The impact of educational materials on compliance and persistence rates with adjuvant aromatase inhibitor treatment: first-year results from the compliance of ARomatase inhibitors AssessmenT in daily practice through educational approach (CARIATIDE) study
Open accessAbstract
The CARIATIDE study was designed to assess the impact of educational materials (EMs) on compliance and persistence rates with aromatase inhibitor (AI) treatment in postmenopausal women with hormone-receptor-positive early breast cancer. Patients were randomized to standard AI treatment (Group A; N = 1379) or standard AI treatment plus EMs containing information on a range of breast-cancer-related topics (Group B; N = 1379). Standardized questionnaires assessed investigator-perceived levels of care and evaluated patient compliance and behavior. At 1 year, there was no significant difference in compliance between Group A and Group B (81% vs. 82%, p = 0.4524). However, higher compliance in patients receiving EMs was observed in Sweden/Finland (p = 0.0246). Compliance with initial AI and persistence rate were not significantly altered by EM. Other factors associated with improved compliance, irrespective of EMs, e.g. administration of chemotherapy were identified.
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Osterberg, L., & Blaschke, T. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050100 · Cited by 7,974 · see citing works
Goldhirsch, A., Wood, W. C., Coates, A. S., Gelber, R. D., Thurlimann, B. J. K., & Senn, H.-J. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr304 · Cited by 3,839 · see citing works
Interventions for enhancing medication adherence
Nieuwlaat, R., Wilczynski, N., Navarro, T., Hobson, N., Jeffery, R., Keepanasseril, A., Agoritsas, T., Mistry, N., Iorio, A., Jack, S., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub4 · Cited by 2,945 · see citing works
Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Aebi, S. P., Davidson, T., Gruber, G., & Castiglione, M. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq159 · Cited by 2,849 · see citing works
Horne, R., Weinman, J. A., & Hankins, M. C. (1999) · Psychology and Health · doi:10.1080/08870449908407311 · Cited by 2,383 · see citing works
Horne, R., & Weinman, J. (1999) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(99)00057-4 · Cited by 2,201 · see citing works
Cuzick, J., Sestak, I., Baum, M., Buzdar, A., Howell, A., Dowsett, M., & Forbes, J. F. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70257-6 · Cited by 1,674 · see citing works
Interventions for enhancing medication adherence
Haynes, R. B., Ackloo, E., Sahota, N., McDonald, H. P., & Yao, X. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000011.pub3 · Cited by 1,244 · see citing works
Williams, N. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(07)70385-6 · Cited by 918 · see citing works
Hershman, D. L., Shao, T., Kushi, L. H., Buono, D., Tsai, W. Y., Fehrenbacher, L., Kwan, M., Gomez, S. L., & Neugut, A. I. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1132-4 · Cited by 870 · see citing works
Burstein, H. J., Prestrud, A. A., Seidenfeld, J., Anderson, H., Buchholz, T. A., Davidson, N. E., Gelmon, K. A., Giordano, S. H., Hudis, C. A., Malin, J. L., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2009.26.3756 · Cited by 794 · see citing works
Mouridsen, H. T., Gershanovich, M., Sun, Y., Pérez-Carrión, R., Boni, C., Monnier, A., Apffelstaedt, J., Smith, R., Sleeboom, H. P., Jaenicke, F., et al. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.04.194 · Cited by 741 · see citing works
Nonadherence to adjuvant tamoxifen therapy in women with primary breast cancer
Partridge, A. H., Wang, P. S., Winer, E. P., & Avorn, J. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.07.071 · Cited by 676 · see citing works
Adherence to Initial Adjuvant Anastrozole Therapy Among Women With Early-Stage Breast Cancer
Partridge, A. H., LaFountain, A., Mayer, E. L., Taylor, B. S., Winer, E. P., & Asnis-Alibozek, A. G. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.5451 · Cited by 483 · see citing works
Clifford, S., Barber, N., & Horne, R. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.05.004 · Cited by 384 · see citing works
