APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

The Amyloid-β Pathway in Alzheimer’s Disease

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Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C.-C., & Bu, G. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0228-7 · Cited by 1,425 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

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A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

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A brief history of human disease genetics

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APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

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Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications

Cerneckis, J., Cai, H., & Shi, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01809-0 · Cited by 452 · see citing works

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

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Long-term maturation of human cortical organoids matches key early postnatal transitions

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Astrocyte Biomarkers in Alzheimer’s Disease

Carter, S. F., Herholz, K., Rosa-Neto, P., Pellerin, L., Nordberg, A., & Zimmer, E. R. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.11.006 · Cited by 355 · see citing works

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias

Martens, Y. A., Zhao, N., Liu, C.-C., Kanekiyo, T., Yang, A. J., Goate, A. M., Holtzman, D. M., & Bu, G. (2022) · Neuron · doi:10.1016/j.neuron.2022.03.004 · Cited by 316 · see citing works

Multi-lineage human iPSC-derived platforms for disease modeling and drug discovery

Sharma, A., Sances, S., Workman, M. J., & Svendsen, C. N. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2020.02.011 · Cited by 296 · see citing works

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

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ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response

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Generation and biobanking of patient-derived glioblastoma organoids and their application in CAR T cell testing

Jacob, F., Ming, G., & Song, H. (2020) · Nature Protocols · doi:10.1038/s41596-020-0402-9 · Cited by 216 · see citing works

REST and neural gene network dysregulation in iPSC models of Alzheimer’s disease

Meyer, K., Feldman, H. M., Lu, T., Drake, D., Lim, E. T., Ling, K.-H., Bishop, N. A., Pan, Y., Seo, J., Lin, Y.-T., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.01.023 · Cited by 216 · see citing works

Assembling human brain organoids

Paşca, S. P. (2019) · Science · doi:10.1126/science.aau5729 · Cited by 208 · see citing works

Modeling Sporadic Alzheimer's Disease in Human Brain Organoids under Serum Exposure

Chen, X., Sun, G., Tian, E., Zhang, M., Davtyan, H., Beach, T. G., Reiman, E. M., Blurton‐Jones, M., Holtzman, D. M., & Shi, Y. (2021) · Advanced Science · doi:10.1002/advs.202101462 · Cited by 200 · see citing works

CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids

Hendriks, D. F. G., Clevers, H. C., & Artegiani, B. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.10.014 · Cited by 196 · see citing works

Microglia as Dynamic Cellular Mediators of Brain Function

Wright-Jin, E. C., & Gutmann, D. H. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.08.013 · Cited by 186 · see citing works

Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation

Ye, X., Zhu, M., Che, X., Wang, H., Liang, X., Wu, C., Xue, X., & Yang, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1644-8 · Cited by 184 · see citing works

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

Najm, R., Jones, E. A., & Huang, Y. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0324-6 · Cited by 183 · see citing works

Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

Knupp, A., Mishra, S., Martinez, R. A., Braggin, J. E., Szabo, M. P., Kinoshita, C., Hailey, D. W., Small, S. A., Jayadev, S., & Young, J. E. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107719 · Cited by 177 · see citing works

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

Williams, T., Borchelt, D., & Chakrabarty, P. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-0358-9 · Cited by 166 · see citing works

Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses

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Brain cell type-specific cholesterol metabolism and implications for learning and memory

Li, D., Zhang, J., & Liu, Q. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.01.002 · Cited by 163 · see citing works

CRISPR-based functional genomics for neurological disease

Kampmann, M. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0373-z · Cited by 163 · see citing works

Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids

Çakır, B., Tanaka, Y., Kiral, F. R., Xiang, Y., Dağliyan, O., Wang, J., Lee, M., Greaney, A. M., Yang, W. S., duBoulay, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28043-y · Cited by 160 · see citing works

Glial Contribution to Excitatory and Inhibitory Synapse Loss in Neurodegeneration

