WNT and β-catenin signalling: diseases and therapies
Abstract
WNT signalling has been studied primarily in developing embryos, in which cells respond to WNTs in a context-dependent manner through changes in survival and proliferation, cell fate and movement. But WNTs also have important functions in adults, and aberrant signalling by WNT pathways is linked to a range of diseases, most notably cancer. What is the full range of diseases that involve WNT pathways? Can inhibition of WNT signalling form the basis of an effective therapy for some cancers? Could activation of WNT signalling provide new therapies for other clinical conditions? Finally, on the basis of recent experiments, might WNTs normally participate in self-renewal, proliferation or differentiation of stem cells? If so, altering WNT signalling might be beneficial to the use of stem cells for therapeutic means.
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Uneven activation of the Wnt/β-catenin pathway has led to the development of a variety of human tumours.
“Uneven activation of the Wnt/β-catenin pathway has led to the development of a variety of human tumours [56], [57].”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [56]
When WNT ligands are present, β-catenin degradation is impeded, causing its nuclear translocation and subsequent binding to T-cell factor (TCF), which results in the transcriptional activation of their target genes.
“When WNT ligands are present, β-catenin degradation is impeded, causing its nuclear translocation and subsequent binding to T-cell factor (TCF), which results in the transcriptional activation of their target genes.443,445,446”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [445]
Wnt2 and other proteins usually linked to neural development might also play significant roles in regulating neuronal function after critical periods.
“nonetheless, Wnt2 and other proteins traditionally associated with neural development may have important roles in post-critical period regulation of neuronal function (Farias et al., 2007; Moon et al., 2004; Wayman et al., 2006).”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Moon et al., 2004
Cites
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864 · see citing works
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,515 · see citing works
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257 · see citing works
LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development
Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235 · see citing works
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159 · see citing works
Sato, N., Meijer, L., Skaltsounis, A., Greengard, P., & Brivanlou, A. H. (2003) · Nature Medicine · doi:10.1038/nm979 · Cited by 2,107 · see citing works
GSK-3: tricks of the trade for a multi-tasking kinase
Doble, B. W., & Woodgett, J. R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00384 · Cited by 2,084 · see citing works
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
van de Wetering, M., Sancho, E., Verweij, C., de Lau, W., Oving, I., Hurlstone, A., van der Horn, K., Batlle, E., Coudreuse, D., Haramis, A.-P., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)01014-0 · Cited by 2,030 · see citing works
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
Wodarz, A., & Nusse, R. (1998) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.14.1.59 · Cited by 2,017 · see citing works
Inhibition of Adipogenesis by Wnt Signaling
Ross, S. E., Hemati, N., Longo, K. A., Bennett, C. N., Lucas, P. C., Erickson, R. L., & MacDougald, O. A. (2000) · Science · doi:10.1126/science.289.5481.950 · Cited by 1,876 · see citing works
Socializing with the Neighbors
Fuchs, E. V., Tumbar, T., & Guasch, G. (2004) · Cell · doi:10.1016/s0092-8674(04)00255-7 · Cited by 1,711 · see citing works
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
Kořínek, V., Barker, N., Moerer, P., van Donselaar, E. V., Huls, G., Peters, P., & Clevers, H. (1998) · Nature Genetics · doi:10.1038/1270 · Cited by 1,704 · see citing works
Kim, J., Auerbach, J. M., Rodríguez‐Gómez, J. A., Velasco, I., Gavin, D. K., Lumelsky, N. L., Lee, S., Nguyen, J., Sánchez‐Pernaute, R., Bankiewicz, K. S., et al. (2002) · Nature · doi:10.1038/nature00900 · Cited by 1,598 · see citing works
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591 · see citing works
