Nucleotide metabolism, oncogene-induced senescence and cancer

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

The hallmarks of cancer

Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works

The serial cultivation of human diploid cell strains

Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · cited 2× · see citing works

Cellular senescence: when bad things happen to good cells

Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.

Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650 · see citing works

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,359 · see citing works

The regulation of E2F by pRB-family proteins.

Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317 · see citing works

Four faces of cellular senescence

Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · cited 1× · see citing works

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986 · see citing works

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Di Micco, R., Fumagalli, M., Cicalese, A., Piccinin, S., Gasparini, P., Luise, C., Schurra, C., Garre’, M., Giovanni Nuciforo, P., Bensimon, A., et al. (2006) · Nature · doi:10.1038/nature05327 · Cited by 1,821 · see citing works

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works

Gatekeepers and caretakers

Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/386761a0 · Cited by 1,240 · see citing works

Oncogene-induced senescence as an initial barrier in lymphoma development

Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220 · see citing works

Ribonucleotide Reductases

Nordlund, P., & Reichard, P. A. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142443 · Cited by 1,082 · see citing works

Links between metabolism and cancerPreprint

Dang, C. V. (2012) · Genes & Development · doi:10.1101/gad.189365.112 · Cited by 991 · see citing works

Nucleotide deficiency promotes genomic instability in early stages of cancer development

Bester, A. C., Roniger, M., Oren, Y. S., Im, M. M., Sarni, D., Chaoat, M., Bensimon, A., Zamir, G., Shewach, D. S., & Kerem, B. (2011) · Cell · doi:10.1016/j.cell.2011.03.044 · Cited by 858 · see citing works

INTERACTIONS BETWEEN DEOXYRIBONUCLEOTIDE AND DNA SYNTHESIS

Reichard, P. A. (1988) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.57.070188.002025 · Cited by 773 · see citing works

Glutamine and glutamate—their central role in cell metabolism and function

Newsholme, P., Procópio, J., Lima, M. M. R., Pithon‐Curi, T. C., & Curi, R. (2002) · Cell Biochemistry and Function · doi:10.1002/cbf.1003 · Cited by 706 · see citing works

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.Preprint

Hiebert, S. W., Chellappan, S., Horowitz, J. M., & Nevins, J. R. (1992) · Genes & Development · doi:10.1101/gad.6.2.177 · Cited by 576 · see citing works

Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma Protein

Helin, K., Harlow, E. E., & Fattaey, A. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6501 · Cited by 472 · see citing works

The Biological Significance of Purine Salvage

Murray, A. (1971) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.40.070171.004115 · Cited by 418 · see citing works

The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence

Mallette, F. A., Gaumont-Leclerc, M.-F., & Ferbeyre, G. (2007) · Genes & Development · doi:10.1101/gad.1487307 · Cited by 406 · see citing works

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

Alimonti, A., Nardella, C., Chen, Z., Clohessy, J. G., Carracedo, A., Trotman, L. C., Cheng, K., Varmeh, S., Kozma, S. C., Thomas, G., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40535 · Cited by 374 · see citing works

RecQ helicases: suppressors of tumorigenesis and premature aging

Bachrati, C. Z., & Hickson, I. D. (2003) · Biochemical Journal · doi:10.1042/bj20030491 · Cited by 372 · see citing works

Oncogene-Induced Cell Senescence — Halting on the Road to Cancer

Mooi, W. J., & Peeper, D. S. (2006) · New England Journal of Medicine · doi:10.1056/nejmra062285 · Cited by 371 · see citing works

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity

Finch, R. A., Liu, M., Grill, S. P., Rose, W. C., Loomis, R. H., Vásquez, K. M., Cheng, Y.-C., & Sartorelli, A. C. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00419-0 · Cited by 366 · see citing works

E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.

Flemington, E. K., Speck, S. H., & Kaelin, W. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.15.6914 · Cited by 348 · see citing works

Checking on the fork: the DNA-replication stress-response pathway

Osborn, A. J., Elledge, S. J., & Zou, L. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02380-2 · Cited by 345 · see citing works

Dynamics of DNA Replication in Mammalian Somatic Cells

Anglana, M., Apiou, F., Bensimon, A., & Debatisse, M. (2003) · Cell · doi:10.1016/s0092-8674(03)00569-5 · Cited by 339 · see citing works

Mitochondrial DNA Depletion Syndromes: Review and Updates of Genetic Basis, Manifestations, and Therapeutic Options

El‐Hattab, A. W., & Scaglia, F. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0177-6 · Cited by 336 · see citing works

DNA precursor metabolism and genomic stability

Mathews, C. K. (2006) · The FASEB Journal · doi:10.1096/fj.06-5730rev · Cited by 311 · see citing works

Regulation of Mammalian Ribonucleotide Reduction and dNTP Pools after DNA Damage and in Resting Cells

Håkansson, P., Hofer, A., & Thelander, L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512894200 · Cited by 290 · see citing works

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

Aird, K. M., Zhang, G., Li, H., Tu, Z., Bitler, B. G., Garipov, A., Wu, H., Wei, Z., Wagner, S. N., Herlyn, M., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.004 · Cited by 285 · see citing works

Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits.

Engström, Y., Eriksson, S., Jildevik, I., Skog, S., Thelander, L., & Tribukait, B. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)39337-7 · Cited by 285 · see citing works

Ribonucleotide Reductase Inhibitors and Future Drug Design

Shao, J., Zhou, B., Chu, B. W., & Yen, Y. (2006) · Current Cancer Drug Targets · doi:10.2174/156800906777723949 · Cited by 284 · see citing works

Prognostic Value of Thymidylate Synthase, Ki-67, and p53 in Patients With Dukes’ B and C Colon Cancer: A National Cancer Institute–National Surgical Adjuvant Breast and Bowel Project Collaborative Study

Allegra, C. J., Paik, S. Y., Colangelo, L. H., Parr, A. L., Kirsch, I. R., Kim, G., Klein, P. M., Johnston, P. G., Wolmark, N., & Wieand, H. S. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.05.044 · Cited by 282 · see citing works

DNA replication stress, genome instability and aging

Burhans, W. C., & Weinberger, M. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1059 · Cited by 279 · see citing works

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesisPreprint

Vredeveld, L. C. W., Possik, P. A., Smit, M. A., Meissl, K., Michaloglou, C., Horlings, H. M., Ajouaou, A., Kortman, P. C., Dankort, D. L., McMahon, M., et al. (2012) · Genes & Development · doi:10.1101/gad.187252.112 · Cited by 258 · see citing works

Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools.

Weinberg, G. A., Ullman, B., & Martin, D. W. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.4.2447 · Cited by 228 · see citing works

Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis.

