Cited by 609Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 1,115 of the 1,115 references it cites were found in a registry or an index.

Tau and tauopathies

Arendt, Thomas, Stieler, Jens T., Holzer, Max·2016·Brain Research Bulletin

DOI 10.1016/j.brainresbull.2016.08.018

Open this paper in CoChat — free account

Abstract

Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly understood; current nosological concepts are largely based on these molecular signatures of protein aggregates which also provide valuable tools for neuropathological differential diagnosis. The microtubule associated protein tau is one of these proteins that form intracellular fibrillary deposits in neurons and glial cells of a large variety of disorders today collectively referred to as tauopathies. While dysfunction of tau has unequivocally been shown to be able to cause neurodegeneration, the precise mechanisms of how tau is involved in neurodegenerative disorders is still poorly understood. After research has focused for several decades on the axonal function of tau and on the fibrillar tau aggregation, more recent cell biological studies have opened up new insights into the role of tau at the synapse and in the nucleus. According to currently emerging cell biological concepts, tau might play a role in the regulation of neuronal plasticity in a wide array of neuronal networks. In addition, it might be involved in regulating genome stability. The most intriguing question relevant both to physiological and pathophysiological function of tau is the biological meaning of the large heterogeneity of isoforms of tau which apparently is a rather promiscuous molecule. The present review is divided into two parts. First, we give an overview on the molecular biology and cell biology of tau and its physiological functions. The second part deals with the pathophysiology of tau and description of tauopathies which comprise more than 20 disorders including Alzheimer's disease, progressive supranuclear palsy, cortico basal degeneration, Pick's disease and others.

