Effects of inescapable stress on LTP in the amygdala versus the dentate gyrus of freely behaving rats
Abstract
Stress impairs hippocampal long‐term potentiation (LTP), a model of synaptic plasticity that is assumed to underlie memory formation. In the amygdala, little is known about the effects of stress on LTP, or about its longevity. Here we assessed the ability of entorhinal cortex (EC) stimulation to induce LTP simultaneously in the basal amygdaloid nucleus (B) and in the dentate gyrus (DG) of freely behaving Wistar rats. We also tested whether LTP persists over days. Once established, we investigated the effects of acute vs. repeated inescapable stressful experiences on LTP in both structures. Results show that B, like DG, sustained LTP for 7 days. Furthermore, a single exposure to moderate stress facilitated LTP in B but did not affect DG LTP. Stress re‐exposure inhibited LTP in DG but only long‐lasting LTP (>3 days) in B. Behaviourally, animals exhibited a higher immobility when re‐exposed to the stressor than with a single/first exposure. These data support a role for B in memory storage. Furthermore, they support a differential involvement of the amygdala and hippocampus in memory formation and storage depending on the emotional characteristics of the experience.
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Stress either had no effect or suppressed LTP in the DG, and enhanced LTP in the basal amygdala.
“In general, stress either had no effect or suppressed LTP in the DG, and enhanced LTP in the basal amygdala.”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Vouimba et al. [344]
Stress exerted different effects on LTP in the DG versus the basal amygdala in response to stimulation of the entorhinal cortex.
“We showed that stress exerted different effects on LTP in the DG versus the basal amygdala in response to stimulation of the entorhinal cortex.”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Vouimba et al. [344]
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- Authors
- Vouimba, R., Yaniv, D., Diamond, D., & Richter‐Levin, G.
- Affiliations
- University of Haifa (IL)
- University of South Florida (US)
- Corresponding author
- Vouimba, Rose‐Marie
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2004-04
- Volume
- 19
- Issue
- 7
- Pages
- 1887-1894
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- OpenAlex
- W2026356601
- Cited by
- 114
- References
- 8
- Citations by year
- 2026: 2 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 8 · 2014: 6 · 2013: 14 · 2012: 9
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Funders
- Charles H. Revson Foundation
- Israel Science Foundation
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- inescapable stress, long-term potentiation, amygdala, dentate gyrus, stress tolerance, memory storage, emotional memory, hippocampus, synaptic plasticity, immobility
- MeSH terms
- Amygdala, Animals, Behavior, Animal, Electric Stimulation, Immobilization, Male, Synaptic Transmission, Stress, Psychological, Time Factors, Wakefulness, Rats, Wistar, Long-Term Potentiation, Entorhinal Cortex, Dentate Gyrus, Rats
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