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Cited by 3,411Global Cancer Incidence and ScreeningCancer Risks and FactorsWomen's cancer prevention and management

The DOI matches its Crossref record; 42 of the 43 references it cites were found in a registry or an index.

Current and future burden of breast cancer: Global statistics for 2020 and 2040

Open access
Arnold, Melina, Morgan, Eileen, Rumgay, Harriet, Mafra, Allini, Singh, Deependra, Laversanne, Mathieu, Vignat, Jerome, Gralow, Julie R., Cardoso, Fatima, Siesling, Sabine, Soerjomataram, Isabelle·2022·The Breast
DOI 10.1016/j.breast.2022.08.010PMC PMC9465273
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Abstract

BACKGROUND: Breast cancer is the most commonly diagnosed cancer worldwide, and its burden has been rising over the past decades. In this article, we examine and describe the global burden of breast cancer in 2020 and predictions for the year 2040. METHODS: Estimates of new female breast cancer cases and deaths in 2020 were abstracted from the GLOBOCAN database. Age-standardized incidence and mortality rates were calculated per 100,000 females by country, world region, and level of human development. Predicted cases and deaths were computed based on global demographic projections for the year 2040. RESULTS: Over 2.3 million new cases and 685,000 deaths from breast cancer occurred in 2020. Large geographic variation across countries and world regions exists, with incidence rates ranging from <40 per 100,000 females in some Asian and African countries, to over 80 per 100,000 in Australia/New Zealand, Northern America, and parts of Europe. Smaller geographical variation was observed for mortality; however, transitioning countries continue to carry a disproportionate share of breast cancer deaths relative to transitioned countries. By 2040, the burden from breast cancer is predicted to increase to over 3 million new cases and 1 million deaths every year because of population growth and ageing alone. CONCLUSION: Breast cancer is the most common cancer worldwide and continues to have a large impact on the global number of cancer deaths. Global efforts are needed to counteract its growing burden, especially in transitioning countries where incidence is rising rapidly, and mortality rates remain high.

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Fig. 1 Distribution of breast cancer cases and deaths by world area in 2020.
Fig. 1 Distribution of breast cancer cases and deaths by world area in 2020.CC BY-NC-ND · PubMed Central
Fig. 2 Age-standardized breast cancer incidence (top, blue) and mortality (bottom, red) rates per 100,000 females. Breast cancer cases and deaths by country. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 2 Age-standardized breast cancer incidence (top, blue) and mortality (bottom, red) rates per 100,000 females. Breast cancer cases and deaths by country. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)CC BY-NC-ND · PubMed Central
Fig. 3 Age-standardized breast cancer incidence (top, blue) and mortality (bottom, red) rates per 100,000 females by country and world region; countries with highest and lowest rates within region mentioned with their name; full country-level results are available at gco.iarc.fr. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 3 Age-standardized breast cancer incidence (top, blue) and mortality (bottom, red) rates per 100,000 females by country and world region; countries with highest and lowest rates within region mentioned with their name; full country-level results are available at gco.iarc.fr. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)CC BY-NC-ND · PubMed Central
Fig. 4 Estimated number of breast cancer cases and deaths from 2020 to 2040, by level of Human Development Index (HDI).
Fig. 4 Estimated number of breast cancer cases and deaths from 2020 to 2040, by level of Human Development Index (HDI).CC BY-NC-ND · PubMed Central

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Metadata

Authors
Arnold, M., Morgan, E., Rumgay, H., Mafra, A., Singh, D., Laversanne, M., Vignat, J., Gralow, J. R., Cardoso, F., Siesling, S., & Soerjomataram, I.
Affiliations
  • Centre international de recherche sur le cancer (FR)
  • American Society of Clinical Oncology (US)
  • Netherlands Comprehensive Cancer Organisation (NL)
Corresponding author
Morgan, Eileen
ORCID
Venue
The Breast
Publisher
Elsevier BV
Published
2022-12
Volume
66
Pages
15-23
ISSN
0960-9776 (ISSN-L)
DOI
10.1016/j.breast.2022.08.010
PMC
PMC9465273
OpenAlex
W4294189863
Cited by
3,411
References
43
Citations by year
2026: 694 · 2025: 1176 · 2024: 997 · 2023: 516 · 2022: 23
FWCI
284.30
Type
journal article
Language
en
Open access
Licence
Locations
  • The Breast (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • University of Twente Research Information (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • University of Twente Research Information (submittedVersion, cc-by-nc-nd)
Funders
Susan G. Komen (CCR19608129)
Topics
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
Keywords
breast cancer, global burden of disease, incidence, mortality, age-standardized rates, population projections, 2040 projections, regional variation, human development, cancer epidemiology
MeSH terms
Australia, Breast Neoplasms, Europe, Female, Forecasting, Humans, Incidence

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