Regulation of brain-derived neurotrophic factor (BDNF) in the chronic unpredictable stress rat model and the effects of chronic antidepressant treatment
Open accessAbstract
Chronic unpredictable stress (CUS) is a widely used animal model of depression. The present study was undertaken to investigate behavioral, physiological and molecular effects of CUS and/or chronic antidepressant treatment (venlafaxine or imipramine) in the same set of animals. Anhedonia, a core symptom of depression, was assessed by measuring consumption of a palatable solution. Exposure to CUS reduced intake of a palatable solution and this effect was prevented by chronic antidepressant treatment. Moreover, chronic antidepressant treatment decreased depressive-like behavior in a modified forced swim test in stressed rats. Present evidence suggests a role for brain-derived neurotrophic factor (BDNF) in depression. BDNF mRNA levels in the ventral and dorsal hippocampus were assessed by in situ hybridization. Exposure to CUS was not correlated with a decrease but rather with an increase in BDNF mRNA expression in both the dentate gyrus of the dorsal hippocampus and the CA3 region of the ventral hippocampus indicating that there is no simple link between depression-like behaviors per se and brain BDNF levels in rats. However, a significant increase in BDNF mRNA levels in the dentate gyrus of the dorsal hippocampus correlated with chronic antidepressant treatment emphasizing a role for BDNF in the mechanisms underlying antidepressant activity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both MDD patients and animal models of depression show a remarkable reduction in serum BDNF levels.
“Both MDD patients [57–59] and animal models of depression [60, 61] show a remarkable reduction in serum BDNF levels.”
From Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation (2019) · cites this paper as [61]
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works
Behavioural despair in rats: A new model sensitive to antidepressant treatments
Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138 · see citing works
The molecular neurobiology of depression
Krishnan, V., & Nestler, E. J. (2008) · Nature · doi:10.1038/nature07455 · Cited by 2,889 · see citing works
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · cited 1× · see citing works
“The precise neuroanatomical basis of depression is still poorly understood, but strong evidence indicates that the hippocampus is one of the brain regions that play a central role in many aspects of depression (Drevets et al., 2008; Duman and Monteggia, 2006).”
BackgroundNibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109 · see citing works
Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works
Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression
Shirayama, Y., Chen, A. C.-H., Nakagawa, S., Russell, D. S., & Duman, R. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-08-03251.2002 · Cited by 1,654 · see citing works
Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works
Regional dissociations within the hippocampus-memory and anxiety
Bannerman, D. M., Rawlins, J. N. P., McHugh, S. B., Deacon, R. M. J., Yee, B. K., Bast, T., Zhang, W.-N., Pothuizen, H. H. J., & Feldon, J. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.03.004 · Cited by 1,462 · see citing works
Detke, M. J., Rickels, M. R., & Lucki, I. (1995) · Psychopharmacology · doi:10.1007/bf02245592 · Cited by 1,438 · see citing works
Smith, M., Makino, S., Květňanský, R., & Post, R. M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01768.1995 · Cited by 1,429 · see citing works
Brunoni, A. R., Lopes, M., & Fregni, F. (2008) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145708009309 · Cited by 972 · see citing works
Moser, E., Moser, M. ‐., & Andersen, P. N. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-09-03916.1993 · Cited by 916 · see citing works
Reduced fear expression after lesions of the ventral hippocampus
Kjelstrup, K. G., Tuvnes, F. A., Steffenach, H.-A., Murison, R., Moser, E. I., & Moser, M.-B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.152112399 · Cited by 912 · see citing works
Antidepressant-like effect of brain-derived neurotrophic factor (BDNF)
Siuciak, J. A., Lewis, D. R., Wiegand, S. J., & Lindsay, R. M. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00169-4 · Cited by 841 · see citing works
Saarelainen, T., Hendolin, P., Lucas, G., Koponen, E., Sairanen, M., MacDonald, E., Agerman, K., Haapasalo, A., Nawa, H., Aloyz, R., et al. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00349.2003 · Cited by 800 · see citing works