Integrity signals

Registry

Crossref · 10.1016/j.brainresbull.2016.08.018

Cites

1115 of 1115 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

Items 1,001–1,115 of 1,115

Zur Abgrenzung der sog. Alzheimerschen Krankheit
Schnitzler, J. G. (1911) · Zeitschrift für die gesamte Neurologie und Psychiatrie · doi:10.1007/bf02865132 · Cited by 34
Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. I. Mitogen-activated protein kinase cascade
Holzer, M., Gärtner, U., Klinz, F., Narz, F., Heumann, R., & Arendt, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00245-7 · Cited by 34
Self-citation
AMP‐activated protein kinase phosphorylation in brain is dependent on method of killing and tissue preparation
Scharf, M. T., Mackiewicz, M., Naidoo, N. N., O'Callaghan, J. P., & Pack, A. I. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05182.x · Cited by 34
New evidences on Tau–DNA interactions and relevance to neurodegeneration
Padmaraju, V., Indi, S. S., & Rao, K. S. J. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.04.013 · Cited by 34
Biomarkers of Alzheimer’s Disease Risk in Peripheral Tissues; Focus on Buccal Cells
François, M., Leifert, W. R., Martins, R. N., Thomas, P., & Fenech, M. F. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140618103827 · Cited by 34
PRESENILE PSYCHOSIS OF THE JAKOB TYPE
Jervis, G. A., HURDUM, H. M., & O'Neill, F. J. (1942) · American Journal of Psychiatry · doi:10.1176/ajp.99.1.101 · Cited by 33
The Coexistence and Differentiation of Late Onset Huntington's Disease and Alzheimer's Disease: A Case Report and Review of the Literature
Moss, R. J., Mastri, A. R., & Schut, L. J. (1988) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1988.tb01807.x · Cited by 33
Huntington disease associated with Alzheimer disease
McIntosh, G. C., Jameson, H. D., & Markesbery, W. R. (1978) · Annals of Neurology · doi:10.1002/ana.410030616 · Cited by 33
Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. II. Cytoskeletal proteins and dendritic morphology
Holzer, M., Rödel, L., Seeger, G., Gärtner, U., Narz, F., Janke, C., Heumann, R., & Arendt, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00246-9 · Cited by 33
Self-citation
Progress in Hereditary Tauopathies: A Mutation in the Tau Gene (G389R) Causes a Pick Disease‐like Syndrome
Ghetti, B. F., Murrell, J. R., Zolo, P., Spillantini, M. G., & Goedert, M. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06905.x · Cited by 33
The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons
Iovino, M., Pfisterer, U., Holton, J. L., Lashley, T., Swingler, R. J., Calò, L., Treacy, R., Révész, T., Parmar, M., Goedert, M., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1219-1 · Cited by 33
Importance of Neuroanatomy in the Field of Neuropathology
Cécile, & Vogt, O. (1951) · Neurology · doi:10.1212/wnl.1.5.205 · Cited by 33
The progression of the lesions in Alzheimer disease: insights from a prospective clinicopathological study
Duyckaerts, C. J., Colle, M.-A., Dessi, F., Grignon, Y., Piette, F., & Hauw, J. (1998) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6467-9_10 · Cited by 32
A STUDY OF THE MILIARY PLAQUES FOUND IN BRAINS OF THE AGED
Fuller, S. C. (1911) · American Journal of Psychiatry · doi:10.1176/ajp.68.2.147 · Cited by 32
Expression of tau immunoreactivity in the spinal motor neurons of Alzheimer’s disease
Saito, Y., & Murayama, S. (2000) · Neurology · doi:10.1212/wnl.55.11.1727 · Cited by 32
The tau S305S mutation causes frontotemporal dementia with parkinsonism
Skoglund, L., Viitanen, M. H., Kalimo, H., Lannfelt, L., Jönhagen, M. E., Ingelsson, M., Glaser, A., & Herva, R. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.02017.x · Cited by 31
A Novel MAPT Mutation Associated with the Clinical Phenotype of Progressive Nonfluent Aphasia
Villa, C., Ghezzi, L., Pietroboni, A. M., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-102124 · Cited by 31
A Novel Tau Mutation in Exon 12, p.Q336H, Causes Hereditary Pick Disease
Tacik, P. M., Deture, M. A., Hinkle, K. M., Lin, W.-L., Sánchez-Contreras, M., Carlomagno, Y., Pedraza, O., Rademakers, R., Ross, O. A., Wszołek, Z. K., et al. (2015) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0000000000000248 · Cited by 31
