Cited by 59Proteoglycans and glycosaminoglycans researchSeaweed-derived Bioactive CompoundsNF-κB Signaling Pathways

Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-α-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-κB signal in JB6 cells

Xu, Cheng-Xiong, Jin, Hua, Chung, Youn-Sun, Shin, Ji-Young, Woo, Min-Ah, Lee, Kee-Ho, Palmos, Grace N., Choi, Byeong-Dae +1 more·2008·Cancer Letters

Abstract

Inflammatory mediators are known to play a key role in tumorigenesis, therefore, it is a promising strategy to inhibit the inflammation for cancer prevention and/or treatment. Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells. Our results showed that CS inhibited TNF-alpha-induced NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells. Our results suggest that CS may be developed as an effective anti-inflammatory agent in the future.

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Crossref · 10.1016/j.canlet.2008.01.022

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  • Chondroitin sulfate isolated from ascidian Styela clava inhibited phorbol ester- and TNF-α-induced expression of inflammatory factors VCAM-1, COX-2 and iNOS by blocking Akt/NF-κB activation in mouse skin.

    “Chondroitin sulfate isolated from ascidian Styela clava inhibited phorbol ester- and TNF-α-induced expression of inflammatory factors VCAM-1, COX-2 and iNOS by blocking Akt/NF-κB activation in mouse skin [154,155].”

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Authors
Xu, C.-X., Jin, H., Chung, Y.-S., Shin, J.-Y., Woo, M.-A., Lee, K.-H., Palmos, G. N., Choi, B.-D., & Cho, M.-H.
Affiliations
  • Seoul National University (KR)
  • Korea Institute of Radiological and Medical Sciences (KR)
  • Gyeongsang National University (KR)
Corresponding author
  • Choi, Byeong-Dae
  • Cho, Myung-Haing
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2008-06
Volume
264
Issue
1
Pages
93-100
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2114461174
Cited by
59
References
46
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 4
FWCI
1.02
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
  • Seoul National University Open Repository (Seoul National University) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords
chondroitin sulfate, Styela clava, tunicates, TNF-α, inflammation, NF-κB signaling, Akt signaling, VCAM-1, inducible nitric oxide synthase, JB6 cells, anti-inflammatory agents, cancer prevention
MeSH terms
Animals, Anti-Inflammatory Agents, Cell Line, Cell Survival, Chondroitin Sulfates, Epidermis, Inflammation, Tumor Necrosis Factor-alpha, Urochordata, Blotting, Western, Signal Transduction, Down-Regulation, NF-kappa B, Inflammation Mediators, Vascular Cell Adhesion Molecule-1, Proto-Oncogene Proteins c-akt, Mice, Nitric Oxide Synthase Type II

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