Essential role of brain-derived neurotrophic factor in adult hippocampal function
Monteggia, L. M., Barrot, M., Powell, C. M., Berton, O., Galanis, V., Gemelli, T., Meuth, S., Nagy, A., Greene, R. W., & Nestler, E. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402141101 · Cited by 685 · see citing works
Role of neurotrophic factors in depression
CASTREN, E., VOIKAR, V, & RANTAMAKI, T. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2006.08.009 · Cited by 667 · see citing works
Stress, depression, and anhedonia: caveats concerning animal models
Anisman, H., & Matheson, K. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.007 · Cited by 569 · see citing works
Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration
Strekalova, T. V., Spanagel, R., Bartsch, D., Henn, F. A., & Gass, P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300532 · Cited by 564 · see citing works
Castrén, E. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1629 · Cited by 563 · see citing works
Monteggia, L. M., Luikart, B., Barrot, M., Theobold, D., Malkovska, I., Nef, S., Parada, L. F., & Nestler, E. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.021 · Cited by 502 · see citing works
Kendler, K. S., Thornton, L. M., & Gardner, C. O. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.582 · Cited by 480 · see citing works
Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients
Gonul, A. S., Akdeniz, F., Taneli, F., Donat, O., Eker, Ç., & Vahip, S. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0578-6 · Cited by 375 · see citing works
Jayatissa, M. N., Bisgaard, C. F., Tingström, A., Papp, M., & Wiborg, O. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301041 · Cited by 348 · see citing works
Li, S., Wang, C., Wang, M., Murakami, Y., & Matsumoto, K. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.01.004 · Cited by 329 · see citing works
Aydemır, Ö., Deveci, A., & Taneli, F. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.11.009 · Cited by 324 · see citing works
Schumacher, J. H., Jamra, R. A., Becker, T., Ohlraun, S., Klopp, N., Binder, E. B., Schulze, T. G., Deschner, M., Schmäl, C., Höfels, S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.006 · Cited by 305 · see citing works
Bekris, S., Antoniou, K., Daskas, S., & Papadopoulou-Daifoti, Z. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.01.005 · Cited by 281 · see citing works
Aguilera, M., Arias, B., Wichers, M., Barrantes-Vidal, N., Moya, J., Villa, H., van Os, J., Ibáñez, M. I., Ruipérez, M. A., Ortet, G., et al. (2009) · Psychological Medicine · doi:10.1017/s0033291709005248 · Cited by 265 · see citing works
Grønli, J., Bramham, C., Murison, R., Kanhema, T., Fiske, E., Bjorvatn, B., Ursin, R., & Portas, C. M. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.11.021 · Cited by 260 · see citing works
Rasmusson, A. M. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00286-5 · Cited by 259 · see citing works
de Foubert, G., Carney, S. L., Robinson, C. S., Destexhe, E. J., Tomlinson, R., Hicks, C. A., Murray, T. K., Gaillard, J. P., Deville, C., Xhenseval, V., et al. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.06.054 · Cited by 249 · see citing works
Bi-phasic change in BDNF gene expression following antidepressant drug treatment
Coppell, A., Pei, Q., & Zetterström, T. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00077-7 · Cited by 241 · see citing works
Repeated stress increases catalytic TrkB mRNA in rat hippocampus
Nibuya, M., Takahashi, M., Russell, D., & Duman, R. S. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00335-3 · Cited by 236 · see citing works
Suppression of sucrose drinking by chronic mild unpredictable stress: A methodological analysis
Muscat, R., & Willner, P. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80192-7 · Cited by 231 · see citing works
From high anxiety trait to depression: a neurocognitive hypothesis
Sandi, C., & Richter‐Levin, G. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.02.004 · Cited by 227 · see citing works
Self-citationBrain-derived neurotrophic factor (BDNF) changes in the serum of depressed women
Aydemir, Ç., Yalcın, E., Aksaray, S., Kısa, C., Yildirim, S. G., Uzbay, T. I., & Göka, E. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.03.025 · Cited by 210 · see citing works
Pharmacological validation of the chronic mild stress model of depression
Papp, M., Moryl, E., & Willner, P. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00697-4 · Cited by 205 · see citing works