Bianchi, V., Pontis, E., & Reichard, P. A. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66672-4 · Cited by 224 · see citing works

Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity

Finch, R. A., Liu, M., Cory, A. H., Cory, J. G., & Sartorelli, A. C. (1999) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(98)00017-x · Cited by 223 · see citing works

The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells

Meuth, M. (1989) · Experimental Cell Research · doi:10.1016/0014-4827(89)90090-6 · Cited by 219 · see citing works

Iron Chelators for the Treatment of Cancer

Yu, Y., Gutierrez, E., Kovačević, Ž., Saletta, F., Obeidy, P., Rahmanto, Y. S., & Richardson, D. R. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800609706 · Cited by 188 · see citing works

RRM1 and PTEN As Prognostic Parameters for Overall and Disease-Free Survival in Patients With Non–Small-Cell Lung Cancer

Bepler, G., Sharma, S., Cantor, A. B., Gautam, A., Haura, E. B., Simon, G. R., Sharma, A., Sommers, E., & Robinson, L. A. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.12.002 · Cited by 179 · see citing works

Thymidylate synthase as an oncogene

Rahman, L., Voeller, D. M., Rahman, M., Lipkowitz, S., Allegra, C. J., Barrett, J. C., Kaye, F. J., & Zajac‐Kaye, M. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00080-7 · Cited by 179 · see citing works

The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer

Jordheim, L. P., Sève, P., Trédan, O., & Dumontet, C. (2010) · The Lancet Oncology · doi:10.1016/s1470-2045(10)70244-8 · Cited by 164 · see citing works

Gene Expression Levels as Predictive Markers of Outcome in Pancreatic Cancer after Gemcitabine-Based Adjuvant Chemotherapy

Fujita, H., Ohuchida, K., Mizumoto, K., Itaba, S., Ito, T., Nakata, K., Yu, J., Kayashima, T., Souzaki, R., Tajiri, T., et al. (2010) · Neoplasia · doi:10.1593/neo.10458 · Cited by 154 · see citing works

Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma

Nutting, C. M., van Herpen, C. M. L., Miah, A. B., Bhide, S. A., Machiels, J.-P., Buter, J., Kelly, C., Raucourt, D. D., & Harrington, K. J. (2009) · Annals of Oncology · doi:10.1093/annonc/mdn775 · Cited by 147 · see citing works

Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response

Zhang, Y., Jones, T. L., Martin, S. E., Caplen, N. J., & Pommier, Y. G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003020 · Cited by 146 · see citing works

RRM1-induced metastasis suppression through PTEN-regulated pathways

Gautam, A., Li, Z.-R., & Bepler, G. (2003) · Oncogene · doi:10.1038/sj.onc.1206232 · Cited by 142 · see citing works

Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools

Kimura, T., Takeda, S., Sagiya, Y., Gotoh, M., Nakamura, Y., & Arakawa, H. (2003) · Nature Genetics · doi:10.1038/ng1212 · Cited by 141 · see citing works

Oncogene-Induced Senescence Pathways Weave an Intricate Tapestry

Yaswen, P., & Campisi, J. (2007) · Cell · doi:10.1016/j.cell.2007.01.005 · Cited by 138 · see citing works

Hydroxyurea: a key player in cancer chemotherapy

Madaan, K., Kaushik, D., & Verma, T. (2011) · Expert Review of Anticancer Therapy · doi:10.1586/era.11.175 · Cited by 133 · see citing works

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescencePreprint

Aksoy, O., Chicas, A., Zeng, T., Zhao, Z., McCurrach, M. E., Wang, X., & Lowe, S. W. (2012) · Genes & Development · doi:10.1101/gad.196238.112 · Cited by 127 · see citing works

Prognostic importance of thymidylate synthase expression in early breast cancer.

Pestalozzi, B. C., Peterson, H. F., Gelber, R. D., Goldhirsch, A., Gusterson, B. A., Trihia, H., Lindtner, J., Cortés-Funes, H., Simmoncini, E., Byrne, M., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.5.1923 · Cited by 123 · see citing works

Nucleic Acids, Purines, Pyrimidines (Nucleotide Synthesis)

Hartman, S. C., & Buchanan, J. M. (1959) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.28.070159.002053 · Cited by 121 · see citing works

The Control of Nucleotide Biosynthesis

Blakley, R. L., & Vitols, E. (1968) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.37.070168.001221 · Cited by 120 · see citing works

Pharmacokinetics and Pharmacodynamics of Hydroxyurea

Gwilt, P. R., & Tracewell, W. G. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199834050-00002 · Cited by 115 · see citing works

New ribonucleotide reductase inhibitors with antineoplastic activity.

Elford, H. L., Wampler, G. L., & Riet, B. V. (1979) · PubMed · Cited by 114 · see citing works

DNA Replication Stress Is a Determinant of Chronological Lifespan in Budding Yeast

Weinberger, M., Li, F., Paul, A., Smith, D. L., Hontz, R. D., Smith, J. S., Vujcic, M., Singh, K. K., Huberman, J. A., & Burhans, W. C. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000748 · Cited by 109 · see citing works

Ribonucleotide reductase inhibitors: new strategies for cancer chemotherapy

Nocentini, G. (1996) · Critical Reviews in Oncology/Hematology · doi:10.1016/1040-8428(95)00187-5 · Cited by 108 · see citing works

Overview of Ribonucleotide Reductase Inhibitors: An Appealing Target in Anti-Tumour Therapy

Cerqueira, N. M. F. S. A., Pereira, S. R., Fernandes, P. A., & Ramos, M. J. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867054020981 · Cited by 104 · see citing works

EPR stopped-flow studies of the reaction of the tyrosyl radical of protein r2 from ribonucleotide reductase with hydroxyurea

Laßmann, G., Thelander, L., & Gräslund, A. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91138-g · Cited by 102 · see citing works

Ddb1 controls genome stability and meiosis in fission yeastPreprint

Holmberg, C., Fleck, O., Hansen, H. A., Liu, C., Slaaby, R., Carr, A. M., & Nielsen, O. (2005) · Genes & Development · doi:10.1101/gad.329905 · Cited by 100 · see citing works

The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments

Fan, H., Huang, A., Villegas, C., & Wright, J. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13181 · Cited by 100 · see citing works

Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers

Liu, X., Zhang, H., Lai, L. L., Wang, X., Loera, S., Xue, L., Hui-yin, H., Zhang, K., Hu, S., Huang, Y., et al. (2012) · Clinical Science · doi:10.1042/cs20120240 · Cited by 94 · see citing works

Ribonucleotide Reductase: A Critical Enzyme for Cancer Chemotherapy and Antiviral Agents

