Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-κB signal in JB6 cells
Abstract
Inflammatory mediators are known to play a key role in tumorigenesis, therefore, it is a promising strategy to inhibit the inflammation for cancer prevention and/or treatment. Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells. Our results showed that CS inhibited TNF-alpha-induced NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells. Our results suggest that CS may be developed as an effective anti-inflammatory agent in the future.
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Chondroitin sulfate isolated from ascidian Styela clava inhibited phorbol ester- and TNF-α-induced expression of inflammatory factors VCAM-1, COX-2 and iNOS by blocking Akt/NF-κB activation in mouse skin.
“Chondroitin sulfate isolated from ascidian Styela clava inhibited phorbol ester- and TNF-α-induced expression of inflammatory factors VCAM-1, COX-2 and iNOS by blocking Akt/NF-κB activation in mouse skin [154,155].”
From Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects (2013) · cites this paper as [155]
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Anticancer and Cancer Preventive Properties of Marine Polysaccharides: Some Results and Prospects
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- Authors
- Xu, C.-X., Jin, H., Chung, Y.-S., Shin, J.-Y., Woo, M.-A., Lee, K.-H., Palmos, G. N., Choi, B.-D., & Cho, M.-H.
- Affiliations
- Seoul National University (KR)
- Korea Institute of Radiological and Medical Sciences (KR)
- Gyeongsang National University (KR)
- Corresponding author
- Choi, Byeong-Dae
- Cho, Myung-Haing
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 264
- Issue
- 1
- Pages
- 93-100
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W2114461174
- Cited by
- 59
- References
- 46
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 4
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- chondroitin sulfate, Styela clava, tunicates, TNF-α, inflammation, NF-κB signaling, Akt signaling, VCAM-1, inducible nitric oxide synthase, JB6 cells, anti-inflammatory agents, cancer prevention
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Line, Cell Survival, Chondroitin Sulfates, Epidermis, Inflammation, Tumor Necrosis Factor-alpha, Urochordata, Blotting, Western, Signal Transduction, Down-Regulation, NF-kappa B, Inflammation Mediators, Vascular Cell Adhesion Molecule-1, Proto-Oncogene Proteins c-akt, Mice, Nitric Oxide Synthase Type II
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