Gervasoni, N., Aubry, J., Bondolfi, G., Osiek, C., Schwald, M., Bertschy, G., & Karege, F. (2005) · Neuropsychobiology · doi:10.1159/000085725 · Cited by 204 · see citing works
Konkle, A. T. M., Baker, S. L., Kentner, A. C., Barbagallo, L. S.-M., Merali, Z., & Bielajew, C. H. (2003) · Brain Research · doi:10.1016/j.brainres.2003.08.047 · Cited by 199 · see citing works
Bergström, A., Jayatissa, M. N., Mørk, A., & Wiborg, O. (2007) · Brain Research · doi:10.1016/j.brainres.2007.12.025 · Cited by 195 · see citing works
Nair, A., Vadodaria, K. C., Banerjee, S. B., Benekareddy, M., Dias, B. G., Duman, R. S., & Vaidya, V. A. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301276 · Cited by 189 · see citing works
Herrero, A. I., Sandi, C., & Venero, C. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.02.001 · Cited by 183 · see citing works
Self-citationTrivedi, M. (2004) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2004.02.005 · Cited by 179 · see citing works
Lee, K. J., Kim, S.-J., Kim, S.-W., Choi, S.-H., Shin, Y.-C., Park, S.-H., Moon, B., Cho, E., Lee, M.-S., Choi, S.-H., et al. (2006) · Experimental & Molecular Medicine · doi:10.1038/emm.2006.6 · Cited by 138 · see citing works
Jordan, S., Kramer, G. L., Zukas, P. K., Moeller, M., & Petty, F. (1994) · Synapse · doi:10.1002/syn.890180404 · Cited by 137 · see citing works
KAP1-Mediated Epigenetic Repression in the Forebrain Modulates Behavioral Vulnerability to Stress
Jakobsson, J., Cordero, M. I., Bisaz, R., Groner, A. C., Busskamp, V., Bensadoun, J., Cammas, F. M., Losson, R., Mansuy, I. M., Sandi, C., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.036 · Cited by 130 · see citing works
Self-citationWichers, M., Kenis, G., Jacobs, N., Mengelers, R., Derom, C., Vlietinck, R., & van Os, J. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30576 · Cited by 127 · see citing works
Ibargüen-Vargas, Y., Surget, A., Vourc’h, P., Leman, S., Andres, C. R., Gardier, A. M., & Belzung, C. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.03.040 · Cited by 107 · see citing works
Fendt, M., & Endres, T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.010 · Cited by 105 · see citing works
Sillaber, I., Panhuysen, M., Henniger, M. S. H., Ohl, F., Kühne, C., Pütz, B., Pohl, T., Deussing, J. M., Páez-Pereda, M., & Holsboer, F. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1232-6 · Cited by 91 · see citing works
Sandi, C., Cordero, M. I., Ugolini, A., Varea, E., Caberlotto, L., & Large, C. H. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06451.x · Cited by 85 · see citing works
Self-citationVitale, G., Ruggieri, V., Filaferro, M., Frigeri, C., Alboni, S., Tascedda, F., Brunello, N., Guerrini, R., Cifani, C., & Massi, M. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1646-9 · Cited by 77 · see citing works
Larsen, M. H., Hay‐Schmidt, A., Rønn, L. C. B., & Mikkelsen, J. D. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.08.050 · Cited by 75 · see citing works
Self-citationCordero, M. I., Rodríguez, J. J., Davies, H. A., Peddie, C. J., Sandi, C., & Stewart, M. G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.046 · Cited by 73 · see citing works
Self-citationRogóż, Z., Skuza, G., & Legutko, B. (2005) · PubMed · Cited by 72 · see citing works
Xu, H., Luo, C., Richardson, J. S., & Li, X.-M. (2004) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500265 · Cited by 71 · see citing works
Dawson, L. A., Nguyen, H. Q., & Geiger, A. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00052-0 · Cited by 70 · see citing works
Varea, E., Castillo-Gómez, E., Gómez‐Climent, M. Á., Blasco‐Ibáñez, J. M., Crespo, C., Martinez-Guijarro, F. J., & Nácher, J. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.01.001 · Cited by 62 · see citing works
Lucca, G., Comim, C. M., Valvassori, S. S., Pereira, J. G., Stertz, L., Gavioli, E. C., Kapczinski, F. P., & Quevedo, J. (2008) · Current Neurovascular Research · doi:10.2174/156720208786413406 · Cited by 51 · see citing works
Schulte‐Herbrüggen, O., Fuchs, E., Abumaria, N., Ziegler, A. M., Danker‐Hopfe, H., Hiemke, C., & Hellweg, R. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22080 · Cited by 51 · see citing works
Allaman, I., Papp, M., Kraftsik, R., Fiumelli, H., Magistretti, P. J., & Martin, J. (2008) · PubMed · Cited by 40 · see citing works
Larsen, M., Olesen, M. V., Woldbye, D. P. D., Hay‐Schmidt, A., Hansen, H. H., Rønn, L. C. B., & Mikkelsen, J. D. (2005) · Brain Research · doi:10.1016/j.brainres.2005.09.039 · Cited by 37 · see citing works
