CoChat
Sign Up
Cited by 15

The DOI matches its Crossref record.

Lowly expressed lncRNA PVT1 suppresses proliferation and advances apoptosis of glioma cells through up-regulating microRNA-128-1-5p and inhibiting PTBP1

Dahai, Zheng, Daliang, Chen, Famu, Lin, Xiang, Wan, Lenian, Lu, Jianmin, Chen, Xiaobing, Xu·2020·Brain Research Bulletin
DOI 10.1016/j.brainresbull.2020.06.006
Open this paper in CoChat — free account

Abstract

Background Glioma is a primary intracranial malignancy with poor prognosis, of which the pathogenesis remains to be elucidated. Therein, the aim of this study is to discuss the impacts of lncRNA plasmacytoma variant translocation 1 (PVT1)/microRNA-128-1-5p (miR-128-1-5p)/polypyrimidine tract-binding protein 1 (PTBP1) axis on the biological characteristics of glioma cells. Methods Glioma tissue samples (72 cases) and normal brain tissue samples (35 cases) were harvested. The expression of PVT1, miR-128-1-5p and PTBP1 in glioma tissues and cells was detected. Glioma cells were transfected with sh-PVT1, miR-128-1-5p mimics or miR-128-1-5p inhibitors to verify the impacts of PVT1 and miR-128-1-5p on DNA damage, cell colony formation, invasion, proliferation, migration and apoptosis of glioma U87 and U251 cells. The growth of transplanted tumor was tested by tumor xenograft in nude mice. The combination of PVT1 and miR-128-1-5p and the targeting relationship between miR-128-1-5p and PTBP1 were verified. Results PVT1 and PTBP1 expression was enhanced and miR-128-1-5p expression was degraded in glioma tissues and cells. Overexpressed miR-128-1-5p and lowly-expressed PVT1 promoted DNA damage, suppressed colony formation, invasion, proliferation and migration as well as boosted apoptosis of U251 and U87 cells. Up-regulating miR-128-1-5p and down-regulating PVT1 reduced transplanted tumor volume and weight of glioma in mice. Low expression miR-128-1-5p reversed the effect of low expres…

