Cited by 113Parkinson's Disease Mechanisms and TreatmentsMicroRNA in disease regulationNuclear Receptors and Signaling

Midbrain dopamine neurons in Parkinson׳s disease exhibit a dysregulated miRNA and target-gene network

Open access
Briggs, Christine E., Wang, Yulei, Kong, Benjamin, Woo, Tsung-Ung W., Iyer, Lakshmanan K., Sonntag, Kai C.·2015·Brain Research

Abstract

The degeneration of substantia nigra (SN) dopamine (DA) neurons in sporadic Parkinson׳s disease (PD) is characterized by disturbed gene expression networks. Micro(mi)RNAs are post-transcriptional regulators of gene expression and we recently provided evidence that these molecules may play a functional role in the pathogenesis of PD. Here, we document a comprehensive analysis of miRNAs in SN DA neurons and PD, including sex differences. Our data show that miRNAs are dysregulated in disease-affected neurons and differentially expressed between male and female samples with a trend of more up-regulated miRNAs in males and more down-regulated miRNAs in females. Unbiased Ingenuity Pathway Analysis (IPA) revealed a network of miRNA/target-gene associations that is consistent with dysfunctional gene and signaling pathways in PD pathology. Our study provides evidence for a general association of miRNAs with the cellular function and identity of SN DA neurons, and with deregulated gene expression networks and signaling pathways related to PD pathogenesis that may be sex-specific.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2015.05.021

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • miR-29 and five other miRNAs (miR-26, miR-30, miR-199b, miR-212, miR-380-5p) are upregulated in sporadic human PD brain.

    “Out of the 81 miRNAs that inhibited PRKN translocation in our screen, miR-29 and five other miRNAs (miR-26 and miR-30, miR-199b, miR-212, miR-380-5p) have been reported to be upregulated in sporadic human PD brain [40–42].”

    From miRNA family miR-29 inhibits PINK1-PRKN signaling via ATG9A (2026) · cites this paper as [41]

    Results §2.3 reports miR-26a among miRNAs upregulated in dopamine neurons from human PD patients, including the male subgroup. The available text does not report upregulation of miR-29, miR-30, miR-199b, miR-212, or miR-380-5p; searches for those names found no supporting passage. The source therefore supports only the miR-26 portion of the attributed list. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

2 retracted

Flagged first, then by citations

2 of the 103 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Briggs, C. E., Wang, Y., Kong, B., Woo, T.-U. W., Iyer, L. K., & Sonntag, K. C.
Affiliations
  • Tufts University (US)
  • Harvard University (US)
Corresponding author
Sonntag, Kai C.
Venue
Brain Research
Publisher
Elsevier BV
Published
2015-08
Volume
1618
Pages
111-121
ISSN
0006-8993 (ISSN-L)
OpenAlex
W583113781
Cited by
113
References
103
Citations by year
2026: 3 · 2025: 10 · 2024: 7 · 2023: 17 · 2022: 18 · 2021: 7 · 2020: 15 · 2019: 10 · 2018: 12 · 2017: 8 · 2016: 5 · 2015: 1
FWCI
6.11
Type
journal article
Language
en
Open access
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Massachusetts׳ Alzheimer׳s Disease Research Center
  • Harvard NeuroDiscovery Center
  • National Institute of Neurological Disorders and Stroke (R21NS067335)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
Parkinson's disease, substantia nigra, dopaminergic neurons, microRNA, miRNA-target gene network, sex differences, neuronal gene expression, post-transcriptional regulation, signaling pathways, neuronal identity
MeSH terms
Female, Gene Expression Regulation, Humans, Male, Mesencephalon, Parkinson Disease, Signal Transduction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, MicroRNAs, Gene Regulatory Networks, Dopaminergic Neurons

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review