Clinical, Neuropathological, and Biochemical Characterization of the Novel Tau Mutation P332S
Deramecourt, V., Lebert, F., Maurage, C., Fernández-Gómez, F.-J., Dujardin, S., Colin, M., Sergeant, N., Buée‐Scherrer, V., Clot, F., Ber, I. L., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120160 · Cited by 30
ULTRASTRUCTURAL STUDIES OF THE NEUROPIL & NEUROFIBRILLARY TANGLES IN ALZHEIMERʼS DISEASE & POST-TRAUMATIC DEMENTIA
Wisniewski, H. M., Narang, H. K., Corsellis, J., et al. (1976) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-197605000-00143 · Cited by 30
Atypical unclassifiable parkinsonism on Guadeloupe: An environmental toxic hypothesis
Caparros-Lefebvre, D., & Lees, A. J. (2005) · Movement Disorders · doi:10.1002/mds.20553 · Cited by 30
The distribution of Alzheimer's neurofibrillary tangles and gliosis in chronic subacute sclerosing panencephalitis
Mandybur, T. I. (1990) · Acta Neuropathologica · doi:10.1007/bf00294649 · Cited by 30
Low amyloid (Aβ) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer’s disease
Tolnay, M., Calhoun, Pham, Egensperger, & Probst (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00175.x · Cited by 30
Alzheimersche Fibrillenveränderung im Hirnstamm einer 28 jährigen Postencephalitikerin
Fényes, I. (1932) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02064349 · Cited by 30
Recent neuropathologic observations in amyotrophic lateral sclerosis and parkinsonism‐dementia of Guam
Brody, J. A., Hirano, A., & Scott, R. M. (1971) · Neurology · doi:10.1212/wnl.21.5.528 · Cited by 30
Erratum: Post-mortem Interval Effects on the Phosphorylation of Signaling Proteins
Li, J., Gould, T. D., Yuan, P., Manji, H. K., & Chen, G. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300207 · Cited by 30
The Last Tangle of Tau
Ding, H., & Johnson, G. V. W. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-14413 · Cited by 29
Hippocampal sclerosis with four-repeat tau-positive round inclusions in the dentate gyrus: a new type of four-repeat tauopathy
Miki, Y., Mori, F., Hori, E., Kaimori, M., & Wakabayashi, K. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0531-2 · Cited by 29
Dementia of the Alzheimer's type and Huntington's disease
Reyes, M. G., & Gibbons, S. (1985) · Neurology · doi:10.1212/wnl.35.2.273 · Cited by 29
Progressive supranuclear palsy as a disease phenotype caused by the S305S tau gene mutation
Wszołek, Z. K. (2001) · Brain · doi:10.1093/brain/124.8.1666 · Cited by 29
Lower motor neuron disease with respiratory failure caused by a novel MAPT mutation
Fonzo, A. D., Ronchi, D., Gallia, F., Cribiù, F. M., Trezzi, I., Vetro, A., Mina, E. D., Limongelli, I., Bellazzi, R., Ricca, I., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000476 · Cited by 29
A Possible New Diagnostic Biomarker in Early Diagnosis of Alzheimers Disease
Kork, F., Holthues, J., Hellweg, R., Jankowski, V., Tepel, M., Öhring, R., Heuser, I., Bierbrauer, J., Peters, O., Schlattmann, P., et al. (2009) · Current Alzheimer Research · doi:10.2174/156720509790147160 · Cited by 29
Distribution of tuft-shaped astrocytes in the cerebral cortex in progressive supranuclear palsy
Iwasaki, Y., Yoshida, M., Hattori, M., Goto, A., Aiba, I., Hashizume, Y., & Sobue, G. (2004) · Acta Neuropathologica · doi:10.1007/s00401-004-0904-5 · Cited by 28
Relationship of amyloid ?/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia
Schwab, C., Steele, J. C., Akiyama, H., McGeer, E. G., & McGeer, P. L. (1995) · Acta Neuropathologica · doi:10.1007/bf00296513 · Cited by 28
The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration
Schwarz, L., Vollmer, G., & Richter‐Landsberg, C. (2010) · International Journal of Cell Biology · doi:10.1155/2010/717520 · Cited by 28
Modulation of the membrane-binding projection domain of tau protein: splicing regulation of exon 3
Arıkan, M., Memmott, J. E., Broderick, J. A., Lafyatis, R., Screaton, G. R., Stamm, S., & Andreadis, A. (2002) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00178-x · Cited by 27
FIBRE DISORGANIZATION IN THE NEOCORTEX OF PATIENTS WITH SENILE DEMENTIA OF THE ALZHEIMER TYPE
Duyckaerts, C. J., Kawasaki, H., Delaère, P., Rainsard, C., & Hauw, J. (1989) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1989.tb01225.x · Cited by 27
