Lack of clinical response to deep brain stimulation of the medial forebrain bundle in depression
Open accessAbstract
Deep brain stimulation (DBS) is a promising treatment option for severe refractory major depressive disorder (MDD) [1,2]. The most common neural targets for DBS in MDD are the subcallosal cingulate cortex (SCC) and the ventral capsule/ventral striatum (VC/VS) [3–5]. The long-term clinical response after DBS to these targets has been characterized as a gradual improvement in mood, with >40% of patients reaching a responder status by 1 year [3,4].
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In a third case study, two patients with dMRI-guided DBS of the medial forebrain bundle did not reach responder status at any point over the study period of 6 months.
“In a third case study, two patients with dMRI-guided DBS of the MFB did not reach responder status at any point over the study period of 6 months [69].”
From Deep brain stimulation for depression. (2022) · cites this paper as [69]
Non-response was reported in a recent case study of two patients despite following the same tractography-based targeting method.
“Non-response, however, was reported in a recent case study of two patients despite following the same tractography-based targeting method [69].”
From Deep brain stimulation for depression. (2022) · cites this paper as [69]
Cites
Rapid effects of deep brain stimulation for treatment-resistant major depression
Schlaepfer, T. E., Bewernick, B. H., Kayser, S., Mädler, B., & Coenen, V. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.01.034 · Cited by 563 · see citing works
Riva-Posse, P., Choi, K. S., Holtzheimer, P. E., Crowell, A. L., Garlow, S. J., Rajendra, J. K., McIntyre, C. C., Gross, R. E., & Mayberg, H. S. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.59 · Cited by 441 · see citing works
Bergfeld, I. O., Mantione, M., Hoogendoorn, M. L. C., Ruhé, H. G., Notten, P., van Laarhoven, J., Visser, I., Figee, M., de Kwaasteniet, B. P., Horst, F., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0152 · Cited by 336 · see citing works
Crowell, A. L., Riva‐Posse, P., Holtzheimer, P. E., Garlow, S. J., Kelley, M. E., Gross, R. E., Denison, L., Quinn, S., & Mayberg, H. S. (2019) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2019.18121427 · Cited by 185 · see citing works
Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial
Coenen, V. A., Bewernick, B. H., Kayser, S., Kilian, H., Boström, J., Greschus, S., Hurlemann, R., Klein, M. E., Spanier, S., Sajonz, B., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0369-9 · Cited by 176 · see citing works
Closing the Loop on Deep Brain Stimulation for Treatment-Resistant Depression
Widge, A. S., Malone, D. A., & Dougherty, D. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00175 · Cited by 138 · see citing works
Fenoy, A. J., Schulz, P. E., Selvaraj, S., Burrows, C. L., Zunta-Soares, G., Durkin, K., Zanotti-Fregonara, P., Quevedo, J., & Soares, J. C. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0160-4 · Cited by 118 · see citing works
Coenen, V. A., Sajonz, B., Reisert, M., Boström, J. P., Bewernick, B. H., Urbach, H., Jenkner, C., Reinacher, P. C., Schlaepfer, T. E., & Mädler, B. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.08.020 · Cited by 90 · see citing works
van der Wal, J. M., Bergfeld, I. O., Lok, A., Mantione, M., Figee, M., Notten, P., Beute, G., Horst, F., van den Munckhof, P., Schuurman, P. R., et al. (2020) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-321758 · Cited by 79 · see citing works
Deep brain stimulation in clinical trials and animal models of depression
Hamani, C., & Nóbrega, J. N. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07414.x · Cited by 76 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Deep brain stimulation for depression.
Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175 · see citing works
The use of tractography-based targeting in deep brain stimulation for psychiatric indications
Davidson, B., Lipsman, N., Meng, Y., Rabin, J. S., Giacobbe, P., & Hamani, C. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.588423 · Cited by 15 · see citing works
Self-citation
- Authors
- Davidson, B., Giacobbe, P., Mithani, K., Levitt, A., Rabin, J. S., Lipsman, N., & Hamani, C.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- Corresponding author
- Hamani, Clement
- ORCID
- Venue
- Brain stimulation
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 13
- Issue
- 5
- Pages
- 1268-1270
- ISSN
- 1876-4754 (ISSN-L)
- 1935-861X
- OpenAlex
- W3035092608
- Cited by
- 20
- References
- 10
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain stimulation (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- deep brain stimulation, medial forebrain bundle, major depressive disorder, treatment-resistant depression, clinical response, ventral capsule/ventral striatum, mood improvement
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
