Base excision repair and cancer

DNA Repair and Mutagenesis

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

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Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

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Genome-wide association study identifies novel breast cancer susceptibility loci

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Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

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Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors

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Hereditary and Familial Colon Cancer

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Base-excision repair of oxidative DNA damage

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Single-strand break repair and genetic disease

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Structural basis for recognition and repair of the endogenous mutagen 8-oxoguanine in DNA

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Redox activation of Fos‐Jun DNA binding activity is mediated by a DNA repair enzyme.

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MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

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The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

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Requirement of mammalian DNA polymerase-β in base-excision repair

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Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage

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Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells

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Active DNA Demethylation Mediated by DNA Glycosylases

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STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP

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Genome-wide association study identifies five new breast cancer susceptibility loci

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Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair

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Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells

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The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

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Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

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XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro

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An N -Glycosidase from Escherichia coli That Releases Free Uracil from DNA Containing Deaminated Cytosine Residues

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XRCC1 and DNA strand break repair

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Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP

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Cloning and characterization of hOGG1 , a human homolog of the OGG1 gene of Saccharomyces cerevisiae

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DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice

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Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

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A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

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Going APE over ref-1

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Genetic Polymorphisms in the Base Excision Repair Pathway and Cancer Risk: A HuGE Review

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An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III

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Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.

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Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

Hazra, T. K., Izumi, T., Boldogh, I. R., Imhoff, B. R., Kow, Y. W., Jaruga, P., Dizdaroğlu, M., & MITRA, S. P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062053799 · Cited by 497 · see citing works

Uracil in DNA – occurrence, consequences and repair

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AP Endonuclease-Independent DNA Base Excision Repair in Human Cells

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XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein–protein interactions

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Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA

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A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification

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Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

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Molecular Cloning of the Human XRCC1 Gene, Which Corrects Defective DNA Strand Break Repair and Sister Chromatid Exchange

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Polymorphisms of DNA repair genes and risk of non-small cell lung cancer

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Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C->T:A mutations

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The structural basis of specific base-excision repair by uracil–DNA glycosylase

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Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability

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Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage

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The enzymology of apurinic/apyrimidinic endonucleases

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Base excision repair of DNA in mammalian cells

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Molecular cloning and functional expression of a human cDNA encoding the antimutator enzyme 8-hydroxyguanine-DNA glycosylase

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Crystal structure and mutational analysis of human uracil-DNA glycosylase: Structural basis for specificity and catalysis

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Opposite base‐dependent reactions of a human base excision repair enzyme on DNA containing 7,8‐dihydro‐8‐oxoguanine and abasic sites

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Mmh / Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

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Expanded Extracolonic Tumor Spectrum in MUTYH-Associated Polyposis

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hUNG2 Is the Major Repair Enzyme for Removal of Uracil from U:A Matches, U:G Mismatches, and U in Single-stranded DNA, with hSMUG1 as a Broad Specificity Backup

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Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2

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The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity

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Post‐replicative base excision repair in replication foci

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Requirement for theXrcc1DNA Base Excision Repair Gene during Early Mouse Development

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Enzymatic Processing of Radiation-Induced Free Radical Damage in DNA

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Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue.

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Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase

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A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII

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Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice

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DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

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Identification and Characterization of a Novel Human DNA Glycosylase for Repair of Cytosine-derived Lesions

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MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily

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A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer

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The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra‐helical deoxyribose at DNA abasic sites

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Structure and function in the uracil-DNA glycosylase superfamily

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A CHO-cell strain having hypersensitivity to mutagens, a defect in DNA strand-break repair, and an extraordinary baseline frequency of sister-chromatid exchange

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Uracil-DNA Glycosylase (UNG)-Deficient Mice Reveal a Primary Role of the Enzyme during DNA Replication

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The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations.

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Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase

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Base excision DNA repair

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Solution Structure of the Methyl-CpG Binding Domain of Human MBD1 in Complex with Methylated DNA

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Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA

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A Vital Role for Ape1/Ref1 Protein in Repairing Spontaneous DNA Damage in Human Cells

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Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA

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Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III

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Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA

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Oxidative DNA damage repair in mammalian cells: A new perspective

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New class of enzymes acting on damaged DNA

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