Tau isoforms which contain the domain encoded by exon 6 and their role in neurite elongation
Luo, M., Leski, M. L., & Andreadis, A. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20029 · Cited by 27
A Novel MAPT Mutation, G55R, in a Frontotemporal Dementia Patient Leads to Altered Tau Function
Iyer, A., LaPointe, N. E., Zielke, K., Berdyński, M., Guzman, E., Barczak, A. K., Chodakowska-Żebrowska, M., Barcikowska, M., Feinstein, S. C., & Żekanowski, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076409 · Cited by 27
5′-upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration
Cruchaga, C., Vidal-Taboada, J. M., Ezquerra, M., Lorenzo, E., Martínez‐Lage, P., Estrada, M. B., TOLOSA, E. S., & Pástor, P. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.027 · Cited by 27
Tuft-shaped astrocytes in Lewy body disease
Hishikawa, N., Hashizume, Y., Yoshida, M., Niwa, J.-I., Tanaka, F., & Sobue, G. (2005) · Acta Neuropathologica · doi:10.1007/s00401-004-0967-3 · Cited by 26
Identification of okadaic acid-induced phosphorylation events by a mass spectrometry approach
Hill, J. J., Callaghan, D., Ding, W., Kelly, J. F., & Chakravarthy, B. R. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.02.029 · Cited by 26
Hook Proteins: Association with Alzheimer Pathology and Regulatory Role of Hook3 in Amyloid Beta Generation
Herrmann, L., Wiegmann, C., Arsalan-Werner, A., Hilbrich, I., Jäger, C., Flach, K., Suttkus, A., Lachmann, I., Arendt, T., & Holzer, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119423 · Cited by 26
Self-citation
A New family with frontotemporal dementia with intronic 10+3 splice site mutation in the tau gene: neuropathology and molecular effects
Neumann, M., Mittelbronn, M. G. A., Simon, P. D., Vanmassenhove, B., de Silva, R., Lees, A. J., Klapp, J., Meyermann, R., & Kretzschmar, H. A. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00629.x · Cited by 26
Neuropathology of Neurodegenerative Diseases
(2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107588660 · Cited by 26
Ultrastructure and immunoreactivity of dystrophic axons indicate a different pathogenesis of Hallervorden-Spatz disease and infantile neuroaxonal dystrophy
Malandrini, A., Cavallaro, T., Fabrizi, G. M., et al. (1995) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00199391 · Cited by 25
Estrogen dissociates Tau and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit in postischemic hippocampus
Cardona‐Gómez, G. P., Arango-Dávila, C. A., Gallego-Gómez, J. C., Barrera-Ocampo, A. A., Pimienta, H. J., & García‐Segura, L. M. (2006) · Neuroreport · doi:10.1097/01.wnr.0000230508.78467.96 · Cited by 25
Association of corticobasal degeneration and Huntington's disease: Can Tau aggregates protect Huntingtin toxicity?
Caparros-Lefebvre, D., Kerdraon, O., Devos, D., et al. (2009) · Movement Disorders · doi:10.1002/mds.22204 · Cited by 24
Neurodegenerative lesions: Seeding and spreading
Duyckaerts, C. J. (2013) · Revue Neurologique · doi:10.1016/j.neurol.2013.07.018 · Cited by 24
In vivo phosphorylation in the rat basal nucleus induces PHF-like and APP immunoreactivity
Arendt, T., Hanisch, F., Holzer, M., & Bruckner, M. K. (1994) · Neuroreport · doi:10.1097/00001756-199406000-00027 · Cited by 23
Self-citation
Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification
Hashimoto, N., Takeuchi, T., Ishihara, R., Ukai, K., Kobayashi, H., Iwata, H., Iwai, K., Mizuno, Y., Yamaguchi, H., & Shibayama, H. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0715-0 · Cited by 23
Cortical load of PHF-tau in Alzheimer's disease is correlated to cholinergic dysfunction
Arendt, T., Holzer, M., Gertz, H., & Brückner, M. K. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050175 · Cited by 23
Self-citation
Expression of the embryonal isoform (0N/3R) of the microtubule‐associated protein tau in the adult rat central nervous system
Bullmann, T., Härtig, W., Holzer, M., & Arendt, T. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22351 · Cited by 23
Self-citation
Human protein tau represses DNA replication in vitro
Li, W., Wang, X. S., Qu, M., Liu, Y. M., & He, R. Q. (2005) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.08.014 · Cited by 23
