Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling

Wnt signalling in stem cells and cancer

Reya, T., & Clevers, H. (2005) · Nature · doi:10.1038/nature03319 · Cited by 3,666

WNT and β-catenin signalling: diseases and therapies

Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1427 · Cited by 1,763

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., & Niehrs, C. (2001) · Nature · doi:10.1038/35077108 · Cited by 1,042

Human Bone Marrow–Derived Mesenchymal Stem Cells in the Treatment of Gliomas

Nakamizo, A., Marini, F. C., Amano, T., Khan, A., Studeny, M., Gumin, J., Chen, J. J., Hentschel, S. J., Vecil, G. G., Dembinski, J. L., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1874 · Cited by 1,029

Notch signalling regulates stem cell numbers in vitro and in vivo

Androutsellis‐Theotokis, A., Leker, R. R., Soldner, F., Hoeppner, D. J., Ravin, R., Poser, S., Rueger, M. A., Bae, S., Kittappa, R., & McKay, R. D. G. (2006) · Nature · doi:10.1038/nature04940 · Cited by 963

Mesenchymal Stem Cells: Potential Precursors for Tumor Stroma and Targeted-Delivery Vehicles for Anticancer Agents

Studeny, M., Marini, F. C., Dembinski, J. L., Zompetta, C., Cabreira-Hansen, M. D. G., Bekele, B. N., Champlin, R. E., & Andreeff, M. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djh299 · Cited by 841

Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma

Khakoo, A. Y., Pati, S., Anderson, S. A., Reid, W., Elshal, M. F., Rovira, I. I., Nguyen, A. T., Malide, D., Combs, C. A., Hall, G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20051921 · Cited by 747

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

(1998) · British Journal of Cancer · doi:10.1038/bjc.1998.1 · Cited by 651

Trends in cancer incidence and mortality in Scotland: description and possible explanations

Swerdlow, A. J., Silva, I. D. S., Reid, A., Qiao, Z., Brewster, D., & Arrundale, J. (1998) · British Journal of Cancer · doi:10.1038/bjc.1998.424 · Cited by 531

One strategy for cell and gene therapy: Harnessing the power of adult stem cells to repair tissues

Prockop, D. J., Gregory, C. A., & Spees, J. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834138100 · Cited by 417

Suppression of tumorigenesis by human mesenchymal stem cells in a hepatoma model

Qiao, L., Xu, Z., Zhao, T., Zhao, Z., Shi, M., Zhao, R. C., Ye, L., & Zhang, X. (2008) · Cell Research · doi:10.1038/cr.2008.40 · Cited by 390

The Wnt antagonist DICKKOPF-1 gene is a downstream target of β-catenin/TCF and is downregulated in human colon cancer

González‐Sancho, J. M., Aguilera, Ó., García, J. M., Pendás-Franco, N., Peña, C., Cal, S., de Herreros, A. G., Bonilla, F., & Múñoz, A. (2004) · Oncogene · doi:10.1038/sj.onc.1208303 · Cited by 370

Expression Profiling and Functional Analysis of Wnt Signaling Mechanisms in Mesenchymal Stem Cells

Etheridge, S. L., Spencer, G. J., Heath, D. J., & Genever, P. G. (2004) · Stem Cells · doi:10.1634/stemcells.22-5-849 · Cited by 353

Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer

Aguilera, Ó., Fraga, M. F., Ballestar, E., Paz, M. F., Herranz, M., Espada, J., García, J. M., Múñoz, A., Esteller, M., & González‐Sancho, J. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209439 · Cited by 340

Prostate Cancer Cells Promote Osteoblastic Bone Metastases through Wnts

Hall, C. L., Bafico, A., Dai, J., Aaronson, S. A., & Keller, E. T. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1317 · Cited by 308

The Wnt Signaling Inhibitor Dickkopf-1 Is Required for Reentry into the Cell Cycle of Human Adult Stem Cells from Bone Marrow

Gregory, C. A., Singh, H., Perry, A. S., & Prockop, D. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300373200 · Cited by 284

Expression of Concern: Up‐regulation of Wnt‐1 and β‐catenin production in patients with advanced metastatic prostate carcinoma

Chen, G., Shukeir, N., Potti, A., Sircar, K., Aprikian, A., Goltzman, D., & Rabbani, S. A. (2004) · Cancer · doi:10.1002/cncr.20518 · Cited by 283

Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc

Muncan, V., Sansom, O. J., Tertoolen, L. G. J., Phesse, T. J., Begthel, H., Sancho, E., Cole, A. M., Gregorieff, A., de Alborán, I. M., Clevers, H. C., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00821-06 · Cited by 249

Regulation of Wnt/LRP Signaling by Distinct Domains of Dickkopf Proteins

Brott, B. K., & Sokol, S. Y. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6100-6110.2002 · Cited by 234

Mesenchymal–epithelial interactions in the skin

Yamaguchi, Y., Itami, S., Watabe, H., Yasumoto, K., ABDEL‐MALEK, Z. A., Kubo, T., Rouzaud, F., Tanemura, A., Yoshikawa, K., & Hearing, V. J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200311122 · Cited by 232

The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo

Lu, Y.-R., Yuan, Y., Wang, X.-J., Wei, L.-L., Chen, Y.-N., Cong, C., Li, S.-F., Long, D., Tan, W.-D., Mao, Y.-Q., et al. (2008) · Cancer Biology & Therapy · doi:10.4161/cbt.7.2.5296 · Cited by 225

Expression of Dickkopf genes is strongly reduced in malignant melanoma

Kuphal, S., Lodermeyer, S., Bataille, F., Schuierer, M. M., Hoang, B. H., & Bosserhoff, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209508 · Cited by 222

The Wnt Signaling Receptor Lrp5 Is Required for Mammary Ductal Stem Cell Activity and Wnt1-induced Tumorigenesis

Lindvall, C. J., Evans, N. C., Diegel, C. R., Li, Y., Alexander, C. M., & Williams, B. O. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607571200 · Cited by 169

Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

Shou, J., Ali‐Osman, F., Multani, A. S., Pathak, S., Fedi, P., & Srivenugopal, K. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205138 · Cited by 164

Wnt Signaling Regulates the Invasion Capacity of Human Mesenchymal Stem Cells

Neth, P., Karow, M., Egea, V., Hoelters, J., Jochum, M., & Ries, C. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0503 · Cited by 152

Regulated subset of G 1 growth-control genes in response to derepression by the Wnt pathway

Baek, S. H., Kioussi, C., Briata, P., Wang, D., Nguyen, H., Ohgi, K. A., Glass, C. K., Wynshaw-Boris, A. J., Rose, D. W., & Rosenfeld, M. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0330217100 · Cited by 148

PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model

Kim, S., Cargioli, T. G., Machluf, M., Yang, W., Sun, Y., Al-Hashem, R., Kim, S. U., Black, P. M., & Carroll, R. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0371 · Cited by 134

APC dosage effects in tumorigenesis and stem cell differentiation

Gaspar, C., & Fodde, R. (2004) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041807cg · Cited by 123

Interleukin-23–Expressing Bone Marrow–Derived Neural Stem-Like Cells Exhibit Antitumor Activity against Intracranial Glioma

Yuan, X., Hu, J., Belladonna, M. L., Black, K. L., & Yu, J. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1682 · Cited by 121

Wnt/β-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC

Yang, F., Zeng, Q., Yu, G., Li, H., & Wang, C. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.06.015 · Cited by 105

Interleukin-23-expressing Bone Marrow-derived Neural Stem-like Cells Exhibit Antitumor Activity against Intracranial Glioma

Yu, J. S., Yuan, X., Liu, G., Zeng, Z., Morris-Irvin, D., & Black, K. L. (2005) · Neurosurgery · doi:10.1093/neurosurgery/57.2.411a · Cited by 104

A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation

Mikheev, A. M., Mikheeva, S. A., Liu, B., Cohen, P., & Zarbl, H. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg190 · Cited by 95

Expression of secreted Wnt antagonists in gastrointestinal tissues: potential role in stem cell homeostasis

Byun, T., Karimi, M., Marsh, J., Milovanović, T., Lin, F., & Holcombe, R. F. (2005) · Journal of Clinical Pathology · doi:10.1136/jcp.2004.018598 · Cited by 87

FTY720, a fungus metabolite, inhibits in vivo growth of androgen‐independent prostate cancer

Chua, C. W., Lee, D. T., Ling, M., Zhou, C., Man, K., Ho, J., Chan, F. L., Wang, X., & Wong, Y. C. (2005) · International Journal of Cancer · doi:10.1002/ijc.21243 · Cited by 79

