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Cited by 22Neuroscience and Neuropharmacology ResearchStress Responses and CortisolMemory and Neural Mechanisms

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Brief neck restraint stress enhances long-term potentiation and suppresses long-term depression in the dentate gyrus of the mouse

Spyrka, Jadwiga, Danielewicz, Joanna, Hess, Grzegorz·2011·Brain Research Bulletin
DOI 10.1016/j.brainresbull.2011.05.008
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Abstract

We studied the effects of brief (10 min) neck restraint on long-term potentiation (LTP) and long-term depression (LTD) in mouse dentate gyrus (DG) slices. Brain slices were prepared immediately after neck restraint and LTP/LTD induction was attempted 3.5h later. LTP enhancement and LTD suppression was observed in slices prepared from stressed animals. The corticosterone plasma concentration was elevated approx. fourfold just after the neck restraint session. To examine the role of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) activation in mediating the effects of neck restraint on LTP and LTD, the animals were pretreated with either the specific GR antagonist RU38486, the specific MR antagonist spironolactone, the corticosterone synthesis inhibitor metyrapone, or vehicle Tween 80. Injection with Tween 80 and subsequent neck restraint did not influence LTP enhancement or LTD suppression, but the effects of neck restraint were prevented by RU38486, spironolactone and metyrapone pretreatment. These data indicate that acute stress caused by brief neck restraint enhances LTP and impairs LTD in the dentate gyrus and that these effects are mediated by activation of GRs and MRs.

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Metadata

Authors
Spyrka, J., Danielewicz, J., & Hess, G.
Affiliations
Jagiellonian University (PL)
ORCID
Venue
Brain Research Bulletin
Publisher
Elsevier BV
Published
2011-07
Volume
85
Issue
6
Pages
363-367
ISSN
0361-9230 (ISSN-L)
DOI
10.1016/j.brainresbull.2011.05.008
OpenAlex
W2091102093
Cited by
22
References
2
Citations by year
2022: 1 · 2020: 1 · 2018: 3 · 2017: 4 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 4
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Brain Research Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Science and Higher Education
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
acute stress, long-term potentiation, long-term depression, dentate gyrus, glucocorticoid receptor, mineralocorticoid receptor, corticosterone, mifepristone, spironolactone, metyrapone, synaptic plasticity
MeSH terms
Mineralocorticoid Receptor Antagonists, Animals, Corticosterone, Enzyme Inhibitors, Hormone Antagonists, Male, Metyrapone, Mice, Inbred C57BL, Neck, Synaptic Transmission, Receptors, Glucocorticoid, Restraint, Physical, Spironolactone, Mifepristone, Long-Term Potentiation, Receptors, Mineralocorticoid, Dentate Gyrus, Long-Term Synaptic Depression, Mice

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CoChat. (2026). Citation check: Brief neck restraint stress enhances long-term potentiation and suppresses long-term depression in the dentate gyrus of the mouse. https://app.cochat.ai/papers/10.1016/j.brainresbull.2011.05.008
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Spyrka, J., Danielewicz, J., & Hess, G. (2011). Brief neck restraint stress enhances long-term potentiation and suppresses long-term depression in the dentate gyrus of the mouse. Brain Research Bulletin. https://doi.org/10.1016/j.brainresbull.2011.05.008