Effects of treadmill exercise on hippocampal neurogenesis in an MPTP/probenecid-induced Parkinson’s disease mouse model
Open accessAbstract
[Purpose] This study aimed to investigate the effect of treadmill exercise on non-motor function, specifically long-term memory, in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-induced Parkinson's disease mouse model. [Methods] A mouse model of Parkinson's disease was developed by injecting 20 mg/kg of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 250 mg/kg of probenecid (P). We divided in into four groups: probenecid group, probenecid-exercise group, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid group, and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-exercise group. Mice in the exercise groups ran on treadmill for 30 min/day, five times per week for 4 weeks. [Results] Latency in the passive avoidance test increased in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-exercise group compared with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid group. In addition, the number of 5-bromo-2-deoxyuridine/NeuN-positive cells and 5-bromo-2-deoxyuridine/doublecortin-positive cells in the hippocampal dentate gyrus was higher in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid-exercise group than that in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid group. These changes were associated with the expression of brain-derived neurotrophic factor in the hippocampus. [Conclusion] Our results suggest that treadmill exercise may improve long-term memory in Parkinson's disease mice by facilitating neurogenesis via increased expression of neurotrophic factors.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Long-term endurance training increases TrkB receptor expression in structures involved in extrapyramidal movement regulation, i.e., the ST and midbrain.
“Animal studies have shown that long-term endurance training increased both TrkB receptor and TH expression in structures involved in extrapyramidal movement regulation, i.e., in the ST and midbrain [128,129,179,183,184,185].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [185]
Long-term endurance training increases TH expression in structures involved in extrapyramidal movement regulation, i.e., the ST and midbrain.
“Animal studies have shown that long-term endurance training increased both TrkB receptor and TH expression in structures involved in extrapyramidal movement regulation, i.e., in the ST and midbrain [128,129,179,183,184,185].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [185]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904 · see citing works
Exercise enhances learning and hippocampal neurogenesis in aged mice
van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775 · see citing works
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
Vaynman, S., Ying, Z., & Gomez‐Pinilla, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03720.x · Cited by 1,460 · see citing works
Protocol for the MPTP mouse model of Parkinson's disease
Jackson-Lewis, V. R., & Przedborski, S. (2007) · Nature Protocols · doi:10.1038/nprot.2006.342 · Cited by 1,118 · see citing works
Dopamine depletion impairs precursor cell proliferation in Parkinson disease
Höglinger, G. U., Rizk, P., Mp, M., Duyckaerts, C. J., Oertel, W. H., Caillé, I., & Hirsch, É. C. (2004) · Nature Neuroscience · doi:10.1038/nn1265 · Cited by 946 · see citing works
Farmer, J., Zhao, X., van Praag, H., Wodtke, K., Gage, F. H., & Christie, B. R. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.09.029 · Cited by 836 · see citing works
Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors
Baik, J., Picetti, R., Saiardi, A., Thiriet, G., Dierich, A., Depaulis, A., LeMeur, M., & Borrelli, E. (1995) · Nature · doi:10.1038/377424a0 · Cited by 651 · see citing works
TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Li, Y., Luikart, B. W., Birnbaum, S., Chen, J., Kwon, C.-H., Kernie, S. G., Bassel-Duby, R., & Parada, L. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.023 · Cited by 634 · see citing works
Alonso, M., Vianna, M. R. M., Depino, A. M., Mello e Souza, T., Pereira, P., Szapiro, G., Viola, H., Pitossi, F., Izquierdo, I., & Medina, J. H. (2002) · Hippocampus · doi:10.1002/hipo.10035 · Cited by 339 · see citing works
Fisher, B. E., Petzinger, G. M., Nixon, K., Hogg, E., Bremmer, S., Meshul, C. K., & Jakowec, M. W. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20162 · Cited by 311 · see citing works
Adult hippocampal neurogenesis and related neurotrophic factors
Lee, E., & Son, H. (2009) · BMB Reports · doi:10.5483/bmbrep.2009.42.5.239 · Cited by 240 · see citing works
Doublecortin Functions at the Extremities of Growing Neuronal Processes
Friocourt, G. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.620 · Cited by 182 · see citing works
Lee, N.-Y., Lee, D.-K., & Song, H.-S. (2015) · Journal of Physical Therapy Science · doi:10.1589/jpts.27.145 · Cited by 180 · see citing works
Toy, W. A., Petzinger, G. M., Leyshon, B. J., Akopian, G. K., Walsh, J. P., Hoffman, M., Vuckovic, M. G., & Jakowec, M. W. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.11.017 · Cited by 173 · see citing works
de Paula, F. R., Teixeira‐Salmela, L. F., Faria, C. D. C. D. M., de Brito, P. R., & Cardoso, F. (2006) · Movement Disorders · doi:10.1002/mds.20763 · Cited by 149 · see citing works
Both Doublecortin and Doublecortin-Like Kinase Play a Role in Cortical Interneuron Migration
Friocourt, G., Liu, J. S.-H., Antypa, M., Rakić, S., Walsh, C. A., & Parnavelas, J. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4530-06.2007 · Cited by 147 · see citing works
Prediger, R. D., Aguiar, A. S., Rojas-Mayorquín, A. E., Figueiredo, C. P., MATHEUS, F. C., Ginestet, L., Chevarin, C., Bel, E. D., Mongeau, R., Hamon, M., et al. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9087-0 · Cited by 127 · see citing works
Tuon, T., Valvassori, S. S., Dal Pont, G. C., Paganini, C. S., Pozzi, B. G., Luciano, T. F., Souza, P. S., Quevedo, J., Souza, C. T., & Pinho, R. A. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.09.006 · Cited by 116 · see citing works
Ferreira, A. F. B., Real, C. C., Rodrigues, A. C., Alves, A. S., & Britto, L. R. (2011) · Brain Research · doi:10.1016/j.brainres.2011.10.004 · Cited by 113 · see citing works
The effect of dopamine on adult hippocampal neurogenesis
Takamura, N., Nakagawa, S., Masuda, T., Boku, S., Kato, A., Song, N., An, Y., Kitaichi, Y., Inoue, T., Koyama, T., et al. (2014) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.12.011 · Cited by 86 · see citing works
Baek, S., Jun, T.-W., Kim, K.-J., Shin, M., Kang, S.-Y., & Kim, C. (2011) · Brain and Development · doi:10.1016/j.braindev.2011.01.011 · Cited by 84 · see citing works
de Castro, A. A., Ghisoni, K., Latini, A., Quevedo, J., Tasca, C. I., & Prediger, R. D. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.01.016 · Cited by 79 · see citing works
Givalois, L., Arancibia, S., Alonso, G., & Tapia‐Arancibia, L. (2004) · Endocrinology · doi:10.1210/en.2004-0616 · Cited by 65 · see citing works
Subjective memory complaints, depressive symptoms and cognition in Parkinson's disease patients
Lehrner, J. P., Moser, D., Klug, S., Gleiß, A., Auff, E., Pirker, W., & Pußwald, G. (2014) · European Journal of Neurology · doi:10.1111/ene.12470 · Cited by 62 · see citing works
Shin, M., Ko, I., Kim, S., Kim, B., Kim, T. S., Lee, S., Hwang, D. S., Kim, C., Park, J., & Lim, B. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.01.003 · Cited by 60 · see citing works
The human dopamine D2Longer receptor has a high-affinity state and inhibits adenylyl cyclase
Liu, I. S. C., George, S. R., & Seeman, P. M. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00064-4 · Cited by 35 · see citing works
