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Characterization of the 3xTg-AD mouse model of Alzheimer’s disease: Part 2. Behavioral and cognitive changes
Abstract
Alzheimer's disease (AD) is characterized by distinct behavioral and cognitive deficits that differ from those observed in normal aging. Transgenic models of AD are a promising tool in understanding the underlying mechanisms and cause of disease. The triple-transgenic mouse model of AD (3xTg-AD) is the only model to exhibit both Abeta and tau pathology that is characteristic of the human form. The present study characterized the performance of 3xTg-AD mice on several tasks measuring behavioral and cognitive ability. Aged 3xTg-AD females exhibited a higher level of fear and anxiety demonstrated by increased restlessness, startle responses, and freezing behaviors. No differences were observed in muscle strength and visuo-motor coordination. Understanding the behavioral manifestations that occur in this model of AD may aid in the early diagnosis and appropriate treatment of AD symptomology.
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“Here Aβ deposition has not altered hippocampal functioning and the animals do not display long term memory alterations (Sterniczuk et al., 2010).”
From Early stage alterations in white matter and decreased functional interhemispheric hippocampal connectivity in the 3xTg mouse model of Alzheimer’s disease. (2019) · cites this paper as Sterniczuk et al., 2010
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Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126
Self-citationThe open-field test: A critical review.
WALSH, R. N., & Cummins, R. A. (1976) · Psychological Bulletin · doi:10.1037/0033-2909.83.3.482 · Cited by 2,389
Billings, L. M., Oddo, S., Green, K. N., McGaugh, J. L., & LaFerla, F. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.040 · Cited by 1,294
Self-citationAttention and executive deficits in Alzheimer's disease: A critical review
Perry, R. J. (1999) · Brain · doi:10.1093/brain/122.3.383 · Cited by 1,252
Irwin, S. (1968) · Psychopharmacology · doi:10.1007/bf00401402 · Cited by 1,240
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
Oddo, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.012 · Cited by 980
The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease.
Delacourte, A., David, J. P., Sergeant, N., Buée, L., Wattez, A., Vermersch, P., Ghozali, F., Fallet-Bianco, C., Pasquier, F., Lebert, F., et al. (1999) · Neurology · doi:10.1212/wnl.52.6.1158 · Cited by 828
Alterations in the circadian rest-activity rhythm in aging and Alzheimer's disease
Witting, W., Kwa, I. H., Eikelenboom, P., Mirmiran, M., & Swaab, D. F. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90523-5 · Cited by 621
Estrogen Replacement Therapy in Older Women
Henderson, V. W. (1994) · Archives of Neurology · doi:10.1001/archneur.1994.00540210068014 · Cited by 590
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Neutrophils promote Alzheimer's disease–like pathology and cognitive decline via LFA-1 integrin
Zenaro, E., Pietronigro, E., Bianca, V. D., Piacentino, G., Marongiu, L., Budui, S., Turano, E., Rossi, B., Angiari, S., Dusi, S., et al. (2015) · Nature Medicine · doi:10.1038/nm.3913 · Cited by 865
Sabogal-Guáqueta, A. M., Muñoz‐Manco, J. I., Ramírez‐Pineda, J. R., Lamprea, M. R., Osorio, E., & Cardona‐Gómez, G. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.027 · Cited by 453
Kashiwaya, Y., Bergman, C., Lee, J.-H., Wan, R., King, M. T., Mughal, M. R., Okun, E., Clarke, K., Mattson, M. P., & Veech, R. L. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.023 · Cited by 363
Chen, Y., Liang, Z., Blanchard, J., Dai, C., Sun, S., Lee, M. H., Grundke, I., Iqbal, K., Liu, F., & Gong, C. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8375-5 · Cited by 294
Superoxide Dismutase Administration: A Review of Proposed Human Uses
Rosa, A. C., Corsi, D., Cavi, N., Bruni, N., & Dosio, F. (2021) · Molecules · doi:10.3390/molecules26071844 · Cited by 297
Physical Exercise Protects Against Alzheimer's Disease in 3xTg-AD Mice
García‐Mesa, Y., López, J. C., Giménez‐Llort, L., Revilla, S., Guerra, R., Gruart, A., LaFerla, F. M., Cristòfol, R. M., Delgado-Garcia, J. M., & Sanfeliu, C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101635 · Cited by 258
Self-citationGenetic mouse models of brain ageing and Alzheimer's disease
Bilkei‐Gorzó, A. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.12.009 · Cited by 253
Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146476 · Cited by 243
Livingston, G., Kelly, L., Lewis-Holmes, E., Baio, G., Stephen Morris, A., Patel, N. V., Omar, R., Katona, C., & Cooper, C. (2014) · Health Technology Assessment · doi:10.3310/hta18390 · Cited by 259
Rodent models for Alzheimer’s disease drug discovery
Puzzo, D., Gulisano, W., Palmeri, A., & Arancio, O. (2015) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.1041913 · Cited by 222
Therapeutic B-cell depletion reverses progression of Alzheimer’s disease
Kim, K., Wang, X., Ragonnaud, E., Bodogai, M., Illouz, T., DeLuca, M., McDevitt, R. A., Gusev, F., Okun, E., Rogaev, E., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22479-4 · Cited by 206
DHA Improves Cognition and Prevents Dysfunction of Entorhinal Cortex Neurons in 3xTg-AD Mice
Arsenault, D., Julien, C., Tremblay, C., & Calon, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017397 · Cited by 177
Pang, T. Y., & Hannan, A. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.029 · Cited by 186
Behavioral and EEG changes in male 5xFAD mice
Schneider, F., Baldauf, K., Wetzel, W., & Reymann, K. G. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.05.041 · Cited by 176
Attar, A., Liu, T., Chan, W.-T. C., Hayes, J., Nejad, M., Lei, K., & Bitan, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080355 · Cited by 174
Kosel, F., Pelley, J. M. S., & Franklin, T. B. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.012 · Cited by 173
Flores-Dorantes, M. T., Díaz‐López, Y. E., & Gutiérrez‐Aguilar, R. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00863 · Cited by 170
Searcy, J. L., Phelps, J. T., Pancani, T., Kadish, I., Popovic, J., Anderson, K. L., Beckett, T. L., Murphy, M. P., Chen, K.-C., Blalock, E. M., et al. (2012) · Journal of Alzheimer's Disease · doi:10.3233/jad-2012-111661 · Cited by 154
Ramkisoensing, A., & Meijer, J. H. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00128 · Cited by 166
González-Marrero, I., Giménez‐Llort, L., Johanson, C. E., Carmona-Calero, E. M., Castañeyra-Ruiz, L., Armas, J. M. B., Castañeyra-Perdomo, A., & Castro-Fuentes, R. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00017 · Cited by 146
Webster, S. J., Bachstetter, A. D., & Eldik, L. J. V. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt182 · Cited by 153
Mably, A. J., Gereke, B. J., Jones, D. T., & Colgin, L. L. (2016) · Hippocampus · doi:10.1002/hipo.22697 · Cited by 135
Modeling human neurodegenerative diseases in transgenic systems
Sosa, M. A. G., Gasperi, R. D., & Elder, G. A. (2011) · Human Genetics · doi:10.1007/s00439-011-1119-1 · Cited by 114
Duncan, M. J., Smith, J. T., Franklin, K. M., Beckett, T. L., Murphy, M. P., Clair, D. K. S., Donohue, K. D., Striz, M., & O’Hara, B. F. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.05.011 · Cited by 106
Age‐dependent impairment of glucose tolerance in the 3xTg‐AD mouse model of Alzheimer's disease
Vandal, M., White, P. J., Chevrier, G., Tremblay, C., St‐Amour, I., Planel, E., Marette, A., & Calon, F. (2015) · The FASEB Journal · doi:10.1096/fj.14-268482 · Cited by 107
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Rothman, S. M., & Mattson, M. P. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8181-2 · Cited by 102
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Marchese, M., Cowan, D., Head, E., Ma, D., Karimi, K., Ashthorpe, V., Kapadia, M., Zhao, H., Davis, P., & Sakic, B. (2014) · Journal of Alzheimer's Disease · doi:10.3233/jad-131490 · Cited by 94
3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress
Rothman, S. M., Herdener, N. D., Camandola, S., Texel, S. J., Mughal, M. R., Cong, W., Martin, B., & Mattson, M. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.005 · Cited by 104
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Ziv, Y., & Ghosh, K. K. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.04.001 · Cited by 93
Stevens, L. M., & Brown, R. E. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.10.033 · Cited by 92
Romano, A., Pace, L., Tempesta, B., Lavecchia, A. M., Macheda, T., Bedse, G., Petrella, A., Cifani, C., Serviddio, G., Vendemiale, G., et al. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu020 · Cited by 88
Millot, P., San, C., Bennana, E., Porte, B., Vignal, N., Hugon, J., Paquet, C., Hosten, B., & Mouton‐Liger, F. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.10.004 · Cited by 90