Caught up in a Wnt storm: Wnt signaling in cancer
Giles, R. H., van Es, J. H., & Clevers, H. (2003) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(03)00005-2 · Cited by 1,482 · see citing works
Control of osteoblast function and regulation of bone mass
Harada, S.-I., & Rodan, G. A. (2003) · Nature · doi:10.1038/nature01660 · Cited by 1,451 · see citing works
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431 · see citing works
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359 · see citing works
Self-citationLittle, R. D., Folz, C., Manning, S. P., Swain, P. M., Zhao, S.-C., Eustace, B., Lappe, M. M., Spitzer, L., Zweier, S., Braunschweiger, K., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/338450 · Cited by 1,282 · see citing works
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
Phiel, C. J., Wilson, C., Lee, V. M. ‐., & Klein, P. S. (2003) · Nature · doi:10.1038/nature01640 · Cited by 1,200 · see citing works
Terry, A. V., & Buccafusco, J. J. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.041616 · Cited by 1,159 · see citing works
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
Suzuki, H., Watkins, D. N., Jair, K.-W., Schuebel, K. E., Markowitz, S. D., Chen, W. D., Pretlow, T. P., Yang, B., Akiyama, Y., van Engeland, M., et al. (2004) · Nature Genetics · doi:10.1038/ng1330 · Cited by 1,070 · see citing works
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
He, X., Semenov, M., Tamai, K., & Zeng, X. (2004) · Development · doi:10.1242/dev.01117 · Cited by 1,044 · see citing works
The Promise and Perils of Wnt Signaling Through β-Catenin
Moon, R. T., Bowerman, B. A., Boutros, M., & Perrimon, N. (2002) · Science · doi:10.1126/science.1071549 · Cited by 970 · see citing works
Self-citationWnt5a signaling directly affects cell motility and invasion of metastatic melanoma
Weeraratna, A. T., Jiang, Y., Hostetter, G. H., Rosenblatt, K. P., Duray, P. H., Bittner, M. L., & Trent, J. M. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00045-4 · Cited by 960 · see citing works
Vascular Development in the Retina and Inner Ear
Xu, Q., Wang, Y., Dabdoub, A., Smallwood, P. M., Williams, J., Woods, C., Kelley, M. W., Jiang, L., Tasman, W., Zhang, K., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00216-8 · Cited by 875 · see citing works
Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation
Topol, L. Z., Jiang, X., Choi, H., Garrett-Beal, L. J., Carolan, P. J., & Yang, Y. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200303158 · Cited by 724 · see citing works
Aberrant Wnt/β-Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis
Chilosi, M., Poletti, V., Zamò, A., Lestani, M., Montagna, L., Piccoli, P., Pedron, S., Bertaso, M., Scarpa, A., Murer, B., et al. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64282-4 · Cited by 708 · see citing works
Mutations in AXIN2 Cause Familial Tooth Agenesis and Predispose to Colorectal Cancer
Lammi, L., Arte, S., Somer, M., Järvinen, H., Lahermo, P., Thesleff, I., Pirinen, S., & Nieminen, P. (2004) · The American Journal of Human Genetics · doi:10.1086/386293 · Cited by 689 · see citing works
Small-molecule antagonists of the oncogenic Tcf/β-catenin protein complex
Lepourcelet, M., Chen, Y.-N. P., France, D. S., Wang, H., Crews, P., Petersen, F., Bruseo, C. W., Wood, A. W., & Shivdasani, R. A. (2004) · Cancer Cell · doi:10.1016/s1535-6108(03)00334-9 · Cited by 653 · see citing works
Kuhnert, F., Davis, C. R., Wang, H.-T., Chu, P., Lee, M. A., Yuan, J., Nusse, R., & Kuo, C. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2536800100 · Cited by 638 · see citing works
A common human skin tumour is caused by activating mutations in β-catenin
Chan, E., Gat, U., McNiff, J. M., & Fuchs, E. (1999) · Nature Genetics · doi:10.1038/7747 · Cited by 612 · see citing works
New aspects of Wnt signaling pathways in higher vertebrates
Huelsken, J., & Birchmeier, W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00231-8 · Cited by 552 · see citing works
Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
Pandur, P., Läsche, M., Eisenberg, L. M., & Kühl, M. (2002) · Nature · doi:10.1038/nature00921 · Cited by 536 · see citing works
Polesskaya, A., Seale, P., & Rudnicki, M. A. (2003) · Cell · doi:10.1016/s0092-8674(03)00437-9 · Cited by 515 · see citing works
Alzheimer's disease – do tauists and baptists finally shake hands?