Henstridge, C. M., Tzioras, M., & Paolicelli, R. C. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00063 · Cited by 145 · see citing works

Neuronal apolipoprotein E4 increases cell death and phosphorylated tau release in alzheimer disease

Wadhwani, A. R., Affaneh, A., Van Gulden, S., & Kessler, J. A. (2019) · Annals of Neurology · doi:10.1002/ana.25455 · Cited by 142 · see citing works

Stem Cells, Genome Editing, and the Path to Translational Medicine

Soldner, F., & Jaenisch, R. (2018) · Cell · doi:10.1016/j.cell.2018.09.010 · Cited by 139 · see citing works

APOE-amyloid interaction: Therapeutic targets

Wısnıewskı, T., & Drummond, E. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104784 · Cited by 125 · see citing works

Three-dimensional modeling of human neurodegeneration: brain organoids coming of age

Grenier, K., Kao, J., & Diamandis, P. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0500-7 · Cited by 127 · see citing works

The APOE-R136S mutation protects against APOE4-driven tau pathology, neurodegeneration, and neuroinflammation

Nelson, M. R., Liu, P., Agrawal, A., Yip, O., Blumenfeld, J., Traglia, M., Kim, M. J., Koutsodendris, N., Rao, A., Grone, B., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01480-8 · Cited by 118 · see citing works

Amyloid-β oligomers in cellular models of Alzheimer’s disease

Fontana, I. C., Zimmer, A. R., Rocha, A. S., Gosmann, G., Souza, D. O., Lourenco, M. V., Ferreira, S. T., & Zimmer, E. R. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15030 · Cited by 115 · see citing works

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Hesse, R., Hurtado, M. L., Jackson, R. J., Eaton, S. L., Herrmann, A. G., Colom‐Cadena, M., Tzioras, M., King, D., Rose, J. L., Tulloch, J., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0847-7 · Cited by 103 · see citing works

Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease

Young‐Pearse, T. L., Lee, H., Hsieh, Y., Chou, V., & Selkoe, D. J. (2023) · Trends in Neurosciences · doi:10.1016/j.tins.2023.03.005 · Cited by 99 · see citing works

CNTN5-/+or EHMT2-/+human iPSC-derived neurons from individuals with autism develop hyperactive neuronal networks

Deneault, É., Faheem, M., White, S. H., Rodrigues, D. C., Sun, S., Wei, W., Piekna, A., Thompson, T., Howe, J., Chalil, L., et al. (2019) · eLife · doi:10.7554/elife.40092 · Cited by 96 · see citing works

Cholesterol as a key player in amyloid β-mediated toxicity in Alzheimer’s disease

Rudajev, V., & Novotný, J. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.937056 · Cited by 94 · see citing works

ApoE4-dependent lysosomal cholesterol accumulation impairs mitochondrial homeostasis and oxidative phosphorylation in human astrocytes

Lee, H., Cho, S., Kim, M.-J., Park, Y. J., Cho, E., Jo, Y. S., Kim, Y.-S., Lee, J. Y., Thoudam, T., Woo, S.-H., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113183 · Cited by 93 · see citing works

Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors

Meharena, H. S., Marco, A., Dileep, V., Lockshin, E. R., Akatsu, G. Y., Mullahoo, J., Watson, L. A., Ko, T., Guerin, L. N., Abdurrob, F., et al. (2022) · Cell Stem Cell · doi:10.1016/j.stem.2021.12.002 · Cited by 92 · see citing works

Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids

Costamagna, G., Comi, G. P., & Corti, S. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052659 · Cited by 89 · see citing works

Apolipoprotein E in Alzheimer’s disease: molecular insights and therapeutic opportunities

Belaidi, A. A., Bush, A. I., & Ayton, S. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00843-y · Cited by 91 · see citing works

Precision Nutrition for Alzheimer’s Prevention in ApoE4 Carriers

Norwitz, N. G., Saif, N., Ariza, I. E., & Isaacson, R. (2021) · Nutrients · doi:10.3390/nu13041362 · Cited by 87 · see citing works

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Wang, N., Wang, M., Jeevaratnam, S., Rosenberg, C., Ikezu, T. C., Shue, F., Doss, S. V., Alnobani, A., Martens, Y. A., Wren, M., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00577-1 · Cited by 82 · see citing works

What are activated and reactive glia and what is their role in neurodegeneration?

