Probability of Pancreatic Cancer Following Diabetes: A Population-Based Study
Open accessAbstract
Background & aims Although diabetes occurs frequently in pancreatic cancer, the value of new-onset diabetes as a marker of underlying pancreatic cancer is unknown. Methods We assembled a population-based cohort of 2122 Rochester, Minnesota, residents age > or =50 years who first met standardized criteria for diabetes between January 1, 1950, and December 31, 1994, and identified those who developed pancreatic cancer within 3 years of meeting criteria for diabetes. We compared observed rates of pancreatic cancer with expected rates based on the Iowa Surveillance Epidemiology and End Results registry. In a nested case control study, we compared body mass index (BMI) and smoking status in diabetes subjects with and without pancreatic cancer. Results Of 2122 diabetic subjects, 18 (0.85%) were diagnosed with pancreatic cancer within 3 years of meeting criteria for diabetes; 10 of 18 (56%) were diagnosed <6 months after first meeting criteria for diabetes, and 3 were resected. The observed-to-expected ratio of pancreatic cancer in the cohort was 7.94 (95% CI, 4.70-12.55). Compared with subjects without pancreatic cancer, diabetic subjects with pancreatic cancer were more likely to have met diabetes criteria after age 69 (OR = 4.52, 95% CI, 1.61-12.74) years but did not differ significantly with respect to BMI values (29.2 +/- 6.8 vs 26.5 +/- 5.0, respectively). A larger proportion of those who developed pancreatic cancer were ever smokers (92% vs 69%, respectively), but this did not reach statistical significance. Conclusions Approximately 1% of diabetes subjects aged > or =50 years will be diagnosed with pancreatic cancer within 3 years of first meeting criteria for diabetes. The usefulness of new-onset diabetes as marker of early pancreatic cancer needs further evaluation.
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For sporadic pancreatic cancer, there is currently only one HRG and that is glycemically defined NOD.
“For sporadic pancreatic cancer, there is currently only one HRG and that is glycemically defined NOD.68,71”
From Artificial Intelligence and Early Detection of Pancreatic Cancer: 2020 Summative Review (2021) · cites this paper as [71]
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- Authors
- Chari, S. T., Leibson, C. L., Rabe, K. G., Ransom, J., de Andrade, M., & Petersen, G. M.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Chari, Suresh T.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 129
- Issue
- 2
- Pages
- 504-511
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC2377196
- OpenAlex
- W4229835970
- Cited by
- 603
- References
- 0
- Citations by year
- 2026: 28 · 2025: 34 · 2024: 34 · 2023: 36 · 2022: 39 · 2021: 40 · 2020: 35 · 2019: 30 · 2018: 36 · 2017: 32 · 2016: 26 · 2015: 27 · 2014: 32 · 2013: 29 · 2012: 22
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P50CA102701, R01CA100685, P20 CA 10270)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- pancreatic cancer, diabetes mellitus, new-onset diabetes, cancer risk, body mass index, smoking, cancer screening marker, older adults, Rochester, Minnesota
- MeSH terms
- Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Pancreatic Neoplasms, Probability, Prognosis, Reference Values, Severity of Illness Index, United States, Cohort Studies, Comorbidity, Incidence, Confidence Intervals, Odds Ratio, Survival Analysis, Case-Control Studies, Age Distribution, Sex Distribution, Risk Assessment
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