Ropinirole therapy for Parkinson’s disease
Pahwa, R., Lyons, K. E., & Hauser, R. A. (2004) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.4.4.581 · Cited by 29 · see citing works
Kim, G., & Kim, E. (2013) · PubMed · doi:10.1589/jpts.25.553 · Cited by 22 · see citing works
Kim, G., & Kim, L. E. (2013) · Journal of Physical Therapy Science · doi:10.1589/jpts.25.5_553 · Cited by 21 · see citing works
Yoon, Y.-J., & Lee, B. (2014) · Journal of Physical Therapy Science · doi:10.1589/jpts.26.905 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
BDNF as a Promising Therapeutic Agent in Parkinson’s Disease
Palasz, E., Wysocka, A., Gasiorowska, A., Chalimoniuk, M., Niewiadomski, W., & Niewiadomska, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031170 · Cited by 504 · see citing works
Therapies for Prevention and Treatment of Alzheimer’s Disease
Mendiola-Precoma, J., Berumen, L. C., Padilla, K., & García‐Alcocer, G. (2016) · BioMed Research International · doi:10.1155/2016/2589276 · Cited by 245 · see citing works
Neurogenesis in aging and age-related neurodegenerative diseases
Čulig, L., Chu, X., & Bohr, V. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101636 · Cited by 192 · see citing works
Allan, J., McMinn, D., & Daly, M. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00386 · Cited by 198 · see citing works
Physical exercise induces hippocampal neurogenesis and prevents cognitive decline
Ma, C., Ma, X., Wang, J., Liu, H., Chen, Y., & Yang, Y. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.067 · Cited by 192 · see citing works
Marchetti, B., Tirolo, C., L’Episcopo, F., Caniglia, S., Testa, N., Smith, J. A., Pluchino, S., & Serapide, M. F. (2020) · Aging Cell · doi:10.1111/acel.13101 · Cited by 185 · see citing works
Aerobic Exercise: Evidence for a Direct Brain Effect to Slow Parkinson Disease Progression
Ahlskog, J. E. (2018) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2017.12.015 · Cited by 145 · see citing works
Exercise for Parkinson's disease
Mak, K. Y., & Wong-Yu, I. S. K. (2019) · International review of neurobiology · doi:10.1016/bs.irn.2019.06.001 · Cited by 116 · see citing works
Lim, J., Bang, Y., & Choi, H. J. (2018) · Archives of Pharmacal Research · doi:10.1007/s12272-018-1063-x · Cited by 80 · see citing works
Mishra, A., Singh, S., Tiwari, V., Parul, P., & Shukla, S. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.11.020 · Cited by 68 · see citing works
Crowley, E. K., Nolan, Y. M., & Sullivan, A. M. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.11.003 · Cited by 65 · see citing works
da Costa Daniele, T. M., de Bruin, P. F. C., de Matos, R. S., de Bruin, G. S., Maia Chaves, C., & de Bruin, V. M. S. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112488 · Cited by 59 · see citing works
Physical Activity and Alzheimer’s Disease: A Narrative Review
Gronek, P., Balkó, Š., Gronek, J., Zając, A., Maszczyk, A., Celka, R., Doberska, A., Czarny, W., Podstawski, R., Clark, C. C. T., et al. (2019) · Aging and Disease · doi:10.14336/ad.2019.0226 · Cited by 42 · see citing works
Leem, Y., Park, J., Park, J., Kim, D., & Kim, H.-S. (2022) · Scientific Reports · doi:10.1038/s41598-022-14823-5 · Cited by 41 · see citing works
Ricci, G. (2019) · Behavioural Neurology · doi:10.1155/2019/8720904 · Cited by 41 · see citing works
Siteneski, A., Olescowicz, G., Pazini, F. L., Camargo, A., Fraga, D. B., Brocardo, P., Gil-Mohapel, J., Cunha, M., & Rodrigues, A. L. S. (2020) · Journal of neural transmission · doi:10.1007/s00702-020-02143-9 · Cited by 37 · see citing works
Hain, E. G., Sparenberg, M., Rasińska, J., Klein, C., Akyüz, L., & Steiner, B. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1179-4 · Cited by 35 · see citing works
Zhang, J., Sun, B., Yang, J., Chen, Z., Li, Z., Zhang, N., Li, H., & Shen, L. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12607 · Cited by 34 · see citing works