Mutations in MAPT give rise to aneuploidy in animal models of tauopathy
Rossi, G., Conconi, D., Panzeri, E., Paoletta, L., Piccoli, E., Ferretti, M. G., Mangieri, M., Ruggerone, M., Dalprà, L., & Tagliavini, F. (2013) · Neurogenetics · doi:10.1007/s10048-013-0380-y · Cited by 23
Tau Phosphorylation and Sevoflurane Anesthesia
Freche, H. L., Brouillette, J., Fernández-Gómez, F.-J., et al. (2012) · Survey of Anesthesiology · doi:10.1097/sa.0b013e31825c1f11 · Cited by 23
Relationship of Adult Neurogenesis with Tau Phosphorylation and GSK-3β Activity in Subventricular Zone
Hong, X., Peng, C., Wei, W., Tian, Q., Liu, Y., Cao, F.-Y., Wang, Q., & Wang, J. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0316-y · Cited by 22
Zur Histopathologie der senilen Hirnrinde
Hübner, A. H. (1909) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02012920 · Cited by 21
�ber den Verfall der Sprache bei der Pickschen Krankheit (umschriebene Atrophie der Gro�hirnrinde)
L�ers, T. (1947) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf00352851 · Cited by 21
The Extended Tau Haplotype and the Age of Onset of Dementia in Down Syndrome
Jones, E. L., Margallo‐Lana, M., Prasher, V. P., & Ballard, C. G. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000152044 · Cited by 21
A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17.
Kowalska, A., Hasegawa, M., Miyamoto, K., Akiguchi, I., Ikemoto, A., Takahashi, K., Araki, W., & Tabira, T. (2002) · PubMed · Cited by 20
The Induction of Serine/Threonine Protein Phosphorylations by a PDGFR/TrkA Chimera in Stably Transfected PC12 Cells
Biarc, J., Chalkley, R. J., Burlingame, A. L., & Bradshaw, R. A. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.013375 · Cited by 20
A novel MAPT mutation (P301T) associated with familial frontotemporal dementia
Lladó, A., Ezquerra, M., Sánchez‐Valle, R., et al. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01763.x · Cited by 20
An immunohistochemical study of neurofibrillary tangle formation in post-encephalitic Parkinsonism.
Wong, K., Allen, I. V., McQuaid, S., & McConnell, R. S. (1996) · PubMed · Cited by 20
A Novel MAPT Mutation Causing Corticobasal Syndrome Led by Progressive Apraxia of Speech
Marshall, C. R., Guerreiro, R. J., Thust, S. C., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150477 · Cited by 19
Zur pathogenese der amyotrophischen lateralsklerose
Matzdorff, P. (1925) · Zeitschrift für die gesamte Neurologie und Psychiatrie · doi:10.1007/bf02878078 · Cited by 19
Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes
Filipčík, P., Cente, M., Žilka, N., Smolek, T., Hanes, J., Kučerák, J., Opattová, A., Kováčech, B., & Novák, M. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.03.003 · Cited by 19
Pathological changes of the spinal cord in centenarians
Wang, Y., Hashizume, Y., Yoshida, M., et al. (1999) · Pathology International · doi:10.1046/j.1440-1827.1999.00832.x · Cited by 19
Novel MAPT Val75Ala mutation and PSEN2 Arg62Hys in two siblings with frontotemporal dementia
Gallo, M., Tomaino, C., Puccio, G., Frangipane, F., Curcio, S. A. M., Bernardi, L., Geracitano, S., Anfossi, M., Mirabelli, M., Colao, R., et al. (2009) · Neurological Sciences · doi:10.1007/s10072-009-0132-9 · Cited by 18
The role of MAPT sequence variation in mechanisms of disease susceptibility
Caffrey, T. M., & Wade‐Martins, R. (2012) · Biochemical Society Transactions · doi:10.1042/bst20120063 · Cited by 18
Phosphorylation Pattern of tau Associated with Distinct Changes of the Growth Cone Cytoskeleton
Šimić, G., Diana, A., & Hof, P. R. (2003) · Progress in molecular and subcellular biology · doi:10.1007/978-3-642-55557-2_2 · Cited by 17
Pick’s Disease
Takeda, N., Kishimoto, Y., & Yokota, O. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0653-2_23 · Cited by 17
Mutation frequency of PRKAR1B and the major familial dementia genes in a Dutch early onset dementia cohort
Cohn‐Hokke, P. E., Wong, T. H., Rizzu, P., et al. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7456-y · Cited by 17
Frontotemporal dementia and Parkinsonism linked to chromosome 17 in a young Australian patient with the G389R Tau mutation