Cerqueira, N. M. F. S. A., & Ramos, M. J. (2007) · Recent Patents on Anti-Cancer Drug Discovery · doi:10.2174/157489207779561408 · Cited by 93 · see citing works

Broad Overexpression of Ribonucleotide Reductase Genes in Mice Specifically Induces Lung Neoplasms

Xu, X., Page, J. L., Surtees, J. A., Liu, H., Lagedrost, S. J., Lu, Y., Bronson, R. T., Alani, E., Nikitin, A. Y., & Weiss, R. S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5873 · Cited by 91 · see citing works

Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers

Kunos, C. A., Radivoyevitch, T., Waggoner, S. E., Debernardo, R., Zanotti, K. M., Resnick, K. E., Fusco, N. L., Adams, R., Redline, R. W., Faulhaber, P., et al. (2013) · Gynecologic Oncology · doi:10.1016/j.ygyno.2013.04.019 · Cited by 87 · see citing works

Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome

CHABOSSEAU, P. L., Buhagiar‐Labarchède, G., Onclercq, R., Lambert, S., Debatisse, M., Brison, O., & Amor-Guéret, M. (2011) · Nature Communications · doi:10.1038/ncomms1363 · Cited by 84 · see citing works

Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence

Mannava, S., Moparthy, K., Wheeler, L. J., Natarajan, V., Zucker, S. N., Fink, E. E., Im, M. M., Flanagan, S. A., Burhans, W. C., Zeitouni, N. C., et al. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.09.011 · Cited by 83 · see citing works

A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

Attia, S., Kolesar, J., Mahoney, M. R., Pitot, H. C., Laheru, D. A., Heun, J. M., Huang, W., Eickhoff, J. C., Erlichman, C., & Holen, K. D. (2008) · Investigational New Drugs · doi:10.1007/s10637-008-9123-6 · Cited by 81 · see citing works

Adults with RRM2B-related mitochondrial disease have distinct clinical and molecular characteristics

Pitceathly, R. D. S., Smith, C., Fratter, C., Alston, C. L., He, L., Craig, K., Blakely, E. L., Evans, J., Taylor, J. M., Shabbir, Z., et al. (2012) · Brain · doi:10.1093/brain/aws231 · Cited by 81 · see citing works

Rothmund–Thomson syndrome and RECQL4 defect: Splitting and lumping

Larizza, L., Magnani, I., & Roversi, G. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.07.042 · Cited by 80 · see citing works

Suppression of Lung Tumor Formation by the Regulatory Subunit of Ribonucleotide Reductase

Gautam, A., & Bepler, G. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4462 · Cited by 80 · see citing works

Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents

Elford, H. L., Riet, B. V., Wampler, G. L., Lin, A. L., & Elford, R. M. (1981) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(81)90014-5 · Cited by 80 · see citing works

Ribonucleotide Reductase Small Subunit M2B Prognoses Better Survival in Colorectal Cancer

Liu, X., Lai, L. L., Wang, X., Xue, L., Leora, S., Wu, J., Hu, S., Zhang, K., Kuo, M.-L., Zhou, L., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0054 · Cited by 66 · see citing works

Biochemical and antitumor activity of trimidox, a new inhibitor of ribonucleotide reductase

Szekeres, T., Gharehbaghi, K., Fritzer, M., Woody, M. J., Srivastava, A., Riet, B. V., Jayaram, H. N., & Elford, H. L. (1994) · Cancer Chemotherapy and Pharmacology · doi:10.1007/bf00686113 · Cited by 61 · see citing works

Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease

Dobrovolsky, V. N., Bucci, T. J., Heflich, R. H., Desjardins, J. P., & Richardson, F. C. (2003) · Molecular Genetics and Metabolism · doi:10.1016/s1096-7192(02)00224-x · Cited by 58 · see citing works

Ribonucleotide reductase as a chemotherapeutic target

Cory, J. G. (1988) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(88)90030-1 · Cited by 56 · see citing works

Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer

Aird, K. M., Li, H., Xin, F., Konstantinopoulos, P. A., & Zhang, R. (2013) · Cell Cycle · doi:10.4161/cc.26953 · Cited by 55 · see citing works

Functional Regulation of Mammalian Ribonucleotide Reductase

Elford, H. L. (1972) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(72)90004-0 · Cited by 54 · see citing works

Hydroxyurea (NSC-32065) in biologic fluids: dose-concentration relationship.

Beckloff, G. L., Lerner, H. J., Frost, D., Russo‐Alesi, F. M., & Gitomer, S. D. (1965) · PubMed · Cited by 51 · see citing works

Expression of p53R2 Is Related to Prognosis in Patients with Esophageal Squamous Cell Carcinoma

Okumura, H., Natsugoe, S., Yokomakura, N., Kita, Y., Matsumoto, M., Uchikado, Y., Setoyama, T., Owaki, T., Ishigami, S., & Aikou, T. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2416 · Cited by 50 · see citing works

Elevated Levels of Thymidylate Synthase Linked to Neoplastic Transformation of Mammalian Cells

Voeller, D. M., Rahman, L., & Zajac‐Kaye, M. (2004) · Cell Cycle · doi:10.4161/cc.3.8.1064 · Cited by 48 · see citing works

Gene Expression Analysis in Human Breast Cancer Associated Blood Vessels

Jones, D. T., Lechertier, T., Mitter, R., Herbert, J. M. J., Bicknell, R., Jones, J. L., Li, J., Buffa, F. M., Harris, A. L., & Hodivala‐Dilke, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044294 · Cited by 43 · see citing works

Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma

Yanamoto, S., Kawasaki, G., Yoshitomi, I., & Mizuno, A. (2003) · Cancer Letters · doi:10.1016/s0304-3835(02)00588-8 · Cited by 39 · see citing works

GENETIC DEFECTS IN HUMAN PURINE AND PYRIMIDINE METABOLISM

Boss, G. R., & Seegmiller, J. E. (1982) · Annual Review of Genetics · doi:10.1146/annurev.ge.16.120182.001501 · Cited by 35 · see citing works

P53R2, p53 inducible ribonucleotide reductase gene, correlated with tumor progression of non-small cell lung cancer.