Waterhouse, D. M., Calzone, K. A., Mele, C., & Brenner, D. E. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.6.1189 · Cited by 313 · see citing works
Intentional and non-intentional non-adherence to medication amongst breast cancer patients
Atkins, L., & Fallowfield, L. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.03.004 · Cited by 300 · see citing works
Self-citationPrimary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Aebi, S. P., Davidson, T., Gruber, G., & Cardoso, F. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr371 · Cited by 255 · see citing works
Cuzick, J. M., Šestak, I., Cella, D. F., & Fallowfield, L. J. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70259-6 · Cited by 186 · see citing works
Sedjo, R. L., & Devine, S. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0952-6 · Cited by 169 · see citing works
Improving compliance and persistence to adjuvant tamoxifen and aromatase inhibitor therapy
Hadji, P. (2009) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2009.02.001 · Cited by 133 · see citing works
Cluze, C., Rey, D., Huiart, L., BenDiane, M. K., Bouhnik, A. D., Berenger, C., Carrieri, M. P., & Giorgi, R. (2012) · Annals of Oncology · doi:10.1093/annonc/mdr330 · Cited by 133 · see citing works
Hadji, P., Blettner, M., Harbeck, N., Jackisch, C., Lück, H.-J., Windemuth-Kieselbach, C., Zaun, S., & Kreienberg, R. (2013) · Annals of Oncology · doi:10.1093/annonc/mds653 · Cited by 122 · see citing works
Self-citationAromatase inhibitor-induced arthralgia: Clinical experience and treatment recommendations
Coleman, R. E., Bolten, W. W., Lansdown, M., Dale, S., Jackisch, C., Merkel, D. E., Maass, N., & Hadji, P. (2007) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2007.10.004 · Cited by 122 · see citing works
Noncompliance with adjuvant radiation, chemotherapy, or hormonal therapy in breast cancer patients
Ma, A. M. T., Barone, J., Wallis, A. E., Wu, N. J., Garcia, L. B., Estabrook, A., Rosenbaum-Smith, S. M., & Tartter, P. I. (2008) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2008.06.027 · Cited by 115 · see citing works
Rodríguez, L. V., Blander, D. S., Dorey, F. J., Raz, S., & Zimmern, P. E. (2003) · Urology · doi:10.1016/s0090-4295(03)00144-4 · Cited by 108 · see citing works
Insight into Barriers Against Optimal Adherence to Oral Hormonal Therapy in Women with Breast Cancer
Kirk, M. C., & Hudis, C. A. (2008) · Clinical Breast Cancer · doi:10.3816/cbc.2008.n.016 · Cited by 87 · see citing works
Adherence to adjuvant therapy in post-menopausal breast cancer patients: a review
Banning, M. (2011) · European Journal of Cancer Care · doi:10.1111/j.1365-2354.2011.01295.x · Cited by 83 · see citing works
Kokko, R., Hakama, M., & Holli, K. A. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-005-5199-2 · Cited by 74 · see citing works
Hadji, P., Jackisch, C., Bolten, W. W., Blettner, M., Hindenburg, H., Klein, P., König, K., Kreienberg, R., Rief, W., Wallwiener, D. R., et al. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt513 · Cited by 69 · see citing works
Self-citationWengström, Y., Aapro, M., di Priolo, S. L., Cannon, H., & Georgiou, V. (2007) · Breast · doi:10.1016/j.breast.2007.02.007 · Cited by 54 · see citing works
Yu, K.-D., Zhou, Y., Liu, G.-Y., Li, B., He, P.-Q., Zhang, H.-W., Lou, L.-H., Wang, X.-J., Wang, S., Tang, J.-H., et al. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2059-8 · Cited by 50 · see citing works
Fontein, D. B. Y., Nortier, J. W. R., Liefers, G., Putter, H., Kranenbarg, E. M., Bosch, J., Maartense, E., Rutgers, E. J. T., & van de Velde, C. J. H. (2011) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2011.11.010 · Cited by 50 · see citing works
Davidson, B., Vogel, V. G., & Wickerham, D. L. (2007) · PubMed · Cited by 42 · see citing works
Hasnaoui, A. E., Vray, M., Blin, P., et al. (2004) · Cephalalgia · doi:10.1111/j.1468-2982.2004.00660.x · Cited by 36 · see citing works
Rosenzweig, M. Q., Brufsky, A., Rastogi, P., Puhalla, S., Simon, J., & Underwood, S. M. (2010) · Oncology nursing forum · doi:10.1188/11.onf.85-89 · Cited by 35 · see citing works
Existing treatment strategies: does noncompliance make a difference?