NF-κB downregulation may be involved the depression of tumor cell proliferation mediated by human mesenchymal stem cells

Qiao, L., Zhao, T., Wang, F.-Z., Shan, C., Ye, L., & Zhang, X. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00751.x · Cited by 63

A comparative study of the expression of Wnt-1, WISP-1, survivin and cyclin-D1 in colorectal carcinoma

Khor, T. O., Gul, Y. A., Ithnin, H., & Seow, H. F. (2005) · International Journal of Colorectal Disease · doi:10.1007/s00384-005-0002-8 · Cited by 46

Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells

Wang, F.-Z., Li, S. H. A., Zhang, W., Wu, L., Qiao, L., Li, N., Zhang, X., & Ye, L. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00531.x · Cited by 41

Establishment and properties of fetal dermis-derived mesenchymal stem cell lines: plasticity in vitro and hematopoietic protection in vivo

Zhao, Z., Liao, L., Cao, Y., Jiang, X., & Zhao, R. C. (2005) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705062 · Cited by 33

Close apposition of dynorphin-positive nerve fibres to lymphocytes in the liver suggests opioidergic neuroimmunomodulation

Kaiser, M., Tiegs, G., & Neuhuber, W. (2003) · Histochemistry and Cell Biology · doi:10.1007/s00418-003-0561-0 · Cited by 22

Present results and perspectives of allogeneic non-myeloablative hematopoietic stem cell transplantation for treatment of human solid tumors

Renga, M., Pedrazzoli, P., & Siena, S. (2003) · Annals of Oncology · doi:10.1093/annonc/mdg317 · Cited by 22

Mesenchymale Stammzellen des Knochenmarks

Wulf, G. G., Chapuy, B., & Trümper, L. H. P. (2006) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-006-1052-6 · Cited by 19

Embryonic stem cells: a great hope for a new era of medicine.

Tutter, A. V., Baltus, G. A., & Kadam, S. (2006) · PubMed · Cited by 11

Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth?

Klopp, A. H., Gupta, A., Spaeth, E., Andreeff, M., & Marini, F. (2011) · Stem Cells · doi:10.1002/stem.559 · Cited by 562

Mesenchymal Stem Cell Delivery of TRAIL Can Eliminate Metastatic Cancer

Loebinger, M. R., Eddaoudi, A., Davies, D., & Janes, S. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4698 · Cited by 417

Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production

McLean, K., Gong, Y., Choi, Y., Deng, N., Yang, K., Bai, S., Cabrera, L., Keller, E., McCauley, L., Cho, K. R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45273 · Cited by 380

Therapeutic Potential of Mesenchymal Stem Cells for Cancer Therapy

Hmadcha, A., Martín‐Montalvo, A., Gauthier, B. R., Soria, B., & Capilla‐González, V. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00043 · Cited by 346

Tumor microenvironment promotes breast cancer chemoresistance

Mehraj, U., Dar, A. H., Wani, N. A., & Mir, M. A. (2021) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-020-04222-w · Cited by 294

Investigation of Inhibition of Wnt/β-catenin Pathway in Breast Cancer Cells Mediated by Dkk-1 Released From Human Mesenchymal Stem Cells

乔玲, 徐治立, 谭旭, 叶丽虹, & 张晓东 (2007) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · Cited by 3

Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK-1

Zhu, Y., Sun, Z., Han, Q., Liao, L., Wang, J., Bian, C., Li, J., Yan, X., Liu, Y., Shao, C., et al. (2009) · Leukemia · doi:10.1038/leu.2008.384 · Cited by 347

Perichondrium mesenchymal stem cells inhibit the growth of breast cancer cells via the DKK-1/Wnt/β-catenin signaling pathway

Li, M., Cai, H., Yang, Y. P., Zhang, J., Sun, K., Yan, Y., Qu, H., Wang, W., Wang, J., & Duan, X. (2016) · Oncology Reports · doi:10.3892/or.2016.4853 · Cited by 27

Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt/β-catenin signaling

Zhou, X., Qin, X., Zhang, X., & Ye, L. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.200 · Cited by 47

Chemotherapy-induced Dkk-1 expression by primary human mesenchymal stem cells is p53 dependent

Hare, I., Evans, R., Fortney, J. E., Moses, B. S., Piktel, D., Slone, W. L., & Gibson, L. F. (2016) · Medical Oncology · doi:10.1007/s12032-016-0826-9 · Cited by 4