Self-citationEffects of chronic imipramine on exploration, locomotion, and food/water intake in rats
Mogensen, J., Pedersen, T. K., & Holm, S. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90139-2 · Cited by 25 · see citing works
Chronic imipramine effects on exploratory behavior in rats
Hughes, R. N., & Pither, J. M. (1987) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(87)90581-8 · Cited by 16 · see citing works
Adding complexity to emotion-cognition interactions: the stressed individual
Sandi, C. (2008) · Frontiers in Neuroscience · doi:10.3389/neuro.01.042.2008 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
1 of the 71 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Miranda, M., Morici, J. F., Zanoni, M. B., & Bekinschtein, P. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00363 · Cited by 1,416 · see citing works
Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation
Lima Giacobbo, B., Doorduin, J., Klein, H. C., Dierckx, R. A. J. O., Bromberg, E., & de Vries, E. F. J. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1283-6 · Cited by 750 · see citing works
Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects
Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works
Neurobiology of chronic mild stress: parallels to major depression
Hill, M. N., Hellemans, K. G. C., Verma, P., Gorzalka, B. B., & Weinberg, J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.001 · Cited by 420 · see citing works
Neuroplastic changes in depression: A role for the immune system
Eyre, H., & Baune, B. T. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.019 · Cited by 319 · see citing works
Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Wu, A., & Zhang, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02964-x · Cited by 327 · see citing works
Depression, Antidepressants, and Neurogenesis: A Critical Reappraisal
Hanson, N. D., Owens, M. J., & Nemeroff, C. B. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.220 · Cited by 302 · see citing works
Andrews, P. W., Bharwani, A., Lee, K. R., Fox, M., & Thomson, J. A. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.01.018 · Cited by 281 · see citing works
Berry, A., Bellisario, V., Capoccia, S., Tirassa, P., Calza, A., Alleva, E., & Cirulli, F. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.09.007 · Cited by 220 · see citing works
Tanti, A., & Belzung, C. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.017 · Cited by 220 · see citing works
Moretti, M., Colla, A. R. D. S., Balen, G. O., Santos, D. B., Budni, J., Freitas, A. E., Farina, M., & Rodrigues, A. L. S. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.11.009 · Cited by 210 · see citing works
Bai, M., Zhu, X., Zhang, Y., Zhang, S., Zhang, L., Xue, L., Yi, J., Yao, S., & Zhang, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046921 · Cited by 195 · see citing works
Understanding stress: Insights from rodent models
Atrooz, F., Alkadhi, K. A., & Salim, S. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100013 · Cited by 201 · see citing works
Neuroimmunological effects of physical exercise in depression
Eyre, H. A., & Baune, B. T. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.015 · Cited by 188 · see citing works
<scp>BDNF</scp> isoforms: a round trip ticket between neurogenesis and serotonin?
Foltran, R. B., & Diaz, S. L. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13658 · Cited by 187 · see citing works
The role of mTOR in depression and antidepressant responses
Abelaira, H. M., Réus, G. Z., Neotti, M. V., & Quevedo, J. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.02.014 · Cited by 186 · see citing works
Serum BDNF levels before treatment predict SSRI response in depression
Wolkowitz, O. M., Wolf, J. S., Shelly, W. B., Rosser, R., Burke, H. M., Lerner, G. K., Reus, V. I., Nelson, J. C., Epel, E. S., & Mellon, S. H. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.06.013 · Cited by 174 · see citing works
Update in the methodology of the chronic stress paradigm: internal control matters
Strekalova, T., Couch, Y., Kholod, N., Boyks, M., Malin, D., Leprince, P., & Steinbusch, H. M. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-9 · Cited by 163 · see citing works
Teixeira, A. L., Barbosa, I. G., Diniz, B. S., & Kümmer, A. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.10.111 · Cited by 162 · see citing works
Akinfiresoye, L. R., & Tizabi, Y. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3153-2 · Cited by 149 · see citing works
