Cited by 291Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsIon Transport and Channel Regulation

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Factors influencing the blood-brain barrier permeability

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Zhao, Yibin, Gan, Lin, Ren, Li, Lin, Yubo, Ma, Congcong, Lin, Xianming·2022·Brain Research

DOI 10.1016/j.brainres.2022.147937

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Abstract

The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful blood-borne, endogenous and exogenous substances and maintains the homeostatic microenvironment. All constituent cell types play indispensable roles in the BBB's integrity, and other structural BBB components, such as tight junction proteins, adherens junctions, and junctional proteins, can control the barrier permeability. Regarding the need to exchange nutrients and toxic materials, solute carriers, ATP-binding case families, and ion transporter, as well as transcytosis regulate the influx and efflux transport, while the difference in localisation and expression can contribute to functional differences in transport properties. Numerous chemical mediators and other factors such as non-physicochemical factors have been identified to alter BBB permeability by mediating the structural components and barrier function, because of the close relationship with inflammation. In this review, we highlight recently gained mechanistic insights into the maintenance and disruption of the BBB. A better understanding of the factors influencing BBB permeability could contribute to supporting promising potential therapeutic targets for protecting the BBB and the delivery of central nervous system drugs via BBB permeability interventions under pathological conditions.

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Brain endothelial barrier passage by monocytes is controlled by the endothelin system
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Delivery of siRNA Silencing P-gp in Peptide-Functionalized Nanoparticles Causes Efflux Modulation at the Blood–Brain Barrier
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See all 291

Authors: Zhao, Y., Gan, L., Ren, L., Lin, Y., Ma, C., & Lin, X.
Affiliations: Zhejiang Chinese Medical University (CN)
Corresponding author: Lin, Xianming
ORCID: Zhao, Yibin
Ren, Li
Lin, Yubo
Ma, Congcong
Lin, Xianming
Venue: Brain Research
Publisher: Elsevier BV
Published: 2022-08
Volume: 1788
Pages: 147937
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2022.147937
OpenAlex: W4280550830
Cited by: 291
References: 222
Citations by year: 2026: 68 · 2025: 112 · 2024: 72 · 2023: 36 · 2022: 3
FWCI: 19.57
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Brain Research (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (82174502)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords: blood-brain barrier, blood-brain barrier permeability, tight junction proteins, adherens junctions, junctional proteins, solute carrier transporters, ABC transporters, ion transporters, transcytosis, blood-brain barrier disruption, inflammation, brain drug delivery, therapeutic target
MeSH terms: Biological Transport, Blood-Brain Barrier, Brain, Humans, Permeability, Tight Junctions, Tight Junction Proteins

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Factors influencing the blood-brain barrier permeability

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