Physical training prevents depressive symptoms and a decrease in brain-derived neurotrophic factor in Parkinson's disease
Abstract
Depression is a neuropsychiatric disorder that is commonly found in patients with Parkinson's disease (PD). Many studies have suggested that physical exercise can have an antidepressant effect by increasing the levels of brain-derived neurotrophic factor (BDNF), and may also prevent neurodegenerative disease. However, different forms of training may promote different changes in the brain. The aim of this study was to investigate the effects of two types of physical training on depressive-like behavior, and on the levels of proBDNF, BDNF, and its receptor, TrkB, in a mouse model of PD. C57BL/6 mice were subjected to 60 days of exercise: either running on a treadmill or performing a strength exercise. PD was induced by striatal administration of 6-OHDA 24h after the last physical exercise session. Seven days after 6-OHDA injection, depressive-like behavior and apomorphine-induced rotational behavior were evaluated. The levels of proBDNF, BDNF, and TRKB were measured in the striatum and the hippocampus of mice by immunoblotting assay. The 6-OHDA-treated animals showed a significant increase in immobility time and rotational behavior compared with the control group. In addition, significant decreases in the levels of proBDNF, BDNF, and its receptor, TrkB were observed in the 6-OHDA group. Both types of physical exercise prevented depressive-like behavior and restored the levels of proBDNF, BDNF, and TrkB in the striatum and hippocampus of mice administered 6-OHDA. Our results demonstrate that exercise training was effective for neuroprotection in the striatum and the hippocampus in an experimental model of PD.
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BDNF upregulation due to exercise was observed in midbrain, substantia nigra, striatum, hippocampus, and cortex.
“BDNF upregulation was observed in midbrain [125], SN [126,128,129], ST [127,129,131,133], hippocampus [133], and cortex [132,133].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [131]
In another study, TrkB content was significantly decreased in striatum even below the level in sedentary Parkinson's disease mice.
“In another study, it was shown that exercise increased TrkB content in SN [129]; however, in yet another study, TrkB content was significantly decreased in ST even below the level in the sedentary PD mice [131].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [131]
Training increases BDNF expression in the hippocampus, cerebral cortex, ST, brainstem, and spinal cord.
“Under the influence of the training process, increased BDNF expression in the hippocampus, cerebral cortex, ST, brainstem, and spinal cord was observed [131,174,179,181,182].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [131]
Physical activity augments neuronal protection in brain disorders by stimulating BDNF expression.
“These studies indeed indicated that physical activity augments neuronal protection in brain disorders by stimulating BDNF expression.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [215]
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- Authors
- Tuon, T., Valvassori, S. S., Dal Pont, G. C., Paganini, C. S., Pozzi, B. G., Luciano, T. F., Souza, P. S., Quevedo, J., Souza, C. T., & Pinho, R. A.
- Affiliations
- Universidade do Extremo Sul Catarinense (BR)
- Corresponding author
- Pinho, R.A.
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 108
- Pages
- 106-112
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W1986758082
- Cited by
- 116
- References
- 63
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 7 · 2023: 11 · 2022: 8 · 2021: 6 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 11 · 2015: 9
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Funders
- UNESC
- CNPq
- FAPESC
- NENASC
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- Parkinson's disease, physical activity, depression-like behavior, brain-derived neurotrophic factor, proBDNF, TrkB receptor, 6-hydroxydopamine, treadmill running, resistance training, neuroprotection, striatum, hippocampus, apomorphine-induced rotation, exercise intensity
- MeSH terms
- Animals, Depression, Disease Models, Animal, Exercise Therapy, Male, Mice, Inbred C57BL, Motor Activity, Parkinson Disease, Oxidopamine, Brain-Derived Neurotrophic Factor, Receptor, trkB, Mice
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