Foley, A. M., Ammar, Z., Lee, R. H., & Mitchell, C. S. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142208 · Cited by 90
Dujardin, S., Colin, M., & Buée, L. (2014) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12200 · Cited by 101
Carvalho, C., Machado, N. J., Mota, P. C., Correia, S. C., Cardoso, S., Santos, R. X., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130005 · Cited by 88
Melatonin induces mechanisms of brain resilience against neurodegeneration
Corpas, R., Griñán‐Ferré, C., Palomera‐Ávalos, V., Porquet, D., de Frutos, P. G., Cozzolino, S. M. F., Rodrı́guez-Farré, E., Pallàs, M., Sanfeliu, C., & Cardoso, B. R. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12515 · Cited by 86
Bories, C., Guitton, M. J., Julien, C., Tremblay, C., Vandal, M., Msaid, M., Koninck, Y. D., & Calon, F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046111 · Cited by 80
Treadmill Running Reverses Cognitive Declines due to Alzheimer Disease
Cho, J., Shin, M., Kim, D., Lee, I., Kim, S., & Kang, H. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000612 · Cited by 77
Shapira, R., Solomon, B., Efrati, S., Frenkel, D., & Ashery, U. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.10.007 · Cited by 80
Pramanik, S., Sulistio, Y. A., & Heese, K. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0214-7 · Cited by 77
Neves, A. F., Camargo, C. J., Premer, C., Hare, J. M., Baumel, B. S., & Pinto, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113706 · Cited by 77
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Grammas, P., Martinez, J. M., Sanchez, A. C., Yin, X., Riley, J., Gay, D., Desobry, K., Tripathy, D., Luo, J., Evola, M., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-2014-132057 · Cited by 74
Blázquez, G., Cañete, T., Tobeña, A., Giménez‐Llort, L., & Fernández‐Teruel, A. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.04.008 · Cited by 81
Rangan, P., Lobo, F., Parrella, E., Rochette, N. C., Morselli, M., Stephen, T., Cremonini, A. L., Tagliafico, L., Persia, A., Caffa, I., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111417 · Cited by 73
Physiological links of circadian clock and biological clock of aging
Liu, F., & Chang, H.-C. (2017) · Protein & Cell · doi:10.1007/s13238-016-0366-2 · Cited by 69
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Bellanti, F., Iannelli, G., Blonda, M., Tamborra, R., Villani, R., Romano, A., Calcagnini, S., Mazzoccoli, G., Vinciguerra, M., Gaetani, S., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160942 · Cited by 70
Kim, S., Cho, Y.-S., Kim, Y., Park, J., Yoo, S., Gwak, J., Kim, Y., Gwon, Y., Kam, T., & Jung, Y. (2023) · Autophagy · doi:10.1080/15548627.2023.2181614 · Cited by 65
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Creighton, S. D., Mendell, A. L., Palmer, D. D., Kalisch, B. E., MacLusky, N. J., Prado, V. F., Prado, M. A. M., & Winters, B. D. (2019) · Scientific Reports · doi:10.1038/s41598-018-37312-0 · Cited by 63
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Armijo, E., Edwards, G. A., Flores, A., Vera, J. R., Shahnawaz, M., Moda, F., González, C., Sanhueza, M., & Soto, C. A. (2021) · Cells · doi:10.3390/cells10071802 · Cited by 57
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Manno, F. A. M., Isla, A. G., Manno, S. H. C., Ahmed, I., Cheng, S. H., Barrios, F. A., & Lau, C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00039 · Cited by 49
Liu, Y., Zhang, Y., Liu, P., Bai, H., Li, X., Xiao, J., Yuan, Q., Geng, S., Yin, H., Zhang, H., et al. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.11.004 · Cited by 45
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Cheng, D., Lei, Z., Chu, K., Lam, O. J. H., Chiang, C. Y., & Zhang, Z.-J. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01462-3 · Cited by 47
Platt, T. L., Reeves, V. L., & Murphy, M. P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.017 · Cited by 48
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Haider, A., Zhao, C., Wang, L., Xiao, Z., Rong, J., Xia, X., Chen, Z., Pfister, S. K., Mast, N., Yutuc, E., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.adc9967 · Cited by 44
Winslow, W., McDonough, I., Tallino, S., Decker, A., Vural, A. S., & Velázquez, R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.720214 · Cited by 42
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Růžička, J., Kulijewicz‐Nawrot, M., Rodrigez-Arellano, J., Jendelová, P., & Syková, E. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020152 · Cited by 44