Bennett, M. L., & Viaene, A. N. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105172 · Cited by 77 · see citing works

Application of CRISPR/Cas9 in Alzheimer’s Disease

Lu, L., Xi, Y., Cai, Y., Sun, M., & Yang, H. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.803894 · Cited by 78 · see citing works

Organoids to study immune functions, immunological diseases and immunotherapy

Ye, W., Luo, C., Li, C., Huang, J., & Liu, F. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.02.027 · Cited by 67 · see citing works

Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models

Franklin, H., Clarke, B. E., & Patani, R. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101973 · Cited by 66 · see citing works

Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration

La Cunza, N., Tan, L. X., Thamban, T., Germer, C. J., Rathnasamy, G., Toops, K. A., & Lakkaraju, A. (2021) · JCI Insight · doi:10.1172/jci.insight.142254 · Cited by 65 · see citing works

The synthetic TRPML1 agonist ML-SA1 rescues Alzheimer-related alterations of the endosomal-autophagic-lysosomal system

Somogyi, A., Kirkham, E. D., Lloyd‐Evans, E., Winston, J., Allen, N. D., Mackrill, J. J., Anderson, K. E., Hawkins, P. T., Gardiner, S. E., Waller‐Evans, H., et al. (2023) · Journal of Cell Science · doi:10.1242/jcs.259875 · Cited by 63 · see citing works

Cancer Chemotherapy Related Cognitive Impairment and the Impact of the Alzheimer’s Disease Risk Factor APOE

Fernandez, H. R., Varma, A., Flowers, S. A., & Rebeck, G. W. (2020) · Cancers · doi:10.3390/cancers12123842 · Cited by 62 · see citing works

A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance

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Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities

Söderberg, L., Johannesson, M., Gkanatsiou, E., Nygren, P., Fritz, N., Zachrisson, O., Rachalski, A., Svensson, A.-S., Button, E. B., Dentoni, G., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-61691-2 · Cited by 60 · see citing works

Concise Review: Modeling Neurodegenerative Diseases with Human Pluripotent Stem Cell-Derived Microglia

Haenseler, W., & Rajendran, L. (2019) · Stem Cells · doi:10.1002/stem.2995 · Cited by 54 · see citing works

Cerebral organoids as tools to identify the developmental roots of autism

Chan, W. K., Griffiths, R., Price, D. J., & Mason, J. O. (2020) · Molecular Autism · doi:10.1186/s13229-020-00360-3 · Cited by 54 · see citing works

APOE: The New Frontier in the Development of a Therapeutic Target towards Precision Medicine in Late-Onset Alzheimer’s

Yang, A., Kantor, B., & Chiba‐Falek, O. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031244 · Cited by 50 · see citing works

Microglial Senescence and Activation in Healthy Aging and Alzheimer’s Disease: Systematic Review and Neuropathological Scoring

Malvaso, A., Gatti, A., Negro, G., Calatozzolo, C., Medici, V., & Poloni, T. E. (2023) · Cells · doi:10.3390/cells12242824 · Cited by 51 · see citing works

Phagocytosis of Apoptotic Cells Is Specifically Upregulated in ApoE4 Expressing Microglia in vitro

Muth, C., Hartmann, A., Falla, D. S., Glatzel, M., & Krasemann, S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00181 · Cited by 47 · see citing works

