Intentional and non-intentional non-adherence to medication amongst breast cancer patients
Abstract
This study aimed to investigate the prevalence of and factors associated with non-adherence to medication amongst a sample of breast cancer patients. 131 women with stable disease were interviewed and completed standardised psychological measures. 55% of women reported non-adherence to medication frequently or occasionally, with younger women and those who disliked taking their medication being significantly less adherent (P = 0.015, P = 0.001). Women who deliberately omitted taking their tablets occasionally or frequently had significantly lower scores, indicative of a weaker influence, on 'internal' and 'powerful others' dimensions of health locus of control (P = 0.032, P = 0.009). Despite a life-threatening diagnosis, patients may not adhere to medication representing a potential missed opportunity for health gain and waste of resources. Furthermore, interpretation of clinical trial data may be misleading without adherence information. More research is needed to identify those at risk for non-adherence. If other routes of administration are available these options should be discussed with patients to maximise efficacy of therapy.
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Unintentional non-adherence, such as forgetting, may be more common than intentionally missing doses.
“Unintentional non-adherence, such as forgetting, may be more common than intentionally missing doses.14–16”
Hot flushes and night sweats can compromise quality of life.
“and can compromise quality of life [17, 18].”
The lack of association between adverse effects and non-adherence is unexpected.
“The lack of association between adverse effects and non-adherence is unexpected; several papers have reported this finding (Grunfeld et al, 2005; Atkins and Fallowfield, 2006; Hershman et al, 2010a), which we failed to observe”
From Prescription refill, patient self-report and physician report in assessing adherence to oral endocrine therapy in early breast cancer patients: a retrospective cohort study in Catalonia, Spain (2012) · cites this paper as Atkins and Fallowfield, 2006
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- Authors
- Atkins, L., & Fallowfield, L.
- Affiliations
- Brighton and Sussex Medical School (GB)
- ORCID
- Fallowfield, Lesley
- Venue
- European Journal of Cancer
- Publisher
- Elsevier BV
- Published
- 2006-09
- Volume
- 42
- Issue
- 14
- Pages
- 2271-2276
- ISSN
- 0959-8049 (ISSN-L)
- OpenAlex
- W1982828937
- Cited by
- 300
- References
- 17
- Citations by year
- 2025: 5 · 2024: 5 · 2023: 11 · 2022: 17 · 2021: 14 · 2020: 11 · 2019: 5 · 2018: 9 · 2017: 15 · 2016: 13 · 2015: 19 · 2014: 19 · 2013: 15 · 2012: 19
- FWCI
- 20.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AstraZeneca
- Cancer Research UK
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Health Professions › General Health Professions › Patient-Provider Communication in Healthcare
- Keywords
- medication non-adherence, breast cancer, intentional non-adherence, health locus of control, patient attitudes toward medication, age and adherence, routes of drug administration
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antineoplastic Agents, Breast Neoplasms, Female, Humans, Middle Aged, Treatment Refusal
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