Cited by 53Medication Adherence and ComplianceCancer survivorship and careBreast Cancer Treatment Studies

The impact of educational materials on compliance and persistence rates with adjuvant aromatase inhibitor treatment: first-year results from the compliance of ARomatase inhibitors AssessmenT in daily practice through educational approach (CARIATIDE) study

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Neven, Patrick, Markopoulos, Christos, Tanner, Minna, Marty, Michel, Kreienberg, Rolf, Atkins, Louise, Franquet, Ann, Gnant, Michael +4 more·2014·The Breast

Abstract

The CARIATIDE study was designed to assess the impact of educational materials (EMs) on compliance and persistence rates with aromatase inhibitor (AI) treatment in postmenopausal women with hormone-receptor-positive early breast cancer. Patients were randomized to standard AI treatment (Group A; N = 1379) or standard AI treatment plus EMs containing information on a range of breast-cancer-related topics (Group B; N = 1379). Standardized questionnaires assessed investigator-perceived levels of care and evaluated patient compliance and behavior. At 1 year, there was no significant difference in compliance between Group A and Group B (81% vs. 82%, p = 0.4524). However, higher compliance in patients receiving EMs was observed in Sweden/Finland (p = 0.0246). Compliance with initial AI and persistence rate were not significantly altered by EM. Other factors associated with improved compliance, irrespective of EMs, e.g. administration of chemotherapy were identified.

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Crossref · 10.1016/j.breast.2014.02.009

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Authors
Neven, P., Markopoulos, C., Tanner, M., Marty, M., Kreienberg, R., Atkins, L., Franquet, A., Gnant, M., Neciosup, S., Tesarova, P., Barni, S., & Deschamp, V.
Affiliations
  • Universitair Ziekenhuis Leuven (BE)
  • National and Kapodistrian University of Athens (GR)
  • Tampere University Hospital (FI)
  • Hôpital Saint-Louis (FR)
  • University Hospital Ulm (DE)
  • International Drug Development Institute (Belgium) (BE)
  • Comprehensive Cancer Center Vienna (AT)
  • Instituto Nacional de Enfermedades Neoplásicas (PE)
  • Azienda Ospedaliera Treviglio (IT)
Corresponding author
Neven, Patrick
Venue
The Breast
Publisher
Elsevier BV
Published
2014-08
Volume
23
Issue
4
Pages
393-399
ISSN
0960-9776 (ISSN-L)
OpenAlex
W1979271232
Cited by
53
References
38
Citations by year
2025: 1 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 7 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 2
FWCI
5.47
Type
journal article
Language
en
Open access
Locations
  • The Breast (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • AstraZeneca
  • Novartis
  • Pfizer Inc
  • Genomic Health Inc
  • Sanofi-Aventis
  • Amgen
  • Roche
Topics
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Breast Cancer Treatment Studies
Keywords
aromatase inhibitors, medication adherence, treatment persistence, teaching materials, patient education, hormone receptor-positive breast cancer, early breast cancer, adjuvant therapy, postmenopausal women
MeSH terms
Letrozole, Anastrozole, Aged, Breast Neoplasms, Female, Humans, Lymph Node Excision, Mastectomy, Middle Aged, Nitriles, Patient Education as Topic, Triazoles, Drug Monitoring, Chemotherapy, Adjuvant, Postmenopause, Antineoplastic Agents, Hormonal, Aromatase Inhibitors

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