Uramoto, H., Sugio, K., Oyama, T., Hanagiri, T., & Yasumoto, K. (2006) · PubMed · Cited by 34 · see citing works

Predictive and prognostic roles of ribonucleotide reductase M1 in resectable pancreatic adenocarcinoma

Xie, H., Jiang, W., Jiang, J., Wang, Y., Kim, R., Liu, X., & Liu, X. (2012) · Cancer · doi:10.1002/cncr.27715 · Cited by 31 · see citing works

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

Mannava, S., Moparthy, K., Wheeler, L. J., Leonova, K. I., Wawrzyniak, J. A., Bianchi, A., Berman, A. E., Flanagan, S. A., Shewach, D. S., Zeitouni, N. C., et al. (2012) · Aging · doi:10.18632/aging.100512 · Cited by 30 · see citing works

Management of 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone-Induced Methemoglobinemia

Kunos, C. A., Radivoyevitch, T., Ingalls, S. T., & Hoppel, C. L. (2012) · Future Oncology · doi:10.2217/fon.11.147 · Cited by 30 · see citing works

Chromosomal Instability Triggered by Rrm2b Loss Leads to IL-6 Secretion and Plasmacytic Neoplasms

Chang, L., Guo, R., Huang, Q. M., & Yen, Y. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.040 · Cited by 28 · see citing works

A Phase I/II study of GTI-2040 and capecitabine in patients with renal cell carcinoma

Stadler, W. M., Desai, A. A., Quinn, D. I., Bukowski, R. M., Poiesz, B. J., Kardinal, C. G., Lewis, N. L., Makalinao, A., Murray, P., & Torti, F. M. (2007) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-007-0524-6 · Cited by 27 · see citing works

A phase II study of the antisense oligonucleotide GTI-2040 plus docetaxel and prednisone as first-line treatment in castration-resistant prostate cancer

Sridhar, S. S., Canil, C. M., Chi, K. N., Hotte, S. J., Ernst, S., Wang, L. E., Chen, E. X., Juhasz, A. N., Yen, Y., Murray, P., et al. (2010) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-010-1389-7 · Cited by 27 · see citing works

Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas

Chen, M., Rahman, L., Voeller, D. M., Kastanos, E. K., Yang, S. X., Feigenbaum, L., Allegra, C. J., Kaye, F. J., Steeg, P. S., & Zajac‐Kaye, M. (2007) · Oncogene · doi:10.1038/sj.onc.1210273 · Cited by 26 · see citing works

Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study

Kunos, C. A., Radivoyevitch, T., Abdul‐Karim, F. W., Fanning, J., Abulafia, O., Bonebrake, A. J., & Usha, L. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-79 · Cited by 25 · see citing works

Ribonucleotide Reductase Large Subunit M1 Predicts Poor Survival Due to Modulation of Proliferative and Invasive Ability of Gastric Cancer

Wang, Q., Liu, X., Zhou, J., Huang, Y., Zhang, S., Shen, J., Loera, S., Yuan, X., Chen, W., Jin, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070191 · Cited by 25 · see citing works

Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer.

Pešta, M., Kulda, V., Fiala, O., Šafránek, J., Topolčan, O., Krákorová, G., Cerny, R., & Pešek, M. (2012) · PubMed · Cited by 21 · see citing works

Electron transfer in N-hydroxyurea complexes with iron(III)

Nigović, B., Kujundžić, N., & Sanković, K. (2004) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2004.09.012 · Cited by 19 · see citing works

A Phase I/II Study of GTI-2040 Plus Docetaxel as Second-Line Treatment in Advanced Non-small Cell Lung Cancer: A Study of the PMH Phase II Consortium

Leighl, N. B., Laurie, S. A., Chen, X. E., Ellis, P., Shepherd, F. A., Knox, J. J., Goss, G. D., Burkes, R. L., Pond, G. R., Dick, C., et al. (2009) · Journal of Thoracic Oncology · doi:10.1097/jto.0b013e3181a949b2 · Cited by 18 · see citing works

p53R2 is a prognostic factor of melanoma and regulates proliferation and chemosensitivity of melanoma cells

Matsushita, S., Ikeda, R., Fukushige, T., Tajitsu, Y., Gunshin, K., Okumura, H., Ushiyama, M., Akiyama, S., Kawai, K., Takeda, Y., et al. (2012) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2012.07.005 · Cited by 17 · see citing works

Purine Nucleotide Imbalance in Immunodeficiency Disorders

Ammann, A. J. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2449-2_32 · Cited by 9 · see citing works

p53R2 expression as a prognostic biomarker in early stage non-small cell lung cancer

Hsu, N., Wu, J., Liu, X., Yen, Y., Chen, C., Chou, M., Lee, H., & Cheng, Y. (2010) · Oncology Letters · doi:10.3892/ol_00000108 · Cited by 8 · see citing works

Effects of cytosine arabinoside and hydroxyurea on the synthesis of deoxyribonucleotides and DNA replication in L1210 cells

Masahiko, M., Rey, D. A., & Cory, J. G. (1990) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(90)90008-p · Cited by 8 · see citing works

Mechanisms and Regulation of Cellular Senescence

Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395 · see citing works

Biomarkers in Cancer Detection, Diagnosis, and Prognosis

Das, S., Dey, M. K., Devireddy, R. V., & Gartia, M. R. (2023) · Sensors · doi:10.3390/s24010037 · Cited by 445 · see citing works

Redox control of senescence and age-related disease.

Chandrasekaran, A., Idelchik, M. D. P. S., & Melendez, J. A. (2017) · Redox Biology · doi:10.1016/j.redox.2016.11.005 · Cited by 360 · see citing works

Advances in umami taste and aroma of edible mushrooms

Sun, L., Zhang, Z., Xin, G., Sun, B., Bao, X., Wei, Y., Zhao, X., & Xu, H. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.12.018 · Cited by 321 · see citing works

Tumor suppressor p53 and metabolism

Liu, J., Zhang, C., Hu, W., & Feng, Z. (2018) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjy070 · Cited by 298 · see citing works

Critical Functions of the Lysosome in Cancer Biology

Davidson, S. M., & Heiden, M. G. V. (2016) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103101 · Cited by 209 · see citing works

Nucleotide imbalance decouples cell growth from cell proliferation

Diehl, F. F., Miettinen, T. P., Elbashir, R., Nabel, C. S., Darnell, A. M., Do, B. T., Manalis, S. R., Lewis, C. A., & Heiden, M. G. V. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00965-1 · Cited by 201 · see citing works

Deoxyribonucleotide metabolism, mutagenesis and cancer

Mathews, C. K. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3981 · Cited by 200 · see citing works

Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy

Wu, H., Gong, Y., Ji, P., Xie, Y., Jiang, Y.-Z., & Liu, G. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01263-x · Cited by 192 · see citing works

The role of lysosomes in cancer development and progression

Tang, T., Yang, Z., Wang, D., Yang, X., Wang, J., Li, L., Wen, Q., Gao, L., Bian, X., & Yu, S. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00489-x · Cited by 169 · see citing works

The lncRNA lincNMR regulates nucleotide metabolism via a YBX1 - RRM2 axis in cancer