Bermingham, N., Cowie, T., Paine, M., Storey, E., & McLean, C. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00918.x · Cited by 17
Quantitative neuropathologic analysis of Pick's disease cases
Jellinger, K. A. (1994) · Acta Neuropathologica · doi:10.1007/bf00296194 · Cited by 17
Compound heterozygosity of 2 novel MAPT mutations in frontotemporal dementia
Anfossi, M., Vuono, R., Maletta, R., Virdee, K., Mirabelli, M., Colao, R., Puccio, G., Bernardi, L., Frangipane, F., Gallo, M., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.12.013 · Cited by 16
Analysis of the molecular heterogeneity of the microtubule-associated protein tau by two-dimensional electrophoresis and RT-PCR
Janke, C., Beck, M., Holzer, M., Bigl, V., & Arendt, T. (2000) · Brain Research Protocols · doi:10.1016/s1385-299x(00)00018-0 · Cited by 16
Self-citation
Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A
Malmqvist, T., Anthony, K., & Gallo, J. (2014) · Brain Research · doi:10.1016/j.brainres.2013.12.033 · Cited by 16
A cognitive chameleon: Lessons from a novelMAPTmutation case
Liang, Y., Gordón, E., Rohrer, J. D., Downey, L. E., de Silva, R., Jäger, H. R., Nicholas, J. M., Marc Modat, A., Cardoso, M. J., Mahoney, C., et al. (2013) · Neurocase · doi:10.1080/13554794.2013.826697 · Cited by 16
PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation
Stieler, J., Bullmann, T., Kohl, F., Barnes, B. M., & Arendt, T. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0181-x · Cited by 16
Self-citation
MAPT V363I Variation in a Sporadic Case of Frontotemporal Dementia
Anfossi, M., Bernardi, L., Gallo, M., Geracitano, S., Colao, R., Puccio, G., Curcio, S. A. M., Frangipane, F., Mirabelli, M., Tomaino, C., et al. (2010) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e3181eff860 · Cited by 16
Cerebrotendinous xanthomatosis with the c.379 C > T (p. R 127 W ) mutation in the CYP27A1 gene associated with premature age‐associated limbic tauopathy
Kapás, I., Katkó, M., Harangi, M., Paragh, G., Balogh, I., Kóczi, Z., Regelsberger, G., Molnár, M. J., & Kovács, G. G. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12058 · Cited by 16
Encephalitis Lethargica
Maier (1924) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-192405000-00049 · Cited by 16
Low initial tau phosphorylation in human brain biopsy samples.
Song, J., Combs, C. K., Pilcher, W. H., Song, L. Y., Utal, A. K., & Coleman, P. D. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00043-2 · Cited by 15
HISTOLOGIC CHANGES IN SENILE DEMENTIA AND RELATED CONDITIONS
Alexander, L. (1938) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1938.02270120025002 · Cited by 15
[Affective disorders and dementia of the frontal lobe type. Hypothesis of a pathogenic relationship].
Luauté, J.-P., Favel, P., Rémy, C., et al. (1994) · PubMed · Cited by 14
Neuropathology of Hereditary Forms of Frontotemporal Dementia and Parkinsonism
Muñoz, D. G., & Ferrer, I. (2008) · Handbook of clinical neurology · doi:10.1016/s0072-9752(07)01237-7 · Cited by 14
Tau modifiers as therapeutic targets for Alzheimer's disease
Liu, Q., Lee, H., Honda, K., Siedlak, S. L., Harris, P. L. R., Cash, A., Zhu, X., Ávila, J., Nunomura, A., Takeda, A., et al. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.06.021 · Cited by 14
[A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people].
Kuzuhara, S., Ihara, Y., TOYOKURA, Y., et al. (1989) · PubMed · Cited by 14
Combined use of insulin and endothelin-1 causes decrease of protein expression of ?-subunit of insulin receptor, insulin receptor substrate-1, and insulin-stimulated glucose uptake in rat adipocytes
Shih, K., Kwok, C., & Ho, L.-T. (2000) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(20000801)78:2 · Cited by 13
On the Distribution of Senile Changes in the Spinal Cord
Yamada, M. (1978) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1978.tb00146.x · Cited by 13
Tau Proteins Harboring Neurodegeneration-Linked Mutations Impair Kinesin Translocation in vitro
Yu, D., LaPointe, N. E., Guzman, E., Pessino, V., Wilson, L., Feinstein, S. C., & Valentine, M. T. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131274 · Cited by 12
Pathological tau proteins in argyrophilic grain disease
