The growth inhibitory effect of mesenchymal stem cells on tumor cells in vitro and in vivo
Open accessAbstract
Mesenchymal stem cells (MSCs) play an important role in the development and growth of tumor cells. The purpose of this study is to confirm the effect of MSCs on tumor cell growth in vitro and in vivo and to elucidate the mechanism. MSCs were isolated from mouse bone marrow and cocultured with murine hepatoma H22, lymphoma (YAC-1 and EL-4) and rat insulinoma INS-1 cell lines. The growth inhibitory effect of MSCs on tumor cells was tested through MTT and 3H-TdR incorporation assay. The apoptosis induction effect of MSCs on tumor cells was assessed with flow cytometry (FCM) and RT-PCR assay. MSCs were inoculated into BALB/c mice alone or coinoculated with ascitogenous hepatoma cells intraperitonealy, respectively. The tumor growth inhibition of MSCs was investigaed through the incidence and volume of ascites formation, and the immunosuppression effect was studied with splenocyte response to ConA stimulation test and T cell subsets analysis (FCM). The results showed that MSCs exhibited a number-dependent growth inhibitory effect on murine tumor cell lines in vitro and inhibited the growth of ascitogenous hepatoma cells in vivo without host immunosuppression. MSCs could upregulate tumor cells mRNA expression of cell cycle negative regulator p21 and apoptosis associated protease caspase 3. The findings of this experimental study demonstrated that MSCs had potential inhibitory effects on tumor cell growth in vitro and in vivo without host immunosuppression, by inducing apoptotic cell death and G(0)/G(1) phase arrest of cancer cells.
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MSC-derived secretome promotes cell cycle arrest and induction of apoptosis through upregulation of pro-apoptotic Bax and p21, and downregulation of anti-apoptotic Bcl2, Survivin and Xiap genes.
“MSC-derived secretome promote cell cycle arrest and induction of apoptosis through the upregulation of pro-apoptotic Bax gene and negative regulator of cell cycle such as p21, and downregulation of anti-apoptotic Bcl2, Survinin and Xiap genes [108], [109], [110], [111], [112].”
From Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? (2025) · cites this paper as [108]
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Ge, X., Lv, X., Feng, L., Liu, X., Gao, J., Chen, N., & Wang, X. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039449 · Cited by 30 · see citing works
Self-citationBianchi, G., Morandi, F., Cilli, M., Daga, A., Bocelli‐Tyndall, C., Gambini, C., Pistoia, V., & Raffaghello, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048654 · Cited by 28 · see citing works
Rationale and Design of the SENECA (StEm cell iNjECtion in cAncer survivors) Trial
Bolli, R., Hare, J. M., Henry, T. D., Lenneman, C. G., March, K. L., Miller, K. D., Pepine, C. J., Perin, E. C., Traverse, J. H., Willerson, J. T., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.02.009 · Cited by 29 · see citing works
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Afkhami, H., Mahmoudvand, G., Fakouri, A., Shadab, A., Mahjoor, M., & Komeili Movahhed, T. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1255697 · Cited by 27 · see citing works
Role of stem cells during diabetic liver injury
Wan, Y., Garner, J., Wu, N., Levine, P., Han, Y., McDaniel, K. M., Annable, T., Zhou, T., Francis, H., Glaser, S. S., et al. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12723 · Cited by 27 · see citing works
- Authors
- Lu, Y.-R., Yuan, Y., Wang, X.-J., Wei, L.-L., Chen, Y.-N., Cong, C., Li, S.-F., Long, D., Tan, W.-D., Mao, Y.-Q., Zhang, J., Li, Y.-P., & Cheng, J.-Q.
- Affiliations
- Sichuan University (CN)
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2008-02-04
- Volume
- 7
- Issue
- 2
- Pages
- 245-251
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- OpenAlex
- W2065902307
- Cited by
- 225
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 11 · 2023: 12 · 2022: 12 · 2021: 13 · 2020: 14 · 2019: 21 · 2018: 10 · 2017: 12 · 2016: 7 · 2015: 23 · 2014: 24 · 2013: 14 · 2012: 11
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cancer Biology & Therapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30270588)
- National Key Research and Development Program of China (2003CB515504)
- Program for Changjiang Scholars and Innovative Research Team in University
- Topics
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Keywords
- mesenchymal stem cells, tumor cell growth inhibition, apoptosis, p21, caspase-3, G0/G1 cell cycle arrest, hepatocellular carcinoma, lymphoma, insulinoma, ascites, immunosuppression, bone marrow-derived stem cells, tumor microenvironment
- MeSH terms
- Animals, Cell Cycle, Cell Survival, Male, Mice, Inbred BALB C, Neoplasm Transplantation, Neoplasms, Spleen, Tetrazolium Salts, Time Factors, Apoptosis, Coculture Techniques, Cell Line, Tumor, Cell Proliferation, Mice, Rats, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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