Mudher, A. K., & Lovestone, S. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)02031-2 · Cited by 512 · see citing works
Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
Zhang, Z., Hartmann, H., Do, V. M., Abramowski, D., Sturchler, C., Staufenbiel, M., Sommer, B., van de Wetering, M., Clevers, H. C., Säftig, P., et al. (1998) · Nature · doi:10.1038/27208 · Cited by 511 · see citing works
Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
Robitaille, J. M., MacDonald, M. L. E., Kaykas, A., Sheldahl, L. C., Zeisler, J., Dubé, M., Zhang, L., Singaraja, R. R., Guernsey, D. L., Zheng, B., et al. (2002) · Nature Genetics · doi:10.1038/ng957 · Cited by 482 · see citing works
Self-citationSocial interaction and sensorimotor gating abnormalities in mice lacking Dvl1
Lijam, N., Paylor, R., McDonald, M. P., Crawley, J. N., Deng, C.-X., Herrup, K., Stevens, K. E., Maccaferri, G., McBain, C. J., Sussman, D. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80354-2 · Cited by 470 · see citing works
Bodine, P. V. N., Zhao, W., Kharode, Y. P., Bex, F. J., Lambert, A.-J., Goad, M. B., Gaur, T., Stein, G. S., Lian, J. B., & Komm, B. S. (2004) · Molecular Endocrinology · doi:10.1210/me.2003-0498 · Cited by 450 · see citing works
Activation of the Wnt signaling pathway in chronic lymphocytic leukemia
Lu, D., Zhao, Y., Tawatao, R. I., Cottam, H. B., Sen, M., Leoni, L. M., Kipps, T. J., Corr, M., & Carson, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308648100 · Cited by 420 · see citing works
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells
Hori, Y., Rulifson, I. C., Tsai, B. C., Heit, J. J., Cahoy, J. D., & Kim, S. K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.252618999 · Cited by 419 · see citing works
Instructive Role of Wnt/ß-Catenin in Sensory Fate Specification in Neural Crest Stem Cells
Lee, H.-Y., Kléber, M., Hari, L., Brault, V., Suter, U., Taketo, M. M., Kemler, R., & Sommer, L. (2004) · Science · doi:10.1126/science.1091611 · Cited by 418 · see citing works
Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
Takashima, A., Murayama, M., Murayama, O., Kohno, T., Honda, T., Yasutake, K., Nihonmatsu, N., Mercken, M. H., Yamaguchi, H., Sugihara, S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9637 · Cited by 404 · see citing works
Loughlin, J. A., Dowling, B., Chapman, K. E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403456101 · Cited by 402 · see citing works
Sizing up the heart: development redux in diseasePreprint
Olson, E. N., & Schneider, M. D. (2003) · Genes & Development · doi:10.1101/gad.1110103 · Cited by 382 · see citing works
Toomes, C., Bottomley, H. M., Jackson, R. M., Towns, K. V., Scott, S., Mackey, D. A., Craig, J. E., Jiang, L., Yang, Z., Trembath, R. C., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/383202 · Cited by 381 · see citing works
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
Castelo‐Branco, G., Wagner, J., Rodríguez, F. J., Kele, J., Sousa, K. M., Rawal, N., Pasolli, H. A., Fuchs, E. V., Kitajewski, J., & Arenas, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1534900100 · Cited by 367 · see citing works
Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
Kielman, M. F., Rindapää, M., Gaspar, C., van Poppel, N., Breukel, C., van Leeuwen, S., Taketo, M. M., Roberts, S., Smits, R., & Fodde, R. (2002) · Nature Genetics · doi:10.1038/ng1045 · Cited by 362 · see citing works
Ferrari, G. V. D., Chacón, M. A., Barría, M. I., Garrido, J., Godoy, J. A., Olivares, G. H., Reyes, A. E., Alvarez, A. R., Bronfman, M., & Inestrosa, N. C. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001208 · Cited by 331 · see citing works
Self-citationWnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue
Liang, H., Chen, Q., Coles, A. H., Anderson, S. J., Pihan, G. A., Bradley, A., Gerstein, R. M., Jurecic, R., & Jones, S. N. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00268-x · Cited by 329 · see citing works