Šimić, G. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00130-8 · Cited by 12
Zur Pathogenese der Tay-Sachs'schen Amaurotischen Idiotie
Coriat, I. H., & Schaffer, K. (1905) · The American Journal of Psychology · doi:10.2307/1412340 · Cited by 12
Das Syndrom der partiellen cholinergen Deafferentierung des kortikalen Mantels - ein Konzept zur Beschreibung des brain-behaviour-relationships bei dementiellen Erkrankungen
Arendt, T. (1991) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-2007-1000682 · Cited by 11
Self-citation
Clinicopathological study of diffuse neurofibrillary tangles with calcification
Habuchi, C., Iritani, S., Sekiguchi, H., Torii, Y., Ishihara, R., Arai, T., Hasegawa, M., Tsuchiya, K., Akiyama, H., Shibayama, H., et al. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2010.10.021 · Cited by 10
Die Silberkornkrankheit - Abgrenzung zur Alzheimer'schen Erkrankung
Tolnay, M., Monsch, A. U., Staehelin, H. B., & Probst, A. (1999) · Der Pathologe · doi:10.1007/s002920050339 · Cited by 10
Tau protein mutation P364S in two sisters: clinical course and neuropathology with emphasis on new, composite neuronal tau inclusions
Popović, M., Fabjan, A., Mraz, J., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1293-z · Cited by 10
Reversible in vivo phosphorylation of tau induced by okadaic acid and by unspecific brain lesion in rat.
Janke, C., Gärtner, U., Holzer, M., & Arendt, T. (1998) · PubMed · Cited by 10
Self-citation
The Spectrum of Tau Pathology in Human Prion Disease
Kovács, G. G., & Budka, H. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5338-3_7 · Cited by 9
Accumulation of amyloid precursor protein in brain lesions of patients with Pick disease
Yasuhara, O., Aimi, Y., McGeer, E. G., et al. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90605-x · Cited by 9
Alterations in content and phosphorylation state of cytoskeletal proteins in the sciatic nerve during ageing and in Alzheimer's disease
Holzer, M., Holzapfel, H.-P., Krohn, K., et al. (1999) · Journal of Neural Transmission · doi:10.1007/s007020050195 · Cited by 8
Self-citation
Activity-state profile of tau kinases in hibernating animals
Stieler, J., Boerema, A. S., Bullmann, T., Kohl, F., Strijkstra, A. M., & Barnes, B. M. (2008) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 8
Self-citation
Role for peroxisome proliferator-activated receptor-gamma in Alzheimer's disease.
van Geel (2001) · Open Repository and Bibliography (University of Luxembourg) · doi:10.1002/1531-8249(20010201)49:2 · Cited by 7
Inhibitor-1 and -2 of PP2A have preference between PP2A complexes
Hino, H., Takaki, K., & Mochida, S. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.09.168 · Cited by 7
Neurofibrillary tangles in the brain of a 16 month old infant.
Bancher, C., Jellinger, K. A., & Zwiauer, K. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.60.2.231 · Cited by 6
Pick's disease in 2 brothers with S305N mutation: note in supplement to an earlier communication.
Kobayashi, K., Hayashi, M., Kidani, T., et al. (2003) · PubMed · Cited by 6
Frontotemporal dementia with parkinsonism linked to Chromosome 17
Forman, M. S., Lee, V. M. ‐., & Trojanowski, J. Q. (2005) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544873.036 · Cited by 3
Untitled work
Solano (2000) · doi:10.1002/1531-8249(200002)47:2 · Cited by 3
[Expression of tau-related protein in spinal cord of patients with Alzheimer's disease].
Yj, G., Ln, W., Mw, Z., et al. (2011) · PubMed · Cited by 3
Prions and Diseases
Zou, W., & Gambetti, P. L. (2012) · Springer eBooks · doi:10.1007/978-1-4614-5338-3 · Cited by 3
Axonal loss in multiple sclerosis lesions: magnetic resonance imaging insights substrates of disability
Sperfeld (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199911)46:5 · Cited by 2
Untitled work
Cann, S. A. H., Netten, J. P. V., & Netten, C. V. (2000) · Pure Amsterdam UMC · doi:10.1002/1531-8249(200003)47:3
Untitled work
(2000) · doi:10.1002/1531-8249(200012)48:6
Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects
Parchi, P., Giese, A., Capellari, S., Brown, P., Schulz-Schaeffer, W., Windl, O., Zerr, I., Budka, H., Kopp, N., Piccardo, P., et al. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199908)46:2