Neurotrophins Role in Depression Neurobiology: A Review of Basic and Clinical Evidence
Neto, F. L. M., Borges, G., Torres-Sánchez, S., Micó, J. A., & Berrocoso, E. (2011) · Current Neuropharmacology · doi:10.2174/157015911798376262 · Cited by 150 · see citing works
Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives
Strekalova, T. V., Liu, Y., Kiselev, D., Khairuddin, S., Chiu, J. L. Y., Lam, J., Chan, Y., Pavlov, D., Proshin, A. T., Lesch, K., et al. (2022) · Psychopharmacology · doi:10.1007/s00213-021-05982-w · Cited by 146 · see citing works
Maniam, J., & Morris, M. J. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.05.012 · Cited by 140 · see citing works
Qiao, H., An, S.-C., Xu, C. S., & Ma, X. (2017) · Brain Research · doi:10.1016/j.brainres.2017.02.020 · Cited by 137 · see citing works
Ye, Y., Wang, G., Wang, H., & Wang, X. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.07.055 · Cited by 131 · see citing works
Dual Role of Autophagy in Diseases of the Central Nervous System
Bar-Yosef, T., Damri, O., & Agam, G. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00196 · Cited by 126 · see citing works
O'Mahony, C. O., Clarke, G., Gibney, S., Dinan, T., & Cryan, J. (2011) · Pharmacology, Biochemistry and Behavior · doi:10.1016/j.pbb.2010.11.012 · Cited by 97 · see citing works
Chiu, C., Chyau, C.-C., Chen, C., Lee, L., Chen, W.-P., Liu, J.-L., Lin, W., & Mong, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020341 · Cited by 116 · see citing works
The role of neurotrophins in major depressive disorder
Jiang, C. S., & Salton, S. R. (2013) · Translational Neuroscience · doi:10.2478/s13380-013-0103-8 · Cited by 112 · see citing works
Hippocampal BDNF in physiological conditions and social isolation
Zaletel, I. V., Filipović, D., & Puškaš, N. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2016-0072 · Cited by 107 · see citing works
Cognitive Dysfunction in Depression – Pathophysiology and Novel Targets
Carvalho, A., Miskowiak, K., Hyphantis, T., Kohler, C., Alves, G., Bortolato, B., G. Sales, P., Machado-Vieira, R., Berk, M., & McIntyre, R. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666141130203627 · Cited by 107 · see citing works
Tanti, A., Westphal, W.-P., Girault, V., Brizard, B., Devers, S., Leguisquet, A.-M., Surget, A., & Belzung, C. (2013) · Hippocampus · doi:10.1002/hipo.22134 · Cited by 106 · see citing works
Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression
Qiao, H., An, S.-C., Ren, W., & Ma, X. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.040 · Cited by 105 · see citing works
Hill, R. A., Klug, M., Kiss Von Soly, S., Binder, M. D., Hannan, A. J., & van den Buuse, M. (2014) · Hippocampus · doi:10.1002/hipo.22302 · Cited by 99 · see citing works
Castro, J. E., Diessler, S., Varea, E., Márquez, C., Larsen, M. H., Cordero, M. I., & Sandi, C. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.014 · Cited by 94 · see citing works
Self-citationHolzmann, I., da Silva, L. M., da Silva, J. A. C., Steimbach, V. M. B., & de Souza, M. M. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.07.003 · Cited by 92 · see citing works
Abdel-Wahab, B. A., & Salama, R. H. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.07.015 · Cited by 86 · see citing works
Odaira, T., Nakagawasai, O., Takahashi, K., Nemoto, W., Sakuma, W., Lin, J.-R., & Tan–No, K. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.026 · Cited by 80 · see citing works
Dionisie, V., Ciobanu, A. M., Toma, V. A., Manea, M. C., Baldea, I., Olteanu, D., Sevastre-Berghian, A., Clichici, S., Manea, M., Riga, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147483 · Cited by 78 · see citing works
The role of the GPR39 receptor in zinc deficient-animal model of depression.
Młyniec, K., Budziszewska, B., Reczynski, W., Sowa-Kućma, M., & Nowak, G. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.10.020 · Cited by 71 · see citing works
Hesperidin attenuates depression-related symptoms in mice with mild traumatic brain injury
Kosari‐Nasab, M., Shokouhi, G., Ghorbanihaghjo, A., Abbasi, M. M., & Salari, A. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.10.040 · Cited by 70 · see citing works
Liu, D., Zhang, Y., Gharavi, R., Park, H. R., Lee, J., Siddiqui, S., Telljohann, R., Nassar, M. R., Cutler, R. G., Becker, K. G., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13176 · Cited by 68 · see citing works
“BDNF regulates neuronal energy metabolism and stress responses (Nakagawa et al. 2002; Arancibia et al. 2003; Larsen et al. 2010; Marosi and Mattson 2014).”