β-Catenin Is Required for Specification of Proximal/Distal Cell Fate during Lung Morphogenesis
Mucenski, M. L., Wert, S. E., Nation, J. M., Loudy, D. E., Huelsken, J., Birchmeier, W., Morrisey, E. E., & Whitsett, J. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305892200 · Cited by 322 · see citing works
Linkage of a Gene Causing High Bone Mass to Human Chromosome 11 (11q12-13)
Johnson, M. L., Gong, G., Kimberling, W., et al. (1997) · The American Journal of Human Genetics · doi:10.1086/515470 · Cited by 321 · see citing works
Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression
Uematsu, K., He, B., You, L., Xu, Z., McCormick, F. P., & Jablons, D. M. (2003) · Oncogene · doi:10.1038/sj.onc.1206817 · Cited by 314 · see citing works
Frizzled6 controls hair patterning in mice
Guo, N., Hawkins, C. E., & Nathans, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402802101 · Cited by 313 · see citing works
Cheon, S. S., Cheah, A. Y. L., Turley, S., Nadesan, P., Poon, R. W. M., Clevers, H. C., & Alman, B. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102657399 · Cited by 312 · see citing works
Homozygous WNT3 Mutation Causes Tetra-Amelia in a Large Consanguineous Family
Niemann, S., Zhao, C., Pascu, F., Stahl, U., Aulepp, U., Niswander, L. A., Weber, J. L., & Müller, U. (2004) · The American Journal of Human Genetics · doi:10.1086/382196 · Cited by 311 · see citing works
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
Derksen, P. W. B., Tjin, E. P. M., Meijer, H. P., Klok, M. D., MacGillavry, H. D., van Oers, M. H. J., Lokhorst, H. M., Bloem, A. C., Clevers, H. C., Nusse, R., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305855101 · Cited by 306 · see citing works
Thompson, W. J., Piazza, G. A., Li, H., Liu, L., Fetter, J. R., Zhu, B., Sperl, G. J., Ahnen, D. J., & Pamukcu, R. (2000) · PubMed · Cited by 305 · see citing works
Liu, B. Y., McDermott, S., Khwaja, S. S., & Alexander, C. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400699101 · Cited by 293 · see citing works
Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm
Okubo, T., & Hogan, B. L. M. (2004) · Journal of Biology · doi:10.1186/jbiol3 · Cited by 290 · see citing works
Wnt signaling function in Alzheimer’s disease
Ferrari, G. V. D., & Inestrosa, N. C. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00021-7 · Cited by 288 · see citing works
Self-citationbeta-Catenin regulates vascular endothelial growth factor expression in colon cancer.
Easwaran, V., Lee, S. H., Inge, L. J., Guo, L., Goldbeck, C., Garrett, E. N., Wiesmann, M., García, P. D., Fuller, J. H., Chan, V. W.-F., et al. (2003) · PubMed · Cited by 273 · see citing works
Westfall, T. A., Brimeyer, R., Twedt, J., Gladon, J., Olberding, A., Furutani‐Seiki, M., & Slusarski, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200303107 · Cited by 271 · see citing works
Lithium protects cultured neurons against β‐amyloid‐induced neurodegeneration
Alvarez, G., Muñoz-Montaño, J. R., Satrústegui, J., Ávila, J., Bogónez, E., & Díaz‐Nido, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00685-7 · Cited by 270 · see citing works
A Monoclonal Antibody against Wnt-1 Induces Apoptosis in Human Cancer Cells
He, B., You, L., Uematsu, K., Xu, Z., Lee, A. Y., Matsangou, M., McCormick, F. P., & Jablons, D. M. (2004) · Neoplasia · doi:10.1016/s1476-5586(04)80048-4 · Cited by 270 · see citing works
Kratochwil, K., Galcerán, J., Tontsch, S., Roth, W., & Grosschedl, R. (2002) · Genes & Development · doi:10.1101/gad.1035602 · Cited by 270 · see citing works
You, L., He, B., Xu, Z., Uematsu, K., Mazières, J., Mikami, I., Reguart, N., Moody, T. W., Kitajewski, J., McCormick, F. P., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1207844 · Cited by 258 · see citing works
A Wnt- and β-catenin-dependent pathway for mammalian cardiac myogenesis
Nakamura, T., Sano, M., Songyang, Z., & Schneider, M. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0935626100 · Cited by 248 · see citing works
