects of the Herbal Formula B401 in Both Cell and Mouse Models of Alzheimer’s Disease

Hsu, C.-H., Wang, S.-E., Lin, C.-L., Hsiao, C.-J., Sheu, S., & Wu, C. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/1939052 · Cited by 8

Animal Models of Alzheimer’s Disease

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Adiponectin improves amyloid‐β 31‐35‐induced circadian rhythm disorder in mice

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Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer’s Disease Mice

Frame, G., Schuller, A. J., Smith, M. A., Crish, S. D., & Crish, S. D. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220016 · Cited by 8

Generation of gene-targeted mice using embryonic stem cells derived from a transgenic mouse model of Alzheimer’s disease

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Animal Models of Acquired Epilepsy and Tauopathies

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Exercise Improves Alzheimer’s Disease Phenotype in the TgF344-AD Rat, a Behavioral Time Course Study of Males and Females

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Sleep in neurodegenerative diseases: A focus on melatonin, melanin‐concentrating hormone and orexin

Guillot, S. J., Luppi, P., Dupuis, L., & Bolborea, M. (2025) · Journal of Neuroendocrinology · doi:10.1111/jne.70085 · Cited by 6

Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption in Vitro and Cognitive Impairment in Vivo

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Two decades testing interventions in transgenic mouse models of Alzheimer's disease: designing and interpreting studies for clinical trial success

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Sex-dependent worsening of NMDA-induced responses, anxiety, hypercortisolemia, and organometry of early peripheral immunoendocrine impairment in adult 3xTg-AD mice and their long-lasting ontogenic modulation by neonatal handling

Baeta-Corral, R., la Fuente, M. D., & Giménez‐Llort, L. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114189 · Cited by 7

Signature of paraoxonases in the altered redox homeostasis in Alzheimer's disease

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Medium-chain triglycerides improve cognition and systemic metabolism in mouse models of Alzheimer’s disease

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