Cited by 179Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Transgenic mouse models of alzheimer disease: Developing a better model as a tool for therapeutic interventions.

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Kitazawa, Masashi, Medeiros, Rodrigo, M. LaFerla, Frank·2012·Current Pharmaceutical Design

Abstract

Alzheimer disease (AD) is the leading cause of dementia among elderly. Currently, no effective treatment is available for AD. Analysis of transgenic mouse models of AD has facilitated our understanding of disease mechanisms and provided valuable tools for evaluating potential therapeutic strategies. In this review, we will discuss the strengths and weaknesses of current mouse models of AD and the contribution towards understanding the pathological mechanisms and developing effective therapies. Keywords: Alzheimer disease, amyloid-beta, tau, transgenic mouse models, dementia, neurodegeneration, amyloid precursor protein (APP), mild cognitive impairment (MCI), synaptic dysfunction, mutations

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Authors
Kitazawa, M., Medeiros, R., & M. LaFerla, F.
Affiliations
  • University of California, Merced (US)
  • University of California, Irvine (US)
Corresponding author
Kitazawa, Masashi
Venue
Current Pharmaceutical Design
Published
2012-03-01
Volume
18
Issue
8
Pages
1131-1147
ISSN
1381-6128 (ISSN-L)
OpenAlex
W2095268222
Cited by
178
References
239
Citations by year
2026: 10 · 2025: 8 · 2024: 12 · 2023: 17 · 2022: 13 · 2021: 17 · 2020: 20 · 2019: 18 · 2018: 25 · 2017: 10 · 2016: 8 · 2015: 6 · 2014: 6 · 2013: 7 · 2012: 1
FWCI
0.72
Type
journal article
Language
en
Open access
Locations
  • Current Pharmaceutical Design (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Institute on Aging (R01AG021982)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, transgenic mouse model, amyloid-beta, tau protein, amyloid precursor protein, mild cognitive impairment, synaptic dysfunction, neurodegeneration, dementia, therapeutic interventions, APP mutations
MeSH terms
Aged, Alzheimer Disease, Animals, Disease Models, Animal, Humans, Mice, Transgenic, Drug Design, Mice

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