Tan, C., Costello, P., Sanghera, J. S., Dominguez-Sola, D., Baulida, J., de Herreros, A. G., & Dedhar, S. (2001) · Oncogene · doi:10.1038/sj.onc.1204052 · Cited by 248 · see citing works
Zhu, A. J., & Watt, F. M. (1999) · Development · doi:10.1242/dev.126.10.2285 · Cited by 240 · see citing works
Presenilin Couples the Paired Phosphorylation of β-Catenin Independent of Axin
Kang, D. E., Soriano, S., Xia, X., Eberhart, C. G., Strooper, B. D., Zheng, H., & Koo, E. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00970-4 · Cited by 232 · see citing works
Nishimura, M., Yu, G., Lévesque, G., Zhang, D. M., Ruel, L., Chen, F., Milman, P., Holmes, E., Liang, Y., Kawarai, T., et al. (1999) · Nature Medicine · doi:10.1038/5526 · Cited by 218 · see citing works
Wnt2b controls retinal cell differentiation at the ciliary marginal zone
Kubo, F., Takeichi, M., & Nakagawa, S. (2003) · Development · doi:10.1242/dev.00244 · Cited by 215 · see citing works
Murdoch, B., Chadwick, K., Martin, M. A., Shojaei, F., Shah, K. V., Gallacher, L. M., Moon, R. T., & Bhatia, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0130233100 · Cited by 214 · see citing works
Self-citationImpact of p53 loss on reversal and recurrence of conditional Wnt-induced tumorigenesisPreprint
Gunther, E. J., Moody, S. E., Belka, G. K., Hahn, K. T., Innocent, N., Dugan, K. D., Cardiff, R. D., & Chodosh, L. A. (2003) · Genes & Development · doi:10.1101/gad.1051603 · Cited by 214 · see citing works
Reduction of Infarct Size and Prevention of Cardiac Rupture in Transgenic Mice Overexpressing FrzA
Barandon, L., Couffinhal, T., Ezan, J., Dufourcq, P., Costet, P., Alzieu, P., Leroux, L., Moreau, C., Dare, D., & Duplàa, C. (2003) · Circulation · doi:10.1161/01.cir.0000093186.22847.4c · Cited by 211 · see citing works
Chakrabarty, S., Radjendirane, V., Appelman, H. D., & Varani, J. (2003) · PubMed · Cited by 208 · see citing works
Kahler, R. A., & Westendorf, J. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211443200 · Cited by 193 · see citing works
Jordan, B. K., Shen, J. H.-C., Olaso, R., Ingraham, H. A., & Vilain, E. J. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1834480100 · Cited by 192 · see citing works
Boon, E. M. J., Keller, J. J., Wormhoudt, T. A. M., et al. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601505 · Cited by 190 · see citing works
Kaykas, A., Yang-Snyder, J., Héroux, M., Shah, K. V., Bouvier, M., & Moon, R. T. (2003) · Nature Cell Biology · doi:10.1038/ncb1081 · Cited by 174 · see citing works
Self-citationThe LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd
Zhang, Y., Wang, Y., Li, X., Zhang, J., Mao, J., Li, Z., Zheng, J., Li, L., Harris, S., & Wu, D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.11.4677-4684.2004 · Cited by 164 · see citing works
Terada, Y., Tanaka, H., Okado, T., Shimamura, H., Inoshita, S., Kuwahara, M., & Sasaki, S. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000060577.94532.06 · Cited by 162 · see citing works
Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100
Sun, X., Sato, S., Murayama, O., Murayama, M., Park, J.-M., Yamaguchi, H., & Takashima, A. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02583-6 · Cited by 161 · see citing works
Increased expression of Wnt-1 in schizophrenic brains
Miyaoka, T., Seno, H., & Ishino, H. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00179-0 · Cited by 161 · see citing works
Tolwinski, N. S., & Wieschaus, E. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.02.003 · Cited by 151 · cited 1× · see citing works
“A core set of proteins and an ever-growing list of proteins that modify their function have been identified in this way, as thoroughly reviewed elsewher”
BackgroundCheon, S. S., Nadesan, P., Poon, R. W. M., & Alman, B. A. (2003) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.09.029 · Cited by 143 · see citing works
GSK-3 and the neurodevelopmental hypothesis of schizophrenia
