Cited by 63Pancreatic and Hepatic Oncology ResearchPancreatic function and diabetesNeuroendocrine Tumor Research Advances

VNN1, a potential biomarker for pancreatic cancer-associated new-onset diabetes, aggravates paraneoplastic islet dysfunction by increasing oxidative stress

Kang, Muxing, Qin, Wenjie, Buya, Miranbieke, Dong, Xin, Zheng, Wen, Lu, Wenjie, Chen, Jian, Guo, Qingqu +1 more·2016·Cancer Letters

Abstract

In our previous clinical microarray analysis, we were the first to report on Vanin-1 (VNN1) as a novel clinically derived biomarker of pancreatic cancer-associated new-onset diabetes (PCAND). The functional mechanisms of VNN1 in the pathogenesis of PCAND, however, are not completely understood. In the present study, we further extend our previous clinical study to include laboratory research. The functions and mechanisms of neoplastic overexpressed VNN1 in PCAND have been explored using a co-culture model. Furthermore, the serum concentrations and discrimination power of downstream molecules of VNN1 were tested in a PCAND cohort. Pancreatic ductal adenocarcinoma (PDA) overexpressed VNN1 further aggravates paraneoplastic islet dysfunction; decreases in GSH/PPAR-γ concentrations and increases in ROS/cysteamine might be primary cause of this effect. Clinical serum analyses revealed that the expression profiles of these molecules were aberrant in the PCAND group. Our results further demonstrated that PCAND is a type of paraneoplastic diabetes. As the only clinically derived biomarker for PCAND screening available today, the biological role of VNN1 in triggering oxidative stress within the pancreatic microenvironment is important. The molecules downstream of VNN1 are also potential biomarkers for PCAND screening.

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Crossref · 10.1016/j.canlet.2015.12.031

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Authors
Kang, M., Qin, W., Buya, M., Dong, X., Zheng, W., Lu, W., Chen, J., Guo, Q., & Wu, Y.
Affiliations
Second Affiliated Hospital of Zhejiang University (CN)
Corresponding author
Wu, Yulian
Venue
Cancer Letters
Publisher
Elsevier BV
Published
2016-04
Volume
373
Issue
2
Pages
241-250
ISSN
0304-3835 (ISSN-L)
OpenAlex
W2253972966
Cited by
63
References
40
Citations by year
2026: 5 · 2025: 9 · 2024: 10 · 2023: 14 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1
FWCI
1.44
Type
journal article
Language
en
Open access
closed
Locations
  • Cancer Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81172158, 81272332, 81301889, 81001094, 81372620)
Topics
  • Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Epidemiology › Neuroendocrine Tumor Research Advances
Keywords
vanin-1, pancreatic ductal adenocarcinoma, oxidative stress, pancreatic islet dysfunction, glutathione, PPARγ, reactive oxygen species, cysteamine, biomarkers, serum biomarkers
MeSH terms
Adenocarcinoma, Aged, Amidohydrolases, Animals, Cysteamine, Diabetes Mellitus, Female, Glutathione, Humans, Islets of Langerhans, Middle Aged, Pancreatic Neoplasms, Paraneoplastic Syndromes, Biomarkers, Oxidative Stress, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, PPAR gamma, Mice, GPI-Linked Proteins

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