The DOI matches its Crossref record; 338 of the 340 references it cites were found in a registry or an index.
Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments
Abstract
Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a significant cause of mortality around the world. On a molecular level, the condition is characterized by widespread cell death and poor regeneration, which can result in severe morbidity in survivors. Potential therapeutics are of major interest, with a promising candidate being brain-derived neurotrophic factor (BDNF), a ubiquitous agent in the brain which has been associated with neural development and may facilitate protective and regenerative effects following injury. This review summarizes the available information on the potential benefits of BDNF and the molecular mechanisms involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer's disease and Parkinson's disease. It further explores the methods in which BDNF can be applied in clinical and therapeutic settings, and the potential challenges to overcome.
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“Furthermore, currently, it is not possible to ensure that BDNF acts on precise target regions without affecting the function of neighboring areas [112].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [112]
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Cites
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
PLGA-based nanoparticles: An overview of biomedical applications
Danhier, F., Ansorena, E., Silva, J. M., Coco, R., Breton, A. L., & Véronique Préat, A. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.043 · Cited by 4,006
SELECTIVE LOSS OF CENTRAL CHOLINERGIC NEURONS IN ALZHEIMER'S DISEASE
DAVIES, P. (1976) · The Lancet · doi:10.1016/s0140-6736(76)91936-x · Cited by 3,565
Roles of CHOP/GADD153 in endoplasmic reticulum stress
Oyadomari, S., & Mori, M. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401373 · Cited by 2,879
Trk Receptors: Roles in Neuronal Signal Transduction
Huang, E. J., & Reichardt, L. F. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161629 · Cited by 2,537
Donnan, G. A., Fisher, M., Macleod, M. R., & Davis, S. M. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60694-7 · Cited by 2,288
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders
Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174
Alzheimer Disease in the US Population: Prevalence Estimates Using the 2000 Census
Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A., & Evans, D. A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1119 · Cited by 2,168
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Zhong, J., Yu, X.-H., & Lin, Z. (2025) · PeerJ · doi:10.7717/peerj.18905 · Cited by 1
Wang, L., Su, F., Huang, H., Jiang, Q., Kong, H., & Pei, Z. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.102788 · Cited by 1
Renal BDNF mRNA Downregulation in a Mouse Model of Adenine-Induced Chronic Kidney Disease
Nakajima, K., & Ohgami, M. (2025) · Journal of Oleo Science · doi:10.5650/jos.ess25216 · Cited by 1
Correlation between Biomarkers and Ischemic Stroke
梁, 明. (2021) · Advances in Clinical Medicine · doi:10.12677/acm.2021.116392 · Cited by 1
EFFECT OF MONDAY THURSDAY FASTING ON WORKING MEMORY AFTER ACUTE STRESS EXPOSURE
Faqih, A., Jusup, S. A., Wiyono, N., & Qadrijati, I. (2023) · International Journal of Islamic and Complementary Medicine · doi:10.55116/ijicm.v4i2.54 · Cited by 1
Molecular insights into the effects of cancer and chemotherapy on the brain
Kovalchuk, A. (2017)
THE CHARACTERIZATION OF BEHAVIORAL ABNORMALITIES IN BDNF LOXP TRANSGENIC MICE
Brandt, R. D. (2018)
Mitroshina, Е. V., Epifanova, E. A., Mishchenko, T. A., Yarkov, R. S., Babaev, A. A., & Vedunova, M. V. (2018) · Современные технологии в медицине · doi:10.17691/stm2018.10.2.05
Michelon, L. (2019) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2019.tde-25102019-131555
Investigation of Plasma PGC1-α, Irisin, BDNF, GAL, and GALP Levels in Parkinson's Disease
Gül, H. F., Yıldırım, C., ERDOĞAN, C., Gül, Ö., & ARSLANTÜRK, İ. (2021) · Cumhuriyet Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi · doi:10.51754/cusbed.948015
Roh, E., Hwang, S. Y., Song, E., Park, M., Yoo, H. J., Baik, S. H., Kim, M., Won, C. W., & Choi, K. M. (2022) · Research Square · doi:10.21203/rs.3.rs-1652373/v1
Monnet‐Tschudi, F., Zurich, M., Nunes, C., Sandström, J., FitzGerald, R., Aschner, M., & da Rocha, J. B. T. (2022) · OECD series on adverse outcome pathways · doi:10.1787/4df0e9e4-en · Cited by 2
Application of Polymeric Nanoparticles for Brain Targeting
Agrawal, M., Rathod, K., & Roy, U. (2024) · Springer eBooks · doi:10.1007/978-981-97-2859-6_4
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Sharma, P., Choudhary, G., Sachdeva, M., Mehta, G., & Tripathi, R. (2024) · Current Drug Therapy · doi:10.2174/0115748855312643241004111641
Zhu, S., Ye, L., & Chen, J. (2025) · International Journal of General Medicine · doi:10.2147/ijgm.s527691
Potential Mechanisms of Exercise-Mediated Ferroptosis Regulation in Central Nervous System Diseases
Li, X., Guo, Z., Li, Q., Li, C., & Zhang, X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05347-w
Khan, Z., Jain, A., Garg, A., Bano, Z., & Khan, M. A. (2025) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-025-02196-5
Safety and exploratory functional effects of topical cord blood serum in glaucoma patients
Lupardi, E., Odorici, S., Buzzi, M., Bergantin, E., Bisti, S., Polizzi, S., Fontana, L., & Versura, P. (2026) · Scientific Reports · doi:10.1038/s41598-026-37774-7
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Pandey, A., Park, D., Ha, W.-B., Kim, C. S., Lee, E. S., Park, C., Leem, J., & Kwon, K. (2026) · Pharmaceuticals · doi:10.3390/ph19101558
Ali, S. B., Jamal, M., Ayub, M., Nisar, U., Malhi, S. M., Faizi, S., Sımjee, S. U., & Iriti, M. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.111244
Metadata
- Authors
- Zhao, H., Alam, A., San, C.-Y., Eguchi, S., Chen, Q., Lian, Q., & Ma, D.
- Affiliations
- Chelsea and Westminster Hospital (GB)
- Army Medical University (CN)
- Wenzhou Medical University (CN)
- Corresponding author
- Lian, Qingquan
- Ma, Daqing
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 1665
- Pages
- 1-21
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2604803509
- Cited by
- 122
- References
- 340
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 9 · 2023: 7 · 2022: 16 · 2021: 11 · 2020: 14 · 2019: 22 · 2018: 17 · 2017: 9
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sparks
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- brain-derived neurotrophic factor, neuroprotection, neuronal cell death, neurological trauma, hypoxic brain injury, stroke, Alzheimer's disease, Parkinson's disease, nerve regeneration, therapeutic target
- MeSH terms
- Alzheimer Disease, Animals, Brain, Hypoxia, Brain, Humans, Neurons, Parkinson Disease, Brain-Derived Neurotrophic Factor
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