BackgroundMikoteit, T., Beck, J., Eckert, A., Hemmeter, U., Brand, S., Bischof, R., Holsboer-trachsler, E., & Delini-stula, A. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3475-8 · Cited by 68 · see citing works
Stress-induced anhedonia is associated with an increase in Alzheimer’s disease-related markers
Briones, A., Gagno, S., Martisova, E., Dobarro, M., Aisa, B., Solas, M., Tordera, R., & Ramírez, M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01602.x · Cited by 64 · see citing works
Calabrese, F., Molteni, R., Gabriel, C., Mocaër, E., Racagni, G., & Riva, M. A. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2129-8 · Cited by 64 · see citing works
Antidepressant-like effect of n-3 PUFAs in CUMS rats: role of tPA/PAI-1 system
Tang, M., Jiang, P., Huan-de, L., Cai, H., Liu, Y., Gong, H., & Zhang, L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.054 · Cited by 60 · see citing works
Diaz, S. L., Narboux‐Nême, N., Boutourlinsky, K., Doly, S., & Maroteaux, L. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.012 · Cited by 55 · see citing works
Jindal, A., Mahesh, R., & Bhatt, S. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.01.020 · Cited by 57 · see citing works
Sedaghat, K., Yousefian, Z., Vafaei, A. A., Rashidy‐Pour, A., Parsaei, H., Khaleghian, A., & Choobdar, S. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.08.020 · Cited by 57 · see citing works
Wu, L., Hu, M., Tong, X., Han, H., Shen, N., Jin, R., Wang, W., Zhou, G.-X., He, G., & Liu, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052331 · Cited by 56 · see citing works
SIRT2 is involved in the modulation of depressive behaviors
Liu, R., Dang, W., Du, Y., Zhou, Q., Jiao, K., & Liu, Z. (2015) · Scientific Reports · doi:10.1038/srep08415 · Cited by 56 · see citing works
Dandekar, M. P., Saxena, A., Scaini, G., Shin, J. H., Migut, A., Giridharan, V. V., Zhou, Y., Barichello, T., Soares, J. C., Quevedo, J., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1381-5 · Cited by 56 · see citing works
Sharma, V., Singh, T. G., Kaur, A., Mannan, A., & Dhiman, S. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03755-1 · Cited by 55 · see citing works
Cieślik, K., Sowa-Kućma, M., Ossowska, G., Legutko, B., Wolak, M., Opoka, W., & Nowak, G. (2011) · Pharmacological Reports · doi:10.1016/s1734-1140(11)70520-5 · Cited by 54 · see citing works
Brás, J. P., de Suduiraut, I. G., Zanoletti, O., Monari, S., Meijer, M., Grosse, J., Barbosa, M. A., Santos, S. G., Sandi, C., & Almeida, M. I. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.10.018 · Cited by 54 · see citing works
Self-citationIFN-γ differentially modulates memory-related processes under basal and chronic stressor conditions
Litteljohn, D., Nelson, E., & Hayley, S. P. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00391 · Cited by 52 · see citing works
Drug withdrawal-induced depression: Serotonergic and plasticity changes in animal models
Renoir, T., Pang, T. Y., & Lanfumey, L. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.003 · Cited by 52 · see citing works
Vásquez, C. E., Riener, R. M., Reynolds, E., & Britton, G. B. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.09.007 · Cited by 49 · see citing works
Region‐specific response of the hippocampus to chronic unpredictable stress
Hawley, D. F., & Leasure, J. L. (2011) · Hippocampus · doi:10.1002/hipo.20970 · Cited by 51 · see citing works
Jindal, A., Mahesh, R., & Bhatt, S. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.08.005 · Cited by 49 · see citing works
Reyes-Izquierdo, T., Nemzer, B. V., Shu, C., Huynh, L., Argumedo, R., Keller, R., & Pietrzkowski, Z. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114512005338 · Cited by 48 · see citing works
Mishra, S. K., Hidau, M. K., & Rai, S. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104932 · Cited by 49 · see citing works
Abelaira, H. M., Réus, G. Z., Ribeiro, K. F., Zappellini, G., Ferreira, G. K., Gomes, L. M., Carvalho‐Silva, M., Luciano, T. F., Marques, S. D. O., STRECK, E. L., et al. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.10.007 · Cited by 46 · see citing works
Wuchter, J., Beuter, S., Treindl, F., Herrmann, T., Zeck, G. M., Templin, M. F., & Volkmer, H. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1261-12.2012 · Cited by 44 · see citing works