Overview

Integrity signals

Registry

Crossref · 10.1016/j.brainresbull.2020.06.006

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 38

  1. Ayuk, 2016, The role of photobiomodulation on gene expression of cell adhesion molecules in diabetic wounded fibroblasts in vitro, J. Photochem. Photobiol. B, 161, 368, 10.1016/j.jphotobiol.2016.05.027 · DOI
  2. Chen, 2016, The inhibition of microRNA-128 on IGF-1-Activating mTOR signaling involves in temozolomide-induced glioma cell apoptotic death, PLoS One, 11, e0167096, 10.1371/journal.pone.0167096 · DOI · Paper page
  3. Cheung, 2009, Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines, Brain, 132, 2277, 10.1093/brain/awp153 · DOI
  4. Fang, 2019, Clinical significance of the expression of long non-coding RNA PVT1 in glioma, Cancer Biomark., 24, 509, 10.3233/CBM-182253 · DOI
  5. Fu, 2018, LncRNA PVT1 facilitates tumorigenesis and progression of glioma via regulation of MiR-128-3p/GREM1 Axis and BMP signaling pathway, Neurotherapeutics, 15, 1139, 10.1007/s13311-018-0649-9 · DOI · Paper page
  6. Gallego, 2015, Nonsurgical treatment of recurrent glioblastoma, Curr. Oncol., 22, e273, 10.3747/co.22.2436 · DOI
  7. Geraldo, 2019, Glioblastoma therapy in the age of molecular medicine, Trends Cancer, 5, 46, 10.1016/j.trecan.2018.11.002 · DOI
  8. Han, 2019, Knockdown of lncRNA PVT1 inhibits glioma progression by regulating miR-424 expression, Oncol. Res., 27, 681, 10.3727/096504018X15424939990246 · DOI
  9. Hua, 2019, LINK-A lncRNA participates in the pathogenesis of glioma by interacting with survivin, Exp. Ther. Med., 18, 1581
  10. Huang, 2019, lncRNA NEF inhibits glioma by downregulating TGF-beta1, Exp. Ther. Med., 18, 692
  11. Kang, 2019, A miR-194/PTBP1/CCND3 axis regulates tumor growth in human hepatocellular carcinoma, J. Pathol., 10.1002/path.5325 · DOI
  12. Kaya, 2017, Automated fluorescent miscroscopic image analysis of PTBP1 expression in glioma, PLoS One, 12, e0170991, 10.1371/journal.pone.0170991 · DOI
  13. Lages, 2011, MicroRNA and target protein patterns reveal physiopathological features of glioma subtypes, PLoS One, 6, e20600, 10.1371/journal.pone.0020600 · DOI · Paper page
  14. Li, 2019, Integrative analysis of DNA methylation and gene expression profiles identifies MIR4435-2HG as an oncogenic lncRNA for glioma progression, Gene, 715, 144012, 10.1016/j.gene.2019.144012 · DOI
  15. Liang, 2017, Circulating miR-128 as a potential diagnostic biomarker for glioma, Clin. Neurol. Neurosurg., 160, 88, 10.1016/j.clineuro.2017.06.020 · DOI
  16. Lin, 2018, MicroRNA-128 inhibits proliferation and invasion of glioma cells by targeting COX-2, Gene, 658, 63, 10.1016/j.gene.2018.03.020 · DOI
  17. Liu, 2019, LncRNA SNHG20 promoted the proliferation of glioma cells via sponging miR-4486 to regulate the MDM2-p53 pathway, Eur. Rev. Med. Pharmacol. Sci., 23, 5323
  18. Ma, 2017, PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186, Tumour Biol., 39, 10.1177/1010428317694326 · DOI
  19. Pan, 2018, LncRNA PVT1: a novel therapeutic target for cancers, Clin. Lab., 64, 655
  20. Pan, 2018, MiR-128-1-5p regulates tight junction induced by selenium deficiency via targeting cell adhesion molecule 1 in broilers vein endothelial cells, J. Cell. Physiol., 233, 8802, 10.1002/jcp.26794 · DOI
  21. Papagiannakopoulos, 2012, Pro-neural miR-128 is a glioma tumor suppressor that targets mitogenic kinases, Oncogene, 31, 1884, 10.1038/onc.2011.380 · DOI · Paper page
  22. Pellecchia, 2020, The long non-coding RNA prader Willi/Angelman region RNA5 (PAR5) is downregulated in anaplastic thyroid carcinomas where it acts as a tumor suppressor by reducing EZH2 activity, Cancers (Basel), 12, 10.3390/cancers12010235 · DOI
  23. Qian, 2019, MicroRNA 145 enhances chemosensitivity of glioblastoma stem cells to demethoxycurcumin, Cancer Manag. Res., 11, 6829, 10.2147/CMAR.S210076 · DOI
  24. Shang, 2016, miR-128 regulates the apoptosis and proliferation of glioma cells by targeting RhoE, Oncol. Lett., 11, 904, 10.3892/ol.2015.3927 · DOI
  25. Shi, 2012, MiR-128 inhibits tumor growth and angiogenesis by targeting p70S6K1, PLoS One, 7, e32709, 10.1371/journal.pone.0032709 · DOI
  26. Song, 2018, Downregulation of long noncoding RNA PVT1 attenuates paclitaxel resistance in glioma cells, Cancer Biomark., 23, 447, 10.3233/CBM-181573 · DOI
  27. Taniguchi, 2016, PTBP1-associated microRNA-1 and -133b suppress the Warburg effect in colorectal tumors, Oncotarget, 7, 18940, 10.18632/oncotarget.8005 · DOI
  28. Xue, 2018, PVT1 regulates the malignant behaviors of human glioma cells by targeting miR-190a-5p and miR-488-3p, Biochim Biophys Acta Mol Basis Dis, 1864, 1783, 10.1016/j.bbadis.2018.02.022 · DOI
  29. Yang, 2015, PTBP1 induces ADAR1 p110 isoform expression through IRES-like dependent translation control and influences cell proliferation in gliomas, Cell. Mol. Life Sci., 72, 4383, 10.1007/s00018-015-1938-7 · DOI
  30. Yang, 2017, Long non-coding RNA PVT1 indicates a poor prognosis of glioma and promotes cell proliferation and invasion via target EZH2, Biosci. Rep., 37, 10.1042/BSR20170871 · DOI
  31. Ye, 2018, MiR-128 promotes the apoptosis of glioma cells via binding to NEK2, Eur. Rev. Med. Pharmacol. Sci., 22, 8781
  32. Yu, 2019, LncRNA PVT1 regulates VEGFC through inhibiting miR-128 in bladder cancer cells, J. Cell. Physiol., 234, 1346, 10.1002/jcp.26929 · DOI
  33. Yuan, 2016, Dysregulation of microRNA-128 expression in WHO grades 2 glioma is associated with glioma-associated epilepsy: down-regulation of miR-128 induces glioma-associated seizure, Epilepsy Res., 127, 6, 10.1016/j.eplepsyres.2016.08.005 · DOI · Paper page
  34. Zhang, 2019, Long noncoding RNA ASB16-AS1 promotes proliferation, migration, and invasion in glioma cells, Biomed Res. Int., 2019, 5437531
  35. Zhang, 2019, Long non-coding RNA PVT1 promotes glioma cell proliferation and invasion by targeting miR-200a, Exp. Ther. Med., 17, 1337
  36. Zheng, 2018, lncRNA PVT1 promotes the angiogenesis of vascular endothelial cell by targeting miR26b to activate CTGF/ANGPT2, Int. J. Mol. Med., 42, 489
  37. Zheng, 2019, Long non-coding RNA AGAP2-AS1 promotes the proliferation of glioma cells by sponging miR-15a/b-5p to upregulate the expression of HDGF and activating Wnt/beta-catenin signaling pathway, Int. J. Biol. Macromol., 128, 521, 10.1016/j.ijbiomac.2019.01.121 · DOI
  38. Zhu, 2019, PTB-AS, a novel natural antisense transcript, promotes glioma progression by improving PTBP1 mRNA stability with SND1, Mol. Ther., 10.1016/j.ymthe.2019.05.023 · DOI

Cited by

Sorted by citations

Metadata

Authors
Dahai, Z., Daliang, C., Famu, L., Xiang, W., Lenian, L., Jianmin, C., & Xiaobing, X.
Venue
Brain Research Bulletin
Publisher
Elsevier BV
Published
2020-10
Volume
163
Pages
1-13
ISSN
0361-9230
DOI
10.1016/j.brainresbull.2020.06.006
Cited by
15
References
0
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review