Kozlovsky, N., Belmaker, R. H., & Agam, G. (2002) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(01)00131-6 · Cited by 128 · see citing works
Suksaweang, S., Lin, C., Jiang, T., Hughes, M. W., Widelitz, R. B., & Chuong, C. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.10.010 · Cited by 127 · see citing works
Caricasole, A., Copani, A., Caruso, A., Caraci, F., Iacovelli, L., Sortino, M. A., Terstappen, G. C., & Nicoletti, F. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00100-7 · Cited by 124 · see citing works
Mudher, A. K., Chapman, S. C., Richardson, J. C., Asuni, A. A., Gibb, G., Pollard, C. C., Killick, R., Iqbal, T. A., Raymond, F. L., Varndell, I. M., et al. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-14-04987.2001 · Cited by 122 · see citing works
Wnt Signaling and Pulmonary Fibrosis
Morrisey, E. E. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64271-x · Cited by 119 · see citing works
Nath, N., Kashfi, K., Chen, J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2134840100 · Cited by 117 · see citing works
Chang, C., Jiang, T., Lin, C., Burrus, L. W., Chuong, C., & Widelitz, R. B. (2004) · Mechanisms of Development · doi:10.1016/j.mod.2003.12.004 · Cited by 117 · see citing works
Kondo, H. (2003) · British Journal of Ophthalmology · doi:10.1136/bjo.87.10.1291 · Cited by 115 · see citing works
Ouko, L., Ziegler, T. R., Gu, L. H., Eisenberg, L. M., & Yang, V. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402877200 · Cited by 109 · see citing works
Dihlmann, S., Klein, S., & Mv, M. V. K. D. (2003) · PubMed · Cited by 108 · see citing works
Shutting down Wnt signal–activated cancer
Taketo, M. M. (2004) · Nature Genetics · doi:10.1038/ng0404-320 · Cited by 105 · see citing works
Antisensewnt-5a Mimicswnt-1-Mediated C57MG Mammary Epithelial Cell Transformation
Olson, D. J., & Gibo, D. M. (1998) · Experimental Cell Research · doi:10.1006/excr.1998.4030 · Cited by 102 · see citing works
A Wnt- and beta-catenin-dependent pathway for mammalian cardiac myogenesis
Nakamoura, T. (2003) · Medical Entomology and Zoology · Cited by 100 · see citing works
The Tuberin-Hamartin Complex Negatively Regulates β-Catenin Signaling Activity
Mak, B. C., Takemaru, K., Kenerson, H. L., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200473200 · Cited by 99 · see citing works
Levina, E. M., Oren, M., & Ben‐Ze'ev, A. (2004) · Oncogene · doi:10.1038/sj.onc.1207587 · Cited by 94 · see citing works
Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the β-catenin signaling activity
Zhou, L., An, N., Haydon, R. C., Zhou, Q., Cheng, H., Peng, Y., Jiang, W., Luu, H. H., Vanichakarn, P., Szatkowski, J. P., et al. (2003) · Cancer Letters · doi:10.1016/s0304-3835(03)00013-2 · Cited by 90 · see citing works
The wnt-frizzled cascade in cardiovascular disease
van Gijn, M. E. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00221-3 · Cited by 89 · see citing works
Katsu, T., Ujike, H., Nakano, T., Tanaka, Y., Nomura, A., Nakata, K., Takaki, M., Sakai, A., Uchida, N., Imamura, T., et al. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.017 · Cited by 80 · see citing works
Kim, J.-S., Crooks, H., Foxworth, A., & Waldman, T. A. (2002) · PubMed · Cited by 69 · see citing works
Varallo, V. M., Gan, B. S., Seney, S. L., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206415 · Cited by 67 · see citing works
Surendran, K., & Simon, T. C. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00343.2002 · Cited by 55 · see citing works
The Polycystic Kidney Disease-1 Promoter Is a Target of the β-Catenin/T-cell Factor Pathway
Rodova, M., Islam, M. R., Maser, R. L., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203570200 · Cited by 52 · see citing works
Renal development: perspectives on a Wnt-dependent process
Perantoni, A. O. (2003) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(03)00022-3 · Cited by 50 · see citing works
Reversion of uroepithelial cell tumorigenesis by the ectopic expression of human wnt-5a.