Gandhi, M., Groß, M., Holler, J. M., Coggins, S. A., Patil, N., Leupold, J. H., Munschauer, M., Schenone, M., Hartigan, C. R., Allgayer, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17007-9 · Cited by 143 · see citing works

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability

Guervilly, J.-H., Takedachi, A., Naim, V., Scaglione, S., Chawhan, C., Lovera, Y., Despras, E., Kuraoka, I., Kannouche, P. L., Rosselli, F., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.11.014 · Cited by 137 · see citing works

Regulation of nucleotide metabolism in cancers and immune disorders

Ali, E. S., & Ben‐Sahra, I. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.03.003 · Cited by 131 · see citing works

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications

Kohnken, R. A., Kodigepalli, K. M., & Wu, L. J. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0446-6 · Cited by 120 · see citing works

The roles of sirtuins family in cell metabolism during tumor development

Zhu, S., Dong, Z., Ke, X., Hou, J., Zhao, E., Zhang, K., Wang, F., Yang, L., Xiang, Z., & Cui, H. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.11.003 · Cited by 113 · see citing works

Dysregulation of de novo nucleotide biosynthetic pathway enzymes in cancer and targeting opportunities

Robinson, A. D., Eich, M., & Varambally, S. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.013 · Cited by 104 · see citing works

Toxicological effects of microplastics in Litopenaeus vannamei as indicated by an integrated microbiome, proteomic and metabolomic approach

Duan, Y., Xiong, D., Wang, Y., Zhang, Z., Li, H., Dong, H., & Zhang, J. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143311 · Cited by 104 · see citing works

The FHIT gene product: tumor suppressor and genome “caretaker”

Waters, C. E., Saldivar, J. C., Hosseini, S. A., & Huebner, K. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1722-0 · Cited by 98 · see citing works

Suppression of p16 alleviates the senescence-associated secretory phenotype

(2021) · doi:10.18632/aging.202640 · Cited by 84 · see citing works

Deoxyribonucleotide Triphosphate Metabolism in Cancer and Metabolic Disease

Buj, R., & Aird, K. M. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00177 · Cited by 74 · see citing works

The roles of ferroptosis regulatory gene SLC7A11 in renal cell carcinoma: A multi‐omics study

Xu, F., Guan, Y., Li, X., Zhang, P., Li, M., Gao, M., & Chong, T. (2021) · Cancer Medicine · doi:10.1002/cam4.4395 · Cited by 73 · see citing works

TOR coordinates nucleotide availability with ribosome biogenesis in plants

Busche, M., Scarpin, M. R., Hnasko, R. M., & Brunkard, J. O. (2021) · The Plant Cell · doi:10.1093/plcell/koab043 · Cited by 68 · see citing works

Emerging roles of nucleotide metabolism in cancer development: progress and prospect

Ma, J., Zhong, M., Xiong, Y., Gao, Z., Wu, Z., Liu, Y., & Hong, X. (2021) · Aging · doi:10.18632/aging.202962 · Cited by 66 · see citing works

Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

Buj, R., Chen, C., Dahl, E. S., Leon, K. E., Kuskovsky, R., Maglakelidze, N., Navaratnarajah, M., Zhang, G., Doan, M. T., Jiang, H., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.084 · Cited by 64 · see citing works

Metabolic Reprogramming in Cancer is Induced to Increase Proton Production.

Sun, H., Zhou, Y., Skaro, M., Wu, Y.-R., Qu, Z.-X., Mao, F., Zhao, S.-W., & Xu, Y. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3392 · Cited by 54 · see citing works

HPV31 utilizes the ATR-Chk1 pathway to maintain elevated RRM2 levels and a replication-competent environment in differentiating Keratinocytes

Anacker, D. C., Aloor, H. L., Shepard, C., Lenzi, G. M., Johnson, B. A., Kim, B., & Moody, C. A. (2016) · Virology · doi:10.1016/j.virol.2016.09.028 · Cited by 60 · see citing works

RaMP: A Comprehensive Relational Database of Metabolomics Pathways for Pathway Enrichment Analysis of Genes and Metabolites

Zhang, B., Hu, S., Baskin, E., Patt, A. C., Siddiqui, J., & Mathé, E. A. (2018) · Metabolites · doi:10.3390/metabo8010016 · Cited by 59 · see citing works

Metabolomics in bladder cancer: a systematic review.

Cheng, Y., Yang, X. F., Deng, X., Zhang, X., Li, P., Tao, J., Qin, C., Wei, J., & Lü, Q. (2015) · PubMed Central · Cited by 59 · see citing works

Preharvest and postharvest applications of 1-MCP affect umami taste and aroma profiles of mushrooms (Flammulina velutipes)

Xia, R., Wang, L., Xin, G., Bao, X., Sun, L., Xu, H., & Hou, Z. (2021) · LWT · doi:10.1016/j.lwt.2021.111176 · Cited by 54 · see citing works

Cellular senescence or stemness: hypoxia flips the coin

Otero-Albiol, D., & Carnero, A. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02035-0 · Cited by 53 · see citing works

SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity

Mauney, C. H., & Hollis, T. (2018) · Autoimmunity · doi:10.1080/08916934.2018.1454912 · Cited by 50 · see citing works

Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion

Elliott, I. A., Dann, A. M., Xu, S., Kim, S. S., Abt, E. R., Kim, W., Poddar, S., Moore, A. M., Zhou, L., Williams, J. L., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812410116 · Cited by 50 · see citing works

Generation of Osteosarcomas from a Combination of Rb Silencing and c-Myc Overexpression in Human Mesenchymal Stem Cells

Wang, J., Wu, P., Chen, P. C.-H., Lee, C.-W., Chen, W., & Hung, S. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0226 · Cited by 49 · see citing works

Advance in the role of chemokines/chemokine receptors in carcinogenesis: Focus on pancreatic cancer

Song, N., Cui, K., Zeng, L., Li, M., Fan, Y., Shi, P., Wang, Z., Su, W., & Wang, H. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176357 · Cited by 48 · see citing works

IntLIM: integration using linear models of metabolomics and gene expression data

Siddiqui, J., Baskin, E., Liu, M., Cantemir-Stone, C. Z., Zhang, B., Bonneville, R., McElroy, J. P., Coombes, K. R., & Mathé, E. A. (2018) · BMC Bioinformatics · doi:10.1186/s12859-018-2085-6 · Cited by 48 · see citing works

Klotho‐mediated targeting of CCL 2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments

Liu, Y., Pan, J., Pan, X., Wu, L., Bian, J., Lin, Z., Xue, M., Su, T., Lai, S., Chen, F., et al. (2019) · Molecular Oncology · doi:10.1002/1878-0261.12577 · Cited by 48 · see citing works

