The DOI matches its Crossref record; 220 of the 222 references it cites were found in a registry or an index.
Factors influencing the blood-brain barrier permeability
Open accessAbstract
The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful blood-borne, endogenous and exogenous substances and maintains the homeostatic microenvironment. All constituent cell types play indispensable roles in the BBB's integrity, and other structural BBB components, such as tight junction proteins, adherens junctions, and junctional proteins, can control the barrier permeability. Regarding the need to exchange nutrients and toxic materials, solute carriers, ATP-binding case families, and ion transporter, as well as transcytosis regulate the influx and efflux transport, while the difference in localisation and expression can contribute to functional differences in transport properties. Numerous chemical mediators and other factors such as non-physicochemical factors have been identified to alter BBB permeability by mediating the structural components and barrier function, because of the close relationship with inflammation. In this review, we highlight recently gained mechanistic insights into the maintenance and disruption of the BBB. A better understanding of the factors influencing BBB permeability could contribute to supporting promising potential therapeutic targets for protecting the BBB and the delivery of central nervous system drugs via BBB permeability interventions under pathological conditions.
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“Adherens junction is extra crucial for the BBB structural integrity and appropriate assembly of proteins of tight junctions.109,110”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [110]
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“Additionally, various microbiota throughout the body can circulate in the blood and potentially enter the brain, particularly if the BBB becomes more permeable [140].”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [140]
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The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X., Han, F., Chen, Z., & Wang, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01481-w · Cited by 1,906
“Adherens junction is extra crucial for the BBB structural integrity and appropriate assembly of proteins of tight junctions.(109,110) At cellular interfaces, they build spatially, chemically, and mechanically discrete microdomains.”
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Chen, Z.-A., Wu, C. ‐., Wu, S., Huang, C.-Y., Mou, C., Wei, K., Yen, Y., Chien, I.-T., Runa, S., Chen, Y., et al. (2024) · ACS Nano · doi:10.1021/acsnano.3c08993 · Cited by 132
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Metadata
- Authors
- Zhao, Y., Gan, L., Ren, L., Lin, Y., Ma, C., & Lin, X.
- Affiliations
- Zhejiang Chinese Medical University (CN)
- Corresponding author
- Lin, Xianming
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 1788
- Pages
- 147937
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W4280550830
- Cited by
- 291
- References
- 222
- Citations by year
- 2026: 68 · 2025: 112 · 2024: 72 · 2023: 36 · 2022: 3
- FWCI
- 19.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Research (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82174502)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- blood-brain barrier, blood-brain barrier permeability, tight junction proteins, adherens junctions, junctional proteins, solute carrier transporters, ABC transporters, ion transporters, transcytosis, blood-brain barrier disruption, inflammation, brain drug delivery, therapeutic target
- MeSH terms
- Biological Transport, Blood-Brain Barrier, Brain, Humans, Permeability, Tight Junctions, Tight Junction Proteins
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