Rosa, J. M., Pazini, F. L., Olescowicz, G., Camargo, A., Moretti, M., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109646 · Cited by 31 · see citing works
The effects of treadmill exercise in animal models of Parkinson’s disease: A systematic review
Ferreira, A. F. F., Binda, K. H., & Real, C. C. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.019 · Cited by 29 · see citing works
Crowley, E. K., Nolan, Y. M., & Sullivan, A. M. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.01.011 · Cited by 22 · see citing works
Tsai, C., Pan, C., Wang, T.-C., Tseng, Y., Ukropec, J., Ukropcová, B., & Lin, T. (2024) · Mental health and physical activity · doi:10.1016/j.mhpa.2024.100582 · Cited by 14 · see citing works
Xiangming, Y., Ma, F., Cao, X., Ma, X., & Hu, C. (2019) · Neurological Research · doi:10.1080/01616412.2019.1672381 · Cited by 14 · see citing works
van Rensburg, D. J., Lindeque, J. Z., Harvey, B. H., & Steyn, S. F. (2022) · Mitochondrion · doi:10.1016/j.mito.2022.03.002 · Cited by 13 · see citing works
Qing, Y., Yuan, X., Jie, Z., Canxing, Y., & Xuming, Y. (2017) · 中医杂志：英文版 · doi:10.1016/s0254-6272(17)30051-1 · Cited by 9 · see citing works
Intranigral Injection of Endotoxin Suppresses Proliferation of Hippocampal Progenitor Cells
Darwish, B., Chamaa, F., Al–Chaer, E. D., Saadé, N. E., & Abou-Kheir, W. G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00687 · Cited by 8 · see citing works
Memorcise in the Context of Parkinson’s Disease
Loprinzi, P. D., & Frith, E. (2018) · Journal of Cognitive Enhancement · doi:10.1007/s41465-018-0075-2 · Cited by 6 · see citing works
Shahidani, S., Rajaei, Z., Alaei, H., & Mohammadzadeh, S. (2022) · Physiology and Pharmacology · doi:10.52547/phypha.26.1.6 · Cited by 5 · see citing works
Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders
Loprinzi, P. D. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1792-1_30 · Cited by 4 · see citing works
Physical activity sustains memory retrieval in dopamine-depleted mice previously treated with L-Dopa
Iggena, D., Klein, C., Rasińska, J., Sparenberg, M., Winter, Y., & Steiner, B. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111915 · Cited by 3 · see citing works
Wang, X., Ma, T., He, W., Shan, T., Zhang, G., Peng, F., Chen, L., Ma, J., Ding, C., Niu, P., et al. (2025) · Environment & Health · doi:10.1021/envhealth.5c00264 · Cited by 2 · see citing works
The latest in dementia prevention: A review of the promising role of aerobic exercise
Shigemori, K. (2016) · Journal of allied health sciences · doi:10.15563/jalliedhealthsci.7.37
Abshenas, R., Artimani, T., Amiri, I., Shahidi, ., & Asl, S. S. (2020) · Physiology and Pharmacology · doi:10.32598/ppj.24.4.50
Fear Memory in Experimental Models of Parkinson’s Disease
Timofeeva, E., Dubrovina, N. I., Tikhonova, M. A., & Amstislavskaya, T. G. (2024) · Advances in Gerontology · doi:10.1134/s207905702460040x
- Authors
- Sung, Y.-H.
- Affiliations
- Kyungnam University (KR)
- Corresponding author
- Sung, Yun-Hee
- ORCID
- Sung, Yun-Hee
- Venue
- Journal of Physical Therapy Science
- Publisher
- Society of Physical Therapy Science
- Published
- 2015
- Volume
- 27
- Issue
- 10
- Pages
- 3203-3206
- ISSN
- 0915-5287 (ISSN-L)
- 2187-5626
- PMC
- PMC4668166
- OpenAlex
- W2192120300
- Cited by
- 34
- References
- 30
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 5 · 2021: 1 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 1 · 2016: 4
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of Physical Therapy Science (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Kyungnam University
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- treadmill exercise, hippocampal neurogenesis, Parkinson's disease, long-term memory, passive avoidance, dentate gyrus, brain-derived neurotrophic factor, non-motor symptoms, exercise therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