Contribution of astrocytes to metabolic dysfunction in the Alzheimer’s disease brain

Zulfiqar, S., Garg, P., & Nieweg, K. (2019) · Biological Chemistry · doi:10.1515/hsz-2019-0140 · Cited by 45 · see citing works

From Brain Organoids to Networking Assembloids: Implications for Neuroendocrinology and Stress Medicine

Makrygianni, E. A., & Chrousos, G. P. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.621970 · Cited by 47 · see citing works

Optimization of cerebral organoids: a more qualified model for Alzheimer’s disease research

Bi, F.-C., Yang, X.-H., Cheng, X.-Y., Deng, W.-B., Guo, X.-L., Yang, H., Wang, Y., Li, J., & Yao, Y. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00252-3 · Cited by 47 · see citing works

Generation of pure monocultures of human microglia-like cells from induced pluripotent stem cells

Banerjee, P., Paza, E., Perkins, E., James, O. G., Kenkhuis, B., Lloyd, A. F., Burr, K., Story, D., Yusuf, D., He, X., et al. (2020) · Stem Cell Research · doi:10.1016/j.scr.2020.102046 · Cited by 46 · see citing works

Microglial VPS35 deficiency impairs Aβ phagocytosis and Aβ-induced disease-associated microglia, and enhances Aβ associated pathology

Ren, X., Yao, L., Wang, Y., Mei, L., & Xiong, W. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02422-0 · Cited by 44 · see citing works

Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?

Staurenghi, E., Giannelli, S., Testa, G., Sottero, B., Leonarduzzi, G., & Gamba, P. (2021) · Antioxidants · doi:10.3390/antiox10121890 · Cited by 44 · see citing works

LilrB3 is a putative cell surface receptor of APOE4

Zhou, J., Wang, Y., Huang, G., Yang, M., Zhu, Y., Jin, C., Jing, D., Ji, K., & Shi, Y. (2023) · Cell Research · doi:10.1038/s41422-022-00759-y · Cited by 44 · see citing works

Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury

Wang, W., Hou, T., Jia, L.-F., Wu, Q., Quan, M., & Jia, J. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.049 · Cited by 42 · see citing works

Mitochondrial dysfunction and oxidative stress in induced pluripotent stem cell models of Parkinson's disease

Bose, A., & Beal, M. F. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14264 · Cited by 41 · see citing works

Next Generation Precision Medicine: CRISPR-mediated Genome Editing for the Treatment of Neurodegenerative Disorders

Raikwar, S. P., Kikkeri, N. S., Sakuru, R. C., Saeed, D., Zahoor, H., Premkumar, K., Mentor, S., Thangavel, R., Dubova, I., Ahmed, M. E., et al. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09849-y · Cited by 47 · see citing works

Invited Review – Understanding cause and effect in Alzheimer's pathophysiology: Implications for clinical trials

Boche, D., & Nicoll, J. A. R. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12642 · Cited by 40 · see citing works

Multi-functional role of apolipoprotein E in neurodegenerative diseases

Islam, S., Noorani, A., Sun, Y., Michikawa, M., & Zou, K. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1535280 · Cited by 30 · see citing works

Critical Molecular and Cellular Contributors to Tau Pathology

Song, L., Wells, E. A., & Robinson, A. S. (2021) · Biomedicines · doi:10.3390/biomedicines9020190 · Cited by 36 · see citing works

The role of ApoE-mediated microglial lipid metabolism in brain aging and disease

Yen, J.-H. J., & Yu, I.-C. I. (2023) · Immunometabolism · doi:10.1097/in9.0000000000000018 · Cited by 37 · see citing works

Simplified Brain Organoids for Rapid and Robust Modeling of Brain Disease

Ha, J., Kang, J. S., Lee, M., Baek, A., Kim, S., Chung, S., Lee, M., & Kim, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.594090 · Cited by 40 · see citing works

Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease

Jun, G., You, Y., Zhu, C., Meng, G., Chung, J., Panitch, R., Hu, J., Xia, W., Bennett, D. A., Foroud, T., et al. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12607 · Cited by 35 · see citing works

Modeling Alzheimer’s disease with human iPS cells: advancements, lessons, and applications

Essayan-Perez, S., Zhou, B., Nabet, A. M., Wernig, M., & Huang, Y. A. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104503 · Cited by 37 · see citing works

ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells

Lee, J., Lee, H., Lee, H. G., Shin, M., Shin, M.-G., Seo, J., Lee, E. J., Park, S. A., & Park, S. (2023) · Nature Communications · doi:10.1038/s41467-023-44319-3 · Cited by 36 · see citing works

The application of in vitro ‐derived human neurons in neurodegenerative disease modeling

D’Souza, G. X., Rose, S. E., Knupp, A., Nicholson, D. A., Keene, C. D., & Young, J. E. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24615 · Cited by 35 · see citing works

Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative Diseases

Gupta, S., You, P., SenGupta, T., Nilsen, H. L., & Sharma, K. (2021) · Biology · doi:10.3390/biology10020163 · Cited by 34 · see citing works

APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer’s disease

Brookhouser, N., Raman, S., Frisch, C., Srinivasan, G., & Brafman, D. A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01076-3 · Cited by 33 · see citing works

PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity

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A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice

Balu, D., Valencia‐Olvera, A. C., Nguyen, A. Q., Patnam, M., York, J. M., Peri, F., Neumann, F., LaDu, M. J., & Tai, L. M. (2023) · Alzheimer s Research & Therapy · doi:10.1186/s13195-023-01330-6 · Cited by 32 · see citing works

Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology

Pramotton, F. M., Spitz, S., & Kamm, R. D. (2024) · Advanced Science · doi:10.1002/advs.202403892 · Cited by 33 · see citing works

Advanced in vitro models: Microglia in action

Cakir, B., Kiral, F. R., & Park, I.-H. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.004 · Cited by 32 · see citing works

Astrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model

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Astrocytes: From the Physiology to the Disease

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Microglia and its Genetics in Alzheimer's Disease

Liang, X., Wu, H., Colt, M., Guo, X., Pluimer, B. R., Zeng, J., Dong, S., & Zhao, Z. (2021) · Current Alzheimer Research · doi:10.2174/1567205018666211105140732 · Cited by 31 · see citing works

Current understanding of the interactions between metal ions and Apolipoprotein E in Alzheimer’s disease

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Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice

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Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE

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Prevention of Alzheimer's disease through diet: An exploratory review

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Implication of tau propagation on neurodegeneration in Alzheimer’s disease

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Back to the origins: Human brain organoids to investigate neurodegeneration

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A combined physiologically‐based pharmacokinetic and quantitative systems pharmacology model for modeling amyloid aggregation in Alzheimer's disease

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Comprehensive Bibliometric Analysis of Stem Cell Research in Alzheimer’s Disease from 2004 to 2022

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Latest advances in mechanisms of epileptic activity in Alzheimer’s disease and dementia with Lewy Bodies

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Human iPSC-derived microglial cells protect neurons from neurodegeneration in long-term cultured adhesion brain organoids

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Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

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iPSC-derived blood-brain barrier modeling reveals APOE isoform-dependent interactions with amyloid beta

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Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease

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APOE4 transforms the transcriptome

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Differential effects of apolipoprotein E on the molecular and cellular phenotypes associated with Alzheimer’s disease in isogenic human iPSC‐derived neurons

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Trading places

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Modelling AD‐relevant pathophysiology in neurons, astrocytes and microglia from two complete sets of isogenic iPSC lines generated by the ADAPTED project

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P4‐263: NEURONAL APOE MODULATES A SPORADIC ALZHEIMER'S DISEASE PHENOTYPE IN PATIENT‐DERIVED INDUCED NEURONS

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