Olson, D. J., Gibo, D. M., Saggers, G. C., et al. (1997) · PubMed · Cited by 43 · see citing works
Morin, P. J., & Weeraratna, A. T. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-48158-8_7 · Cited by 33 · see citing works
Ozaki, K., Ohnishi, Y., Iida, A., et al. (2002) · Nature Genetics · doi:10.1038/ng0103-107a · Cited by 17 · see citing works
Manipulating hematopoietic stem cell amplification with Wnt
Eaves, C. J. (2003) · Nature Immunology · doi:10.1038/ni0603-511 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.055 · Cited by 1,377 · see citing works
Regulation of bone mass by Wnt signaling
Krishnan, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28551 · Cited by 1,407 · see citing works
Wnt Signaling: Multiple Pathways, Multiple Receptors, and Multiple Transcription Factors
Gordon, M. D., & Nusse, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600015200 · Cited by 1,333 · see citing works
Function and biological roles of the Dickkopf family of Wnt modulators
Niehrs, C. (2006) · Oncogene · doi:10.1038/sj.onc.1210054 · Cited by 995 · see citing works
Potential Adverse Effects of Resveratrol: A Literature Review
Shaito, A., Posadino, A. M., Younes, N., Hasan, H., Halabi, S., Alhababi, D., Al-Mohannadi, A., Abdel-Rahman, W. M., Eid, A. H., Nasrallah, G. K., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062084 · Cited by 716 · see citing works
Genetic Control of Bone Formation
Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667 · see citing works
β-Catenin destruction complex: insights and questions from a structural perspective
Kimelman, D., & Xu, W. (2006) · Oncogene · doi:10.1038/sj.onc.1210055 · Cited by 628 · see citing works
Königshoff, M., Kramer, M., Balsara, N., Wilhelm, J., Amarie, O. V., Jahn, A., Rose, F., Fink, L., Seeger, W., Schaefer, L., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci33950 · Cited by 558 · see citing works
Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396 · see citing works
Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities
Bhattacharyya, S., Wei, J., & Varga, J. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.149 · Cited by 381 · see citing works
mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging
Castilho, R. M., Squarize, C. H., Chodosh, L. A., Williams, B. O., & Gutkind, J. S. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.06.017 · Cited by 371 · see citing works
Gonsalves, F. C., Klein, K., Carson, B. B., Katz, S., Ekas, L. A., Evans, S., Nagourney, R., Cardozo, T., Brown, A. M. C., & DasGupta, R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1017496108 · Cited by 337 · see citing works
Qiao, L., Xu, Z.-L., Zhao, T.-J., Ye, L.-H., & Zhang, X.-D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.04.032 · Cited by 313 · see citing works
Li, Z., Zhu, S., Liu, Q., Wei, J., Jin, Y., Wang, X., & Zhang, L. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.115025 · Cited by 301 · see citing works
Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation
Chen, J., Park, C. S., & Tang, S.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511920200 · Cited by 298 · see citing works
Osada, T., Chen, M., Yang, X. Y., Spasojevic, I., Vandeusen, J. B., Hsu, D., Clary, B. M., Clay, T. M., Chen, W., Morse, M. A., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3978 · Cited by 271 · see citing works
Ji, H., Wang, J., Nika, H., Hawke, D., Keezer, S., Ge, Q., Fang, B., Fang, X., Fang, D., Litchfield, D. W., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.034 · Cited by 270 · see citing works
In vivo base editing of post-mitotic sensory cells
Yeh, W.-H., Chiang, H., Rees, H. A., Edge, A. S. B., & Liu, D. R. (2018) · Nature Communications · doi:10.1038/s41467-018-04580-3 · Cited by 225 · see citing works
The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway
Hung, C.-C., Chaya, A., Liu, K., Verdelis, K., & Sfeir, C. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.06.001 · Cited by 237 · see citing works
The c‐myc Promoter: Still MysterY and Challenge
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211 · see citing works
Matsuzaki, S., & Darcha, C. (2012) · Human Reproduction · doi:10.1093/humrep/der442 · Cited by 216 · see citing works
Gurley, K. A., Elliott, S. A., Simakov, O., Schmidt, H. A., Holstein, T. W., & Alvarado, A. S. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.007 · Cited by 212 · see citing works
Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
Trigo, C. M., Rodrigues, J. S., Camões, S. P., Solá, S., & Miranda, J. P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2024.05.004 · Cited by 205 · see citing works
“…of the cancer-associated signaling pathways, such as PI3K/AKT [107,113], via upregulation of PTEN, and of WNT/ b - catenin signaling pathway by MSCs-secreted antagonist of the Wnt signaling DKK-1 [114] contributes to the inhibition of tumor cell migration, invasion, and survival [114–118].”