Caro, J. J., & Speckman, J. L. (1998) · PubMed · Cited by 34 · see citing works
Duration of adjuvant endocrine therapy of breast cancer: how much is enough?
Ward, J. H. (2009) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328334ff40 · Cited by 15 · see citing works
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Bodai, B. I., & Tuso, P. (2015) · The Permanente Journal · doi:10.7812/tpp/14-241 · Cited by 397 · see citing works
Leonard Grabeel, K., Russomanno, J., Oelschlegel, S., Tester, E., & Heidel, R. E. (2018) · Journal of the Medical Library Association · doi:10.5195/jmla.2018.262 · Cited by 96 · see citing works
Hurtado-de-Mendoza, A., Cabling, M. L., Lobo, T., Dash, C., & Sheppard, V. B. (2016) · Clinical Breast Cancer · doi:10.1016/j.clbc.2016.03.006 · Cited by 79 · see citing works
Finitsis, D. J., Vose, B. A., Mahalak, J. G., & Salner, A. L. (2019) · Psycho-Oncology · doi:10.1002/pon.4959 · Cited by 68 · see citing works
Bright, E. E., Finkelstein, L. B., Nealis, M. S., Genung, S. R., Wrigley, J., Gu, H. C. J., Schmiege, S. J., & Arch, J. J. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.23.00697 · Cited by 74 · see citing works
A systematic review of interventions to improve adherence to endocrine therapy
Heiney, S. P., Parker, P. D., Felder, T. M., Adams, S. A., Omofuma, O. O., & Hulett, J. M. (2019) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-5012-7 · Cited by 69 · see citing works
- Authors
- Neven, P., Markopoulos, C., Tanner, M., Marty, M., Kreienberg, R., Atkins, L., Franquet, A., Gnant, M., Neciosup, S., Tesarova, P., Barni, S., & Deschamp, V.
- Affiliations
- Universitair Ziekenhuis Leuven (BE)
- National and Kapodistrian University of Athens (GR)
- Tampere University Hospital (FI)
- Hôpital Saint-Louis (FR)
- University Hospital Ulm (DE)
- International Drug Development Institute (Belgium) (BE)
- Comprehensive Cancer Center Vienna (AT)
- Instituto Nacional de Enfermedades Neoplásicas (PE)
- Azienda Ospedaliera Treviglio (IT)
- Corresponding author
- Neven, Patrick
- Venue
- The Breast
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 23
- Issue
- 4
- Pages
- 393-399
- ISSN
- 0960-9776 (ISSN-L)
- OpenAlex
- W1979271232
- Cited by
- 53
- References
- 38
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 2
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The Breast (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- AstraZeneca
- Novartis
- Pfizer Inc
- Genomic Health Inc
- Sanofi-Aventis
- Amgen
- Roche
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
- Keywords
- aromatase inhibitors, medication adherence, treatment persistence, teaching materials, patient education, hormone receptor-positive breast cancer, early breast cancer, adjuvant therapy, postmenopausal women
- MeSH terms
- Letrozole, Anastrozole, Aged, Breast Neoplasms, Female, Humans, Lymph Node Excision, Mastectomy, Middle Aged, Nitriles, Patient Education as Topic, Triazoles, Drug Monitoring, Chemotherapy, Adjuvant, Postmenopause, Antineoplastic Agents, Hormonal, Aromatase Inhibitors
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