RETRACTED: The antidepressant effects of L-arginine on chronic mild stress-induced depression by augmenting the expression of brain-derived neurotrophic factor in rats
Abstract
In the present study, the antidepressant effects of l-arginine in a rat model of chronic mild stress-induced depression were investigated. Animals were divided into group I (sham), group II (control, depression), group III (10 mg/kg l-arginine), group IV (20 mg/kg l-arginine), and group V (10 mg/kg venlafaxine, positive control). The doses were orally administered for 30 consecutive days. Sucrose preference analysis as well as forced swim and open field tests were performed. Serum cortisol, nitric oxide (NO), and monoamine levels in brain tissue were then measured. Brain-derived neurotrophic factor (BDNF) expression was also examined. Supplementation with l-arginine significantly increased the sucrose preference ratio, locomotor activity, and monoamines and decreased serum cortisol and NO levels. The mRNA and protein expression of BDNF in the brain tissue was significantly reduced (>50 %) in control rats. However, supplementation with l-arginine significantly increased BDNF mRNA expression (>50 %) in both groups. Similarly, increased BDNF protein expression after l-arginine treatment was confirmed using Western blot and immunohistochemical analyses. In conclusion, l-arginine supplementation may be effective against chronic stress-induced depression.
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In animal studies, using L-arginine has reduced depression and related biological signals.
“Based on some animal studies, using L-arginine has reduced depression and related biological signals [27, 28].”
From Effect of l-arginine compared to placebo on sexual function in women with major depressive disorder: a randomized controlled trial (2024) · cites this paper as [27]
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“Based on some animal studies, using L-arginine has reduced depression and related biological signals [27, 28].”
Result
- Authors
- Dong, D., Lei, T., Song, M., Ma, L., & Zhao, H.
- Affiliations
- Jilin University (CN)
- First Hospital of Jilin University (CN)
- Corresponding author
- Zhao, Hua
- ORCID
- Zhao, Hua
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 158
- Pages
- 128-134
- ISSN
- 0361-9230 (ISSN-L)
- OpenAlex
- W3006769899
- Cited by
- 13
- References
- 36
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 2 · 2020: 4
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
- Locations
- Brain Research Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- L-arginine, antidepressant effects, chronic mild stress, depression, brain-derived neurotrophic factor, nitric oxide, serum cortisol, monoamines, sucrose preference, locomotor activity, venlafaxine
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