Targeting cancer-specific metabolic pathways for developing novel cancer therapeutics

Pal, S., Sharma, A. K., Mathew, S. P., & Jaganathan, B. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.955476 · Cited by 49 · see citing works

Resveratrol stimulates the metabolic reprogramming of human CD4 + T cells to enhance effector function

Craveiro, M., Cretenet, G., Mongellaz, C., Matias, M. I., Caron, O., de Lima, M. C. P., Zimmermann, V. S., Solary, É., Dardalhon, V., Dulić, V., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aal3024 · Cited by 46 · see citing works

Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegansPreprint

Chi, C., Ronai, D., Than, M. T., Walker, C. J., Sewell, A. K., & Han, M. (2016) · Genes & Development · doi:10.1101/gad.275107.115 · Cited by 46 · see citing works

Metabolic alterations accompanying oncogene-induced senescence

Aird, K. M., & Zhang, R. (2014) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.963481 · Cited by 39 · see citing works

Combined effects of salinity and polystyrene microplastics exposure on the Pacific oysters Crassostrea gigas: Oxidative stress and energy metabolism

Du, Y., Zhao, J., Teng, J., Ren, J., Shan, E., Zhu, X., Zhang, W., Wang, L., Hou, C., & Wang, Q. (2023) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2023.115153 · Cited by 43 · see citing works

Connecting the dots: investigating the link between environmental, genetic, and epigenetic influences in metabolomic alterations in oral squamous cell carcinoma

Gupta, I., Badrzadeh, F., Tsentalovich, Y. P., & Gaykalova, D. A. (2024) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03141-5 · Cited by 41 · see citing works

Unveiling functional heterogeneity in breast cancer multicellular tumor spheroids through single-cell RNA-seq

Muciño-Olmos, E. A., Vázquez-Jiménez, A., de León, U. A.-P., Matadamas-Guzman, M. L., Maldonado, V., López-Santaella, T., Hernández‐Hernández, A., & Reséndis-Antonio, O. (2020) · Scientific Reports · doi:10.1038/s41598-020-69026-7 · Cited by 39 · see citing works

Emerging methods and techniques for cancer biomarker discovery

Dakal, T. C., Dhakar, R., Beura, A., Moar, K., Maurya, P. K., Sharma, N. K., Ranga, V., & Kumar, A. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155567 · Cited by 39 · see citing works

Drug repositioning for non-small cell lung cancer by using machine learning algorithms and topological graph theory

Huang, C., Chang, P. M., Hsu, C.-W., Huang, C. F., & Ng, K. (2016) · BMC Bioinformatics · doi:10.1186/s12859-015-0845-0 · Cited by 36 · see citing works

SAMHD1 Specifically Affects the Antiviral Potency of Thymidine Analog HIV Reverse Transcriptase Inhibitors

Ballana, E., Badía, R., Terradas, G., Torres‐Torronteras, J., Ruiz, A., Pauls, E., Riveira‐Muñoz, E., Clotet, B., Martí, R., & Esté, J. A. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03145-14 · Cited by 35 · see citing works

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral Response

Antonucci, J. M., Gelais, C. S., & Wu, L. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01541 · Cited by 31 · see citing works

Targeting RRM2 and Mutant BRAF Is a Novel Combinatorial Strategy for Melanoma

Fatkhutdinov, N., Sproesser, K., Krepler, C., Liu, Q., Brafford, P. A., Herlyn, M., Aird, K. M., & Zhang, R. (2016) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-16-0099 · Cited by 31 · see citing works

The intra-S phase checkpoint directly regulates replication elongation to preserve the integrity of stalled replisomes

Liu, Y., Wang, L., Xu, X., Yuan, Y., Zhang, B., Li, Z., Xie, Y., Yan, R., Zheng, Z., Ji, J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2019183118 · Cited by 29 · see citing works

Metabolomics identifies the intersection of phosphoethanolamine with menaquinone-triggered apoptosis in an in vitro model of leukemia

Suganthagunthalam, D., Dinh, N.-T., Skolnick, J., & Styczynski, M. P. (2015) · Molecular BioSystems · doi:10.1039/c5mb00237k · Cited by 30 · see citing works

A longitudinal analysis of the effects of age on the blood plasma metabolome in the common marmoset, Callithrix jacchus

Hoffman, J. M., Tran, V., Wachtman, L. M., Green, C. L., Jones, D. P., & Promislow, D. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.01.007 · Cited by 29 · see citing works

Metabolomic analysis of short-term sulfamethazine exposure on marine medaka ( Oryzias melastigma ) by comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry

Liu, Y., Wang, X., Li, Y., & Chen, X. (2018) · Aquatic Toxicology · doi:10.1016/j.aquatox.2018.03.006 · Cited by 30 · see citing works

An Overview of Molecular Cancer Pathogenesis, Prognosis, and Diagnosis

Cullen, J. M., & Breen, M. (2016) · Wiley eBooks · doi:10.1002/9781119181200.ch1 · Cited by 31 · see citing works

Microflora and umami alterations of different packaging material preserved mushroom (Flammulina filiformis) during cold storage

Fang, D., Wang, C., Deng, Z., Ma, N., Hu, Q., & Zhao, L. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110481 · Cited by 29 · see citing works

Understanding the interplay between dNTP metabolism and genome stability in cancer

Yagüe-Capilla, M., & Rudd, S. G. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050775 · Cited by 30 · see citing works

Analysis of the expression of metabolism-related genes and histopathology of the hepatopancreas of white shrimp Litopenaeus vannamei fed with aflatoxin B1

Zhao, W., Wang, M., Wang, L., Liu, M., Jiang, K., Xia, S., Qi, C., & Wang, B. (2017) · Aquaculture · doi:10.1016/j.aquaculture.2017.11.044 · Cited by 28 · see citing works

Genome-Resolved Metaproteomic Analysis of Microbiota and Metabolic Pathways Involved in Taste Formation During Chinese Traditional Fish Sauce (Yu-lu) Fermentation

Wang, Y., Wu, Y., Li, C., Zhao, Y., Xiang, H., Li, L., Yang, X., Chen, S., Sun, L., & Qi, B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.851895 · Cited by 27 · see citing works

Comprehensive analysis of the ubiquitinome during oncogene-induced senescence in human fibroblasts

Bengsch, F., Tu, Z., Tang, H., Zhu, H., Speicher, D. W., & Zhang, R. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1026492 · Cited by 27 · see citing works