A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities
Handeli, S., & Simon, J. A. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2063 · Cited by 183 · see citing works
Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops
Mullins, C., Fishell, G., & Tsien, R. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.017 · Cited by 167 · see citing works
Wnts in adult brain: from synaptic plasticity to cognitive deficiencies
Oliva, C. A., Vargas, J. Y., & Inestrosa, N. C. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00224 · Cited by 162 · see citing works
Notaras, M., Lodhi, A., Dündar, F., Collier, P., Sayles, N. M., Tilgner, H., Greening, D., & Colak, D. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01316-6 · Cited by 150 · see citing works
Frequent mutations of <i>β‐catenin</i> gene in sporadic secreting adrenocortical adenomas*
Tadjine, M., Lampron, A., Ouadi, L., & Bourdeau, I. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.03033.x · Cited by 153 · see citing works
Xiao, Q., Wu, J., Wang, W.-J., Chen, S., Zheng, Y., Yu, X., Meeth, K., Sahraei, M., Bothwell, A. L. M., Chen, L., et al. (2018) · Nature Medicine · doi:10.1038/nm.4496 · Cited by 130 · see citing works
Farías, G. G., Vallés, A. S., Colombres, M., Godoy, J. A., Toledo, E. M., Lukas, R. J., Barrantes, F. J., & Inestrosa, N. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3934-06.2007 · Cited by 108 · see citing works
Detection of somatic β-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD)
Tadjine, M., Lampron, A., Ouadi, L., Horvath, A., Stratakis, C. A., & Bourdeau, I. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03273.x · Cited by 108 · see citing works
Potential implications of mesenchymal stem cells in cancer therapy
Dai, L.-J., Moniri, M. R., Zeng, Z.-R., Zhou, J. X., Rayat, J., & Warnock, G. L. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.02.012 · Cited by 99 · see citing works
Mesenchymal stem cells and cancer: Friends or enemies?
Hong, I.-S., Lee, H.-Y., & Kang, K.-S. (2014) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2014.01.006 · Cited by 82 · see citing works
Haack, F., Lemcke, H., Ewald, R., Rharass, T., & Uhrmacher, A. M. (2015) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1004106 · Cited by 66 · see citing works
Kokkinopoulos, I., Shahabi, G., Colman, A., & Jeffery, G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018921 · Cited by 58 · see citing works
Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice
Stamatopoulos, A., Stamatopoulos, T., Gamie, Z., Kenanidis, E., Ribeiro, R. D. C., Rankin, K. S., Gerrand, C., Dalgarno, K., & Tsiridis, E. (2019) · Journal of Bone Oncology · doi:10.1016/j.jbo.2019.100231 · Cited by 37 · see citing works
“the development of a variety of human tumours [56,57].”
BackgroundGong, K., Zhou, F., Huang, H., Gong, Y., & Zhang, L. (2012) · Protein & Cell · doi:10.1007/s13238-012-2058-x · Cited by 29 · see citing works
Mutations modifying sporadic Alzheimer’s disease age of onset
Vélez, J. I., Lopera, F., Patel, H. R., Johar, A. S., Cai, Y., Rivera, D., Tobón, C., Villegas, A., Sepulveda‐Falla, D., Lehmann, S. G., et al. (2016) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32493 · Cited by 19 · see citing works
Exploring the mechanistic and temporal regulation of LRP6 endocytosis in canonical WNT signaling
Haack, F., Budde, K., & Uhrmacher, A. M. (2020) · Journal of Cell Science · doi:10.1242/jcs.243675 · Cited by 18 · see citing works
RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry
Patnaik, S. R., Zhang, X., Biswas, L., Akhtar, S., Zhou, X., Kusuluri, D. K., Reilly, J., May-Simera, H., Chalmers, S., McCarron, J. G., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25259 · Cited by 17 · see citing works
- Authors
- Moon, R. T., Kohn, A. D., Ferrari, G. V. D., & Kaykas, A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Moon, Randall T.
- Venue
- Nature Reviews Genetics
- Published
- 2004-09
- Volume
- 5
- Issue
- 9
- Pages
- 691-701
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W1967803088
- Cited by
- 1,763
- References
- 115
- Citations by year
- 2026: 17 · 2025: 33 · 2024: 42 · 2023: 33 · 2022: 40 · 2021: 63 · 2020: 67 · 2019: 74 · 2018: 72 · 2017: 86 · 2016: 88 · 2015: 103 · 2014: 103 · 2013: 110 · 2012: 126
- FWCI
- 6.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- Wnt signaling, β-catenin, cancer, Wnt inhibitors, cancer therapy, stem cells, self-renewal, cell proliferation, cell differentiation, developmental signalling, disease
- MeSH terms
- Animals, Cytoskeletal Proteins, Forecasting, Humans, Neoplasms, Proto-Oncogene Proteins, Signal Transduction, Trans-Activators, Wnt Proteins, beta Catenin
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