The DOI matches its Crossref record; 214 of the 215 references it cites were found in a registry or an index.
Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
Open accessAbstract
The strength of the blood-brain barrier (BBB) in providing protection to the central nervous system from exposure to circulating chemicals is maintained by tight junctions between endothelial cells and by a broad range of transporter proteins that regulate exchange between CNS and blood. The most important transporters that restrict the permeability of large number of toxins as well as therapeutic agents are the ABC transporters. Among them, P-gp, BCRP, MRP1 and MRP2 are the utmost studied. These efflux transporters are neuroprotective, limiting the brain entry of neurotoxins; however, they could also restrict the entry of many therapeutics and contribute to CNS pharmacoresistance. Characterization of several regulatory pathways that govern expression and activity of ABC efflux transporters in the endothelium of brain capillaries have led to an emerging consensus that these processes are complex and contain several cellular and molecular elements. Alterations in ABC efflux transporters expression and/or activity occur in several neurological diseases. Here, we review the signaling pathways that regulate expression and transport activity of P-gp, BCRP, MRP1 and MRP2 as well as how their expression/activity changes in neurological diseases. This article is part of a Special Issue entitled SI: Neuroprotection.
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“ATP-binding cassette (ABC) transporters utilize ATP as an energy source and are primarily expressed at the luminal side of the BBB endothelium (2, 488, 682).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [488]
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Blood-Brain Barrier: From Physiology to Disease and Back
Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,312
Vatansever, S., Schlessinger, A., Wacker, D., Kaniskan, H. Ü., Jin, J., Zhou, M., & Zhang, B. (2021) · Medicinal Research Reviews · doi:10.1002/med.21764 · Cited by 429
Erickson, M. A., & Banks, W. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014647 · Cited by 398
The blood–brain barrier in psychosis
Pollak, T. A., Drndarski, S., Stone, J. M., David, A. S., McGuire, P. K., & Abbott, N. J. (2017) · The Lancet Psychiatry · doi:10.1016/s2215-0366(17)30293-6 · Cited by 311
Correia, A. D. A., Monteiro, A. R., Silva, R., Moreira, J. N., Lobo, J. M. S., & Silva, A. C. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114485 · Cited by 219
Metadata
- Authors
- Qosa, H., Miller, D. S., Pasinelli, P., & Trotti, D.
- Affiliations
- Thomas Jefferson University (US)
- National Institutes of Health (US)
- Corresponding author
- Qosa, Hisham
- Trotti, Davide
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 1628
- Issue
- Pt B
- Pages
- 298-316
- ISSN
- 0006-8993 (ISSN-L)
- PMC
- PMC4681613
- OpenAlex
- W908901015
- Cited by
- 249
- References
- 215
- Citations by year
- 2026: 17 · 2025: 15 · 2024: 19 · 2023: 27 · 2022: 26 · 2021: 30 · 2020: 27 · 2019: 23 · 2018: 22 · 2017: 18 · 2016: 23 · 2015: 1
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Health (RO1-NS074886)
- Intramural Research program NIH/NIEHS
- Topics
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- ABC transporters, blood-brain barrier, P-glycoprotein, ABCG2, MRP1, MRP2, efflux pumps, transporter regulation, tight junctions, neurological disorders, neuroprotection, signaling pathways, brain capillary endothelium
- MeSH terms
- Animals, Blood-Brain Barrier, Humans, Nervous System Diseases, ATP-Binding Cassette Transporters
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