Research works printed but not linked: 22

Alzheimer, 1907, Über eine eigenartige Erkrankung der Hirnrinde. 37. Versammlung Südwestdeutscher Irrenärzte in Tübingen, 1906, Centralbl. f. Nervenheilkunde u. Psych., 18, 177
Arendt, 1993, Neuronal dedifferentiation and degeneration in Alzheimer's disease, Biol. Chem. Hoppe-Seyler, 374, 911
Bayon, 1905, Die Anwendung neuer Imprägnationsverfahren in the pathologisch-histologischen Analyse des Zentralnervensystems, Zentr.bl. für allg. Pathol. u. pathol. Anat., 14, 52
Bertrand, 1946, Cas d’idiote mongolienne adulte avec nombreuses plaques seniles et concretions calcaires pallidales, Rev. Neurol., 78, 338
Bielschowsky, 1905, Zur feineren Histologie und Histopathologie der Grosshirnrinde mit besonderer Berücksichtigung der Dementia paralytica, Dementia senilis und Idiotie, J. Psychol. Neurol., 5, 173
Bielschowsky, 1902, Die Silberimprägnation der Axencylinder, Neurol. Zentralb (Leipzig), 21, 579
Bielschowsky, 1903, Die Silberimpregnation der Neurofibrillen, J. Psychol. Neurol. 1904 oder, 3, 169
Blocq, 1892, Sur les lésions et la pathogénie de l’épilepsie dite essentielle, Semaine Médicale, 12, 445
Goedert, 1989, Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain, EMBO J., 8, 393, 10.1002/j.1460-2075.1989.tb03390.x · DOI · Paper page
Hübner, 1908, Zur Histologie des senilen Gehirns, Neurol Centralbl, 27, 997
Igelmund, 1993, Hibernation-related modification of activity-dependent properties of synaptic transmission in hamster hippocampus, Neurosci. Res. Commun., 13, 167
Kouri, 2012, FTDP-17 with MAPT Exon 13 mutations: comparison of neuropath-ologic features of Gly389Arg to a novel mutation, Glu372Gly, J. Neuropathol. Exp. Neurol., 2012, 547
Ley, 1922, Étude anatomique de la sénilité. Livre jubilaire de la Société Belge de Neurologie et Psychiatrie, Imprim méd et scient, 32
Mailliot, 2002, Impaired tau protein function following nitration-induced oxidative stress in vitro and in vivo, Neurobiol. Aging, 23, 415
Pickering-Brown, 2000, Pick's disease is associated with mutations in the tau gene, Ann. Neurol., 48, 859, 10.1002/1531-8249(200012)48:6<859::AID-ANA6>3.0.CO;2-1 · DOI
Redlich, 1898, Über miliare Sklerose der Hirnrinde bei seniler Atrophie, Jahrbücher Psych Neurol, 17, 208
Regan, 2014, Long-term depression: a new conceptual understanding of Alzheimer's disease, Eur. J. Neurodegener Dis., 3, 79
Richardson, 1963, Supranuclear ophthalmoplegia, pseudobulbar palsy, nuchal dystonia and dementia, Trans. Am. Neurol. Assoc., 88, 25
Spillantini, 2000, A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies, Ann. Neurol., 48, 939, 10.1002/1531-8249(200012)48:6<939::AID-ANA17>3.0.CO;2-1 · DOI
Stieler, 2009, PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation, J. Neural Transm. (Vienna), 116, 345, 10.1007/s00702-008-0181-x · DOI
Van Bogaert, 1925, Les troubles mentaux dans la sclerose laterale amyotrophic, Encephale, 20, 27
Walker, 1977, Sleep and hibernation in ground squirrels: electrophysiological observations, Am. J. Physiol., 233, 213

Sorted by citations

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242
Roles of tau protein in health and disease
Guo, T., Noble, W., & Hanger, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1707-9 · Cited by 1,003
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease
Wesseling, H., Mair, W., Kumar, M., Schlaffner, C. N., Tang, S., Beerepoot, P., Fatou, B., Guise, A. J., Cheng, L., Takeda, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.029 · Cited by 688
“Although 86 phosphorylation events have been described on Tau in general (Arendt et al., 2016) (i.”
Background
Alzheimer’s disease: Recent treatment strategies
Vaz, M., & Silvestre, S. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173554 · Cited by 547
Glial contributions to neurodegeneration in tauopathies
Leyns, C. E. G., & Holtzman, D. M. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0192-x · Cited by 409

See all 609

Authors: Arendt, T., Stieler, J. T., & Holzer, M.
Affiliations: Leipzig University (DE)
Corresponding author: Arendt, Thomas
ORCID: Arendt, Thomas
Stieler, Jens T.
Holzer, Max
Venue: Brain Research Bulletin
Publisher: Elsevier BV
Published: 2016-09
Volume: 126
Issue: Pt 3
Pages: 238-292
ISSN: 0361-9230 (ISSN-L)
DOI: 10.1016/j.brainresbull.2016.08.018
OpenAlex: W2519516239
Cited by: 609
References: 1,115
Citations by year: 2026: 34 · 2025: 62 · 2024: 75 · 2023: 65 · 2022: 80 · 2021: 74 · 2020: 74 · 2019: 48 · 2018: 46 · 2017: 49 · 2016: 1
FWCI: 5.63
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Brain Research Bulletin (publishedVersion)
PubMed (publishedVersion)
Funders: DFG (AR 200/17-1, HO2368-4/1)
Era Net Rus Plus (DLR/01DJ16018)
Fritz Thyssen Foundation
EU funds (100111005)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: tau protein, tauopathy, neurodegeneration, protein aggregation, synapses, neuroplasticity, genome stability, tau isoforms, Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, Pick's disease
MeSH terms: Animals, Humans, tau Proteins, Tauopathies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Tau and tauopathies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks