Opposing roles of type I and type II adrenal steroid receptors in hippocampal long-term potentiation
Abstract
Studies were performed in vivo on the dentate gyrus to investigate the possible involvement of Type I and Type II adrenal steroid receptors in the mediation of reported adrenal steroid effects on long-term potentiation, through the use of specific Type I and Type II receptor agonists and antagonists. In adrenalectomized rats, administration of aldosterone, a specific Type I agonist, produced a marked enhancement in long-term potentiation, in comparison to either the adrenalectomized or sham adrenalectomized controls. Administration of RU 28318, a Type I antagonist, which by itself had minimal effects, blocked the aldosterone enhancement. In contrast, administration of the specific Type II agonist, RU 28362, produced a marked decrement in the induction of long-term potentiation. The RU 28362 effect was blocked by a prior injection of the Type II antagonist, RU 38486. Neither adrenalectomy nor administration of any of the steroid agonists or antagonists had noticeable effects on neuronal excitability (as determined by the field potentials), nor on post-tetanic potentiation. These findings are consistent with other studies that have shown a biphasic effect of increasing levels of corticosterone on long-term or prime burst potentiation. Taken together, these studies suggest that Type I receptors, with a high affinity for corticosterone, and Type II receptors, having a lower affinity for corticosterone, form a two-level recognition system to modulate induced synaptic plasticity in opposite directions in the dentate gyrus and possibly also in Ammon's horn.
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Adrenal steroids exert biphasic effects on excitability of hippocampal neurons in terms of long-term potentiation and primed burst potentiation.
“Adrenal steroids exert biphasic effects on excitability of hippocampal neurons in terms of long-term potentiation and primed burst potentiation (Diamond et al., 1992; Pavlides et al., 1994; Pavlides et al., 1995)”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Pavlides et al., 1995
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Self-citation
- Authors
- Pavlides, C., Watanabe, Y., Magarin˜os, A. M., & McEwen, B. S.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Pavlides, C.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1995-09
- Volume
- 68
- Issue
- 2
- Pages
- 387-394
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2092247159
- Cited by
- 261
- References
- 32
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 2 · 2021: 1 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 3 · 2016: 3 · 2015: 11 · 2014: 10 · 2013: 4 · 2012: 11
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-41256)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- type II glucocorticoid receptor, hippocampal long-term potentiation, dentate gyrus, aldosterone, corticosterone, RU 28362, mifepristone, adrenalectomy, synaptic plasticity, glucocorticoid receptor antagonist, field potentials
- MeSH terms
- Adrenal Cortex Hormones, Adrenalectomy, Aldosterone, Mineralocorticoid Receptor Antagonists, Animals, Corticosterone, Electric Stimulation, Hippocampus, Hormone Antagonists, Male, Neural Pathways, Neurons, Receptors, Steroid, Spironolactone, Mifepristone, Rats, Sprague-Dawley, Long-Term Potentiation, Dentate Gyrus, Rats
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