First, M., Gil‐Ad, I., Taler, M., Tarasenko, I., Novak, N., & Weizman, A. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9872-8 · Cited by 44 · see citing works
Amidfar, M., Réus, G. Z., Quevedo, J., & Kim, Y.-K. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.03.023 · Cited by 43 · see citing works
Della, F. P., Abelaira, H. M., Réus, G. Z., Ribeiro, K. F., Antunes, A. R., Scaini, G., Jeremias, I. C., Mello-Santos, L. M., Jeremias, G. C., STRECK, E. L., et al. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.039 · Cited by 43 · see citing works
Antidepressant-like effect of valproic acid—Possible involvement of PI3K/Akt/mTOR pathway
Lima, I. V. D. A., Almeida-Santos, A. F., Ferreira-Vieira, T. H., de Aguiar, D. C., Ribeiro, F. M., Campos, A. C., & de Oliveira, A. C. P. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.015 · Cited by 43 · see citing works
Doron, R., Lotan, D., Versano, Z., Benatav, L., Franko, M., Armoza-Eilat, S., Kately, N., & Rehavi, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091455 · Cited by 41 · see citing works
Antistress properties of antidepressant drugs and their clinical implications
Calabrese, F., Molteni, R., & Riva, M. A. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.05.007 · Cited by 41 · see citing works
Iturra-Mena, A. M., Arriagada-Solimano, M., Anders, A. L., & Dagnino‐Subiabre, A. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12609 · Cited by 41 · see citing works
Behavioral changes after maternal separation are reversed by chronic constant light treatment
Dimatelis, J. J., Stein, D. J., & Russell, V. A. (2012) · Brain Research · doi:10.1016/j.brainres.2012.07.013 · Cited by 39 · see citing works
Ye, D., Li, Y., Zhang, X., Guo, F., Geng, L., Zhang, Q., & Zhang, Z. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.09.007 · Cited by 38 · see citing works
Zinc and Fatty Acids in Depression
Irmisch, G., Schläfke, D., & Richter, J. (2010) · Neurochemical Research · doi:10.1007/s11064-010-0194-3 · Cited by 38 · see citing works
Rojas, P. S., Rosemarie Fritsch, M., Rojas, R., Jara, P., & Fiedler, J. L. (2011) · Psychiatry Research · doi:10.1016/j.psychres.2011.04.032 · Cited by 37 · see citing works
Post‐weaning environmental enrichment improves BDNF response of adult male rats
Mosaferi, B., Babri, S., Mohaddes, G., Khamnei, S., & Abbasi, M. M. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.07.008 · Cited by 36 · see citing works
Freitas, A. E., Bettio, L. E. B., Neis, V. B., Moretti, M., Ribeiro, C. M., Lopes, M. W., Leal, R. B., & Rodrigues, A. L. S. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.07.024 · Cited by 36 · see citing works
Antidepressant-like effect of celecoxib piroxicam in rat models of depression
Santiago, R. M., Barbiero, J. K., Martynhak, B. J., Boschen, S. L., da Silva, L. M., Werner, M. F. D. P., Cunha, C. D., Andreatini, R., Lima, M. M. S., & Vital, M. A. B. F. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1159-5 · Cited by 38 · see citing works
Gupta, D., Radhakrishnan, M., & Kurhe, Y. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.05.024 · Cited by 36 · see citing works
Moradikor, N., Ghanbari, A., Rashidipour, H., Yousefi, B., Bandegi, A. R., & Rashidy‐Pour, A. (2019) · Hormones and Behavior · doi:10.1016/j.yhbeh.2019.03.004 · Cited by 36 · see citing works
Feng, L., Xing, H., & Zhang, K. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.153980 · Cited by 36 · see citing works
Yasuda, S., Yoshida, M., Yamagata, H., Iwanaga, Y., Suenaga, H., Ishikawa, K., Nakano, M., Okuyama, S., Furukawa, Y., Furukawa, S., et al. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0097-y · Cited by 34 · see citing works
Wang, Y., Xiao, Z., Liu, X., & Berk, M. (2011) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.1177 · Cited by 33 · see citing works
Berghauzen-Maciejewska, K., Wardas, J., Kosmowska, B., Głowacka, U., Kuter, K. Z., & Ossowska, K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117698 · Cited by 33 · see citing works
van Zyl, P. J., Dimatelis, J. J., & Russell, V. A. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9757-y · Cited by 32 · see citing works
Duan, D.-M., Tu, Y., Liu, P., & Jiao, S. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.193238 · Cited by 33 · see citing works