A Metabolomics Pilot Study on Desmoid Tumors and Novel Drug Candidates

Mercier, K., Al‐Jazrawe, M., Poon, R. W. M., Acuff, Z., & Alman, B. A. (2018) · Scientific Reports · doi:10.1038/s41598-017-18921-7 · Cited by 27 · see citing works

Activity and electrochemical properties: iron complexes of the anticancer drug triapine and its analogs

Plamthottam, S., Sun, D. L., Valkenburgh, J. S. V., Valenzuela, J., Ruehle, B., Steele, D., Poddar, S., Marshalik, M., Hernandez, S., Radu, C. G., et al. (2019) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-019-01675-0 · Cited by 25 · see citing works

Spatial transcriptome and single-cell reveal the role of nucleotide metabolism in colorectal cancer progression and tumor microenvironment

Liu, J., Li, H., Wang, L., Wang, S., & Tang, Q. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05495-y · Cited by 24 · see citing works

Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer

Wu, W., Zhao, Y., Qin, B., Jiang, X. M., Wang, C., Hu, R., Ma, R., Lee, M., Liu, H., Li, K., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104650 · Cited by 24 · see citing works

Apoptotic transition of senescent cells accompanied with mitochondrial hyper-function

Wang, D., Liu, Y., Zhang, R., Zhang, F., Sui, W., Chen, L., Zheng, R., Chen, X., Wen, F., Ouyang, H., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8536 · Cited by 24 · see citing works

Exceptionally Selective and Tunable Sensing of Guanine Derivatives and Analogues by Structural Complementation in a G‐Quadruplex

Li, X., Zheng, K., Hao, Y., & Tan, Z. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201607195 · Cited by 24 · see citing works

Glucose metabolism and its direct action in cancer and immune regulation: opportunities and challenges for metabolic targeting

Pan, B., Hsu, C.-C., Wu, H., Chen, Y.-R., Zhou, X., Wang, S., Li, C., & Lin, H.-K. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01167-1 · Cited by 24 · see citing works

Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

Nile, D. L., Rae, C. J., Walker, D. J., Waddington, J. C., Vincent, I. M., Burgess, K. E., Gaze, M. N., Mairs, R. J., & Chalmers, A. J. (2021) · Cancer & Metabolism · doi:10.1186/s40170-021-00258-5 · Cited by 22 · see citing works

PAICS as a potential target for cancer therapy linking purine biosynthesis to cancer progression

Ma, A. H., & Xiong, X. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122070 · Cited by 22 · see citing works

Small RNA Sequencing Uncovers New miRNAs and moRNAs Differentially Expressed in Normal and Primary Myelofibrosis CD34+ Cells

Guglielmelli, P., Bisognin, A., Saccoman, C., Mannarelli, C., Coppe, A., Vannucchi, A. M., & Bortoluzzi, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140445 · Cited by 21 · see citing works

Pharmacological Modulation of SAMHD1 Activity by CDK4/6 Inhibitors Improves Anticancer Therapy

Castellví, M., Felip, E., Ezeonwumelu, I. J., Badía, R., García-Vidal, E., Pujantell, M., Gutiérrez-Chamorro, L., Teruel, I., Martínez‐Cardús, A., Clotet, B., et al. (2020) · Cancers · doi:10.3390/cancers12030713 · Cited by 21 · see citing works

Pre- and Post-Resection Urine Metabolic Profiles of Bladder Cancer Patients: Results of Preliminary Studies on Time Series Metabolomics Analysis

Jacyna, J., Kordalewska, M., Artymowicz, M., Markuszewski, M., Matuszewski, M., & Matuszewski, M. (2022) · Cancers · doi:10.3390/cancers14051210 · Cited by 19 · see citing works

Control of Nucleotide Metabolism Enables Mutant p53’s Oncogenic Gain-of-Function Activity

Schmidt, V. A., Nagar, R., & Martinez, L. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122759 · Cited by 19 · see citing works

Loss of p16: A Bouncer of the Immunological Surveillance?

Leon, K. E., Tangudu, N. K., Aird, K. M., & Buj, R. (2021) · Life · doi:10.3390/life11040309 · Cited by 19 · see citing works

Integrated transcriptomics and metabolomics analyses to investigate the anticancer mechanisms of cinobufagin against liver cancer through interfering with lipid, amino acid, carbohydrate, and nucleotide metabolism

Yang, A., Wu, Q., Wang, A.-M., Chen, Q., Yang, J., Tao, Y., Sun, Y., & Zhang, J. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.106229 · Cited by 18 · see citing works

Discovering the strength of immunometabolism in cancer therapy: Employing metabolic pathways to enhance immune responses

Huldani, H., Malviya, J., Rodrigues, P., Hjazi, A. M., Deorari, M. M., Al‐Hetty, H. R. A. K., Qasim, Q. A., Alasheqi, M. Q., & Ihsan, A. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.3934 · Cited by 18 · see citing works

A new insight into cell biological and biochemical changes through aging

Sahabi, S., Jafari-Gharabaghlou, D., & Zarghami, N. (2022) · Acta Histochemica · doi:10.1016/j.acthis.2021.151841 · Cited by 16 · see citing works

Suppression of Ribose-5-Phosphate Isomerase a Induces ROS to Activate Autophagy, Apoptosis, and Cellular Senescence in Lung Cancer

Nieh, Y., Chou, Y., Chou, Y., Wang, C., Lin, S., Ciou, S., Yuh, C., & Wang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147883 · Cited by 17 · see citing works

Characterization of the urinary metabolic profile of cholangiocarcinoma in a United Kingdom population

Alsaleh, M., Barbera, T. A., Reeves, H. L., Cramp, M., Ryder, S. D., Gabra, H., Nash, K. L., Shen, E. Y.-L., Holmes, E. C., Williams, R. L., et al. (2019) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s193996 · Cited by 16 · see citing works

Selenoproteins and the senescence-associated epitranscriptome

Lee, M. Y., Ojeda-Britez, S., Ehrbar, D. J., Samwer, A., Begley, T. J., & Melendez, J. A. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702221116592 · Cited by 15 · see citing works

Commonalities in Metabolic Reprogramming between Tobacco Use and Oral Cancer

Rushing, B. R., Tilley, S., Molina, S., Schroder, M., & Sumner, S. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191610261 · Cited by 14 · see citing works

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis

Kafer, G. R., & Cesare, A. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00416 · Cited by 12 · see citing works

RRM1 gene expression evaluated in the liquid biopsy (blood cfRNA) as a non-invasive, predictive factor for radiotherapy-induced oral mucositis and potential prognostic biomarker in head and neck cancer patients

Mlak, R., Powrózek, T., Brzozowska, A., Homa‐Mlak, I., Mazurek, M., & Malecka-Massalska, T. J. (2018) · Cancer Biomarkers · doi:10.3233/cbm-171082 · Cited by 13 · see citing works

