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Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments
Abstract
Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a significant cause of mortality around the world. On a molecular level, the condition is characterized by widespread cell death and poor regeneration, which can result in severe morbidity in survivors. Potential therapeutics are of major interest, with a promising candidate being brain-derived neurotrophic factor (BDNF), a ubiquitous agent in the brain which has been associated with neural development and may facilitate protective and regenerative effects following injury. This review summarizes the available information on the potential benefits of BDNF and the molecular mechanisms involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer's disease and Parkinson's disease. It further explores the methods in which BDNF can be applied in clinical and therapeutic settings, and the potential challenges to overcome.
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“Furthermore, currently, it is not possible to ensure that BDNF acts on precise target regions without affecting the function of neighboring areas [112].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [112]
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Metadata
- Authors
- Zhao, H., Alam, A., San, C.-Y., Eguchi, S., Chen, Q., Lian, Q., & Ma, D.
- Affiliations
- Chelsea and Westminster Hospital (GB)
- Army Medical University (CN)
- Wenzhou Medical University (CN)
- Corresponding author
- Lian, Qingquan
- Ma, Daqing
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 1665
- Pages
- 1-21
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2604803509
- Cited by
- 122
- References
- 340
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 9 · 2023: 7 · 2022: 16 · 2021: 11 · 2020: 14 · 2019: 22 · 2018: 17 · 2017: 9
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sparks
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Keywords
- brain-derived neurotrophic factor, neuroprotection, neuronal cell death, neurological trauma, hypoxic brain injury, stroke, Alzheimer's disease, Parkinson's disease, nerve regeneration, therapeutic target
- MeSH terms
- Alzheimer Disease, Animals, Brain, Hypoxia, Brain, Humans, Neurons, Parkinson Disease, Brain-Derived Neurotrophic Factor
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