Tau and tauopathies

Neuropathological stageing of Alzheimer-related changes.

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Analysis of protein-coding genetic variation in 60,706 humans

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

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Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

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Novel Proteinaceous Infectious Particles Cause Scrapie

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Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria

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Interactive tree of life (iTOL) v3: an online tool for the display and annotation of phylogenetic and other trees

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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

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Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

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Genetic instabilities in human cancers

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BioGRID: a general repository for interaction datasets

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Clinical and biomarker changes in dominantly inherited Alzheimer's disease

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Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

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Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

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Protein aggregation and neurodegenerative disease

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PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

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The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

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Human Protein Reference Database--2009 update

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Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry

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A protein factor essential for microtubule assembly

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Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

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TREM2 Variants in Alzheimer's Disease

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Primary Progressive Aphasia

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National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

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TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

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Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

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Variant of TREM2 Associated with the Risk of Alzheimer's Disease

Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

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Neurodegenerative Tauopathies

Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480

Neurodegenerative Diseases Target Large-Scale Human Brain Networks

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Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury

McKee, A. C., Cantu, R. C., Nowinski, C. J., Hedley-Whyte, E. T., Gavett, B. E., Budson, A. E., Santini, V. E., Lee, H.-S., Kubilus, C. A., & Stern, R. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a9d503 · Cited by 2,295

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

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Tau-mediated neurodegeneration in Alzheimer’s disease and related disorders

Ballatore, C., Lee, V. M.-Y., & Trojanowski, J. Q. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2194 · Cited by 2,174

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

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The spectrum of disease in chronic traumatic encephalopathy

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Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050

Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

Initiative, T. A. D. N., Hollingworth, P., CHARGE consortium, EADI1 consortium, Harold, D., Sims, R., Gerrish, A., Lambert, J.-C., Carrasquillo, M. M., Abraham, R., et al. (2011) · Nature Genetics · doi:10.1038/ng.803 · Cited by 1,997

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

Naj, A. C., Jun, G., Beecham, G. W., Wang, L.-S., Vardarajan, B. N., Buros, J., Gallins, P. J., Buxbaum, J. D., Jarvik, G. P., Crane, P. K., et al. (2011) · Nature Genetics · doi:10.1038/ng.801 · Cited by 1,901

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

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Oxidative stress in neurodegeneration: Cause or consequence?

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The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

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Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

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Transmission and spreading of tauopathy in transgenic mouse brain

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Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

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A tissue-specific atlas of mouse protein phosphorylation and expression

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Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

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Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

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Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

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The distribution of tau in the mammalian central nervous system.

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Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

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Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

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Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

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Clinical and Pathological Diagnosis of Frontotemporal Dementia

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Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

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Primary age-related tauopathy (PART): a common pathology associated with human aging

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Mechanisms of specificity in protein phosphorylation

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Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

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A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

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Tau is a candidate gene for chromosome 17 frontotemporal dementia

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The Human Gene Mutation Database: building a comprehensive mutation repository for clinical and molecular genetics, diagnostic testing and personalized genomic medicine

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Amyloid-β and tau--a toxic pas de deux in Alzheimer’s disease

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Propagation of Tau Misfolding from the Outside to the Inside of a Cell

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Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

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Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer’s Disease

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PET Imaging of Tau Deposition in the Aging Human Brain

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Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

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Metabolic Rate and Body Temperature Reduction During Hibernation and Daily Torpor

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Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

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Tau pathology and neurodegeneration

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Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

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Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

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Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

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Cloning and sequencing of the cDNA encoding an isoform of microtubule‐associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

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Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

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Classification and basic pathology of Alzheimer disease

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Alzheimer’s and Parkinson’s diseases: The prion concept in relation to assembled Aβ, tau, and α-synuclein

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Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

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Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

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