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Cited by 228Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchMemory and Neural Mechanisms

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Characterization of the 3xTg-AD mouse model of Alzheimer’s disease: Part 2. Behavioral and cognitive changes

Sterniczuk, Roxanne, Antle, Michael C., LaFerla, Frank M., Dyck, Richard H.·2010·Brain Research
DOI 10.1016/j.brainres.2010.06.011
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Abstract

Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that differ from those observed in normal aging. Transgenic models of AD are a promising tool in understanding the underlying mechanisms and cause of disease. The triple-transgenic mouse model of AD (3xTg-AD) is the only model to exhibit both Abeta and tau pathology that is characteristic of the human form. The present study characterized the performance of 3xTg-AD mice on several tasks measuring behavioral and cognitive ability. Aged 3xTg-AD females exhibited a higher level of fear and anxiety demonstrated by increased restlessness, startle responses, and freezing behaviors. No differences were observed in muscle strength and visuo-motor coordination. Understanding the behavioral manifestations that occur in this model of AD may aid in the early diagnosis and appropriate treatment of AD symptomology.

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Metadata

Authors
Sterniczuk, R., Antle, M. C., LaFerla, F. M., & Dyck, R. H.
Affiliations
  • University of Calgary (CA)
  • University of California, Irvine (US)
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2010-08
Volume
1348
Pages
149-155
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2010.06.011
OpenAlex
W1967375871
Cited by
228
References
43
Citations by year
2026: 7 · 2025: 14 · 2024: 14 · 2023: 17 · 2022: 18 · 2021: 24 · 2020: 20 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 16 · 2014: 19 · 2013: 12 · 2012: 12
FWCI
7.15
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • NSERC
  • CIHR
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
Alzheimer's disease, 3xTg-AD mice, triple transgenic mice, amyloid-beta pathology, tau pathology, cognitive impairment, behavioral deficits, anxiety, fear, startle response, freezing behavior, visuomotor coordination, muscle strength, aging
MeSH terms
Alzheimer Disease, Animals, Avoidance Learning, Behavioral Symptoms, Cognition Disorders, Disease Models, Animal, Exploratory Behavior, Female, Humans, Male, Mice, Inbred C57BL, Motor Activity, Neurologic Examination, Psychomotor Performance, Reaction Time, Time Factors, Amyloid beta-Protein Precursor, Statistics, Nonparametric, Maze Learning, Animals, Genetically Modified, Mice, Presenilin-1, Amyloid Precursor Protein Secretases

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