Brivio, P., Sbrini, G., Corsini, G., Paladini, M. S., Racagni, G., Molteni, R., & Calabrese, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176261 · Cited by 29 · see citing works
Park, Y., & Lee, B.-H. (2018) · Psychiatry Investigation · doi:10.30773/pi.2018.03.31 · Cited by 27 · see citing works
Regulatory Molecules of Synaptic Plasticity in Anxiety Disorder
Sha, Z., Xu, J., Li, N., & Li, O. (2023) · International Journal of General Medicine · doi:10.2147/ijgm.s413176 · Cited by 27 · see citing works
Comparative Analysis of the Behavioral and Biomolecular Parameters of Four Mouse Strains
Nesher, E., Peskov, V., Rylova, A., Raz, O., & Pinhasov, A. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9544-0 · Cited by 27 · see citing works
Cavigelli, S. A., Bao, A. D., Bourne, R. A., Caruso, M. J., Caulfield, J. I., Chen, M., & Smyth, J. M. (2018) · Stress · doi:10.1080/10253890.2018.1459557 · Cited by 25 · see citing works
Kuşçu, Ö. Ö., Karacaer, F., Biricik, E., Güleç, E., Tamam, L., & Güneş, Y. (2015) · Türk anesteziyoloji ve reanimasyon derneği dergisi · doi:10.5152/tjar.2015.92668 · Cited by 25 · see citing works
Intravenous infusion of xenon‐containing liposomes generates rapid antidepressant‐like effects
Dandekar, M. P., Peng, T., McPherson, D., Quevedo, J., Soares, J., & Huang, S.-L. (2018) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.011 · Cited by 18 · see citing works
Zhu, X., Sun‐Waterhouse, D., Tao, Q., Li, W., Shu, D., & Cui, C. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.103859 · Cited by 25 · see citing works
Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease
Lauterbach, E. C. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.03.011 · Cited by 23 · see citing works
Ventral hippocampus, Stress and Psychopathology: Translational implications
Gulyaeva, N. V. (2015) · Neurochemical Journal · doi:10.1134/s1819712415020075 · Cited by 23 · see citing works
Vakhitova, Y. V., Kalinina, T. S., Zainullina, L. F., Lusta, A. Y., Volkova, A. V., Kudryashov, N. V., Gudasheva, T. A., Shimshirt, A. A., Kadnikov, I. A., Voronin, M. V., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413381 · Cited by 21 · see citing works
Zadeh, Z. T., Rahmani, S., Alidadi, F., Joushi, S., & Esmaeilpour, K. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14949 · Cited by 23 · see citing works
Charoenphandhu, N., Nuntapornsak, A., Wongdee, K., Krishnamra, N., & Charoenphandhu, J. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1527-0 · Cited by 21 · see citing works
Robledo‐Montaña, J., Díaz-García, C., Martínez, M., Ambrosio, N., Montero, E., Marín, M. J., Virto, L., Muñoz‐López, M., Herrera, D., Sanz, M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03213-5 · Cited by 18 · see citing works
- Authors
- Larsen, M. H., Mikkelsen, J. D., Hay-Schmidt, A., & Sandi, C.
- Affiliations
- University of Copenhagen (DK)
- École Polytechnique Fédérale de Lausanne (CH)
- Corresponding author
- Larsen, Marianne H.
- Venue
- Journal of Psychiatric Research
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 44
- Issue
- 13
- Pages
- 808-816
- ISSN
- 0022-3956 (ISSN-L)
- OpenAlex
- W2078116925
- Cited by
- 165
- References
- 71
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 14 · 2020: 7 · 2019: 10 · 2018: 11 · 2017: 5 · 2016: 6 · 2015: 17 · 2014: 15 · 2013: 10 · 2012: 16
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- green
- infoscience.epfl.ch
- Locations
- Journal of Psychiatric Research (publishedVersion)
- PubMed (publishedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (FP7-HEALTH-F2M-2007-201600, 120791)
- FP7 Health
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- brain-derived neurotrophic factor, chronic unpredictable mild stress, depression, anhedonia, antidepressant treatment, venlafaxine, imipramine, hippocampus, dentate gyrus, CA3 region, BDNF mRNA expression, forced swim test
- MeSH terms
- Venlafaxine Hydrochloride, Animals, Antidepressive Agents, Cyclohexanols, Disease Models, Animal, Food Preferences, Hippocampus, Imipramine, Locomotion, Male, RNA, Messenger, Saccharin, Stress, Psychological, Sweetening Agents, Swimming, Time Factors, Rats, Sprague-Dawley, In Situ Hybridization, Maze Learning, Dentate Gyrus, Brain-Derived Neurotrophic Factor, Rats, CA3 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review