Chromosomal instability causes sensitivity to protein folding stress and ATP depletion

Khan, M., Shaukat, Z., Saint, R. B., & Gregory, S. L. (2018) · Biology Open · doi:10.1242/bio.038000 · Cited by 13 · see citing works

The cGAS/STING signaling pathway: a cross-talk of infection, senescence and tumors

Zeng, P.-H., & Yin, W.-J. (2022) · Cell Cycle · doi:10.1080/15384101.2022.2109899 · Cited by 12 · see citing works

MYBL2 regulates de novo purine synthesis by transcriptionally activating IMPDH1 in hepatocellular carcinoma cells

Zhao, J., Wang, W., Liu, T., Zhang, L., Lin, D., Yao, J., Peng, X., Jin, G., Ma, T.-T., Gao, J., et al. (2022) · BMC Cancer · doi:10.1186/s12885-022-10354-4 · Cited by 12 · see citing works

Lysosomes, curcumin, and anti-tumor effects: how are they linked?

Shen, Q., Pan, X., Li, Y., Li, J., Zhang, C.-L., Jiang, X.-C., Liu, F., & Pang, B. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1220983 · Cited by 12 · see citing works

Acetate drives ovarian cancer quiescence via ACSS2-mediated acetyl-CoA production

Sharrow, A. C., Megill, E., Chen, A. J., Farooqi, A., Tangudu, N. K., Uboveja, A., McGonigal, S. C., Hempel, N., Snyder, N. W., Buckanovich, R. J., et al. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102031 · Cited by 11 · see citing works

Multi-omics analysis defines 5-fluorouracil drug resistance in 3D HeLa carcinoma cell model

Wang, L., Wang, X., Wang, T., Zhuang, Y., & Wang, G. (2021) · Bioresources and Bioprocessing · doi:10.1186/s40643-021-00486-z · Cited by 11 · see citing works

De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression

Tangudu, N. K., Buj, R., Wang, H., Wang, J., Cole, A. R., Uboveja, A., Fang, R. S., Amalric, A., Yang, B., Chatoff, A. G., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0450 · Cited by 13 · see citing works

Thymidylate synthase accelerates Men1-mediated pancreatic tumor progression and reduces survival

Vijayakurup, V., Maeng, K., Lee, H. S., Meyer, B. S., Burkett, S. S., Nawab, A., Dougherty, M. W., Jobin, C., Mahmud, I., Garrett, T. J., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.147417 · Cited by 10 · see citing works

Novel GIRlncRNA Signature for Predicting the Clinical Outcome and Therapeutic Response in NSCLC

Zhang, Q., Liu, X., Chen, Z., & Zhang, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.937531 · Cited by 9 · see citing works

Highly Specific Recognition of Guanosine Using Engineered Base‐Excised Aptamers

Li, Y., & Liu, J. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202001835 · Cited by 9 · see citing works

Human Mitochondrial Protein HSPD1 Binds to and Regulates the Repair of Deoxyinosine in DNA

Zheng, X., Chang, S., Liu, Y., Dai, X., & You, C. (2023) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00854 · Cited by 8 · see citing works

Decreased expression of JMJD3 predicts poor prognosis of patients with clear cell renal cell carcinoma

Wang, J., Liu, L., Long, Q., Bai, Q., Xia, Y., Xi, W., Xu, J., & Guo, J. (2017) · Oncology Letters · doi:10.3892/ol.2017.6362 · Cited by 8 · see citing works

Exceptionally Selective and Tunable Sensing of Guanine Derivatives and Analogues by Structural Complementation in a G‐Quadruplex

Li, X., Zheng, K., Hao, Y., & Tan, Z. (2016) · Angewandte Chemie · doi:10.1002/ange.201607195 · Cited by 8 · see citing works

WEE1 inhibitor exerts synergistic effect with KRAS G12C inhibitor via MYBL2-RRM2 axis in KRASG12C-mutant lung cancer

Zhou, C., Liu, Y., Liu, H., Lü, J., Zhang, B., Zhu, L., Wang, S., Lei, H.-M., & Han, B. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07992-4 · Cited by 6 · see citing works

Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia

Zhong, W., Ma, L., Yang, F., Cao, J., Tan, J., & Li, B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1027441 · Cited by 6 · see citing works

DNA repair and replicative stress addiction in neuroblastoma

Durinck, K., & Irwin, M. S. (2024) · EJC Paediatric Oncology · doi:10.1016/j.ejcped.2024.100177 · Cited by 5 · see citing works

S‐Methyl Methanethiosulfonate, the Main Human Metabolite of S‐Methyl‐L‐Cysteine Sulfoxide, Alters Energy Metabolism in Prostate Cancer Cells

Beasy, G., Bernuzzi, F., Day-Walsh, P. E., Tronsco‐Rey, P., Defernez, M., Saha, S., Mithen, R. F., Τράκα, Μ., & Kroon, P. A. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70008 · Cited by 5 · see citing works

Metabolic Regulator IAPP (Amylin) Is Required for BRAF and RAS Oncogene-Induced Senescence

Garnett, S., de Bruyns, A., Provencher-Tom, V., Dutchak, K., Shu, R., & Dankort, D. L. (2021) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0879 · Cited by 5 · see citing works

Shewanella phage encoding a putative anti-CRISPR-like gene represents a novel potential viral family

Wang, H.-Y., Zheng, K., Wang, M., Ma, K., Ren, L., Guo, R., Ma, L., Zhang, H., Liu, Y., Xiong, Y., et al. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.03367-23 · Cited by 5 · see citing works

Perturbation of nucleotide metabolism - the driving force of oncogene-induced senescence

Darżynkiewicz, Z. (2013) · Oncotarget · doi:10.18632/oncotarget.1023 · Cited by 5 · see citing works

Metabolic alterations accompanying oncogene-induced senescence

Aird, K. M., & Zhang, R. (2014) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.963481 · Cited by 39 · see citing works

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

Aird, K. M., Zhang, G., Li, H., Tu, Z., Bitler, B. G., Garipov, A., Wu, H., Wei, Z., Wagner, S. N., Herlyn, M., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.004 · Cited by 285 · see citing works

ATM in senescence

Aird, K. M., & Zhang, R. (2015) · Oncotarget · doi:10.18632/oncotarget.4411 · Cited by 15 · see citing works

The DNA Damage Signaling Pathway Connects Oncogenic Stress to Cellular Senescence

Mallette, F. A., & Ferbeyre, G. (2007) · Cell Cycle · doi:10.4161/cc.6.15.4516 · Cited by 125 · see citing works