Cited by 1,294Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

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Billings, Lauren M., Oddo, Salvatore, Green, Kim N., McGaugh, James L., LaFerla, Frank M.·2005·Neuron

Abstract

Progressive memory loss and cognitive dysfunction are the hallmark clinical features of Alzheimer's disease (AD). Identifying the molecular triggers for the onset of AD-related cognitive decline presently requires the use of suitable animal models, such as the 3xTg-AD mice, which develop both amyloid and tangle pathology. Here, we characterize the onset of learning and memory deficits in this model. We report that 2-month-old, prepathologic mice are cognitively unimpaired. The earliest cognitive impairment manifests at 4 months as a deficit in long-term retention and correlates with the accumulation of intraneuronal Abeta in the hippocampus and amygdala. Plaque or tangle pathology is not apparent at this age, suggesting that they contribute to cognitive dysfunction at later time points. Clearance of the intraneuronal Abeta pathology by immunotherapy rescues the early cognitive deficits on a hippocampal-dependent task. Reemergence of the Abeta pathology again leads to cognitive deficits. This study strongly implicates intraneuronal Abeta in the onset of cognitive dysfunction.

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Crossref · 10.1016/j.neuron.2005.01.040

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Authors
Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M.
Affiliations
University of California, Irvine (US)
Corresponding author
LaFerla, Frank M.
Venue
Neuron
Publisher
Elsevier BV
Published
2005-03
Volume
45
Issue
5
Pages
675-688
ISSN
0896-6273 (ISSN-L)
OpenAlex
W1973276273
Cited by
1,294
References
47
Citations by year
2026: 29 · 2025: 47 · 2024: 55 · 2023: 55 · 2022: 46 · 2021: 61 · 2020: 75 · 2019: 62 · 2018: 55 · 2017: 56 · 2016: 64 · 2015: 59 · 2014: 72 · 2013: 68 · 2012: 65
FWCI
40.55
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-nd)
Funders
  • National Institute on Aging (AG0212982, F32AG024035, F32 AG24035-01)
  • National Institute of Mental Health (MH12526)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
intraneuronal amyloid-beta, Alzheimer's disease, 3xTg-AD mice, learning and memory impairment, long-term memory retention, hippocampus, amygdala, amyloid plaques, neurofibrillary tangles, immunotherapy, animal models of Alzheimer's disease
MeSH terms
Alzheimer Disease, Animals, Cognition Disorders, Female, Hippocampus, Male, Mice, Inbred C57BL, Mice, Transgenic, Neurons, Amyloid beta-Peptides, Mice

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