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Cited by 25Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanismsAlzheimer's disease research and treatments

Back to the origins: Human brain organoids to investigate neurodegeneration

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Faravelli, I., Costamagna, G., Tamanini, S., Corti, S.·2020·Brain Research
DOI 10.1016/j.brainres.2019.146561
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Abstract

Neurodegenerative disorders represent a high burden in terms of individual, social and economical resources. No ultimate therapy has been established so far; human brain morphology and development can not be entirely reproduced by animal models, and genomic, metabolic and biochemical differences might contribute to a limited predictive power for human translation. Thus, the development of human brain organoid models holds a wide potential to investigate the range of physiological and pathological features that characterise the early onset of the degeneration. Moreover, central nervous system development has gained a crucial role in the study of the pathogenesis of neurodegenerative disorders. Premature alterations during brain maturation have been related to late disease manifestations; genetic mutations responsible for neurodegeneration have been found in genes highly expressed during neural development. Elucidating the mechanisms triggering neuronal susceptibility to degeneration is crucial for pathogenetic studies and therapeutic discoveries. In the present work, we provide an overview on the current applications of human brain organoids towards studies of neurodegenerative diseases, with a survey on the recent discoveries and a closing discussion on the present challenges and future perspectives.

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Cited by

Sorted by citations

Authors
Faravelli, I., Costamagna, G., Tamanini, S., & Corti, S.
Affiliations
University of Milan (IT)
Corresponding author
Corti, S.
ORCID
Venue
Brain Research
Publisher
Elsevier BV
Published
2020-01
Volume
1727
Pages
146561
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/j.brainres.2019.146561
OpenAlex
W2991225863
Cited by
25
References
17
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 2 · 2019: 1
FWCI
0.22
Type
journal article
Language
en
Open access
Licence
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
human brain organoids, neurodegenerative diseases, brain development, pathogenesis, animal model limitations, central nervous system development
MeSH terms
Brain, Humans, Models, Neurological, Neurons, Organoids, Neurodegenerative Diseases, Induced Pluripotent Stem Cells

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