Davis, K. E., Burnett, K., & Gigg, J. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.005 · Cited by 45
Atlante, A., Valenti, D., Latina, V., & Amadoro, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147722 · Cited by 44
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Fagan, S. G., Béchet, S., & Dev, K. K. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02613-5 · Cited by 41
Várkonyi, D., Török, B., Sipos, E., Fazekas, C. L., Bánrévi, K., Correia, P., Chaves, T., Farkas, S., Szabó, A., Martínez‐Bellver, S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810816 · Cited by 40
Protective Effects of Wogonin against Alzheimer’s Disease by Inhibition of Amyloidogenic Pathway
Huang, D.-S., Yu, Y.-C., Wu, C., & Lin, J. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/3545169 · Cited by 43
Escrig, A., Canal, C., Sanchís, P., Fernández‐Gayol, O., Montilla, A., Comes, G., Molinero, A., Giralt, M., Giménez‐Llort, L., Becker‐Pauly, C., et al. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.005 · Cited by 43
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Yang, S., Kim, J., Lee, M. J., & Kim, Y. S. (2015) · Scientific Reports · doi:10.1038/srep15703 · Cited by 40
Klakotskaia, D., Agca, C., Richardson, R. A., Stopa, E. G., Schachtman, T. R., & Ağca, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195469 · Cited by 41
Arsenault, D., Dal‐Pan, A., Tremblay, C., Bennett, D. A., Guitton, M. J., Koninck, Y. D., Tonegawa, S., & Calon, F. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1501-13.2013 · Cited by 39
Hohsfield, L. A., Daschil, N., Orädd, G., Strömberg, I., & Humpel, C. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.10.006 · Cited by 37
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Özcan, G. G., Lim, S., Leighton, P. L. A., Allison, W. T., & Rihel, J. (2020) · eLife · doi:10.7554/elife.53995 · Cited by 39
Di, J., Siddique, I. A., Li, Z., Malki, G. J., Hornung, S., Dutta, S., Hurst, I., Ishaaya, E., Wang, A., Tu, S., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00743-x · Cited by 38
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Kamceva, M., Benedict, J., Nairn, A. C., & Lombroso, P. J. (2016) · Neural Plasticity · doi:10.1155/2016/8136925 · Cited by 33
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Pera, M., Montesinos, J., Larrea, D., Agrawal, R. R., VELASCO, K. R., Stavrovskaya, I. G., Yun, T. D., & Área-Gómez, E. (2020) · International review of neurobiology · doi:10.1016/bs.irn.2020.03.016 · Cited by 35
Zhao, Y., Chen, H., Iqbal, J., Liu, X., Zhang, H., Xiao, S., Jin, N., Yao, F., & Shen, L. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24750 · Cited by 32
Guo, K., Huang, W., Chen, K.-H.-Y., Huang, P., Peng, W., Shi, R.-Q., He, T., Zhang, M., Wang, H., Hu, J., et al. (2023) · Aging Cell · doi:10.1111/acel.13937 · Cited by 26
Central CRF system perturbation in an Alzheimer's disease knockin mouse model
Guo, Q., Zheng, H., & Justice, N. J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.01.002 · Cited by 31
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Metadata
- Authors
- Sterniczuk, R., Antle, M. C., LaFerla, F. M., & Dyck, R. H.
- Affiliations
- University of Calgary (CA)
- University of California, Irvine (US)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2010-08
- Volume
- 1348
- Pages
- 149-155
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1967375871
- Cited by
- 228
- References
- 43
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 14 · 2023: 17 · 2022: 18 · 2021: 24 · 2020: 20 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 11 · 2015: 16 · 2014: 19 · 2013: 12 · 2012: 12
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NSERC
- CIHR
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Alzheimer's disease, 3xTg-AD mice, triple transgenic mice, amyloid-beta pathology, tau pathology, cognitive impairment, behavioral deficits, anxiety, fear, startle response, freezing behavior, visuomotor coordination, muscle strength, aging
- MeSH terms
- Alzheimer Disease, Animals, Avoidance Learning, Behavioral Symptoms, Cognition Disorders, Disease Models, Animal, Exploratory Behavior, Female, Humans, Male, Mice, Inbred C57BL, Motor Activity, Neurologic Examination, Psychomotor Performance, Reaction Time, Time Factors, Amyloid beta-Protein Precursor, Statistics, Nonparametric, Maze Learning, Animals, Genetically Modified, Mice, Presenilin-1, Amyloid Precursor Protein Secretases
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